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1. 发明授权

US4224252A Production of pinacolone 失效
标题翻译：频哪酮的生产
公开(公告)号：US4224252A
公开(公告)日：1980-09-23
申请号：US39300
申请日：1979-05-15
申请人： Sunao Kyo , Haruo Tsuchiya , Hidetsugu Tanaka
发明人： Sunao Kyo , Haruo Tsuchiya , Hidetsugu Tanaka
IPC分类号： C07C45/00 , C07C45/45 , C07C45/60 , C07C45/02
CPC分类号： C07C45/45 , C07C45/00 , C07C45/60
摘要： Disclosed are improved procedures for preparing pinacolone from compounds of general formula (I) ##STR1## wherein, either adjacent two of A, B, C and D form a single bond between them and the remaining two are hydrogen atoms, or both A and D are hydrogen atoms and one of B and C is a hydrogen atom and the other represents OH, Cl, Br, HSO.sub.4, H.sub.2 PO.sub.4 or ClO.sub.4, anda new procedure which enables preparing pinacolone from a compound of general formula (II) ##STR2## wherein, both W and Y are each hydrogen atoms and X and Z are the same or different and each represents OH, Cl, Br, HSO.sub.4, H.sub.2 PO.sub.4, ClO.sub.4 or RCOO wherein R is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, or one of W and Y is a hydrogen atom and the other forms a single bond together with X, and Z represents OH, Cl, Br, HSO.sub.4 H.sub.2 PO.sub.4, ClO.sub.4 or RCOO where R is defined as above. In the process of preparing pinacolone from compounds of formula (I) by reacting them with formaldehyde in the presence of a strong inorganic acid, the process can be improved by adding a salt of a strong inorganic acid, or a compound of formula (II). Pinacolone can also be produced by heating a compound of general formula (II) in the presence of a strong inorganic acid and this reaction, too, can be improved by the addition of a salt of a strong inorganic acid. The use of a salt of a strong inorganic acid according to the invention makes it possible to reduce the concentration and the amount of strong acid normally required, and to improve the yield of pinacolone.
摘要翻译：公开了通式（I）化合物（I）制备频哪酮的改进方法，其中A，B，C和D中的相邻两个在它们之间形成单键，其余两个是氢原子或两者 A和D是氢原子，B和C之一是氢原子，另一个表示OH，Cl，Br，HSO 4，H 2 PO 4或ClO 4，以及能够由通式（II）化合物制备频哪酮的新方法（II）其中W和Y各自为氢原子，X和Z相同或不同，并且各自表示OH，Cl，Br，HSO 4，H 2 PO 4，ClO 4或RCOO，其中R是氢原子或烷基 1至3个碳原子，或W和Y中的一个为氢原子，另一个与X一起形成单键，Z表示OH，Cl，Br，HSO 4，H 2 PO 4，ClO 4或RCOO，其中R如上定义。在强力无机酸存在下，通过与式（I）化合物的反应制备频哪酮可以通过加入强无机酸的盐或式（II）的化合物来改善，。倍他乐龙也可以通过在强无机酸存在下加热通式（II）的化合物来制备，该反应也可以通过加入强无机酸的盐来改善。使用根据本发明的强无机酸的盐使得可以降低通常需要的强酸的浓度和量，并且可以提高频那酮的产率。

2. 发明申请

US20120065385A1 DENDRITIC CELL CO-STIMULATORY MOLECULES 审中-公开
标题翻译： DENDRITIC细胞共刺激分子
公开(公告)号：US20120065385A1
公开(公告)日：2012-03-15
申请号：US13243970
申请日：2011-09-23
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： C07H21/04
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefore and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为由此编码的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

3. 发明申请

US20120065374A1 DENDRITIC CELL CO-STIMULATORY MOLECULES 审中-公开
标题翻译： DENDRITIC细胞共刺激分子
公开(公告)号：US20120065374A1
公开(公告)日：2012-03-15
申请号：US13243966
申请日：2011-09-23
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： C07K14/47
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

4. 发明授权

US08053414B2 Methods of using B7-DC molecules to induce or enhance an immune response 有权
标题翻译：使用B7-DC分子诱导或增强免疫应答的方法
公开(公告)号：US08053414B2
公开(公告)日：2011-11-08
申请号：US11932327
申请日：2007-10-31
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： A61K38/16
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

5. 发明申请

US20080241175A1 Dendritic Cell Co-Stimulatory Molecules 有权
标题翻译：树突状细胞共刺激分子
公开(公告)号：US20080241175A1
公开(公告)日：2008-10-02
申请号：US11932327
申请日：2007-10-31
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： A61K39/00 , C07H21/04 , C12N15/63 , C12N5/06 , C07K2/00 , A61P37/02 , C07K16/28 , G01N33/567 , G01N33/53 , C12N15/87
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

6. 发明申请

US20060292593A1 Dendritic cell co-stimulatory molecules 有权
公开(公告)号：US20060292593A1
公开(公告)日：2006-12-28
申请号：US11361057
申请日：2006-02-24
申请人： Drew Pardoll , Haruo Tsuchiya , Kevin Gorski , Su-Yi Tseng
发明人： Drew Pardoll , Haruo Tsuchiya , Kevin Gorski , Su-Yi Tseng
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82 , C07K16/30
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.

7. 发明授权

US08053558B2 Dendritic cell co-stimulatory molecules 有权
标题翻译：树突状细胞共刺激分子
公开(公告)号：US08053558B2
公开(公告)日：2011-11-08
申请号：US11931653
申请日：2007-10-31
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： C07K14/00
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

8. 发明授权

US07560540B2 Nucleic acid encoding dendritic cell co-stimulatory molecules 有权
标题翻译：核酸编码树突状细胞共刺激分子
公开(公告)号：US07560540B2
公开(公告)日：2009-07-14
申请号：US11361057
申请日：2006-02-24
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： C07H21/04 , C12N15/00
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

9. 发明申请

US20080226662A1 Dendritic cell co-stimulatory molecules 有权
标题翻译：树突状细胞共刺激分子
公开(公告)号：US20080226662A1
公开(公告)日：2008-09-18
申请号：US11931653
申请日：2007-10-31
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： A61K39/00 , C07H21/04 , C12Q1/68 , C12N5/00 , C07K16/00 , G01N33/53 , C12N15/87 , A61K48/00
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

10. 发明授权

US07030219B2 B7-DC, Dendritic cell co-stimulatory molecules 失效
标题翻译： B7-DC，树突状细胞共刺激分子
公开(公告)号：US07030219B2
公开(公告)日：2006-04-18
申请号：US09794210
申请日：2001-02-28
申请人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
发明人： Drew M. Pardoll , Haruo Tsuchiya , Kevin S. Gorski , Su-Yi Tseng
IPC分类号： C07K14/435 , C07K14/725 , C07K16/46 , A61K38/17 , A61K39/00
CPC分类号： A61K39/39558 , A61K38/00 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/57 , C07K14/70532 , C07K16/2827 , C07K2319/00 , C07K2319/30
摘要： A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
摘要翻译：作为B7家族成员的新型共刺激蛋白分子B7-DC被描述为编码该DNA的DNA和包含该DNA的表达载体。 B7-DC蛋白，片段，融合多肽/蛋白质和其他功能衍生物，以及表达B7-DC的转化细胞可用于疫苗组合物和方法。公开了用于诱导可被用于抗肿瘤和抗病毒免疫的有效的T细胞介导的应答的组合物和方法。

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