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    • 10. 发明授权
    • Production of pinacolone
    • 频哪酮的生产
    • US4224252A
    • 1980-09-23
    • US39300
    • 1979-05-15
    • Sunao KyoHaruo TsuchiyaHidetsugu Tanaka
    • Sunao KyoHaruo TsuchiyaHidetsugu Tanaka
    • C07C45/00C07C45/45C07C45/60C07C45/02
    • C07C45/45C07C45/00C07C45/60
    • Disclosed are improved procedures for preparing pinacolone from compounds of general formula (I) ##STR1## wherein, either adjacent two of A, B, C and D form a single bond between them and the remaining two are hydrogen atoms, or both A and D are hydrogen atoms and one of B and C is a hydrogen atom and the other represents OH, Cl, Br, HSO.sub.4, H.sub.2 PO.sub.4 or ClO.sub.4, anda new procedure which enables preparing pinacolone from a compound of general formula (II) ##STR2## wherein, both W and Y are each hydrogen atoms and X and Z are the same or different and each represents OH, Cl, Br, HSO.sub.4, H.sub.2 PO.sub.4, ClO.sub.4 or RCOO wherein R is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, or one of W and Y is a hydrogen atom and the other forms a single bond together with X, and Z represents OH, Cl, Br, HSO.sub.4 H.sub.2 PO.sub.4, ClO.sub.4 or RCOO where R is defined as above. In the process of preparing pinacolone from compounds of formula (I) by reacting them with formaldehyde in the presence of a strong inorganic acid, the process can be improved by adding a salt of a strong inorganic acid, or a compound of formula (II). Pinacolone can also be produced by heating a compound of general formula (II) in the presence of a strong inorganic acid and this reaction, too, can be improved by the addition of a salt of a strong inorganic acid. The use of a salt of a strong inorganic acid according to the invention makes it possible to reduce the concentration and the amount of strong acid normally required, and to improve the yield of pinacolone.
    • 公开了通式(I)化合物(I)制备频哪酮的改进方法,其中A,B,C和D中的相邻两个在它们之间形成单键,其余两个是氢原子或两者 A和D是氢原子,B和C之一是氢原子,另一个表示OH,Cl,Br,HSO 4,H 2 PO 4或ClO 4,以及能够由通式(II)化合物制备频哪酮的新方法 (II)其中W和Y各自为氢原子,X和Z相同或不同,并且各自表示OH,Cl,Br,HSO 4,H 2 PO 4,ClO 4或RCOO,其中R是氢原子或烷基 1至3个碳原子,或W和Y中的一个为氢原子,另一个与X一起形成单键,Z表示OH,Cl,Br,HSO 4,H 2 PO 4,ClO 4或RCOO,其中R如上定义。 在强力无机酸存在下,通过与式(I)化合物的反应制备频哪酮可以通过加入强无机酸的盐或式(II)的化合物来改善, 。 倍他乐龙也可以通过在强无机酸存在下加热通式(II)的化合物来制备,该反应也可以通过加入强无机酸的盐来改善。 使用根据本发明的强无机酸的盐使得可以降低通常需要的强酸的浓度和量,并且可以提高频那酮的产率。