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1. 发明授权

US09573907B2 2, 4-pyrimidine derivatives and use thereof 有权
标题翻译： 2,4-嘧啶衍生物及其用途
公开(公告)号：US09573907B2
公开(公告)日：2017-02-21
申请号：US13505651
申请日：2010-11-02
申请人： Sunghoon Kim , Jung Min Han , Hyeong Rae Kim , Dong Ju Jeon , Jong Hwan Song , Kyung Eun Park
发明人： Sunghoon Kim , Jung Min Han , Hyeong Rae Kim , Dong Ju Jeon , Jong Hwan Song , Kyung Eun Park
IPC分类号： A61K31/506 , A61K31/5377 , C07D409/12 , C07D239/60 , C07D413/12 , C07D239/52 , C07D401/12
CPC分类号： C07D239/60 , C07D239/52 , C07D401/12
摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.
摘要翻译：本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和筛选方法本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性自身免疫性疾病因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

2. 发明申请

US20120322802A1 NOVEL 2, 4-PYRIMIDINE DERIVATIVES AND USE THEREOF 有权
标题翻译：新二氢吡啶衍生物及其用途
公开(公告)号：US20120322802A1
公开(公告)日：2012-12-20
申请号：US13505651
申请日：2010-11-02
申请人： Sunghoon Kim , Jung Min Han , Hyeong Rae Kim , Dong Ju Jeon , Jong Hwan Song , Kyung Eun Park
发明人： Sunghoon Kim , Jung Min Han , Hyeong Rae Kim , Dong Ju Jeon , Jong Hwan Song , Kyung Eun Park
IPC分类号： A61K31/505 , C07D401/12 , A61K31/506 , C40B30/04 , A61K31/5377 , A61P29/00 , C07D409/12 , C07D239/60 , C07D413/12
CPC分类号： C07D239/60 , C07D239/52 , C07D401/12
摘要： The present invention relates to novel 2,4-pyrimidine derivatives and a use thereof, and more particularly, to pyrimidine derivatives which are effective for systemic lupus erythematosus, a composition for preventing and treating systemic lupus erythematosus comprising the same as an active ingredient and a method for screening the same. The present inventors found novel materials inhibiting surface translocation of gp96 by mimicking a function of AIMP1 which is a molecular anchor for an intracellular residence of gp96, and identified in vitro and in vivo activity of the materials for preventing and treating SLE by alleviating SLE plasma in autoimmune diseases. Therefore, the present invention provides a novel method for screening a therapeutic agent for SLE, and preventing or treating SLE using the mechanism.
摘要翻译：本发明涉及新的2,4-嘧啶衍生物及其用途，更具体地涉及对系统性红斑狼疮有效的嘧啶衍生物，用于预防和治疗包含其作为活性成分的系统性红斑狼疮的组合物和筛选方法本发明人通过模拟作为gp96细胞内宿主的分子锚的AIMP1的功能，发现抑制gp96的表面易位的新型材料，并通过减轻SLE等离子体来预防和治疗SLE的材料的体外和体内活性自身免疫性疾病因此，本发明提供了用于筛选SLE治疗剂以及使用该机制预防或治疗SLE的新方法。

3. 发明申请

US20110124582A1 NOVEL POLYPEPTIDE HAVING ANTI-TUMOR ACTIVITY 审中-公开
标题翻译：具有抗肿瘤活性的新型多肽
公开(公告)号：US20110124582A1
公开(公告)日：2011-05-26
申请号：US12854843
申请日：2010-08-11
申请人： Sunghoon Kim , Jung Min Han , Sang Gyu Park , Yoen Sook Lee
发明人： Sunghoon Kim , Jung Min Han , Sang Gyu Park , Yoen Sook Lee
IPC分类号： A61K38/17 , C07K14/435 , C07H21/04 , C12N15/63 , C12N1/21 , A61P35/00 , C12N5/00
CPC分类号： C07K14/4747
摘要： The present invention relates to a novel polypeptide having anti-tumor activity through inducing apoptosis of endothelial cell and use thereof. More particularly, the present invention relates to a method for inducing apoptosis of endothelial cell, and for preventing or treating cancer, comprising administering to a subject in need thereof an effective amount of (a) an isolated polypeptide having the amino acid sequence of SEQ ID NO: 9 or the amino acid sequence having at least 90% sequence homology to the amino acid sequence of SEQ ID NO: 9; or (b) an isolated polynucleotide encoding the polypeptide of (a).
摘要翻译：本发明涉及通过诱导内皮细胞凋亡及其用途而具有抗肿瘤活性的新型多肽。更具体地，本发明涉及一种诱导内皮细胞凋亡和预防或治疗癌症的方法，包括向有需要的受试者施用有效量的（a）具有SEQ ID NO：1的氨基酸序列的分离多肽或与SEQ ID NO：9的氨基酸序列具有至少90％序列同源性的氨基酸序列; 或（b）编码（a）的多肽的分离的多核苷酸。

4. 发明申请

US20110250701A1 NOVEL APPLICATION OF AIMP1 POLYPEPTIDE 审中-公开
标题翻译： AIMP1多肽的新应用
公开(公告)号：US20110250701A1
公开(公告)日：2011-10-13
申请号：US13123511
申请日：2009-10-09
申请人： Sunghoon Kim , Jung-Min Han
发明人： Sunghoon Kim , Jung-Min Han
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： G01N33/564 , G01N2800/102
摘要： The present invention relates to a novel use of AIMP1 polypeptide, more particularly to a composition for diagnosis of arthritis comprising an antibody against AIMP1, a kit for diagnosis comprising the same, a method for diagnosis of arthritis comprising: acquiring a specimen from a subject; and detecting AIMP1 polypeptide included in the specimen, and an antibody against the AIMP1 polypeptide for diagnosis of arthritis. The present invention provides a composition for diagnosis of arthritis including an antibody against AIMP1 polypeptide as a novel diagnosis marker of arthritis, a kit for diagnosis including the same, a method for diagnosis of arthritis comprising: acquiring a specimen from a subject; and detecting AIMP1 polypeptide included in the specimen, and an antibody against the AIMP1 polypeptide for diagnosis of arthritis. The composition, kit for diagnosis, method for diagnosis and antibody against the AIMP1 polypeptide may be used to diagnose arthritis early since they allow easy diagnosis of arthritis using a specimen from the patient.
摘要翻译：本发明涉及AIMP1多肽的新用途，更具体地涉及一种用于诊断关节炎的组合物，其包含抗AIMP1抗体，用于诊断AIMP1的诊断用试剂盒，用于诊断关节炎的方法，包括：从受试者获取标本; 并检测样品中包含的AIMP1多肽和针对AIMP1多肽的抗体用于诊断关节炎。本发明提供了一种用于诊断关节炎的组合物，包括抗AIMP1多肽的抗体作为关节炎的新型诊断标志物，包括其的诊断用试剂盒，关节炎诊断方法，包括：从受试者获取标本; 并检测样品中包含的AIMP1多肽和针对AIMP1多肽的抗体用于诊断关节炎。用于诊断的试剂盒，用于诊断的方法和用于AIMP1多肽的抗体可用于早期诊断关节炎，因为它们允许使用来自患者的标本容易地诊断关节炎。

5. 发明授权

US10058397B2 Devices, systems, and methods for containing internal body parts during insertion into the body 有权
公开(公告)号：US10058397B2
公开(公告)日：2018-08-28
申请号：US13364882
申请日：2012-02-02
申请人： Sunghoon Kim , Olajire Idowu
发明人： Sunghoon Kim , Olajire Idowu
IPC分类号： A61F2/00 , A61B90/40 , A61B17/00 , B65D33/25
CPC分类号： A61B90/40 , A61B2017/00287 , B65D33/2566
摘要： Devices for containing exposed internal body parts during insertion into the body of a human or veterinary patient are provided. The devices include a surgical pouch for containing the exposed internal body parts. The devices also include one or more sealing elements disposed on the surgical pouch between the proximal end and the distal end of the surgical pouch such that a section of the pouch is closed off when each sealing element is sealed. Also provided are methods for containing exposed internal body parts of a human or veterinary patient during insertion into the body of the patient.

6. 发明授权

US09478487B2 Semiconductor package 有权
标题翻译：半导体封装
公开(公告)号：US09478487B2
公开(公告)日：2016-10-25
申请号：US14639305
申请日：2015-03-05
申请人： Byeong-Wan Yang , Sunghoon Kim
发明人： Byeong-Wan Yang , Sunghoon Kim
IPC分类号： H01L23/58 , H01L23/498 , H01L21/66 , H01L25/065 , H01L23/522 , H01L23/00
CPC分类号： H01L23/49838 , H01L22/32 , H01L23/49811 , H01L23/49827 , H01L23/522 , H01L24/05 , H01L24/06 , H01L24/32 , H01L24/48 , H01L24/49 , H01L24/73 , H01L25/0657 , H01L2224/04042 , H01L2224/05078 , H01L2224/05554 , H01L2224/05567 , H01L2224/06135 , H01L2224/32145 , H01L2224/32225 , H01L2224/48091 , H01L2224/48145 , H01L2224/48227 , H01L2224/49175 , H01L2224/73265 , H01L2225/06506 , H01L2225/0651 , H01L2225/06562 , H01L2225/06596 , H01L2924/00014 , H01L2924/1434 , H01L2924/1438 , H01L2924/00012 , H01L2924/00 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A semiconductor package includes a substrate including connection pads, a first semiconductor, and conductive wires. The first semiconductor chip is stacked on the substrate and includes bonding pads, non-bonding pads, and a routing area that is provided adjacent a center of an edge of the first semiconductor chip. The conductive wires are connected to the bonding pads and the connection pads. The bonding pads are disposed to form at least one column in a direction extending along the edge of the first semiconductor chip and are not disposed in the routing area. The non-bonding pads are disposed to form a column different from the at least one column formed by the bonding pads.
摘要翻译：半导体封装包括包括连接焊盘，第一半导体和导线的衬底。第一半导体芯片堆叠在基板上，并且包括接合焊盘，非接合焊盘和邻近第一半导体芯片的边缘的中心设置的布线区域。导线连接到接合焊盘和连接焊盘。接合焊盘被设置成沿着沿着第一半导体芯片的边缘延伸的方向形成至少一个列，并且不设置在布线区域中。非接合焊盘被设置成形成与由焊盘形成的至少一个列不同的列。

7. 发明授权

US08431393B2 AIMP2-DX2 gene and its uses 有权
标题翻译： AIMP2-DX2基因及其用途
公开(公告)号：US08431393B2
公开(公告)日：2013-04-30
申请号：US13011174
申请日：2011-01-21
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： C07H21/04 , C07K1/00 , C12N15/00 , C12N5/00
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N33/57438 , G01N2500/04
摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer.
摘要翻译：本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。靶向AIMP2-DX2的AIMP2-DX2基因和siRNA可以成功地用于诊断和治疗癌症。

8. 发明授权

US08350307B2 Semiconductor memory device with power decoupling capacitors and method of fabrication 有权
标题翻译：具有电源去耦电容器的半导体存储器件及其制造方法
公开(公告)号：US08350307B2
公开(公告)日：2013-01-08
申请号：US12539824
申请日：2009-08-12
申请人： Sunghoon Kim
发明人： Sunghoon Kim
IPC分类号： H01L29/94 , H01L21/8242
CPC分类号： H01L27/0629 , G11C11/404 , H01L27/0805 , H01L27/10894 , H01L27/10897
摘要： Provided is a semiconductor memory device including a capacitor structure extending over core and peripheral areas of a substrate. Respective portions of the capacitor structure function as memory cell capacitors in the core area and as first and second capacitors in the peripheral area. A combination of the first and second capacitors functions as a first power decoupling capacitor, and a transistor disposed in the peripheral area functions as a second power decoupling capacitor.
摘要翻译：提供了一种半导体存储器件，其包括在衬底的芯部和外围区域上延伸的电容器结构。电容器结构的各部分用作核心区域中的存储单元电容器，并且用作周边区域中的第一和第二电容器。第一和第二电容器的组合用作第一功率去耦电容器，并且设置在外围区域中的晶体管用作第二功率去耦电容器。

9. 发明申请

US20120015383A1 NOVEL DIAGNOSTIC MARKER FOR TYPE 1 DIABETES MELLITUS 有权
标题翻译： 1型糖尿病新型诊断标记
公开(公告)号：US20120015383A1
公开(公告)日：2012-01-19
申请号：US13198990
申请日：2011-08-05
申请人： Sang Gyu Park , Kyong Soo Park , Sunghoon Kim
发明人： Sang Gyu Park , Kyong Soo Park , Sunghoon Kim
IPC分类号： C12Q1/25 , G01N33/566 , G01N21/64 , C12N9/00
CPC分类号： G01N33/6893 , G01N2800/042
摘要： The present invention provides, as a novel diagnosis marker for type 1 diabetes mellitus, a type 1 diabetes mellitus diagnostic composition comprising alanyl-tRNA synthetase, glycyl-tRNA synthetase, asparaginyl-tRNA synthetase, or tryptophanyl-tRNA synthetase, a diagnostic kit comprising the same, and a diagnostic method using the same. The composition, the kit, and the method, according to the present invention, may be used for early diagnosis and confirmed diagnosis of type 1 diabetes mellitus because type 1 diabetes mellitus can be easily diagnosed from a patient sample.
摘要翻译：本发明提供了作为1型糖尿病的新型诊断标记物，包含丙氨酰-tRNA合成酶，甘氨酰-tRNA合成酶，天冬酰胺酰-tRNA合成酶或色氨酰-tRNA合成酶的1型糖尿病诊断组合物，其包含相同，以及使用其的诊断方法。根据本发明的组合物，试剂盒和方法可以用于1型糖尿病的早期诊断和确认诊断，因为可以容易地从患者样品中诊断1型糖尿病。

10. 发明授权

US07981426B2 Method for stimulating wound healing 失效
标题翻译：刺激伤口愈合的方法
公开(公告)号：US07981426B2
公开(公告)日：2011-07-19
申请号：US12538714
申请日：2009-08-10
申请人： Sunghoon Kim
发明人： Sunghoon Kim
IPC分类号： A61K38/17 , A61K38/18 , C07K14/435 , C07K14/475
CPC分类号： A61K38/19
摘要： The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell re-epithelization, proliferation of fibroblasts or angiogenesis.
摘要翻译：本发明涉及一种刺激伤口愈合的方法，更具体地涉及刺激有需要的受试者的伤口愈合的方法，包括对受试者的伤口施用有效量刺激组合物的伤口愈合，其中组合物包含具有SEQ ID NO：1所示氨基酸序列的p43或其功能等同物。用于本发明方法的组合物可以有效地用于伤口愈合，因为该组合物的有效成分p43通过包括诱导巨噬细胞/单核细胞和内皮细胞的作用对伤口愈合具有极好的效果再上皮化，成纤维细胞增殖或血管生成。

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