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1. 发明申请

US20110189195A1 METHOD FOR CONTROLLING CANCER METASTASIS OR CANCER CELL MIGRATION BY MODULATING THE CELLULAR LEVEL OF LYSYL TRNA SYNTHETASE 有权
标题翻译：通过调节LYSYL TRNA合成酶的细胞水平控制癌症转移或癌细胞迁移的方法
公开(公告)号：US20110189195A1
公开(公告)日：2011-08-04
申请号：US13059006
申请日：2008-08-18
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： A61K39/395 , C12N5/09 , C12N15/63 , C07K16/40 , A61K31/7088 , C12Q1/00 , C12Q1/68 , A61P35/00 , A61P35/04
CPC分类号： A61K31/7088 , A61K48/00 , C12N9/93 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Y601/01006 , G01N33/5017
摘要： The present invention relates to a novel function of lysyl tRNA synthetase (KRS) which enhances tumor cell migration and affects cancer metastasis via KRS's interaction with laminin receptor (67LR) by its translocation to membrane. More particularly, the present invention relates to a method for modulating cancer metastasis or migration, which comprises regulating intracellular levels of KRS; a composition for preventing or treating cancer; use of expression vector for inhibiting the expression of KRS; a method for preventing or treating cancer; use of an agent for inhibiting an activity of KRS; a method for screening an agent which modulates cancer metastasis or migration; and a method for screening an agent which inhibits the interaction of KRS with 67LR, by said novel function. Thus, KRS can modulate cancer metastasis or migration and furthermore, can modulate intra-cellular metabolism related to 67LR. The interaction between KRS and 67LR can be used effectively in treating, preventing and/or diagnosing of various diseases or disorders related to the interaction.
摘要翻译：本发明涉及赖氨酰tRNA合成酶（KRS）的新功能，其通过Kis与层粘连蛋白受体（67LR）的相互作用通过其迁移到膜来增强肿瘤细胞迁移并影响癌症转移。更具体地，本发明涉及一种调节癌症转移或迁移的方法，其包括调节细胞内KRS水平; 用于预防或治疗癌症的组合物; 使用表达载体抑制KRS的表达; 预防或治疗癌症的方法; 使用抑制KRS活性的药剂; 筛选调节癌症转移或迁移的药物的方法; 以及通过所述新功能筛选抑制KRS与67LR的相互作用的药剂的方法。因此，KRS可以调节癌症转移或迁移，此外，可以调节与67LR相关的细胞内代谢。 KRS和67LR之间的相互作用可以有效地用于治疗，预防和/或诊断与相互作用相关的各种疾病或病症。

2. 发明授权

US10130611B2 Use of benzo-heterocycle derivatives for preventing and treating cancer or for inhibiting cancer metastasis 有权
公开(公告)号：US10130611B2
公开(公告)日：2018-11-20
申请号：US13465709
申请日：2012-05-07
申请人： Sunghoon Kim , Jin Woo Choi , Jin Young Lee , Dae Gyu Kim , Gyoon Hee Han , Jee Sun Yang , Chul Ho Lee
发明人： Sunghoon Kim , Jin Woo Choi , Jin Young Lee , Dae Gyu Kim , Gyoon Hee Han , Jee Sun Yang , Chul Ho Lee
IPC分类号： A61K31/4184 , A61K31/423 , A61K31/428
摘要： This application relates to a novel benzo-heterocycle derivative and more particularly, it relates a composition for preventing and treating cancer or for inhibiting metastasis comprising benzo-heterocycle derivative or pharmaceutically acceptable salts thereof as an active ingredient. The present inventors confirmed that KRS has an effect on cancer metastasis by facilitating cancer (or tumor) cell migration through interaction with 67LR, and also found that a substance inhibiting the interaction between KRS and 67LR can prevent and treat cancer by inhibiting cancer cell metastasis. Accordingly, the composition of the present invention can inhibit cancer metastasis, and thus provide a novel means for prevention and treatment of cancer.

3. 发明申请

US20120283300A1 USE OF BENZO-HETEROCYCLE DERIVATIVES FOR PREVENTING AND TREATING CANCER OR FOR INHIBITING CANCER METASTASIS 审中-公开
标题翻译：用于预防和治疗癌症或抑制癌症发生的苯并异恶唑衍生物的用途
公开(公告)号：US20120283300A1
公开(公告)日：2012-11-08
申请号：US13465709
申请日：2012-05-07
申请人： Sunghoon Kim , Jin Woo Choi , Jin Young Lee , Dae Gyu Kim , Gyoon Hee Han , Jee Sun Yang , Chul Ho Lee
发明人： Sunghoon Kim , Jin Woo Choi , Jin Young Lee , Dae Gyu Kim , Gyoon Hee Han , Jee Sun Yang , Chul Ho Lee
IPC分类号： A61K31/423 , C07D263/57 , C07D209/14 , A61K31/4045 , A61P7/06 , A61K31/428 , C07D277/66 , A61P35/00 , A61P35/04 , C07D263/58 , C07D277/82
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/428
摘要： This application relates to a novel benzo-heterocycle derivative and more particularly, it relates a composition for preventing and treating cancer or for inhibiting metastasis comprising benzo-heterocycle derivative or pharmaceutically acceptable salts thereof as an active ingredient. The present inventors confirmed that KRS has an effect on cancer metastasis by facilitating cancer (or tumor) cell migration through interaction with 67LR, and also found that a substance inhibiting the interaction between KRS and 67LR can prevent and treat cancer by inhibiting cancer cell metastasis. Accordingly, the composition of the present invention can inhibit cancer metastasis, and thus provide a novel means for prevention and treatment of cancer.
摘要翻译：本申请涉及新的苯并杂环衍生物，更具体地说，涉及用于预防和治疗癌症或抑制转移的组合物，其包含苯并杂环衍生物或其药学上可接受的盐作为活性成分。本发明人证实，KRS通过与67LR相互作用促进癌症（或肿瘤）细胞迁移而对癌症转移有影响，并且还发现抑制KRS和67LR之间的相互作用的物质可以通过抑制癌细胞转移来预防和治疗癌症。因此，本发明的组合物可以抑制癌症转移，从而提供预防和治疗癌症的新手段。

4. 发明授权

US08003780B2 AIMP2-DX2 gene and SiRNA targeting AIMP2-DX2 有权
标题翻译： AIMP2-DX2基因和靶向AIMP2-DX2的SiRNA
公开(公告)号：US08003780B2
公开(公告)日：2011-08-23
申请号：US12255943
申请日：2008-10-22
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： C07H21/04
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N33/57438 , G01N2500/04
摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer.
摘要翻译：本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。靶向AIMP2-DX2的AIMP2-DX2基因和siRNA可以成功地用于诊断和治疗癌症。

5. 发明授权

US09511085B2 Method for controlling cancer metastasis or cancer cell migration by modulating the cellular level of lysyl tRNA synthetase 有权
标题翻译：通过调节赖氨酰tRNA合成酶的细胞水平来控制癌症转移或癌细胞迁移的方法
公开(公告)号：US09511085B2
公开(公告)日：2016-12-06
申请号：US13059006
申请日：2008-08-18
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： C07K16/30 , C12N15/113 , A61K38/17 , A61K39/395 , A61K31/7088 , C12N9/00 , G01N33/50 , A61K48/00
CPC分类号： A61K31/7088 , A61K48/00 , C12N9/93 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Y601/01006 , G01N33/5017
摘要： The present invention relates to a novel function of lysyl tRNA synthetase (KRS) which enhances tumor cell migration and affects cancer metastasis via KRS's interaction with laminin receptor (67LR) by its translocation to membrane. More particularly, the present invention relates to a method for modulating cancer metastasis or migration, which comprises regulating intracellular levels of KRS; a composition for preventing or treating cancer; use of expression vector for inhibiting the expression of KRS; a method for preventing or treating cancer; use of an agent for inhibiting an activity of KRS; a method for screening an agent which modulates cancer metastasis or migration; and a method for screening an agent which inhibits the interaction of KRS with 67LR, by said novel function. Thus, KRS can modulate cancer metastasis or migration and furthermore, can modulate intracellular metabolism related to 67LR. The interaction between KRS and 67LR can be used effectively in treating, preventing and/or diagnosing of various diseases or disorders related to the interaction.
摘要翻译：本发明涉及赖氨酰tRNA合成酶（KRS）的新功能，其通过Kis与层粘连蛋白受体（67LR）的相互作用通过其迁移到膜来增强肿瘤细胞迁移并影响癌症转移。更具体地，本发明涉及一种调节癌症转移或迁移的方法，其包括调节细胞内KRS水平; 用于预防或治疗癌症的组合物; 使用表达载体抑制KRS的表达; 预防或治疗癌症的方法; 使用抑制KRS活性的药剂; 筛选调节癌症转移或迁移的药物的方法; 以及通过所述新功能筛选抑制KRS与67LR的相互作用的药剂的方法。因此，KRS可以调节癌症转移或迁移，此外，可以调节与67LR相关的细胞内代谢。 KRS和67LR之间的相互作用可以有效地用于治疗，预防和/或诊断与相互作用相关的各种疾病或病症。

6. 发明授权

US08431393B2 AIMP2-DX2 gene and its uses 有权
标题翻译： AIMP2-DX2基因及其用途
公开(公告)号：US08431393B2
公开(公告)日：2013-04-30
申请号：US13011174
申请日：2011-01-21
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： C07H21/04 , C07K1/00 , C12N15/00 , C12N5/00
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N33/57438 , G01N2500/04
摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer.
摘要翻译：本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。靶向AIMP2-DX2的AIMP2-DX2基因和siRNA可以成功地用于诊断和治疗癌症。

7. 发明申请

US20090156536A1 AIMP2-DX2 Gene and SiRNA Targeting AIMP2-DX2 有权
标题翻译： AIMP2-DX2基因和靶向AIMP2-DX2的SiRNA
公开(公告)号：US20090156536A1
公开(公告)日：2009-06-18
申请号：US12255943
申请日：2008-10-22
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： A61K31/7105 , C12N15/11 , C12N15/00 , C12Q1/68 , G01N33/574 , C07K16/18 , C12N1/21
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N33/57438 , G01N2500/04
摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer.
摘要翻译：本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。靶向AIMP2-DX2的AIMP2-DX2基因和siRNA可以成功地用于诊断和治疗癌症。

8. 发明申请

US20110136119A1 AIMP2-DX2 Gene and its Uses 有权
标题翻译： AIMP2-DX2基因及其用途
公开(公告)号：US20110136119A1
公开(公告)日：2011-06-09
申请号：US13011174
申请日：2011-01-21
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N33/57438 , G01N2500/04
摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer
摘要翻译：本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。 AIMP2-DX2基因和靶向AIMP2-DX2的siRNA可以成功应用于癌症诊断和治疗的发展

9. 发明申请

US20110117572A1 Antibody Specific to the AIMP2-DX2 审中-公开
标题翻译：特异于AIMP2-DX2的抗体
公开(公告)号：US20110117572A1
公开(公告)日：2011-05-19
申请号：US13011386
申请日：2011-01-21
申请人： Sunghoon Kim , Jin Woo Choi
发明人： Sunghoon Kim , Jin Woo Choi
IPC分类号： G01N33/566 , C07K16/40
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57423 , G01N33/57438 , G01N2500/04
摘要： The present invention relates to a variant of AIMP2 lacking exon 2 gene, named as AIMP2-DX2 gene, which is specifically expressed in cancer cells. The AIMP2-DX2 gene and siRNA targeting AIMP2-DX2 can be successfully used in the development of diagnosis and treatment of cancer
摘要翻译：本发明涉及在癌细胞中特异性表达的缺失外显子2基因的AIMP2的变体，命名为AIMP2-DX2基因。 AIMP2-DX2基因和靶向AIMP2-DX2的siRNA可以成功应用于癌症诊断和治疗的发展

10. 发明申请

US20130306994A1 DISPLAY PANEL 有权
标题翻译：显示面板
公开(公告)号：US20130306994A1
公开(公告)日：2013-11-21
申请号：US13605669
申请日：2012-09-06
申请人： SEON UK LEE , Sang Il Kim , Jin Bo Shim , Nak Cho Choi , Jin Woo Choi
发明人： SEON UK LEE , Sang Il Kim , Jin Bo Shim , Nak Cho Choi , Jin Woo Choi
IPC分类号： H01L27/15
CPC分类号： H01L51/52 , G02F1/133305 , H01L27/3276 , H01L51/5004 , H01L51/5284 , H01L2251/5338
摘要： A display panel includes a fiber reinforced plastic substrate having a first lattice pattern with a first lattice period P, and a pixel layer disposed on the substrate having a second lattice pattern having a second lattice period H, in which if H>P, P and H satisfy P = 2  H 2  n + 1 , where n is a natural number, and if H>P, P and H satisfy P = ( 2  n + 1 )  H 2 .
摘要翻译：显示面板包括具有第一晶格周期P的第一格子图案的纤维增强塑料基板和设置在具有第二晶格周期H的第二格子图案的基板上的像素层，其中如果H> P，P和 H满足P = 2 H 2 n + 1，其中n是自然数，并且如果H> P，P和H满足P =（2n + 1）H 2。

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