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1. 发明授权

US07648500B2 Sphincter treatment apparatus 失效
标题翻译：括约肌治疗仪
公开(公告)号：US07648500B2
公开(公告)日：2010-01-19
申请号：US11175471
申请日：2005-07-06
申请人： Stuart D Edwards , David Utley , Ronald G Lax , Theodore R Kucklick , Peter H Muller
发明人： Stuart D Edwards , David Utley , Ronald G Lax , Theodore R Kucklick , Peter H Muller
IPC分类号： A61B18/18 , A61N1/00
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00011 , A61B2018/00029 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782
摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.
摘要翻译：括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。能量输送装置联接到引入构件。保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。

2. 发明申请

US20090131928A1 GERD treatment apparatus and method 审中-公开
标题翻译： GERD治疗仪和方法
公开(公告)号：US20090131928A1
公开(公告)日：2009-05-21
申请号：US12315423
申请日：2008-12-03
申请人： Stuart D. Edwards , David Utley
发明人： Stuart D. Edwards , David Utley
IPC分类号： A61B18/18
CPC分类号： A61B18/1485 , A61B18/00 , A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00867 , A61B2017/22062 , A61B2017/22072 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00107 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00738 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1425 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/3966 , A61B2218/002 , A61F7/12 , A61M3/0279 , A61M16/0454 , A61M16/0459 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40 , A61N7/02 , C08L2201/12
摘要： An apparatus includes an expandable member. The expandable member is sized to be positionable in a sphincter. An energy delivery device is positioned on a surface of the expandable member. The energy delivery device has a configuration that provides sufficient energy delivery to create lesions in the interior of the sphincter. When the expandable member is removed from the sphincter, the sphincter returns to its closed or contracted configuration.
摘要翻译：一种装置包括可扩张构件。可扩张构件的大小可定位在括约肌中。能量输送装置位于可膨胀构件的表面上。能量输送装置具有提供足够的能量输送以在括约肌内部产生损伤的构造。当可伸缩构件从括约肌中取出时，括约肌返回到其闭合或收缩的构型。

3. 发明申请

US20120089138A1 GERD TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译： GERD治疗装置和方法
公开(公告)号：US20120089138A1
公开(公告)日：2012-04-12
申请号：US13327105
申请日：2011-12-15
申请人： Stuart D. Edwards , David Utley
发明人： Stuart D. Edwards , David Utley
IPC分类号： A61B18/00
CPC分类号： A61B18/1485 , A61B18/00 , A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00867 , A61B2017/22062 , A61B2017/22072 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00107 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00738 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1425 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/3966 , A61B2218/002 , A61F7/12 , A61M3/0279 , A61M16/0454 , A61M16/0459 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40 , A61N7/02 , C08L2201/12
摘要： An apparatus includes an expandable member. The expandable member is sized to be positionable in a sphincter. An energy delivery device is positioned on a surface of the expandable member. The energy delivery device has a configuration that provides sufficient energy delivery to create lesions in the interior of the sphincter. When the expandable member is removed from the sphincter, the sphincter returns to its closed or contracted configuration.
摘要翻译：一种装置包括可扩张构件。可扩张构件的大小可定位在括约肌中。能量输送装置位于可膨胀构件的表面上。能量输送装置具有提供足够的能量输送以在括约肌内部产生损伤的构造。当可伸缩构件从括约肌中取出时，括约肌返回到其闭合或收缩的构型。

4. 发明授权

US07462179B2 GERD treatment apparatus and method 失效
标题翻译： GERD治疗仪和方法
公开(公告)号：US07462179B2
公开(公告)日：2008-12-09
申请号：US10986687
申请日：2004-11-12
申请人： Stuart D Edwards , David Utley
发明人： Stuart D Edwards , David Utley
IPC分类号： A61B18/18
CPC分类号： A61B18/1485 , A61B18/00 , A61B18/08 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00867 , A61B2017/22062 , A61B2017/22072 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00107 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00738 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1425 , A61B2018/1467 , A61B2018/1472 , A61B2090/3614 , A61B2090/3782 , A61B2090/3966 , A61B2218/002 , A61F7/12 , A61M3/0279 , A61M16/0454 , A61M16/0459 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40 , A61N7/02 , C08L2201/12
摘要： An apparatus includes an expandable member. The expandable member is sized to be positionable in a sphincter. An energy delivery device is positioned on a surface of the expandable member. The energy delivery device has a configuration that provides sufficient energy delivery to create lesions in the interior of the sphincter. When the expandable member is removed from the sphincter, the sphincter returns to its closed or contracted configuration.
摘要翻译：一种装置包括可扩张构件。可扩张构件的大小可定位在括约肌中。能量输送装置位于可膨胀构件的表面上。能量输送装置具有提供足够的能量输送以在括约肌内部产生损伤的构造。当可伸缩构件从括约肌中取出时，括约肌返回到其闭合或收缩的构型。

5. 发明授权

US6139545A Systems and methods for ablating discrete motor nerve regions 失效
标题翻译：用于消融离散运动神经区域的系统和方法
公开(公告)号：US6139545A
公开(公告)日：2000-10-31
申请号：US150078
申请日：1998-09-09
申请人： David Utley , Stuart D Edwards , Richard L Goode
发明人： David Utley , Stuart D Edwards , Richard L Goode
IPC分类号： A61B5/05 , A61B5/053 , A61B18/12 , A61B18/14 , A61N1/06 , A61B18/04
CPC分类号： A61B5/053 , A61B18/1233 , A61B18/1477 , A61B5/4519 , A61N1/06 , A61B2018/00434 , A61B2018/00577 , A61B2018/126
摘要： Systems and method ablate motor nerve tissue by inserting an operative element connectable to an ablation energy generator into a defined percutaneous tissue region. The systems and methods apply stimulant energy in the defined percutaneous tissue region to stimulate targeted motor nerve tissue prior to ablation by the operative element. Application of the nerve ablation energy can permanently eliminate the function of a targeted motor nerve branch, to thereby inactivate a selected muscle. The muscle inactivation may, e.g., treat dystonias and other hyperfunction neuromuscular dysfunctions in the face and neck, such as torticollis, blepharospasm, and uncontrolled grimacing. The muscle inactivation may also provide cosmetic results, to eliminate or prevent aesthetically displeasing skin furrows, frowning wrinkles, or neck bands, which can arise from normal muscle contraction or prolonged exposure of the face to the sun.
摘要翻译：系统和方法通过将可连接到消融能量发生器的操作元件插入到限定的经皮组织区域来消融运动神经组织。系统和方法在定义的经皮组织区域中施加兴奋剂能量，以在手术元件消融之前刺激目标运动神经组织。神经消融能量的应用可以永久地消除目标运动神经分支的功能，从而使所选择的肌肉失活。肌肉失活可以例如治疗面部和颈部的肌张力障碍和其他亢进的神经肌肉功能障碍，例如斜颈，眼睑痉挛和不受控制的做法。肌肉失活还可以提供美容效果，以消除或预防由正常肌肉收缩或面部长时间暴露于太阳而引起的美学上令人不快的皮肤皱纹，皱眉皱纹或颈带。

6. 发明申请

US20070294108A1 Unified systems and methods for controlling use and operation of a family of different treatment devices 有权
标题翻译：用于控制不同处理装置的家庭的使用和操作的统一的系统和方法
公开(公告)号：US20070294108A1
公开(公告)日：2007-12-20
申请号：US11895205
申请日：2007-08-23
申请人： Jay Qin , Robin Bek , John Gaiser , Rachel Croft , Peter Muller , David Utley
发明人： Jay Qin , Robin Bek , John Gaiser , Rachel Croft , Peter Muller , David Utley
IPC分类号： G06Q50/00
CPC分类号： A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1492 , A61B2017/00017 , A61B2017/00199 , A61B2017/00482 , A61B2018/00011 , A61B2018/00214 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00494 , A61B2018/0066 , A61B2018/00898 , A61B2018/1475 , A61B2218/002 , G06F19/00 , G06Q50/22
摘要： Unified systems and methods enable control of the use and operation of a family of different treatment devices, to treat dysfunction in different regions of the body.
摘要翻译：统一的系统和方法能够控制一系列不同治疗装置的使用和操作，以治疗身体不同区域的功能障碍。

7. 发明申请

US20060041256A1 GERD treatment apparatus and method 有权
标题翻译： GERD治疗仪和方法
公开(公告)号：US20060041256A1
公开(公告)日：2006-02-23
申请号：US11254951
申请日：2005-10-20
申请人： Stuart Edwards , David Utley
发明人： Stuart Edwards , David Utley
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00553
摘要： A method of forming a composite lesion pattern in a tissue region at or near a sphincter comprising providing a catheter having a plurality of energy delivery devices coupled to the catheter. The catheter is introduced at least partially into the sphincter. Energy is delivered from the energy delivery devices to produce the composite lesion pattern. The composite lesion pattern comprises a radial distribution of lesions about the tissue region and a longitudinal distribution of lesions along the tissue region.
摘要翻译：在括约肌处或附近在组织区域中形成复合损伤图案的方法，包括提供具有耦合到导管的多个能量输送装置的导管。将导管至少部分地引入括约肌。能量从能量输送装置输送以产生复合损伤模式。复合损伤图案包括围绕组织区域的损伤的径向分布和沿着组织区域的损伤的纵向分布。

8. 发明申请

US20050245926A1 Sphincter treatment apparatus 失效
标题翻译：括约肌治疗仪
公开(公告)号：US20050245926A1
公开(公告)日：2005-11-03
申请号：US11175471
申请日：2005-07-06
申请人： Stuart Edwards , David Utley , Ronald Lax , Theodore Kucklick , Peter Muller
发明人： Stuart Edwards , David Utley , Ronald Lax , Theodore Kucklick , Peter Muller
IPC分类号： A61B18/00 , A61B18/14
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00011 , A61B2018/00029 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782
摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.
摘要翻译：括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。能量输送装置联接到引入构件。保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。

9. 发明授权

US06325798B1 Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions 有权
标题翻译：真空辅助系统和治疗括约肌和邻近组织区域的方法
公开(公告)号：US06325798B1
公开(公告)日：2001-12-04
申请号：US09304743
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2017/22067 , A61B2017/308 , A61B2017/3488 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/036 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods treat a tissue region at or near a sphincter by deploying a carrier, which carries an electrode that can be advanced to penetrate tissue. Negative pressure is applied through a suction port on the carrier near the electrode, to draw tissue in the tissue region inward against the carrier. The systems and methods advance the electrode to penetrate tissue drawn against the carrier. The vacuum anchors the surrounding tissue and mediates against the “tenting” of tissue during electrode penetration. Without tenting, the electrode penetrates mucosal tissue fully, to obtain a desired depth of penetration.
摘要翻译：系统和方法通过展开携带可以被推进穿透组织的电极的载体来处理括约肌处或附近的组织区域。通过电极附近的载体上的吸入口施加负压，将组织区域中的组织向内抵靠载体。这些系统和方法使电极移动以穿透抵靠载体的组织。真空锚定周围的组织，并在电极穿透期间抵抗组织的“隆起”进行介导。没有隆起，电极完全渗透粘膜组织，以获得所需的穿透深度。

10. 发明授权

US07293563B2 Systems and methods for applying a selected treatment agent into contact with tissue to treat disorders of the gastrointestinal tract 有权
标题翻译：将选择的治疗剂施用于与组织接触以治疗胃肠道疾病的系统和方法
公开(公告)号：US07293563B2
公开(公告)日：2007-11-13
申请号：US10912268
申请日：2004-08-05
申请人： David Utley , John W Gaiser , Rachel Croft
发明人： David Utley , John W Gaiser , Rachel Croft
IPC分类号： A61B19/00
CPC分类号： A61B18/1492 , A61B18/1477 , A61B2018/00214 , A61B2018/00232 , A61B2018/00553 , A61B2018/00797 , A61B2018/00815 , A61B2018/1425 , A61M25/0084
摘要： Systems and methods that treat disorders of the gastrointestinal tract by applying one or more treatment agents to tissue at or near the region where abnormal neurological symptoms or abnormal tissue conditions exist. The treatment agent is selected to either disrupt the abnormal nerve pathways and/or to alleviate the abnormal tissue conditions. The treatment agent can include at least one cytokine and/or at least one vanilloid compound to evoke a desired tissue response. The systems and methods can be used a primary treatment modality, or as a neoadjuvent or adjuvant treatment modality.
摘要翻译：通过将一种或多种治疗剂施用于存在异常神经症状或异常组织病状的区域处或附近的组织来治疗胃肠道疾病的系统和方法。选择治疗剂以破坏异常神经通路和/或减轻异常组织状况。治疗剂可以包括至少一种细胞因子和/或至少一种香草酸化合物以引起所需的组织应答。系统和方法可以用作主要治疗方式，或作为新辅助治疗方式。

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