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    • 3. 发明授权
    • RANTES homolog antibody
    • RANTES同系物抗体
    • US06238666B1
    • 2001-05-29
    • US09395918
    • 1999-09-14
    • Phillip R. HawkinsOlga BandmanLynn E. Murry
    • Phillip R. HawkinsOlga BandmanLynn E. Murry
    • A61K39395
    • C07K14/523A61K38/00A61K48/00C12N2799/026Y10S930/14
    • The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a human rantes homolog (PTEC). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
    • 本发明提供从前列腺cDNA文库分离的多核苷酸(PTEC),其鉴定并编码人类群同系物(PTEC)。 本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途,以及用于治疗与PTEC表达相关的病症或疾病的反义分子,抗体,拮抗剂或抑制剂的治疗用途。 本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。
    • 4. 发明授权
    • DNA encoding a cytokine
    • 编码细胞因子的DNA
    • US06204021B1
    • 2001-03-20
    • US08792013
    • 1997-01-31
    • Olga BandmanPhillip R. HawkinsLynn E. MurrySurya K. Goli
    • Olga BandmanPhillip R. HawkinsLynn E. MurrySurya K. Goli
    • C12N1500
    • C07K14/52
    • The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHC and a method for producing NHC. The invention also provides for use of NHC and agonists, antibodies, or antagonists specifically binding NHC, in the prevention and treatment of diseases associated with expression of NHC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHC for the treatment of diseases associated with the expression of NHC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHC.
    • 本发明提供新型人细胞因子(单独命名为NHC-1和NHC-2,统称为NHC)和识别和编码NHC的多核苷酸。 本发明还提供了包含编码NHC的核酸序列和生产NHC的方法的遗传工程表达载体和宿主细胞。 本发明还提供使用NHC和特异性结合NHC的激动剂,抗体或拮抗剂来预防和治疗与NHC表达有关的疾病。 另外,本发明提供了将反义分子用于编码NHC的多核苷酸用于治疗与NHC表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHC的抗体的诊断测定法。
    • 7. 发明授权
    • Method of detecting human phospholipase inhibitor
    • 检测人磷脂酶抑制剂的方法
    • US5948626A
    • 1999-09-07
    • US153751
    • 1998-09-15
    • Phillip R. HawkinsLynn E. Murry
    • Phillip R. HawkinsLynn E. Murry
    • G01N33/53A61K31/7088A61K38/00A61K45/00A61K48/00A61P25/28C07K14/47C07K16/18C12N1/15C12N1/19C12N1/21C12N5/10C12N9/99C12N15/09C12Q1/68
    • C12Q1/6876C07K14/4703A61K38/00C12Q2600/158
    • The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.
    • 本发明提供了一种多核苷酸(gipl),其部分序列最初从THP-1 cDNA文库中分离,并鉴定并编码新的人磷脂酶抑制剂(GIPL)。 本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。 另外,本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。 本发明还描述了利用包含多核苷酸,其片段或其互补物的诊断组合物的诊断测定法,其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。
    • 8. 发明授权
    • Human phospholipase inhibitor protein
    • 人类磷脂酶抑制蛋白
    • US5811520A
    • 1998-09-22
    • US919706
    • 1997-08-29
    • Phillip R. HawkinsLynn E. Murry
    • Phillip R. HawkinsLynn E. Murry
    • G01N33/53A61K31/7088A61K38/00A61K45/00A61K48/00A61P25/28C07K14/47C07K16/18C12N1/15C12N1/19C12N1/21C12N5/10C12N9/99C12N15/09C12Q1/68C07K1/00
    • C12Q1/6876C07K14/4703A61K38/00C12Q2600/158
    • The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.
    • 本发明提供了一种多核苷酸(gipl),其部分序列最初从THP-1 cDNA文库中分离,并鉴定并编码新的人磷脂酶抑制剂(GIPL)。 本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。 本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。 另外,本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。 本发明还描述了利用包含多核苷酸,其片段或其互补物的诊断组合物的诊断测定法,其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。