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1. 发明申请

US20080255060A1 Ester Linked Macrolides Useful For The Treatment of Microbial Infections 审中-公开
标题翻译：用于治疗微生物感染的酯连接大环内酯类物质
公开(公告)号：US20080255060A1
公开(公告)日：2008-10-16
申请号：US11568562
申请日：2005-05-02
申请人： Sulejman Alihodzic , Stjepan Mutak , Drazen Pavlovic , Ivana Palej , Vlado Stimac , Samra Kapic , Adrijana Vinter , Maja Matanovic Skugor
发明人： Sulejman Alihodzic , Stjepan Mutak , Drazen Pavlovic , Ivana Palej , Vlado Stimac , Samra Kapic , Adrijana Vinter , Maja Matanovic Skugor
IPC分类号： A61K31/7048 , C07H17/08 , A61P31/00
CPC分类号： C07H17/08
摘要： The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译：本发明涉及在式（I）的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物，其制备方法及其在治疗或预防全身或局部微生物感染中的用途人或动物体。

2. 发明申请

US20080249033A1 Carbamate Linked Macrolides Useful For The Treatment Of Microbial Infections 审中-公开
标题翻译：氨基甲酸酯连接的大环内酯类可用于治疗微生物感染
公开(公告)号：US20080249033A1
公开(公告)日：2008-10-09
申请号：US11568563
申请日：2005-05-03
申请人： Sulejman Alihodzic , Stjepan Mutak , Ivana Palej
发明人： Sulejman Alihodzic , Stjepan Mutak , Ivana Palej
IPC分类号： A61K31/7048 , C07H17/08 , A61K31/7052 , C07H17/00 , A61P31/04
CPC分类号： C07H17/08
摘要： The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译：本发明涉及在式（I）的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物，其制备方法及其在治疗或预防全身或局部微生物感染中的用途人或动物体。

3. 发明申请

US20060258600A1 Ether linked macrolides useful for the treatment of microbial infections 失效
公开(公告)号：US20060258600A1
公开(公告)日：2006-11-16
申请号：US11431696
申请日：2006-05-09
申请人： Sulejman Alihodzic , Drazen Pavlovic , Eric Hunt , Andrew Forrest , Ivana Palej , Samra Kapic , Vlado Stimac
发明人： Sulejman Alihodzic , Drazen Pavlovic , Eric Hunt , Andrew Forrest , Ivana Palej , Samra Kapic , Vlado Stimac
IPC分类号： A61K31/7052 , A61K31/7048 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

4. 发明申请

US20070213283A1 Macrolides substituted at the 4"-position 审中-公开
标题翻译：大环内酯取代4“位
公开(公告)号：US20070213283A1
公开(公告)日：2007-09-13
申请号：US10556381
申请日：2004-05-11
申请人： Sulejman Alihodzic , Andrea Berdik , John Berge , Richard Jarvest , Stjepan Mutak
发明人： Sulejman Alihodzic , Andrea Berdik , John Berge , Richard Jarvest , Stjepan Mutak
IPC分类号： C07H17/08 , A61K31/7052
CPC分类号： C07H17/08
摘要： The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译：本发明涉及在式（I）的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物，其制备方法及其在治疗或预防全身或局部微生物感染中的用途人或动物体。

5. 发明申请

US20080227730A1 9A-Carbamoyl and Thiocarbamoyl Azalides With Antimalarial Activity 审中-公开
标题翻译：具有抗疟活性的9A-氨基甲酰基和硫代氨基甲酰基氨基脲
公开(公告)号：US20080227730A1
公开(公告)日：2008-09-18
申请号：US11813869
申请日：2006-01-12
申请人： Stjepan Mutak , Zrinka Ivezic , Sulejman Alihodzic
发明人： Stjepan Mutak , Zrinka Ivezic , Sulejman Alihodzic
IPC分类号： A61K31/7052 , A61P33/06
CPC分类号： A61K31/7048 , A61K31/70 , Y02A50/411
摘要： 9a-carbamoyl and thiocarbamoyl azalides A and their pharmaceutically acceptable derivatives are useful for treatment and prevention of malaria.
摘要翻译： 9a-氨基甲酰基和硫代氨基甲酰基二氮杂A及其药学上可接受的衍生物可用于治疗和预防疟疾。

6. 发明授权

US07547679B2 Ether linked macrolides useful for the treatment of microbial infections 失效
标题翻译：醚连接的大环内酯类可用于治疗微生物感染
公开(公告)号：US07547679B2
公开(公告)日：2009-06-16
申请号：US11431696
申请日：2006-05-09
申请人： Sulejman Alihodzic , Drazen Pavlovic , Eric Hunt , Andrew Keith Forrest , Ivana Palej , Samra Kapic , Vlado Stimac
发明人： Sulejman Alihodzic , Drazen Pavlovic , Eric Hunt , Andrew Keith Forrest , Ivana Palej , Samra Kapic , Vlado Stimac
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译：本发明涉及在式（I）的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物，其制备方法及其在治疗或预防全身或局部微生物感染中的用途人或动物体。

7. 发明申请

US20110281812A1 Compounds 审中-公开
公开(公告)号：US20110281812A1
公开(公告)日：2011-11-17
申请号：US13146233
申请日：2010-01-28
申请人： Sulejman Alihodzic , Antun Hutinec , Sanja Kostrun , Maja Matanovic Skugor , Ivana Palej Jakopovic
发明人： Sulejman Alihodzic , Antun Hutinec , Sanja Kostrun , Maja Matanovic Skugor , Ivana Palej Jakopovic
IPC分类号： A61K31/7048 , A61P11/00 , A61P11/08 , A61P17/00 , A61P19/02 , A61P1/00 , A61P9/10 , A61P29/00 , C07H17/08 , A61P11/06
CPC分类号： C07H17/00
摘要： 2′-O-substituted 14- or 15-membered azalide macrolides of Formula (I) wherein R6 represents (i) —C1-8alkyl, unsubstituted or substituted at the terminal carbon atom by a group selected from hydroxy, —C1-3alkoxy and —C(O)OC1-3alkyl, or when —C1-8alkyl is branched, substitution can alternatively be by a hydroxyl group at each of two terminal carbon atoms, (ii) —CH(NH2)C1-4alkyl, wherein the —C1-4alkyl group may be optionally interrupted by a heteroatom selected from O, S and N, (iii) —CH2N(R7)(R8), wherein R7 and R8 each independently represent H or —C1-3alkyl provided that R7 and R8 cannot both simultaneously represent H, (iv) a 4-6-membered heterocyclic ring containing up to 2 heteroatoms independently selected from O, S and N, wherein the heterocyclic ring is unsubstituted or substituted by —C1-3alkyl, (v) 5-6 membered heteroaromatic ring, unsubstituted or substituted by one to three groups independently selected from halo, hydroxyl, —C1-3alkyl, —C1-3alkoxy, —CF3, —OCF3 and —NH2, (vi) —CH(NH2)CH2-aryl wherein the aryl group may be unsubstituted or substituted by one or two substituents independently selected from —C1-3alkyl, —C1-3alkoxy and hydroxyl, (vii) —C3-7cycloalkyl, or (viii) phenyl unsubstituted or substituted by one or two groups independently selected from halo, hydroxyl, —C1-3alkyl, —C1-3alkoxy, —CF3, —OCF3 and —NH2, or salts thereof, useful in the treatment of neutrophil dominated inflammatory diseases, especially in the treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to methods for their preparation, to their use as therapeutic agents, and to salts thereof.

8. 发明申请

US20090170791A1 MACROLONES 审中-公开
标题翻译：麦克罗伦
公开(公告)号：US20090170791A1
公开(公告)日：2009-07-02
申请号：US12093150
申请日：2006-11-07
申请人： Sulejman Alihodzic , John Michael Berge , Catherine Simone Victoire Frydrych , Samra Kapic , Ivana Palej
发明人： Sulejman Alihodzic , John Michael Berge , Catherine Simone Victoire Frydrych , Samra Kapic , Ivana Palej
IPC分类号： A61K31/7042 , C07H17/08 , A61P31/04
CPC分类号： C07H17/08
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, having antimicrobial activity, processes for their preparation, compositions containing them and to their use in medicine.
摘要翻译：具有抗微生物活性的式（I）化合物或其药学上可接受的衍生物，其制备方法，含有它们的组合物及其在医药中的用途。

9. 发明申请

US20070141276A1 Novel 14 and 15 membered ring compounds 审中-公开
标题翻译：新型14和15元环化合物
公开(公告)号：US20070141276A1
公开(公告)日：2007-06-21
申请号：US10556706
申请日：2004-05-11
申请人： Sulejman Alihodzic , Richard Jarvest , Ivana Palej
发明人： Sulejman Alihodzic , Richard Jarvest , Ivana Palej
IPC分类号： B44C5/00
CPC分类号： C07H17/08 , Y10T428/24157
摘要： The present invention relates to 14- or 15-membered macrolides substituted at the 4″ position of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.
摘要翻译：本发明涉及在式（I）的4“位取代的14-或15-元大环内酯及其药学上可接受的衍生物，其制备方法及其在治疗或预防全身或局部微生物感染中的用途人或动物体。

10. 发明授权

US07910559B2 Decladinosyl-macrolides with anti-inflammatory activity 失效
标题翻译：具有抗炎活性的宣称大肠杆菌素
公开(公告)号：US07910559B2
公开(公告)日：2011-03-22
申请号：US11813876
申请日：2006-01-13
申请人： Ognjen Culic , Martina Bosnar , Sulejman Alihodzic , Gorjana Lazarevski , Zorica Marusic Istuk , Antun Hutinec , Vanja Vela , Goran Kragol
发明人： Ognjen Culic , Martina Bosnar , Sulejman Alihodzic , Gorjana Lazarevski , Zorica Marusic Istuk , Antun Hutinec , Vanja Vela , Goran Kragol
IPC分类号： A61K31/70 , C07H17/08
CPC分类号： C07H17/08
摘要： The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides lacking cladinose sugar substituted at the C-3 position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-6, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
摘要翻译：本发明涉及具有抗炎活性的新型半合成大环内酯类。更具体地说，本发明涉及在C-3位上缺少被克拉替糖糖化的14-和15-元大环内酯，其药学上可接受的衍生物，其制备方法和中间体，含有它们的药物组合物及其活性和用途特别是与过量分泌TNF-α，IL-1，IL-6，IL-8，IL-2或IL-5相关的那些疾病的治疗中，和/或过度淋巴细胞增殖的抑制剂; 和/或过量粒细胞脱粒。

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