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    • 5. 发明申请
    • Learning Belief Distributions for Game Moves
    • 学习游戏移动的信念分布
    • US20080004096A1
    • 2008-01-03
    • US11421913
    • 2006-06-02
    • Thore K. H. GraepelRalf HerbrichDavid Stern
    • Thore K. H. GraepelRalf HerbrichDavid Stern
    • A63F9/24
    • A63F3/022A63F3/04G09B19/22
    • We describe an apparatus for learning to predict moves in games such as chess, Go and the like, from historical game records. We obtain a probability distribution over legal moves in a given board configuration. This enables us to provide an automated game playing system, a training tool for players and a move selector/sorter for input to a game tree search system. We use a pattern extraction system to select patterns from historical game records. Our learning algorithm learns a distribution over the values of a move given a board position based on local pattern context. In another embodiment we use an Independent Bernoulli model whereby we assume each moved is played independently of other available moves.
    • 我们描述一种从历史游戏记录中学习来预测诸如象棋,Go等游戏中的移动的装置。 在给定的电路板配置中,我们获得了合法移动的概率分布。 这使我们能够提供一种自动游戏系统,用于玩家的训练工具和用于输入到游戏树搜索系统的移动选择器/分选器。 我们使用模式提取系统从历史游戏记录中选择模式。 我们的学习算法基于局部模式上下文学习一个给定一个董事会职位的动作值的分布。 在另一个实施例中,我们使用独立的伯努利模型,由此我们假设每个移动都是独立于其他可用移动进行的。
    • 6. 发明授权
    • Helical stent with micro-latches
    • 螺旋支架带微型闩锁
    • US07255710B2
    • 2007-08-14
    • US10636323
    • 2003-08-06
    • Jason WhiteDavid SternMark AllenDavid O'Brien
    • Jason WhiteDavid SternMark AllenDavid O'Brien
    • A61F2/06
    • A61F2/88A61F2/90
    • A stent constructed using elements containing micro-mechanical latching mechanisms is disclosed. The micro-mechanical latching elements allow sliding motion between two surfaces in one direction, and restrict sliding motion in the opposite direction. The micro-mechanical latch surface features are formed using microelectronic mechanical systems (MEMS) manufacturing methods. The male surface of the latching components contains an array of ridges or protrusions, and the receiving surface contains a matching array of recesses. The array of ridges or protrusions and the corresponding recesses have uniformly dissimilar slopes that result in a substantially greater frictional force in one direction than in the opposite direction. The separation distance between the two surfaces is such that the male latch surface is engaged with the receiving surface recesses in the low stress “locked” state, preventing motion in the undesired direction.
    • 公开了使用包含微机械闭锁机构的元件构造的支架。 微机械闭锁元件允许在一个方向上的两个表面之间的滑动运动,并且在相反方向上限制滑动运动。 使用微电子机械系统(MEMS)制造方法形成微机械闩锁表面特征。 闩锁部件的阳表面包含脊或突起的阵列,并且接收表面包含匹配的凹槽阵列。 脊或突起的阵列和相应的凹槽具有均匀不相似的斜面,其在一个方向上产生比在相反方向上显着更大的摩擦力。 两个表面之间的分隔距离使得阳锁闩表面在低应力“锁定”状态下与接收表面凹部接合,从而防止在不期望的方向上的运动。
    • 9. 发明申请
    • Method and apparatus for imaging a sample on a device
    • 用于在装置上成像样品的方法和装置
    • US20050247887A1
    • 2005-11-10
    • US11177529
    • 2005-07-07
    • Mark TrulsonJames WinklerMaureen CroninDavid Stern
    • Mark TrulsonJames WinklerMaureen CroninDavid Stern
    • C12M1/34G01J1/20G01N21/64G01T1/10
    • G01N21/6428G01N21/6452G01N21/6456G01N2021/6417G01N2021/6423
    • In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container. The apparatus can further include at least one thermal management module for controlling temperature of the nucleic acid microarray immobilized on the surface of the solid substrate, and the thermal management module thermally can contact the assembly; and a pulse valve in fluid communication with the cavity, the pulse valve adapted to agitate fluid within the cavity.
    • 根据本发明的各种实施方案,提供了一种用于杂交固定在固体基质表面上的核酸微阵列的装置。 该装置包括用于在杂交期间固定固体基底的至少一个组件,该组件包括载体和具有面向载体的表面的盖。 载体和盖的尺寸可以被确定为在载体和盖的表面之间接收固体基质,使得盖和固体基质的表面限定空腔。 在一些实施例中,该装置可以包括流体控制模块,其包括歧管,至少一个液体储存器,至少一个废物容器和与废物容器流体连通的真空源。 歧管可以在液体储存器和空腔之间以及空腔和废物容器之间提供流体连通,并且真空源可以在液体储存器和废物容器之间提供压力差。 该装置还可以包括至少一个用于控制固定在固体基质表面上的核酸微阵列的温度的热管理模块,并且热管理模块可热接触组件; 以及与所述空腔流体连通的脉冲阀,所述脉冲阀适于搅动所述空腔内的流体。