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1. 发明申请

US20070244131A1 2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 有权
公开(公告)号：US20070244131A1
公开(公告)日：2007-10-18
申请号：US11735751
申请日：2007-04-16
申请人： Sungtaek Lim , Keith Harris , David Stefany , Charles Gardner , Bin Cao , Ray Boffey , Timothy Gillespy , Joacy Aguiar , Hazel Dyke , Elsa Dechaux
发明人： Sungtaek Lim , Keith Harris , David Stefany , Charles Gardner , Bin Cao , Ray Boffey , Timothy Gillespy , Joacy Aguiar , Hazel Dyke , Elsa Dechaux
IPC分类号： A61K31/506 , C07D239/47 , C07D239/48 , C07D239/52
CPC分类号： C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention is directed to a compound of Formula (I) wherein Cy1, Cy2, L1, L2, and R1 are as defined herein, a pharmaceutical composition comprising a pharmaceutically effective amount of one or more compounds according to Formula (I) in admixture with a pharmaceutically acceptable carrier, and a method of treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like by administering to said patient a pharmaceutically effective amount of a compound according to Formula (I).

2. 发明申请

US20070099955A1 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS 失效
标题翻译： 3-PIPERIDINYLISOCHROMAN-5-OLS作为DOPAMINE AGONISTS
公开(公告)号：US20070099955A1
公开(公告)日：2007-05-03
申请号：US11552169
申请日：2006-10-24
申请人： Gregory Shutske , Keith Harris , Kenneth Bordeau , Michael Angelastro , Stanly John , Joseph Klein , Jinqi Lu , Catherine Bomont
发明人： Gregory Shutske , Keith Harris , Kenneth Bordeau , Michael Angelastro , Stanly John , Joseph Klein , Jinqi Lu , Catherine Bomont
IPC分类号： A61K31/4709 , A61K31/452 , C07D405/02
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds of formula I: a stereoisomer or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, X and n are defined as defined herein. Additionally, a method for treating dopamine-related neurological disorders selected form the group consisting of neurological, psychological, cardiovascular, cognitive or attention disorders, substance abuse and addictive behavior, or a combination thereof, comprising administering to a patient in need of such treatment a therapeutically effective amount of compounds of formula I.
摘要翻译：本发明提供式I化合物：其立体异构体或其药学上可接受的盐，其中R 1，R 2，R 3， R 4，X和n定义如本文所定义。另外，一种治疗多巴胺相关神经系统疾病的方法，其选自神经学，心理学，心血管学，认知或注意障碍，药物滥用和成瘾行为或其组合，其包括向需要这种治疗的患者施用治疗有效量的式I化合物。

3. 发明申请

US20060049267A1 Water control fixture having thermostatically controlled bypass valve 审中-公开
公开(公告)号：US20060049267A1
公开(公告)日：2006-03-09
申请号：US11203913
申请日：2005-08-16
申请人： Ken Lum , Dale Kempf , Keith Harris
发明人： Ken Lum , Dale Kempf , Keith Harris
IPC分类号： G05D23/12
CPC分类号： F24D17/0078 , E03B7/045 , E03B7/09 , F16K31/002 , G05D23/022 , G05D23/134 , Y02A20/411 , Y10T137/6416 , Y10T137/6497
摘要： A water control fixture having an operating valve and a thermostatically controlled bypass valve disposed in the fixture for bypassing water away from the fixture until the water temperature reaches a desired level. When pressurized water from the hot water heater reaches the desired temperature level at the fixture, the bypass valve closes and hot water is made available to the fixture. The bypass valve has a thermal actuator element that is thermally responsive to the temperature of the water. The fixture can have a housing with an interior chamber for operatively receiving the bypass valve. Various passages or channels can be provided to facilitate communication between the bypass valve and the water supply lines. Alternatively, the bypass valve can be positioned in the operating valve, including the moveable ball and the replaceable cylindrical valving cartridge types. A system using the in-fixture bypass valve is also provided.

4. 发明授权

US06536464B1 Thermostatically controlled bypass valve and water circulating system for same 有权
标题翻译：恒温控制旁通阀和水循环系统相同
公开(公告)号：US06536464B1
公开(公告)日：2003-03-25
申请号：US09697520
申请日：2000-10-25
申请人： Ken Lum , Dale Kempf , Keith Harris
发明人： Ken Lum , Dale Kempf , Keith Harris
IPC分类号： F16K4900
CPC分类号： E03B7/09 , E03B7/045 , Y10T137/6497
摘要： A thermostatically controlled bypass valve for bypassing water away from a hot water valve until the water temperature reaches a desired level at a fixture in use for home or industrial applications. The bypass valve has a valve body with a thermally sensitive actuator disposed between the hot water inlet and discharge ports and the cold water inlet and discharge ports that is thermally responsive to the temperature of the water. A bias spring pushes against the piston on the thermal actuator to close the actuator and open a passage between the cold and hot water sides when water needs to be bypassed. When the water from the hot water heater reaches the desired temperature level at the bypass valve, the bypass valve closes and hot water is made available to the hot water side of the fixture. Until then, the thermal actuator remains open and cold or tepid water is allowed to bypass the hot water side of the fixture. Flexible hoses attach the inlet and discharge ports on the hot and cold water sides to the hot and cold water supply systems and the hot and cold water valves on the fixture. A check valve can be placed on the cold water side to prevent the flow of cold water through the bypass valve when only the hot water side is flowing. The bypass valve can used as part of a water circulating system having a pump placed in the hot water piping system that can also include a pump check valve for bypassing high flows around the pump and a flow rate switch for turning off the pump. The bypass valve can be incorporate integrally into the fixture.
摘要翻译：一个恒温控制的旁通阀，用于将水从热水阀旁通，直到水温在用于家庭或工业应用的夹具处于期望水平。旁通阀具有阀体，其具有设置在热水入口和排出口之间的热敏致动器以及对水的温度热响应的冷水入口和排出口。当需要旁路水时，偏置弹簧推动热致动器上的活塞以关闭致动器并在冷水和热水侧之间打开通道。当热水加热器的水达到旁通阀所需的温度水平时，旁通阀关闭，并将热水供应到固定装置的热水侧。在此之前，热致动器保持打开状态，冷水或温水允许绕过固定装置的热水侧。柔性软管将热水和冷水侧的入口和出口端口连接到冷热水供应系统和固定装置上的冷热水阀。只有热水侧流动时，止回阀可以放置在冷水侧，以防止冷水流过旁通阀。旁通阀可用作水循环系统的一部分，其具有放置在热水管道系统中的泵，其还可以包括用于绕过泵周围的高流量的泵止回阀和用于关闭泵的流量开关。旁通阀可以整体地结合到固定装置中。

5. 外观设计

USD691816S1 Film with repeating surface pattern 有权
公开(公告)号：USD691816S1
公开(公告)日：2013-10-22
申请号：US29425580
申请日：2012-06-25
申请人： Gregory Haverfield , Mark Eilers , Keith Harris , Thomas Schweiss
设计人： Gregory Haverfield , Mark Eilers , Keith Harris , Thomas Schweiss

6. 发明授权

US08033164B2 Corrosion testing apparatus and method 失效
标题翻译：腐蚀试验装置及方法
公开(公告)号：US08033164B2
公开(公告)日：2011-10-11
申请号：US12334760
申请日：2008-12-15
申请人： Daniel L. Dermody , Keith Harris , David A. Hayes
发明人： Daniel L. Dermody , Keith Harris , David A. Hayes
IPC分类号： G01N17/00
CPC分类号： G01N17/043
摘要： The present invention relates to an apparatus and method as described in the specification and drawings for parallel high throughput corrosion testing and electroplating testing of test coupons.
摘要翻译：本发明涉及用于并行高通量腐蚀试验和试样电镀试验的说明书和附图中所述的装置和方法。

7. 发明授权

US07992578B2 Hair treatment device 有权
标题翻译：头发处理装置
公开(公告)号：US07992578B2
公开(公告)日：2011-08-09
申请号：US11646901
申请日：2006-12-28
申请人： Andrew J Tobias , Keith Harris
发明人： Andrew J Tobias , Keith Harris
IPC分类号： A45D2/40
CPC分类号： A45D1/12
摘要： A new hair treatment device is provided for providing lift at the root portion of the hair near the scalp to thereby create volume and body to otherwise limp or flat hair. An embodiment of such a device includes first and second arms. A pivot movably joining the arms about the pivot is provided wherein each arm includes a hair-engaging surface. A heat source is provided for at least one of the hair-engaging surfaces. Each hair-engaging surface has a width suitable for treating a portion of the hair proximate the head, wherein by treating a portion of hair near the scalp, it provides lift and body to the head of hair. A method for adding lift to a head of hair using a hair crimping tool includes the steps of selecting hair from a head of hair for treatment; and using the tool to treat at least one portion of the selected hair proximate the roots of the hairs.
摘要翻译：提供了一种新的头发处理装置，用于在头皮附近的头发根部部分提供提升，从而产生体积和身体，从而使头发平滑或平滑。这种装置的实施例包括第一和第二臂。提供了可枢转地将臂围绕枢轴连接的枢轴，其中每个臂包括头发接合表面。为至少一个毛发接合表面提供热源。每个头发接合表面具有适合于治疗靠近头部的头发的一部分的宽度，其中通过治疗头皮附近的一部分头发，其将毛发头和身体提供给头部。使用卷发工具将头部的头部添加到头部的方法包括从毛发头发选择头发以进行治疗的步骤; 并且使用所述工具来处理所述毛发根部附近的所选毛发的至少一部分。

8. 外观设计

USD690117S1 Film with repeating surface pattern 有权
标题翻译：具有重复表面图案的胶片
公开(公告)号：USD690117S1
公开(公告)日：2013-09-24
申请号：US29425585
申请日：2012-06-25
申请人： Gregory Haverfield , Mark Eilers , Keith Harris , Thomas Schweiss
设计人： Gregory Haverfield , Mark Eilers , Keith Harris , Thomas Schweiss

9. 发明申请

US20070193601A1 Hair treatment device 有权
标题翻译：头发处理装置
公开(公告)号：US20070193601A1
公开(公告)日：2007-08-23
申请号：US11646901
申请日：2006-12-28
申请人： Andrew Tobias , Keith Harris
发明人： Andrew Tobias , Keith Harris
IPC分类号： A45D1/00
CPC分类号： A45D1/12
摘要： A new hair treatment device is provided for providing lift at the root portion of the hair near the scalp to thereby create volume and body to otherwise limp or flat hair. An embodiment of such a device includes first and second arms. A pivot movably joining the arms about the pivot is provided wherein each arm includes a hair-engaging surface. A heat source is provided for at least one of the hair-engaging surfaces. Each hair-engaging surface has a width suitable for treating a portion of the hair proximate the head, wherein by treating a portion of hair near the scalp, it provides lift and body to the head of hair. A method for adding lift to a head of hair using a hair crimping tool includes the steps of selecting hair from a head of hair for treatment; and using the tool to treat at least one portion of the selected hair proximate the roots of the hairs.
摘要翻译：提供了一种新的头发处理装置，用于在头皮附近的头发根部部分提供提升，从而产生体积和身体，从而使头发平滑或平滑。这种装置的实施例包括第一和第二臂。提供了可枢转地将臂围绕枢轴连接的枢轴，其中每个臂包括头发接合表面。为至少一个毛发接合表面提供热源。每个头发接合表面具有适合于治疗靠近头部的头发的一部分的宽度，其中通过治疗头皮附近的头发部分，其将毛发的头部和头部提供。使用卷发工具将头部的头部添加到头部的方法包括从毛发头发选择头发以进行治疗的步骤; 并且使用所述工具来处理所述毛发根部附近的所选毛发的至少一部分。

10. 发明授权

US06638337B1 Method of introducing additives in steelmaking 失效
标题翻译：在炼钢中引入添加剂的方法
公开(公告)号：US06638337B1
公开(公告)日：2003-10-28
申请号：US10070413
申请日：2002-07-16
申请人： Stephen David Bray , Keith Harris
发明人： Stephen David Bray , Keith Harris
IPC分类号： C21C500
CPC分类号： C21C1/02 , C21C7/0037 , C21C7/0043 , F27D3/0026 , F27D3/18
摘要： The additives, in particulate solid form, are conveyed pneumatically in a divergent stream from a pneumatic gun to impinge upon the molten iron and mix therewith. The gun is spaced above a surface of molten iron such that the pneumatically conveyed stream including the additive has a central axis which is either horizontal (or at an acute angle to the horizontal). The gun is prefereably adjustable for adjustment of the stream angle, and the stream may be either added to pouring metal or to cover a surface of the molten iron.
摘要翻译：颗粒状固体形式的添加剂以气流从气动枪气流输送到铁水上并与之混合。枪在铁水表面上方间隔开，使得包括添加剂的气动输送流具有水平（或与水平方向成锐角）的中心轴线。喷枪优选地可调整以调节流角，并且流可以被添加到浇注金属或覆盖铁水的表面。

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