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1. 发明申请

US20050136091A1 Crosslinkable macromers 有权
标题翻译：可交联的大分子单体
公开(公告)号：US20050136091A1
公开(公告)日：2005-06-23
申请号：US10990582
申请日：2004-11-17
申请人： Stephen Chudzik , David Clapper
发明人： Stephen Chudzik , David Clapper
IPC分类号： A61K9/16 , A61K35/12 , A61K38/18 , A61L24/00 , A61L27/34 , A61L29/08 , A61L31/14 , A61F2/00 , A61C5/00
CPC分类号： A61K9/1647 , A61K9/1641 , A61K38/1875 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L27/34 , A61L29/085 , A61L31/148 , Y10S623/92 , Y10S623/921 , Y10S623/923 , Y10S623/926
摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.
摘要翻译：一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个引发剂基团（例如聚合物 - 侧基引发剂基团）。当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。本发明的大分子单体系统可以以足以允许组织生长通过交联基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。

2. 发明申请

US20050255142A1 Coatings for medical articles including natural biodegradable polysaccharides 失效
标题翻译：包括天然可生物降解多糖在内的医疗用品涂料
公开(公告)号：US20050255142A1
公开(公告)日：2005-11-17
申请号：US11127351
申请日：2005-05-12
申请人： Stephen Chudzik , Joseph Chinn , Dale Swan , Michael Burkstrand
发明人： Stephen Chudzik , Joseph Chinn , Dale Swan , Michael Burkstrand
IPC分类号： A61F2/00 , A61F2/02 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16
CPC分类号： A61L31/16 , A61F2210/0004 , A61F2310/00389 , A61L27/34 , A61L27/54 , A61L31/10 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/418 , A61L2300/622 , C08L5/00
摘要： Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译：描述了包括天然可生物降解多糖的可生物降解涂层。涂层由具有侧联偶合基团的多种天然可生物降解多糖形成。

3. 发明申请

US20080089923A1 Biodegradable ocular implants and methods for treating ocular conditions 审中-公开
标题翻译：可生物降解的眼部植入物和治疗眼部病症的方法
公开(公告)号：US20080089923A1
公开(公告)日：2008-04-17
申请号：US11904805
申请日：2007-09-28
申请人： Michael Burkstrand , Signe Erickson , Stephen Chudzik , Pamela Reed
发明人： Michael Burkstrand , Signe Erickson , Stephen Chudzik , Pamela Reed
IPC分类号： A61F2/02 , A61K38/02 , A61K39/395 , A61P27/02
CPC分类号： A61K9/0051 , A61F9/0017 , A61F2210/0004 , A61F2250/0067 , A61K47/36
摘要： Biodegradable ocular implants are described. The ocular implants include a bioactive agent that can be released within the eye to treat an ocular condition or indication. The implants can be used for the administration of a bioactive agent over prolonged periods of time. In some aspects the implants are formed of a matrix of natural biodegradable polysaccharides.
摘要翻译：描述了可生物降解的眼部植入物。眼部植入物包括可以在眼睛内释放以治疗眼睛状况或指征的生物活性剂。植入物可以用于长时间施用生物活性剂。在一些方面，植入物由天然可生物降解多糖的基质形成。

4. 发明申请

US20070065484A1 In situ occlusion using natural biodegradable polysaccharides 审中-公开
标题翻译：使用天然可生物降解多糖的原位闭塞
公开(公告)号：US20070065484A1
公开(公告)日：2007-03-22
申请号：US11525006
申请日：2006-09-21
申请人： Stephen Chudzik , Joseph Chinn , Dale Swan , Michael Burkstrand , Peter Duquette
发明人： Stephen Chudzik , Joseph Chinn , Dale Swan , Michael Burkstrand , Peter Duquette
IPC分类号： A61F2/02
CPC分类号： A61L27/20 , A61F9/0008 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61L24/08 , A61L31/042 , A61L31/148 , C08L5/16
摘要： In situ formed biodegradable occlusions including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译：描述了原位形成的可生物降解的封闭物，包括天然可生物降解的多糖。该基质由多个具有侧联偶合基团的天然可生物降解多糖形成。

5. 发明申请

US20070065481A1 Coatings including natural biodegradable polysaccharides and uses thereof 失效
标题翻译：包括天然可生物降解多糖的涂层及其用途
公开(公告)号：US20070065481A1
公开(公告)日：2007-03-22
申请号：US11271213
申请日：2005-11-11
申请人： Stephen Chudzik , Joseph Chinn , Dale Swan , Michael Burkstrand
发明人： Stephen Chudzik , Joseph Chinn , Dale Swan , Michael Burkstrand
IPC分类号： A61F2/00 , A61K31/715
CPC分类号： A61L27/20 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61K47/34 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2420/02 , B05D1/36 , B05D7/52 , C08B31/006 , C08B31/04 , C08B33/02 , C08B33/04 , C08L3/02 , C08L3/12 , C09D103/02 , C09D103/18
摘要： Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
摘要翻译：描述了包括天然可生物降解多糖的可生物降解的涂层和制品。涂层和制品由具有悬挂偶联基团的多种天然可生物降解多糖形成。

6. 发明申请

US20060067968A1 Bioactive agent release coating 有权
公开(公告)号：US20060067968A1
公开(公告)日：2006-03-30
申请号：US11281845
申请日：2005-11-17
申请人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
发明人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
IPC分类号： A61F13/00 , B05D3/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606 , C08L33/06
摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).

7. 发明申请

US20070292596A1 REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 失效
标题翻译：用于提供表面涂层的试剂和方法
公开(公告)号：US20070292596A1
公开(公告)日：2007-12-20
申请号：US11846955
申请日：2007-08-29
申请人： Ralph Chappa , Sean Stucke , Richard Amos , Terrence Everson , Stephen Chudzik , Dale Swan , Peter Duquette
发明人： Ralph Chappa , Sean Stucke , Richard Amos , Terrence Everson , Stephen Chudzik , Dale Swan , Peter Duquette
IPC分类号： A61L27/28 , A61L2/00
CPC分类号： B82Y30/00 , A61L27/34 , C09D4/00 , Y10S522/904 , Y10T428/249991 , Y10T428/249992 , C08F220/56 , C08F220/54
摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
摘要翻译：以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体，并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

8. 发明申请

US20070065483A1 In vivo formed matrices including natural biodegradable polysaccharides and uses thereof 审中-公开
标题翻译：体内形成的基质包括天然可生物降解的多糖及其用途
公开(公告)号：US20070065483A1
公开(公告)日：2007-03-22
申请号：US11271238
申请日：2005-11-11
申请人： Stephen Chudzik , Dale Swan , Michael Burkstrand
发明人： Stephen Chudzik , Dale Swan , Michael Burkstrand
IPC分类号： A61K9/14 , C08G63/91
CPC分类号： A61L27/20 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61K47/34 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2420/02 , B05D1/36 , B05D7/52 , C08B31/006 , C08B31/04 , C08B33/02 , C08B33/04 , C08L3/02 , C08L3/12 , C09D103/02 , C09D103/18
摘要： In vivo formed matrices including natural biodegradable polysaccharides are described. The matrix is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The matrix can also include a bioactive agent which can be released to provide a therapeutic effect to a patient.
摘要翻译：描述了包括天然可生物降解多糖的体内形成的基质。该基质由多个具有侧联偶合基团的天然可生物降解多糖形成。基质还可以包括可以释放以向患者提供治疗效果的生物活性剂。

9. 发明申请

US20070065482A1 Articles including natural biodegradable polysaccharides and uses thereof 失效
标题翻译：包括天然可生物降解多糖的制品及其用途
公开(公告)号：US20070065482A1
公开(公告)日：2007-03-22
申请号：US11271237
申请日：2005-11-11
申请人： Stephen Chudzik , Dale Swan , Michael Burkstrand
发明人： Stephen Chudzik , Dale Swan , Michael Burkstrand
IPC分类号： A61F2/02 , A61K39/395
CPC分类号： A61L27/20 , A61K9/0024 , A61K9/0051 , A61K9/2027 , A61K9/205 , A61K47/34 , A61L27/34 , A61L27/54 , A61L27/58 , A61L29/085 , A61L29/16 , A61L31/042 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/604 , A61L2300/606 , A61L2420/02 , B05D1/36 , B05D7/52 , C08B31/006 , C08B31/04 , C08B33/02 , C08B33/04 , C08L3/02 , C08L3/12 , C09D103/02 , C09D103/18
摘要： Medical articles having a body member including natural biodegradable polysaccharides are described. The body member is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The body member can also include a bioactive agent which can be released to provide a therapeutic effect to a patient.
摘要翻译：描述具有包括天然可生物降解多糖的主体成分的医疗制品。身体构件由多个具有侧联偶联基团的天然可生物降解多糖形成。身体构件还可以包括可以释放以向患者提供治疗效果的生物活性剂。

10. 发明申请

US20070003588A1 Multifunctional medical articles 有权
标题翻译：多功能医疗用品
公开(公告)号：US20070003588A1
公开(公告)日：2007-01-04
申请号：US11295836
申请日：2005-12-06
申请人： Joseph Chinn , Sean Stucke , Stephen Chudzik
发明人： Joseph Chinn , Sean Stucke , Stephen Chudzik
IPC分类号： A61F2/06
CPC分类号： A61L29/085 , A61L27/34 , A61L31/10 , A61L33/0011
摘要： The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making medical articles, as well as methods of using the same, are also described.
摘要翻译：本发明提供包括多于一种生物相容性促进功能的医疗制品。在一个方面，本发明提供了包括包含多于一种生物相容剂的聚合物基质的医疗制品，其中每个生物相容性试剂提供在医疗用品表面的不同部分。还描述了制造医疗用品的方法及其使用方法。

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