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1. 发明授权

US06534275B1 Cellubrevin homologs 失效
公开(公告)号：US06534275B1
公开(公告)日：2003-03-18
申请号：US09483665
申请日：2000-01-14
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
IPC分类号： G01N3353
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

2. 发明授权

US6060239A Cellubrevin homologs 失效
公开(公告)号：US6060239A
公开(公告)日：2000-05-09
申请号：US621018
申请日：1996-03-22
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer , Lynn E. Murry
IPC分类号： G01N33/566 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C07H21/04 , C12N15/00 , C12N15/63 , C12N15/85
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel cellubrevins (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cbs, expression vectors for the production of purified CBs, antibodies capable of binding specifically to CBs, hybridization probes or oligonucleotides for the detecting the induction of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CBs, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CBs.

3. 发明授权

US06303297B1 Database for storage and analysis of full-length sequences 失效
标题翻译：数据库用于存储和分析全长序列
公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译：本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。

4. 发明授权

US5854413A Synaptogyrin homolog 失效
标题翻译：突触体蛋白同源物
公开(公告)号：US5854413A
公开(公告)日：1998-12-29
申请号：US700637
申请日：1996-04-30
申请人： Phillip R. Hawkins , Susan G. Stuart , Lynn E. Murry
发明人： Phillip R. Hawkins , Susan G. Stuart , Lynn E. Murry
IPC分类号： A61K38/00 , C07K14/47 , C12P21/02 , C07H21/04 , C12N5/10 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a polynucleotide (snpg) initially isolated from a colon cDNA library which identifies and encodes a novel human synaptogyrin homolog (SNPG). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SNPG. The invention also provides for the use of SNPG in the membrane of a vesicle containing a chemical or biological therapeutic composition for the treatment of disease, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the abnormal or excess expression of SNPG. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of snpg, or anti-SNPG antibodies which specifically bind to the polypeptide, SNPG.
摘要翻译：本发明提供了最初从结肠cDNA文库中分离的多核苷酸（snpg），其鉴定并编码新的人类突触蛋白同源物（SNPG）。本发明提供了包含编码SNPG的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了SNPG在含有用于治疗疾病的化学或生物治疗组合物的囊泡的膜中的用途，以及用于治疗相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途与SNPG的异常或过量表达。本发明还描述了使用包含与多肽，其片段或其互补序列的基因组序列或snpg的转录物或特异性结合多肽SNPG的抗SNPG抗体杂交的诊断组合物的诊断测定法。

5. 发明授权

US5650280A Cellubrevin homolog 失效
标题翻译： Cellubrevin同系物
公开(公告)号：US5650280A
公开(公告)日：1997-07-22
申请号：US409373
申请日：1995-03-23
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel cellubrevin (cb). The present invention also provides for antisense molecules to the nucleotide sequences which encode cb, expression vectors for the production of purified CB, antibodies capable of binding specifically to CB, hybridization probes or oligonucleotides for the detecting the upregulation of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CB, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CB.
摘要翻译：本发明提供了鉴定和编码新型纤维连翘蛋白（cb）的核苷酸和氨基酸序列。本发明还提供编码cb的核苷酸序列的反义分子，用于产生纯化的CB的表达载体，能够特异性结合CB的抗体，用于检测CB编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程用于表达CB的宿主细胞，基于编码CB的核酸分子和能够特异性结合CB的抗体的活化的，发炎的或患病的细胞和/或组织的诊断测试。

6. 发明授权

US5843719A Cellubrevin homolog 失效
标题翻译： Cellubrevin同系物
公开(公告)号：US5843719A
公开(公告)日：1998-12-01
申请号：US897429
申请日：1997-07-21
申请人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
发明人： Susan G. Stuart , Phillip R. Hawkins , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , C12P21/06 , C07H21/04 , C07K1/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel cellubrevin (CB). The present invention also provides for antisense molecules to the nucleotide sequences which encode CB, expression vectors for the production of purified CB, antibodies capable of binding specifically to CB, hybridization probes or oligonucleotides for detecting the upregulation of CB encoding nucleotide sequences, genetically engineered host cells for the expression of CB, diagnostic tests for activated, inflamed or diseased cells and/or tissues based on CB-encoding nucleic acid molecules and antibodies capable of binding specifically to CB.
摘要翻译：本发明提供了鉴定和编码新型纤维连翘蛋白（CB）的核苷酸和氨基酸序列。本发明还提供编码CB的核苷酸序列的反义分子，用于产生纯化的CB的表达载体，能够特异性结合CB的抗体，用于检测CB编码核苷酸序列上调的杂交探针或寡核苷酸的遗传工程宿主用于表达CB的细胞，基于编码CB的核酸分子和能够特异性结合CB的抗体的活化，发炎或患病细胞和/或组织的诊断测试。

7. 发明授权

US6015883A Rantes homolog from prostate 失效
标题翻译：来自前列腺的Rantes同系物
公开(公告)号：US6015883A
公开(公告)日：2000-01-18
申请号：US936772
申请日：1997-09-24
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/19
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多核苷酸（PTEC），其鉴定并编码新的人类群同系物PTEC（前列腺表达的趋化因子）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

8. 发明授权

US5948626A Method of detecting human phospholipase inhibitor 失效
标题翻译：检测人磷脂酶抑制剂的方法
公开(公告)号：US5948626A
公开(公告)日：1999-09-07
申请号：US153751
申请日：1998-09-15
申请人： Phillip R. Hawkins , Lynn E. Murry
发明人： Phillip R. Hawkins , Lynn E. Murry
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6876 , C07K14/4703 , A61K38/00 , C12Q2600/158
摘要： The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.
摘要翻译：本发明提供了一种多核苷酸（gipl），其部分序列最初从THP-1 cDNA文库中分离，并鉴定并编码新的人磷脂酶抑制剂（GIPL）。本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。另外，本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。

9. 发明授权

US5811520A Human phospholipase inhibitor protein 失效
标题翻译：人类磷脂酶抑制蛋白
公开(公告)号：US5811520A
公开(公告)日：1998-09-22
申请号：US919706
申请日：1997-08-29
申请人： Phillip R. Hawkins , Lynn E. Murry
发明人： Phillip R. Hawkins , Lynn E. Murry
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/09 , C12Q1/68 , C07K1/00
CPC分类号： C12Q1/6876 , C07K14/4703 , A61K38/00 , C12Q2600/158
摘要： The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.
摘要翻译：本发明提供了一种多核苷酸（gipl），其部分序列最初从THP-1 cDNA文库中分离，并鉴定并编码新的人磷脂酶抑制剂（GIPL）。本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。另外，本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。

10. 发明授权

US5712115A Human cell death-associated protein 失效
标题翻译：人类细胞死亡相关蛋白
公开(公告)号：US5712115A
公开(公告)日：1998-01-27
申请号：US618164
申请日：1996-03-19
申请人： Phillip R. Hawkins , Scott Michael Braxton , Lynn E. Murry
发明人： Phillip R. Hawkins , Scott Michael Braxton , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P19/00 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/02 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/50 , G01N33/53 , C07H21/04 , C12N15/00 , C12N15/63
CPC分类号： C07K14/4747 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a human cell death-associated protein (cdap) which was isolated from a rheumatoid synovium library. The invention provides for genetically engineered expression vectors and host cells comprising a nucleic acid sequence encoding CDAP. The invention also provides for the therapeutic use of purified CDAP, cdap or its antisense molecules, or CDAP inhibitors in pharmaceutical compositions and for treatment of conditions or diseases associated with expression of CDAP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供鉴定和编码从类风湿滑膜文库中分离的人细胞死亡相关蛋白（cdap）的多核苷酸。本发明提供了基因工程表达载体和宿主细胞，其包含编码CDAP的核酸序列。本发明还提供了药物组合物中纯化的CDAP，cdap或其反义分子或CDAP抑制剂的治疗用途以及用于治疗与CDAP表达相关的病症或疾病。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

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