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1. 发明申请

US20070191936A1 Endovascular graft coatings 审中-公开
公开(公告)号：US20070191936A1
公开(公告)日：2007-08-16
申请号：US11728373
申请日：2007-03-26
申请人： Stuart Williams , David Clapper
发明人： Stuart Williams , David Clapper
IPC分类号： A61F2/06
CPC分类号： A61L27/16 , A61L27/56 , A61L31/048 , A61L2430/36 , C08L27/18
摘要： An endovascular graft, e.g., having both an expandable stent portion and a stent cover portion positioned within and/or surrounding the expandable portion, the graft itself and/or a stent cover portion being coated with a bioactive agent adapted to promote initial thrombus formation, preferably followed by long term fibrous tissue ingrowth. The endovascular graft addresses concerns regarding endoleaking by permitting the graft to be deployed and used in a manner that promotes a short term hemostatic effect in the perigraft region. This short term effect can, in turn, be used to promote or permit long term fibrous tissue ingrowth. Particularly where the stent cover portion is prepared from a porous material selected from PET and ePTFE, the bioactive agent can include a thrombogenic agent such as collagen covalently attached in the form of a thin, conformal coating on at least the outer surface of the stent cover. An optimal coating of this type is formed by the activation of photoreactive groups provided by either the cover material itself, by the bioactive agent itself, and/or by a linking agent.

2. 发明申请

US20060210603A1 Implantable medical articles having laminin coatings and methods of use 审中-公开
标题翻译：具有层粘连蛋白涂层和使用方法的可植入医疗制品
公开(公告)号：US20060210603A1
公开(公告)日：2006-09-21
申请号：US11360284
申请日：2006-02-23
申请人： Stuart Williams , David Babcock , Joseph Chinn , David Clapper
发明人： Stuart Williams , David Babcock , Joseph Chinn , David Clapper
IPC分类号： A61K38/10 , A61K38/54 , A61F2/00
CPC分类号： A61K38/39 , A61K38/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L2300/25 , A61L2300/254 , A61L2300/606 , C08L89/00 , C08L89/06
摘要： Laminin-containing coatings for the surfaces of implantable medical devices are disclosed. The coatings promote the formation of vessels in association with the coated surfaces with minimal fibrotic resonse.
摘要翻译：公开了用于可植入医疗装置的表面的含层粘蛋白的涂层。涂层促进与涂层表面相关联的血管的形成，同时具有最小的纤维化反应。

3. 发明申请

US20070179589A1 Endovascular graft coatings 审中-公开
公开(公告)号：US20070179589A1
公开(公告)日：2007-08-02
申请号：US11728467
申请日：2007-03-26
申请人： Stuart Williams , David Clapper
发明人： Stuart Williams , David Clapper
IPC分类号： A61F2/82
CPC分类号： A61L27/16 , A61L27/56 , A61L31/048 , A61L2430/36 , C08L27/18
摘要： An endovascular graft, e.g., having both an expandable stent portion and a stent cover portion positioned within and/or surrounding the expandable portion, the graft itself and/or a stent cover portion being coated with a bioactive agent adapted to promote initial thrombus formation, preferably followed by long term fibrous tissue ingrowth. The endovascular graft addresses concerns regarding endoleaking by permitting the graft to be deployed and used in a manner that promotes a short term hemostatic effect in the perigraft region. This short term effect can, in turn, be used to promote or permit long term fibrous tissue ingrowth. Particularly where the stent cover portion is prepared from a porous material selected from PET and ePTFE, the bioactive agent can include a thrombogenic agent such as collagen covalently attached in the form of a thin, conformal coating on at least the outer surface of the stent cover. An optimal coating of this type is formed by the activation of photoreactive groups provided by either the cover material itself, by the bioactive agent itself, and/or by a linking agent.

4. 发明申请

US20070173922A1 Endovascular graft coatings 审中-公开
标题翻译：血管内移植物涂层
公开(公告)号：US20070173922A1
公开(公告)日：2007-07-26
申请号：US11728415
申请日：2007-03-26
申请人： Stuart Williams , David Clapper
发明人： Stuart Williams , David Clapper
IPC分类号： A61F2/06
CPC分类号： A61L27/16 , A61L27/56 , A61L31/048 , A61L2430/36 , C08L27/18
摘要： An endovascular graft, e.g., having both an expandable stent portion and a stent cover portion positioned within and/or surrounding the expandable portion, the graft itself and/or a stent cover portion being coated with a bioactive agent adapted to promote initial thrombus formation, preferably followed by long term fibrous tissue ingrowth. The endovascular graft addresses concerns regarding endoleaking by permitting the graft to be deployed and used in a manner that promotes a short term hemostatic effect in the perigraft region. This short term effect can, in turn, be used to promote or permit long term fibrous tissue ingrowth. Particularly where the stent cover portion is prepared from a porous material selected from PET and ePTFE, the bioactive agent can include a thrombogenic agent such as collagen covalently attached in the form of a thin, conformal coating on at least the outer surface of the stent cover. An optimal coating of this type is formed by the activation of photoreactive groups provided by either the cover material itself, by the bioactive agent itself, and/or by a linking agent.
摘要翻译：例如，血管内移植物具有位于可膨胀部分内和/或围绕可扩张部分的扩张支架部分和支架盖部分，移植物本身和/或支架覆盖部分涂覆有适于促进初始血栓形成的生物活性剂，最好是长期的纤维组织向内生长。血管内移植物通过允许移植物以促进围手术区域的短期止血作用的方式来部署和使用来解决关于内渗的问题。这种短期效应又可用于促进或允许长期的纤维组织向内生长。特别是在支架覆盖部分由选自PET和ePTFE的多孔材料制备的情况下，生物活性剂可以包括血栓形成剂，例如在支架盖的至少外表面上以薄的保形涂层的形式共价附着的胶原。通过由覆盖材料本身，生物活性剂本身和/或通过连接剂提供的光反应性基团的活化来形成这种类型的最佳涂层。

5. 发明申请

US20050136091A1 Crosslinkable macromers 有权
标题翻译：可交联的大分子单体
公开(公告)号：US20050136091A1
公开(公告)日：2005-06-23
申请号：US10990582
申请日：2004-11-17
申请人： Stephen Chudzik , David Clapper
发明人： Stephen Chudzik , David Clapper
IPC分类号： A61K9/16 , A61K35/12 , A61K38/18 , A61L24/00 , A61L27/34 , A61L29/08 , A61L31/14 , A61F2/00 , A61C5/00
CPC分类号： A61K9/1647 , A61K9/1641 , A61K38/1875 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L27/34 , A61L29/085 , A61L31/148 , Y10S623/92 , Y10S623/921 , Y10S623/923 , Y10S623/926
摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.
摘要翻译：一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个引发剂基团（例如聚合物 - 侧基引发剂基团）。当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。本发明的大分子单体系统可以以足以允许组织生长通过交联基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。

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