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1. 发明授权

US06455297B1 Methods and compositions for regulating cell death and enhancing disease resistance to plant pathogens 有权
标题翻译：用于调节细胞死亡并增强对植物病原体的抗病性的方法和组合物
公开(公告)号：US06455297B1
公开(公告)日：2002-09-24
申请号：US09923654
申请日：2001-08-07
申请人： Gurmukh S. Johal , Steven P. Briggs , John Gray , Gongshe Hu
发明人： Gurmukh S. Johal , Steven P. Briggs , John Gray , Gongshe Hu
IPC分类号： C12N988
CPC分类号： C12N15/8261 , C12N9/88 , C12N15/8242 , C12N15/8243 , C12N15/8263 , C12N15/8282 , C12N15/8289 , Y02A40/146
摘要： Compositions and methods for enhancing disease resistance to a pathogen in a plant are provided. Methods of the invention comprise stably transforming a plant with an antisense nucleotide sequence for a gene encoding an enzyme in the C-5 porphyrin metabolic pathway and operably linking said antisense sequence to a pathogen-inducible promoter, such that invasion of a cell by a pathogen elicits a hypersensitive-like response that results in confinement of the pathogen to cells of initial contact. Transformed plants and seeds are provided. Nucleotide sequences encoding a wild-type maize urod gene useful in the present invention and the amino acid sequence for the protein encoded thereby are provided. These compositions are also useful for regulating cell death in specifically targeted tissues. A maize lesion mimic, dominant mutant phenotype, designated Les22, and the molecular basis for its manifestation are also provided.
摘要翻译：提供了用于提高植物中对病原体的抗病性的组合物和方法。本发明的方法包括用编码C-5卟啉代谢途径中的酶的基因的反义核苷酸序列稳定转化植物，并将所述反义序列可操作地连接到病原体诱导型启动子，使得病原体侵入细胞引起过敏反应，导致病原体与初始接触细胞的限制。提供了转化的植物和种子。提供了编码本发明中有用的野生型玉米urod基因的核苷酸序列和由此编码的蛋白质的氨基酸序列。这些组合物也可用于调节特异性靶向组织中的细胞死亡。还提供了玉米病变模拟物，显性突变体表型，命名为Les22，以及其表现的分子基础。

2. 发明授权

US06211437B1 Nucleic acids from maize encoding proteins which suppress plant cell death 失效
标题翻译：来自玉米编码蛋白质的核酸抑制植物细胞死亡
公开(公告)号：US06211437B1
公开(公告)日：2001-04-03
申请号：US08810009
申请日：1997-03-04
申请人： Steven P. Briggs , Gurmukh S. Johal , John Gray
发明人： Steven P. Briggs , Gurmukh S. Johal , John Gray
IPC分类号： A01H500
CPC分类号： C12N9/0071 , C12N15/8207 , C12N15/8282 , C12N15/8289
摘要： The present invention is drawn to genes from maize encoding proteins which suppress plant cell death and methods of plant transformation therewith.
摘要翻译：本发明涉及抑制植物细胞死亡的玉米编码蛋白质的基因及其植物转化方法。

3. 发明授权

US06271439B1 Methods and compositions for regulating cell death and enhancing disease resistance to plant pathogens 有权
标题翻译：用于调节细胞死亡并增强对植物病原体的抗病性的方法和组合物
公开(公告)号：US06271439B1
公开(公告)日：2001-08-07
申请号：US09260843
申请日：1999-03-02
申请人： Gurmukh S. Johal , Steven P. Briggs , John Gray , Gongshe Hu
发明人： Gurmukh S. Johal , Steven P. Briggs , John Gray , Gongshe Hu
IPC分类号： C12N1529
CPC分类号： C12N15/8261 , C12N9/88 , C12N15/8242 , C12N15/8243 , C12N15/8263 , C12N15/8282 , C12N15/8289 , Y02A40/146
摘要： Compositions and methods for enhancing disease resistance to a pathogen in a plant are provided. Methods of the invention comprise stably transforming a plant with an antisense nucleotide sequence for a gene encoding an enzyme in the C-5 porphyrin metabolic pathway and operably linking the antisense sequence to a pathogen-inducible promoter, such that invasion of a cell by a pathogen elicits a hypersensitive-like response that results in confinement of the pathogen to cells of initial contact. Transformed plants and seeds are provided. Nucleotide sequences encoding a wild-type maize urod gene useful in the present invention and the amino acid sequence for the protein encoded thereby are provided. These compositions are also useful for regulating cell death in specifically targeted tissues. A maize lesion mimic, dominant mutant phenotype, designated Les22, and the molecular basis for its manifestation are also provided.
摘要翻译：提供了用于提高植物中对病原体的抗病性的组合物和方法。本发明的方法包括用编码C-5卟啉代谢途径中的酶的基因的反义核苷酸序列稳定转化植物，并将反义序列可操作地连接到病原体诱导型启动子，使得病原体侵入细胞引起过敏反应，导致病原体与初始接触细胞的限制。提供了转化的植物和种子。提供了编码本发明中有用的野生型玉米urod基因的核苷酸序列和由此编码的蛋白质的氨基酸序列。这些组合物也可用于调节特异性靶向组织中的细胞死亡。还提供了玉米病变模拟物，显性突变体表型，命名为Les22，以及其表现的分子基础。

4. 发明授权

US06599725B2 Polypeptide compositions for controlling cell death and disease resistance in plants 有权
标题翻译：用于控制植物中细胞死亡和抗病性的多肽组合物
公开(公告)号：US06599725B2
公开(公告)日：2003-07-29
申请号：US09776490
申请日：2001-02-02
申请人： Steven P. Briggs , Gurmukh S. Johal , John Gray
发明人： Steven P. Briggs , Gurmukh S. Johal , John Gray
IPC分类号： C12N902
CPC分类号： C12N9/0071 , C12N15/8207 , C12N15/8282 , C12N15/8289
摘要： The present invention is drawn to methods and compositions for suppressing cell death in plants. Specifically, novel proteins and genes are provided for use in plant transformation. The proteins and genes are useful for activating disease resistance, enhancing plant cell transformation efficiency, engineering herbicide resistance, genetically targeting cell ablations, and other methods involving the regulation of cell death in plants.
摘要翻译：本发明涉及抑制植物细胞死亡的方法和组合物。具体地说，提供新的蛋白质和基因用于植物转化。蛋白质和基因可用于激活疾病抗性，增强植物细胞转化效率，工程除草剂抗性，遗传靶向细胞消融以及涉及调节植物细胞死亡的其它方法。

5. 发明授权

US07276584B1 Isolated nucleic acid molecules encoding the Br2 P-glycoprotein of maize and methods of modifying growth in plants transformed therewith 有权
公开(公告)号：US07276584B1
公开(公告)日：2007-10-02
申请号：US11338199
申请日：2006-01-24
申请人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
发明人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
IPC分类号： C07K1/00
CPC分类号： C07K14/415
摘要： The invention relates to the genetic modification of plants, particularly to the expression of P-glycoprotein genes in transformed plants. Nucleotide sequences for the Br2 gene encoding a P-glycoprotein of maize and methods for their use are provided. The sequences find use in modifying the growth of plants.

6. 发明授权

US07612256B2 Isolated nucleic acid molecules encoding the Br2 P-glycoprotein of maize and methods of modifying growth in plants transformed therewith 有权
标题翻译：编码玉米的Br2P-糖蛋白的分离的核酸分子以及用其转化的植物中改变生长的方法
公开(公告)号：US07612256B2
公开(公告)日：2009-11-03
申请号：US11338356
申请日：2006-01-24
申请人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
发明人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
IPC分类号： C12N15/82 , C12N15/29 , A01H5/00 , A01H5/10
CPC分类号： C07K14/415 , C12N15/8261 , Y02A40/146
摘要： The invention relates to the genetic modification of plants, particularly to the expression of P-glycoprotein genes in transformed plants. Nucleotide sequences for the Br2 gene encoding a P-glycoprotein of maize and methods for their use are provided. The sequences find use in modifying the growth of plants.
摘要翻译：本发明涉及植物的遗传修饰，特别涉及转化植物中P-糖蛋白基因的表达。提供了编码玉米P-糖蛋白的Br2基因的核苷酸序列及其使用方法。这些序列用于修饰植物的生长。

7. 发明授权

US5589611A Disease resistance gene from maize and its use for disease resistance as a selectable marker and as a gene identification probe 失效
标题翻译：来自玉米的抗病基因及其作为抗病性的用途作为选择性标记和作为基因鉴定探针
公开(公告)号：US5589611A
公开(公告)日：1996-12-31
申请号：US123761
申请日：1993-09-17
申请人： Steven P. Briggs , Gurmukh S. Johal
发明人： Steven P. Briggs , Gurmukh S. Johal
IPC分类号： C07K14/415 , C12N1/21 , C12N9/02 , C12N15/29 , C12N15/53 , C12N15/82 , A01H1/04 , C07H21/04 , C12N5/00 , C12N15/00
CPC分类号： C12N9/0004 , C07K14/415 , C12N15/8282
摘要： The HM1 gene in maize confers race-specific resistance to the pathogen, Cochliobolus carbonum. We have used transposon mutagenesis to tag, clone, and characterize several HM1 alleles. The gene can be used as a selectable marker in conjunction with the toxin produced by C. carbonum.
摘要翻译：玉米中的HM1基因赋予对病原体碳酸杆菌的种族特异性抗性。我们已经使用转座子诱变来标记，克隆和表征几种HM1等位基因。该基因可以与碳酸钙生产的毒素结合使用作为选择标记。

8. 发明授权

US07041874B2 Isolated nucleic acid molecules encoding the Br2 P-glycoprotein of maize and methods of modifying growth in plants transformed therewith 有权
公开(公告)号：US07041874B2
公开(公告)日：2006-05-09
申请号：US10101388
申请日：2002-03-19
申请人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
发明人： Gurmukh S. Johal , Dilbag S. Multani , Steven P. Briggs
IPC分类号： C12N15/29 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C07K14/415 , C12N15/8261 , Y02A40/146
摘要： The invention relates to the genetic modification of plants, particularly to the expression of P-glycoprotein genes in transformed plants. Nucleotide sequences for the Br2 gene encoding a P-glycoprotein of maize and methods for their use are provided. The sequences find use in modifying the growth of plants.

9. 发明申请

US20100316702A1 COMPOSITIONS AND METHODS FOR REGULATING ERYTHROPOEITIN EXPRESSION AND AMELIORATING ANEMIA AND STIMULATING ERYTHROPOIESIS 审中-公开
标题翻译：用于调节ERYTHROPOEITIN表达和改善ANEMIA和刺激ERYTHROPOIESIS的组合物和方法
公开(公告)号：US20100316702A1
公开(公告)日：2010-12-16
申请号：US12810630
申请日：2009-01-08
申请人： Steven P. Briggs , Kiyoshi Tachikawa
发明人： Steven P. Briggs , Kiyoshi Tachikawa
IPC分类号： A61K38/18 , C07K14/505 , C07H21/04 , C12N15/63 , A61P7/06 , A61K9/127 , C12N5/10
CPC分类号： C07K14/505
摘要： The invention provides compositions (e.g., pharmaceuticals, formulations) and methods for ameliorating (e.g., preventing or treating) an anemia and/or stimulating erythropoiesis and/or EPO erythropoietin synthesis. The invention provides compositions comprising a chimeric protein artificial transcription factor comprising a plurality of (multiple) protein DNA-binding domains, e.g., zinc finger binding domains, specific for the promoter region of an erythropoietin (EPO) gene; a consensus nuclear localization protein sequence; a cell-penetrating peptide sequence; and a transcription activation domain.
摘要翻译：本发明提供用于改善（例如，预防或治疗）贫血和/或刺激红细胞生成和/或EPO促红细胞生成素合成的组合物（例如药物，制剂）和方法。本发明提供包含嵌合蛋白质人工转录因子的组合物，其包含对红细胞生成素（EPO）基因的启动子区域特异的多个（多个）蛋白质DNA结合结构域，例如锌指结合结构域; 共识核定位蛋白序列; 细胞穿透肽序列; 和转录激活结构域。

10. 发明授权

US06300542B1 Functional characterization of genes 有权
标题翻译：基因的功能表征
公开(公告)号：US06300542B1
公开(公告)日：2001-10-09
申请号：US09317378
申请日：1999-05-24
申请人： Steven P. Briggs , Robert B. Meeley
发明人： Steven P. Briggs , Robert B. Meeley
IPC分类号： A01H100
CPC分类号： C12N15/8241 , A01H1/04 , C12Q1/6895
摘要： Insertions into a gene of known sequence can be generated by crossing two parent plants, one of which contains a transposable element, to produce F1 progeny plants in which the insertion is detected by means of a PCR. F1 progeny plants containing such an insertion are self-fertilized to produce F2 progeny which are homozygous for the insertion. The function of a gene disabled by the insertion can be ascertained from a comparison of the phenotype of the F2 progeny with a parental phenotype. Large numbers of F1 progeny can be tested simultaneously for the presence of insertions. A collection of F2 seed can be stored and used for phenotype comparison when an insertion is detected.
摘要翻译：可以通过将两个亲本植物（其中一个含有转座因子）杂交到产生F1后代植物中来产生已知序列的基因，其中通过PCR检测插入。含有这种插入物的F1后代植物是自我受精的，以产生纯合插入的F2后代。可以从F2后代的表型与亲本表型的比较中确定插入能够阻断的基因的功能。可以同时测试大量的F1后代的插入物的存在。当检测到插入时，可以存储F2种子的集合并用于表型比较。

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