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1. 发明申请

US20120122733A1 COMPOSITION, DEVICE AND ASSOCIATED METHOD 有权
标题翻译：组合物，装置和相关方法
公开(公告)号：US20120122733A1
公开(公告)日：2012-05-17
申请号：US11680646
申请日：2007-03-01
申请人： Zhida Pan , Su Lu , Liangliang Qiang , John Yupeng Gui , John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Wei Cai , Zhixin Zheng
发明人： Zhida Pan , Su Lu , Liangliang Qiang , John Yupeng Gui , John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Wei Cai , Zhixin Zheng
IPC分类号： G01N33/53 , C40B40/04 , G01N21/65 , G01N21/75 , G01N21/64 , G01N27/72
CPC分类号： G01N33/58 , G01N31/22
摘要： The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte. An associated kit, device, and method are provided.
摘要翻译：组合物包括第一探针和结合到第一探针的第一引发剂。组合物还包括第二探针和结合到第二探针的第二引发剂。第一个探针和第二个探针能够结合单个分析物。提供相关的套件，设备和方法。

2. 发明授权

US08765643B2 Composition, device and associated method 有权
标题翻译：组成，装置和相关方法
公开(公告)号：US08765643B2
公开(公告)日：2014-07-01
申请号：US11680646
申请日：2007-03-01
申请人： Zhida Pan , Su Lu , Liangliang Qiang , John Yupeng Gui , John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Wei Cai , Zhixin Zheng
发明人： Zhida Pan , Su Lu , Liangliang Qiang , John Yupeng Gui , John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Wei Cai , Zhixin Zheng
IPC分类号： C40B40/04 , G01N33/53 , G01N33/566
CPC分类号： G01N33/58 , G01N31/22
摘要： The composition includes a first probe and a first initiator bonded to the first probe. The composition further includes a second probe and a second initiator bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte. An associated kit, device, and method are provided.
摘要翻译：组合物包括第一探针和结合到第一探针的第一引发剂。组合物还包括第二探针和结合到第二探针的第二引发剂。第一个探针和第二个探针能够结合单个分析物。提供相关的套件，设备和方法。

3. 发明授权

US08741813B2 Composition, device and associated method 有权
标题翻译：组成，装置和相关方法
公开(公告)号：US08741813B2
公开(公告)日：2014-06-03
申请号：US11680597
申请日：2007-02-28
申请人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
发明人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
IPC分类号： C40B40/04 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/6834 , G01N33/533 , G01N33/582
摘要： A composition includes a first probe capable of binding to a first analyte and a first initiator bonded to the first probe. The composition further includes a second probe capable of binding to a second analyte and a second initiator bonded to the second probe. At least one of the first initiator or the second initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided.
摘要翻译：组合物包括能够结合第一分析物的第一探针和与第一探针结合的第一引发剂。组合物还包括能够结合第二分析物的第二探针和与第二探针结合的第二引发剂。第一引发剂或第二引发剂中的至少一种能够引发受控的聚合反应。提供相关的套件，设备和方法。

4. 发明申请

US20120122734A1 COMPOSITION, DEVICE AND ASSOCIATED METHOD 有权
标题翻译：组合物，装置和相关方法
公开(公告)号：US20120122734A1
公开(公告)日：2012-05-17
申请号：US11680647
申请日：2007-03-01
申请人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
发明人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
IPC分类号： G01N33/53 , G01N21/64 , C07K17/02 , C40B40/04 , C07H21/00 , G01N21/75 , G01N21/65
CPC分类号： G01N33/532 , C08G61/08 , C08G2261/1452 , C08G2261/3324 , C08G2261/418 , C08G2261/94 , C40B40/04 , G01N21/6428 , G01N33/5306 , G01N2021/6439
摘要： A composition includes a first probe and a first initiator bonded to the first probe. The first probe is capable of binding to an analyte and the first initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided.
摘要翻译：组合物包括第一探针和结合到第一探针的第一引发剂。第一探针能够结合分析物，并且第一引发剂能够引发受控的聚合反应。提供相关的套件，设备和方法。

5. 发明授权

US08778846B2 Composition, device and associated method 有权
标题翻译：组成，装置和相关方法
公开(公告)号：US08778846B2
公开(公告)日：2014-07-15
申请号：US11680652
申请日：2007-03-01
申请人： John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Su Lu , Zhida Pan , Liangliang Qiang , John Yupeng Gui , Wei Cai , Zhixin Zheng
发明人： John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Su Lu , Zhida Pan , Liangliang Qiang , John Yupeng Gui , Wei Cai , Zhixin Zheng
IPC分类号： C40B40/04 , G01N33/53 , G01N33/566
CPC分类号： G01N33/5308
摘要： A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte, and the first initiator component and the second initiator component are capable of forming an initiator when present in proximity to each other and when the first probe and the second probe are bonded to the analyte. An associated kit, device, and method are provided.
摘要翻译：组合物包括第一探针，结合到第一探针的第一引发剂组分，第二探针和结合到第二探针的第二引发剂组分。第一探针和第二探针能够结合单个分析物，并且第一引发剂组分和第二引发剂组分能够在彼此接近存在时形成引发剂，并且当第一探针和第二探针结合时分析物。提供相关的套件，设备和方法。

6. 发明授权

US08778845B2 Composition, device and associated method 有权
标题翻译：组成，装置和相关方法
公开(公告)号：US08778845B2
公开(公告)日：2014-07-15
申请号：US11680647
申请日：2007-03-01
申请人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
发明人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
IPC分类号： C40B40/04 , G01N33/53 , G01N33/566 , C07K1/00 , C07H21/02
CPC分类号： G01N33/532 , C08G61/08 , C08G2261/1452 , C08G2261/3324 , C08G2261/418 , C08G2261/94 , C40B40/04 , G01N21/6428 , G01N33/5306 , G01N2021/6439
摘要： A composition includes a first probe and a first initiator bonded to the first probe. The first probe is capable of binding to an analyte and the first initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided.
摘要翻译：组合物包括第一探针和结合到第一探针的第一引发剂。第一探针能够结合分析物，并且第一引发剂能够引发受控的聚合反应。提供相关的套件，设备和方法。

7. 发明申请

US20140072956A1 COMPOSITION, DEVICE AND ASSOCIATED METHOD 有权
标题翻译：组合物，装置和相关方法
公开(公告)号：US20140072956A1
公开(公告)日：2014-03-13
申请号：US11680597
申请日：2007-02-28
申请人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
发明人： Su Lu , John Yupeng Gui , Bahram Moasser , Wei Cai , Zhixin Zheng , John Richard Nelson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , G01N33/533 , G01N33/582
摘要： A composition includes a first probe capable of binding to a first analyte and a first initiator bonded to the first probe. The composition further includes a second probe capable of binding to a second analyte and a second initiator bonded to the second probe. At least one of the first initiator or the second initiator is capable of initiating a controlled polymerization reaction. An associated kit, device, and method are provided.
摘要翻译：组合物包括能够结合第一分析物的第一探针和与第一探针结合的第一引发剂。组合物还包括能够结合第二分析物的第二探针和与第二探针结合的第二引发剂。第一引发剂或第二引发剂中的至少一种能够引发受控的聚合反应。提供相关的套件，设备和方法。

8. 发明申请

US20120122735A1 COMPOSITION, DEVICE AND ASSOCIATED METHOD 有权
标题翻译：组合物，装置和相关方法
公开(公告)号：US20120122735A1
公开(公告)日：2012-05-17
申请号：US11680652
申请日：2007-03-01
申请人： John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Su Lu , Zhida Pan , Liangliang Qiang , John Yupeng Gui , Wei Cai , Zhixin Zheng
发明人： John Richard Nelson , Bahram Moasser , Anup Sood , Gregory Andrew Grossmann , Su Lu , Zhida Pan , Liangliang Qiang , John Yupeng Gui , Wei Cai , Zhixin Zheng
IPC分类号： G01N33/53 , C40B40/04 , G01N27/72 , G01N21/75 , G01N21/64 , G01N21/65
CPC分类号： G01N33/5308
摘要： A composition includes a first probe, a first initiator component bonded to the first probe, a second probe, and a second initiator component bonded to the second probe. The first probe and the second probe are capable of binding to a single analyte, and the first initiator component and the second initiator component are capable of forming an initiator when present in proximity to each other and when the first probe and the second probe are bonded to the analyte. An associated kit, device, and method are provided.
摘要翻译：组合物包括第一探针，结合到第一探针的第一引发剂组分，第二探针和结合到第二探针的第二引发剂组分。第一探针和第二探针能够结合单个分析物，并且第一引发剂组分和第二引发剂组分能够在彼此接近存在时形成引发剂，并且当第一探针和第二探针结合时分析物。提供相关的套件，设备和方法。

9. 发明授权

US09574183B2 Method and kits for repairing nucleic acid sequences 有权
标题翻译：用于修复核酸序列的方法和试剂盒
公开(公告)号：US09574183B2
公开(公告)日：2017-02-21
申请号：US13344504
申请日：2012-01-05
申请人： John Richard Nelson , Wei Gao
发明人： John Richard Nelson , Wei Gao
IPC分类号： C12N9/12 , C12N9/00
CPC分类号： C12N9/1252 , C12N9/93
摘要： Methods and kits for DNA repair are provided. The methods and kits described herein repair multiple types of DNA damage. The kit may include a plurality of enzymes to repair a greater variety of lesions than any single enzyme is capable of repairing. Repair of damaged DNA may include releasing damaged bases from the DNA strand, nicking the DNA at the damaged sites, translating the nicks via 5′-3′ exonuclease activity, and sealing the nicks. The enzymes employed in the repair process may then be heat-inactivated, thereby obviating a purification process. The repaired DNA may then be analyzed using a variety of DNA analysis methods.
摘要翻译：提供DNA修复的方法和试剂盒。本文所述的方法和试剂盒修复多种类型的DNA损伤。试剂盒可以包括多种酶，以修复比任何单一酶能够修复的更多种病变。损伤的DNA的修复可以包括从DNA链释放受损的碱基，在受损位点切割DNA，通过5'-3'核酸外切酶活性翻译切口并密封缺口。然后可以将在修复过程中使用的酶热灭活，从而避免纯化过程。然后可以使用各种DNA分析方法分析修复的DNA。

10. 发明授权

US08921072B2 Methods to generate DNA mini-circles 有权
标题翻译：产生DNA迷你圈的方法
公开(公告)号：US08921072B2
公开(公告)日：2014-12-30
申请号：US12202644
申请日：2008-09-02
申请人： John Richard Nelson , Nichole Lea Wood , Gregory Andrew Grossmann , Robert Scott Duthie
发明人： John Richard Nelson , Nichole Lea Wood , Gregory Andrew Grossmann , Robert Scott Duthie
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6844 , A61K2039/53 , C12N15/10 , C12N15/64 , C12N2800/30 , C12Q2531/125 , C12Q2521/107
摘要： Methods and kits for generating circular nucleic acids in a cell-free system, and uses for the generated circular nucleic acids are provided. The methods comprise in vitro amplification of a nucleic acid template comprising a recombination site to produce tandem repeat nucleic acid sequence, and employ a recombination protein to generate the circular nucleic acids from the tandem repeat nucleic acid sequence.
摘要翻译：提供了在无细胞系统中产生环状核酸的方法和试剂盒，以及用于产生的环状核酸的方法和试剂盒。所述方法包括体外扩增包含重组位点以产生串联重复核酸序列的核酸模板，并使用重组蛋白从串联重复核酸序列产生环状核酸。

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