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1. 发明授权

US09314176B2 Apparatus and method for processing signal 有权
标题翻译：信号处理装置及方法
公开(公告)号：US09314176B2
公开(公告)日：2016-04-19
申请号：US13450930
申请日：2012-04-19
申请人： Sun-Hua Pao , Chieh-Neng Young , Tsung-Min Hsieh , Yio-Wha Shau
发明人： Sun-Hua Pao , Chieh-Neng Young , Tsung-Min Hsieh , Yio-Wha Shau
IPC分类号： H03F1/26 , A61B5/04 , H03H17/02 , A61B5/00 , A61B5/0432
CPC分类号： A61B5/04004 , A61B5/04017 , A61B5/04325 , A61B5/725 , A61B2560/0475 , H03H17/0261
摘要： An apparatus and a method for processing signal are provided. The signal processing apparatus comprises an input interface and a processing unit. The input interface receives smoothing parameters and a to-be-separated signal. The processing unit establishes an upper extreme envelope and a lower extreme envelope of the to-be-separated signal, and calculates a mean envelope between the upper extreme envelope and the lower extreme envelope. The processing unit performs smoothing according to the smoothing parameters and the mean envelope to generate a smoothed mean envelope, and determines a trend component or a non-trend component according to the smoothed mean envelope.
摘要翻译：提供了一种用于处理信号的装置和方法。信号处理装置包括输入接口和处理单元。输入接口接收平滑参数和待分离信号。处理单元建立待分离信号的上极限和下极限，并计算上极限和下极限之间的平均包络。处理单元根据平滑参数和平均包络进行平滑处理，以生成平滑的平均包络，并根据平滑的平均包络确定趋势分量或非趋势分量。

2. 发明申请

US20120310600A1 APPARATUS AND METHOD FOR PROCESSING SIGNAL 有权
标题翻译：装置和处理信号的方法
公开(公告)号：US20120310600A1
公开(公告)日：2012-12-06
申请号：US13450930
申请日：2012-04-19
申请人： Sun-Hua Pao , Chieh-Neng Young , Tsung-Min Hsieh , Yio-Wha Shau
发明人： Sun-Hua Pao , Chieh-Neng Young , Tsung-Min Hsieh , Yio-Wha Shau
IPC分类号： G06F15/00
CPC分类号： A61B5/04004 , A61B5/04017 , A61B5/04325 , A61B5/725 , A61B2560/0475 , H03H17/0261
摘要： An apparatus and a method for processing signal are provided. The signal processing apparatus comprises an input interface and a processing unit. The input interface receives smoothing parameters and a to-be-separated signal. The processing unit establishes an upper extreme envelope and a lower extreme envelope of the to-be-separated signal, and calculates a mean envelope between the upper extreme envelope and the lower extreme envelope. The processing unit performs smoothing according to the smoothing parameters and the mean envelope to generate a smoothed mean envelope, and determines a trend component or a non-trend component according to the smoothed mean envelope.
摘要翻译：提供了一种用于处理信号的装置和方法。信号处理装置包括输入接口和处理单元。输入接口接收平滑参数和待分离信号。处理单元建立待分离信号的上极限和下极限，并计算上极限和下极限之间的平均包络。处理单元根据平滑参数和平均包络进行平滑处理，以生成平滑的平均包络，并根据平滑的平均包络确定趋势分量或非趋势分量。

3. 发明申请

US20120089372A1 APPARATUS AND METHOD FOR ADAPTIVE TIME-FREQUENCY ANALYSIS 审中-公开
标题翻译：自适应时频分析的装置和方法
公开(公告)号：US20120089372A1
公开(公告)日：2012-04-12
申请号：US13242471
申请日：2011-09-23
申请人： Sun-Hua Pao , Yio-Wha Shau , Chieh-Neng Young
发明人： Sun-Hua Pao , Yio-Wha Shau , Chieh-Neng Young
IPC分类号： G06F19/00
CPC分类号： G06F17/14
摘要： An apparatus and a method for adaptive adaptive time-frequency analysis are suitable for nonlinear and nonstationary signal analyses. The method includes the following steps. A plurality of positions of local extrema of a signal is determined. Average frequencies between the local extrema and mean energy distribution corresponding thereto are estimated according to the positions of the local extrema of the signal. The estimated instantaneous energy distribution of the signal is determined by way of optimization according to each of the mean energy distribution between the local extrema. Finally, an instantaneous frequency of the signal is estimated according to the estimated instantaneous energy distribution of the signal.
摘要翻译：自适应时频分析的装置和方法适用于非线性和非平稳信号分析。该方法包括以下步骤。确定信号的局部极值的多个位置。根据信号的局部极值的位置来估计与其对应的局部极值和平均能量分布之间的平均频率。通过根据局部极值之间的每个平均能量分布的优化来确定信号的估计瞬时能量分布。最后，根据估计的信号瞬时能量分布来估计信号的瞬时频率。

4. 发明申请

US20100074496A1 MULTI-DIMENSIONAL EMPIRICAL MODE DECOMPOSITION (EMD) METHOD FOR IMAGE TEXTURE ANALYSIS 有权
标题翻译：用于图像纹理分析的多维实体模式分解（EMD）方法
公开(公告)号：US20100074496A1
公开(公告)日：2010-03-25
申请号：US12555158
申请日：2009-09-08
申请人： Sun-Hua Pao , Yio-Wha Shau , Ming-Chien Yu , Chien-Lun Tseng
发明人： Sun-Hua Pao , Yio-Wha Shau , Ming-Chien Yu , Chien-Lun Tseng
IPC分类号： G06K9/00 , G06K9/46
CPC分类号： G06T7/0012 , G06T7/41 , G06T2207/10132 , G06T2207/20108 , G06T2207/30056
摘要： A multi-dimensional empirical mode decomposition method is provided. The method can be applied in image texture analysis, such as medical image analysis. The method can adaptively decompose a three-dimensional image into a number of characteristic image layers and extract characteristic images showing more noticeable textures from the layers. The method uses the physical concept of field to perform the data mode decomposition to obtain envelope and tendency estimation of multi-dimensional data. The method can also be applied in time and frequency analysis of two-dimensional data or multi-channel data.
摘要翻译：提供了一种多维经验模式分解方法。该方法可应用于图像纹理分析，如医学图像分析。该方法可以将三维图像自适应地分解为多个特征图像层，并且从层中提取显示更加显着纹理的特征图像。该方法使用场的物理概念进行数据模式分解，以获得多维数据的包络和趋势估计。该方法也可以应用于二维数据或多通道数据的时间和频率分析。

5. 发明授权

US08777860B2 Method for evaluation of renal vascular perfusion using power doppler ultrasonography 有权
标题翻译：使用多普勒超声检查评估肾血管灌注的方法
公开(公告)号：US08777860B2
公开(公告)日：2014-07-15
申请号：US12646753
申请日：2009-12-23
申请人： Jeou-Jong Shyu , Sun-Hua Pao , Yio-Wha Shau , Shuo-Meng Wang , Nai-Kuan Chou
发明人： Jeou-Jong Shyu , Sun-Hua Pao , Yio-Wha Shau , Shuo-Meng Wang , Nai-Kuan Chou
IPC分类号： A61B8/00 , G06T7/00 , A61B8/06 , A61B8/13 , A61B18/00 , A61B5/20
CPC分类号： G06T7/0016 , A61B5/201 , A61B5/413 , A61B8/06 , A61B8/13 , A61B8/469 , A61B2018/00511 , G06T2207/10016 , G06T2207/10132 , G06T2207/20104 , G06T2207/30084 , G06T2207/30104
摘要： A method for evaluation of renal perfusion with power Doppler ultrasonography is disclosed in the present invention. Serial renal vascular images at different vascular areas including the whole vascular tree, interlobar, arcuate, and interlobular vessels were captured. Imaging processing software was designed to analyze the changes of power Doppler intensity of colored pixels within regions of interest (ROI). Power Doppler Vascularity index (PDVI) has been defined as the percentage of vascular perfusion within a region of interest (ROI). The renal vascular perfusion index (RVPI) is defined as the maximal power Doppler vascular index divided by minimal power Doppler vascular index (PDVImax/PDVImin) among the serial images. The mean of weighted power Doppler vascular index (WPDVImean) is defined as the average of the intensity of color pixels among the ROI within the serial images. By using the RVPI and WPDVImean, a more dynamic sense of vascular perfusion and a novel approach for the evaluation of renal vascular function in clinical practice can be provided.
摘要翻译：在本发明中公开了一种用功率多普勒超声检查肾脏灌注的方法。捕获了包括整个血管树，间叶，弓形和小叶间血管在不同血管区域的连续肾血管图像。成像处理软件旨在分析感兴趣区域（ROI）中彩色像素的功率多普勒强度的变化。功率多普勒血压指数（PDVI）被定义为感兴趣区域（ROI）内血管灌注的百分比。肾血管灌注指数（RVPI）定义为串联图像中最大功率多普勒血管指数除以最小功率多普勒血管指数（PDVImax / PDVImin）。加权功率多普勒血管指数（WPDVImean）的平均值定义为串行图像中ROI之间的彩色像素强度的平均值。通过使用RVPI和WPDVImean，可以提供更具动态血管灌注感和临床实践中评估肾血管功能的新方法。

6. 发明申请

US20100274134A1 METHOD FOR EVALUATION OF RENAL VASCULAR PERFUSION USING POWER DOPPLER ULTRASONOGRAPHY 有权
标题翻译：使用功率多普勒超声波评估肾小管灌注的方法
公开(公告)号：US20100274134A1
公开(公告)日：2010-10-28
申请号：US12646753
申请日：2009-12-23
申请人： Jeou-Jong Shyu , Sun-Hua Pao , Yio-Wha Shau , Shuo-Meng Wang , Nai-Kuan Chou
发明人： Jeou-Jong Shyu , Sun-Hua Pao , Yio-Wha Shau , Shuo-Meng Wang , Nai-Kuan Chou
IPC分类号： A61B8/06
CPC分类号： G06T7/0016 , A61B5/201 , A61B5/413 , A61B8/06 , A61B8/13 , A61B8/469 , A61B2018/00511 , G06T2207/10016 , G06T2207/10132 , G06T2207/20104 , G06T2207/30084 , G06T2207/30104
摘要： A method for evaluation of renal perfusion with power Doppler ultrasonography is disclosed in the present invention. Serial renal vascular images at different vascular areas including the whole vascular tree, interlobar, arcuate, and interlobular vessels were captured. Imaging processing software was designed to analyze the changes of power Doppler intensity of colored pixels within regions of interest (ROI). Power Doppler Vascularity index (PDVI) has been defined as the percentage of vascular perfusion within a region of interest (ROI). The renal vascular perfusion index (RVPI) is defined as the maximal power Doppler vascular index divided by minimal power Doppler vascular index (PDVImax/PDVImin) among the serial images. The mean of weighted power Doppler vascular index (WPDVImean) is defined as the average of the intensity of color pixels among the ROI within the serial images. By using the RVPI and WPDVImean, a more dynamic sense of vascular perfusion and a novel approach for the evaluation of renal vascular function in clinical practice can be provided.
摘要翻译：在本发明中公开了一种用功率多普勒超声检查肾脏灌注的方法。捕获了包括整个血管树，间叶，弓形和小叶间血管在不同血管区域的连续肾血管图像。成像处理软件旨在分析感兴趣区域（ROI）中彩色像素的功率多普勒强度的变化。功率多普勒血压指数（PDVI）被定义为感兴趣区域（ROI）内血管灌注的百分比。肾血管灌注指数（RVPI）定义为串联图像中最大功率多普勒血管指数除以最小功率多普勒血管指数（PDVImax / PDVImin）。加权功率多普勒血管指数（WPDVImean）的平均值定义为串行图像中ROI之间的彩色像素强度的平均值。通过使用RVPI和WPDVImean，可以提供更具动态血管灌注感和临床实践中评估肾血管功能的新方法。

7. 发明授权

US08428389B2 Multi-dimensional empirical mode decomposition (EMD) method for image texture analysis 有权
标题翻译：用于图像纹理分析的多维经验模式分解（EMD）方法
公开(公告)号：US08428389B2
公开(公告)日：2013-04-23
申请号：US12555158
申请日：2009-09-08
申请人： Sun-Hua Pao , Yio-Wha Shau , Ming-Chien Yu , Chien-Lun Tseng
发明人： Sun-Hua Pao , Yio-Wha Shau , Ming-Chien Yu , Chien-Lun Tseng
IPC分类号： G06K9/36
CPC分类号： G06T7/0012 , G06T7/41 , G06T2207/10132 , G06T2207/20108 , G06T2207/30056
摘要： A multi-dimensional empirical mode decomposition method is provided. The method can be applied in image texture analysis, such as medical image analysis. The method can adaptively decompose a three-dimensional image into a number of characteristic image layers and extract characteristic images showing more noticeable textures from the layers. The method uses the physical concept of field to perform the data mode decomposition to obtain envelope and tendency estimation of multi-dimensional data. The method can also be applied in time and frequency analysis of two-dimensional data or multi-channel data.
摘要翻译：提供了一种多维经验模式分解方法。该方法可应用于图像纹理分析，如医学图像分析。该方法可以将三维图像自适应地分解为多个特征图像层，并且从层中提取显示更加显着纹理的特征图像。该方法使用场的物理概念进行数据模式分解，以获得多维数据的包络和趋势估计。该方法也可以应用于二维数据或多通道数据的时间和频率分析。

8. 发明授权

US08047993B2 Quantitative non-invasive method for detecting degree of malignancy in tumors and application thereof 有权
标题翻译：用于检测肿瘤恶性程度的定量非侵入性方法及其应用
公开(公告)号：US08047993B2
公开(公告)日：2011-11-01
申请号：US11099570
申请日：2005-04-06
申请人： Yio-Wha Shau , Fon-Jou Hsieh , King-Jen Chang , Sun-Hua Pao , Chiung-Nein Chen
发明人： Yio-Wha Shau , Fon-Jou Hsieh , King-Jen Chang , Sun-Hua Pao , Chiung-Nein Chen
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： A61B8/08 , A61B5/021 , A61B8/04
摘要： Disclosed is a method for detecting the degree of malignancy in tumors noninvasively, which comprises the steps of: using a Power Doppler ultrasound unit to scan a tumor and capture sequential color imagines in a complete heartbeat cycle, and choosing an area of interest (AREA_ROI) from the images; labeling pixels reflecting signals of bloodflow in the imagines during one heartbeat cycle to contour an area of tumor blood vessels (AREA_vessel); calculating a difference of PDVI between maximal systolic pressure and diastolic pressure during the heartbeat cycle to obtain tumor differential vascularity index (TDVI), in which PDVI is the ratio obtained by dividing pixels of AREA_vessel by a total area in the section of AREA_ROI; and determining the degree of malignancy by the TDVI. The method of the present invention can be applied to monitor the response of tumor to clinical treatment.
摘要翻译：公开了一种用于非侵入性地检测肿瘤恶性程度的方法，其包括以下步骤：使用功率多普勒超声单元扫描肿瘤并捕获完整心跳周期中的连续彩色想象，并选择感兴趣区域（AREA_ROI）从图像; 标记在一个心跳周期中反映想象中血流信号的像素，以轮廓肿瘤血管的区域（AREA_vessel）; 计算心跳周期内最大收缩压和舒张压之间的PDVI差异，以获得肿瘤差异血管指数（TDVI），其中PDVI是通过将AREA_vessel的像素除以AREA_ROI部分的总面积获得的比率; 并确定TDVI的恶性程度。本发明的方法可用于监测肿瘤对临床治疗的反应。

9. 发明申请

US20060241463A1 Quantitative non-invasive method for detecting degree of malignancy in tumors and application thereof 有权
标题翻译：用于检测肿瘤恶性程度的定量非侵入性方法及其应用
公开(公告)号：US20060241463A1
公开(公告)日：2006-10-26
申请号：US11099570
申请日：2005-04-06
申请人： Yio-Wha Shau , Fon-Jou Hsieh , King-Jen Chang , Sun-Hua Pao , Chiung-Nein Chen
发明人： Yio-Wha Shau , Fon-Jou Hsieh , King-Jen Chang , Sun-Hua Pao , Chiung-Nein Chen
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B5/021 , A61B8/04
摘要： Disclosed is a method for detecting the degree of malignancy in tumors noninvasively, which comprises the steps of: using a Power Doppler ultrasound unit to scan a tumor and capture sequential color imagines in a complete heartbeat cycle, and choosing an area of interest (AREA_ROI) from the images; labeling pixels reflecting signals of bloodflow in the imagines during one heartbeat cycle to contour an area of tumor blood vessels (AREA_vessel); calculating a difference of PDVI between maximal systolic pressure and diastolic pressure during the heartbeat cycle to obtain tumor differential vascularity index (TDVI), in which PDVI is the ratio obtained by dividing pixels of AREA_vessel by a total area in the section of AREA_ROI; and determining the degree of malignancy by the TDVI. The method of the present invention can be applied to monitor the response of tumor to clinical treatment.
摘要翻译：公开了一种用于非侵入性地检测肿瘤恶性程度的方法，其包括以下步骤：使用功率多普勒超声单元扫描肿瘤并捕获完整心跳周期中的连续彩色想象，并选择感兴趣区域（AREA_ROI）从图像; 标记在一个心跳周期中反映想象中血流信号的像素，以轮廓肿瘤血管的区域（AREA_vessel）; 计算心跳周期内最大收缩压和舒张压之间的PDVI差异，以获得肿瘤差异血管指数（TDVI），其中PDVI是通过将AREA_vessel的像素除以AREA_ROI部分的总面积获得的比率; 并确定TDVI的恶性程度。本发明的方法可用于监测肿瘤对临床治疗的反应。

10. 发明申请

US20100179974A1 Signal Processing Method for Hierarchical Empirical Mode Decomposition and Apparatus Therefor 审中-公开
标题翻译：用于分层经验模式分解的信号处理方法及其设备
公开(公告)号：US20100179974A1
公开(公告)日：2010-07-15
申请号：US12684446
申请日：2010-01-08
申请人： Sun-Hua Pao , Chien-Lun Tseng
发明人： Sun-Hua Pao , Chien-Lun Tseng
IPC分类号： G06F17/14 , G06F17/10 , G06F7/00
CPC分类号： G06F17/14
摘要： A signal processing method for performing hierarchical empirical mode decomposition (H-EMD) and an apparatus therefor are provided. In an embodiment, when empirical mode decomposition is performed on an input signal, an artificial assisting signal and the input signal are combined to assist the search for extrema and frequency reduction is performed in each iteration to eliminate the artificial assisting signal and make mode decomposition convergent so as to avoid mode mixing. In addition, in an embodiment, a hierarchical decomposition method is provided to decompose the input signal into a fewer number of fundamental modes. For needs in application, one of the fundamental modes can be further decomposed to produce a number of supplementary modes. In an embodiment, the H-EMD with appropriate frequency reduction can result in modes substantially independent of the form or the way of envelopes and can be applied to decompose multi-dimensional signals.
摘要翻译：提供一种用于执行分级经验模式分解（H-EMD）的信号处理方法及其装置。在一个实施例中，当对输入信号执行经验模式分解时，组合人造辅助信号和输入信号以辅助搜索极值，并且在每次迭代中执行频率降低以消除人造辅助信号并使模式分解收敛以避免模式混合。此外，在一个实施例中，提供了一种分级分解方法来将输入信号分解成较少数量的基本模式。对于应用需要，其中一种基本模式可以进一步分解，产生多种辅助模式。在一个实施例中，具有适当频率降低的H-EMD可以导致基本上独立于包络的形式或方式的模式，并且可以应用于分解多维信号。

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