专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050048599A1 Sensitive and rapid determination of antimicrobial susceptibility 有权
标题翻译：敏感和快速测定抗菌药物敏感性
公开(公告)号：US20050048599A1
公开(公告)日：2005-03-03
申请号：US10888828
申请日：2004-07-08
申请人： David Goldberg , David Howson , Steven Metzger , Daniel Buttry , Steven Saavedra
发明人： David Goldberg , David Howson , Steven Metzger , Daniel Buttry , Steven Saavedra
IPC分类号： C12Q1/18 , G01N33/543 , G01N33/561 , C12Q1/04 , C12M1/34
CPC分类号： G01N33/569 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/18 , G01N33/5438 , G01N33/561
摘要： The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.
摘要翻译：本发明涉及将微生物移动到表面，其中它们在存在和不存在抗微生物剂的情况下生长，并且通过在两个条件下随时间监测微生物的生长，可以确定它们对抗微生物剂的敏感性。微生物可通过电泳，离心或过滤移至表面。当运动涉及电泳时，氧化和还原剂的存在降低了可以产生电泳力的电压，并允许可以检测目标的更宽范围的方法。监测可以包括光学检测，并且最方便地包括检测单个微生物。微生物可以被染色以便提供关于它们对抗微生物剂的反应的信息。

2. 发明申请

US20070037225A1 Rapid microbial detection and antimicrobial susceptibility testing 有权
标题翻译：快速微生物检测和抗菌药敏试验
公开(公告)号：US20070037225A1
公开(公告)日：2007-02-15
申请号：US11303803
申请日：2005-12-16
申请人： Steven Metzger , David Howson , David Goldberg , Daniel Buttry
发明人： Steven Metzger , David Howson , David Goldberg , Daniel Buttry
IPC分类号： C12Q1/04 , G01N33/569 , G01N33/554
CPC分类号： C12Q1/04 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/18 , G01N33/5438 , G01N33/561
摘要： A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.
摘要翻译：一种用于检测样品中的微生物的方法，包括使所述样品与生物传感器浓度模块接触，允许微生物长时间生长并检测离散微生物的生长作为所述微生物存在的指示。

3. 发明申请

US20050147758A1 Hydroxyl functional surface coating 失效
标题翻译：羟基官能表面涂层
公开(公告)号：US20050147758A1
公开(公告)日：2005-07-07
申请号：US11035849
申请日：2005-01-13
申请人： Guoqiang Mao , Steven Metzger , Michael Lochhead , David Goldberg , Charles Greef , David Grainger
发明人： Guoqiang Mao , Steven Metzger , Michael Lochhead , David Goldberg , Charles Greef , David Grainger
IPC分类号： G01N33/53 , G01N33/543 , G01N35/00 , B05D3/02
CPC分类号： G01N33/54393 , A61L27/34 , A61L29/085 , A61L31/10 , G01N33/5306 , G01N2035/00158
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

4. 发明申请

US20070298513A1 Enumeration Method of Analyte Detection 审中-公开
标题翻译：分析物检测的计数方法
公开(公告)号：US20070298513A1
公开(公告)日：2007-12-27
申请号：US11552111
申请日：2006-10-23
申请人： Timothy Starzl , Scott Clark , Mary Vellequette , H. Hanlin , Steven Metzger
发明人： Timothy Starzl , Scott Clark , Mary Vellequette , H. Hanlin , Steven Metzger
IPC分类号： G01N21/01
CPC分类号： G01N21/6456 , G01N21/253 , G01N21/47 , G01N21/4738 , G01N21/6428 , G01N21/6452 , G01N2021/4707
摘要： This invention is directed to an optically-based method and system for analyte detection using solid phase immobilization, specific analyte labels adapted for signal generation and corresponding processes for the utilization thereof. The enumeration detection method disclosed herein narrows the area for signal observation, thus, improving detectable signal to background ratio. The system is comprised of a platform/support for immobilizing a sample stage having a labeled sample (analyte complex) bound thereto, a radiation source, an optical apparatus for generating and directing radiation at said sample and a control that obtains data and then conducts analyses using digital image data. Upon engagement of the system, the sample generates a signal capable of differentiation from background signal, both of which are collected and imaged with a signal detector that generated a sample image to a data processing apparatus. This apparatus receives signal measurements and, in turn, enumerates individual binding events. Generated signal may be increased via selected mass enhancement. The invention, enumeration assay methodology detecting individual binding events, may be used, for example, in analyses to detect analyte or confirm results in both research, commercial and point of care applications.
摘要翻译：本发明涉及一种基于光学的方法和系统，用于使用固相固定的分析物检测，适用于信号产生的特定分析物标记及其利用的相应过程。这里公开的枚举检测方法缩小了信号观察的面积，从而提高了可检测信号与背景比。该系统包括用于固定具有与其结合的标记样品（分析物复合物）的样品台的平台/支架，辐射源，用于在所述样品处产生和引导辐射的光学装置，以及获得数据然后进行分析的控制使用数字图像数据。在系统接合时，样本产生能够与背景信号区分开的信号，两者都被信号检测器收集并成像，所述信号检测器产生样本图像到数据处理设备。该装置接收信号测量，并且依次枚举各个绑定事件。可以通过选择的质量增强来增加生成的信号。本发明的检测单个结合事件的计数检测方法可用于例如在分析中检测分析物或在研究，商业和护理点应用中确认结果。

5. 发明申请

US20180221620A1 MODULATION OF BRAINWAVE ACTIVITY USING NON-INVASIVE STIMULATION OF SENSORY PATHWAYS 审中-公开
公开(公告)号：US20180221620A1
公开(公告)日：2018-08-09
申请号：US15571583
申请日：2016-05-04
申请人： Steven Metzger
发明人： Steven Metzger
IPC分类号： A61M21/02 , A61B5/0484 , A61B5/16 , A61B5/00 , A61N1/36 , A61B5/0478
CPC分类号： A61M21/02 , A61B5/0478 , A61B5/04842 , A61B5/04845 , A61B5/168 , A61B5/4064 , A61B5/6803 , A61B5/6814 , A61B2562/0209 , A61M2021/0022 , A61M2021/0027 , A61M2021/005 , A61M2021/0072 , A61M2230/10 , A61N1/0456 , A61N1/0484 , A61N1/36025
摘要： Methods and apparatus for modulation of the central nervous system, and more particularly for modulation of brain oscillatory activity and the brain networks that give rise to it. The methods involve using one or more non-invasive stimuli, either alone or in combination, to increase, decrease, or otherwise modulate neural oscillations in the brain. Also described are methods and devices for detecting sub-optimal or pathological neural oscillatory patterns, developing treatment protocols to modify the neural oscillations in a desired manner, introducing a non-invasive stimulus or stimuli through one or more sensory pathways to treat the conditions, and adjusting the treatment protocol to improve the therapeutic effect of the stimulus or stimuli.

6. 发明申请

US20050100675A1 Functional surface coating 有权
标题翻译：功能性表面涂层
公开(公告)号：US20050100675A1
公开(公告)日：2005-05-12
申请号：US10964845
申请日：2004-10-13
申请人： Guoqiano Mao , Steven Metzger , Michael Lochhead
发明人： Guoqiano Mao , Steven Metzger , Michael Lochhead
IPC分类号： B05D7/24 , G01N33/53 , G01N33/543 , G01N33/547 , G01N35/00 , G01N37/00 , B05D3/02
CPC分类号： G01N33/54393 , G01N33/5306 , G01N2035/00158 , Y10T428/31504 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678
摘要： Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.
摘要翻译：描述了制备具有低非特异性结合的功能性薄膜或表面涂层的组合物和方法。薄膜含有特定的官能团和非特异性结合驱避剂组分。薄膜共价结合或被动地吸附到各种固体基质上。指定的官能团为薄膜改性的固体表面和非特异性结合驱除剂组分提供了特定的活性，显着降低了与薄膜改性固体表面的非特异性结合。非特异性结合驱避剂组分不影响薄膜中指定的官能团活性。在这些方法中，指定的官能团通过间隔基团固定在固体基质上。还描述了表面涂层具有与特异性结合活性的官能团结合的非特异性蛋白质结合特性，从而提供特异性识别靶蛋白但限制与非特异性蛋白结合的表面涂层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式