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1. 发明授权

US5468847A Method of isolating and purifying a biomacromolecule 失效
标题翻译：分离和纯化生物大分子的方法
公开(公告)号：US5468847A
公开(公告)日：1995-11-21
申请号：US209700
申请日：1994-03-10
申请人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson , Jerald K. Rassmussen , Michael G. Williams
发明人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson , Jerald K. Rassmussen , Michael G. Williams
IPC分类号： G01N33/48 , A61K38/00 , A61K47/48 , B01D15/08 , B01D39/08 , B01D39/16 , C07K1/22 , C07K1/34 , C07K17/14 , C08B37/00 , C12P21/00 , G01N1/10 , C07K1/16 , B01D61/08 , C07K1/18
CPC分类号： B01D39/083 , B01D15/08 , B01D39/086 , B01D39/1623 , B01D39/18 , B01D39/2068 , C07K1/34 , B01D15/361 , B01D15/3804 , B01D2239/0407 , B01D2239/0428 , B01D2239/1291
摘要： The invention provides a method of separating a biomacromolecule which comprises the steps of providing a separation system including a filter element which comprises a composite filtration medium, the composite filtration medium comprising a filtration layer on the upstream surface of which are located insoluble stationary phase particulates, the particulates being capable of binding to a biomacromolecule or class of biomacromolecules, a reservoir containing a solution mixture comprising at least one biomacromolecule as solute, and a pump and associated tubing to form a closed loop assembly, and recirculation pumping the solution mixture through the filter cartridge so as to bind the at least one biomacromolecule to the stationary phase particulate so as to form a biomacromolecule:stationary phase particulate product. An eluting solution can be pumped through the closed loop assembly which is capable of reversing the biomacromolecule:stationary phase particulate product binding interaction so as to liberate the biomacromolecule.
摘要翻译：本发明提供了分离生物大分子的方法，其包括提供包括复合过滤介质的过滤元件的分离系统的步骤，所述复合过滤介质在其上游表面上设置有不溶性固定相颗粒的过滤层，能够结合生物大分子或一类生物大分子的颗粒，含有至少一种作为溶质的生物大分子的溶液混合物的储存器，以及泵和相关管道以形成闭环组件，以及再循环泵送溶液混合物通过过滤器以便将至少一种生物大分子结合至固定相颗粒，以便形成生物大分子：固定相颗粒产物。洗脱溶液可以泵送通过闭环组件，其能够逆转生物大分子：固定相颗粒产物结合相互作用以释放生物大分子。

2. 发明授权

US07373430B2 Cluster accelerator network interface with filter 有权
标题翻译：集群加速器网络接口带过滤器
公开(公告)号：US07373430B2
公开(公告)日：2008-05-13
申请号：US10746315
申请日：2003-12-24
申请人： Michael G. Williams
发明人： Michael G. Williams
IPC分类号： G06F13/00
CPC分类号： H04L69/22
摘要： An apparatus for improving communication between network devices in a cluster. is provided. A filter is used to pre-process packets to determine if they need to be further processed by the processor of the network device. If true, the packets are presented on a bus either in real time or buffered and presented at time intervals. A synch component is used to pre-process packets to determine if they are associated with synchronization information, management information, filter configuration information.
摘要翻译：一种用于改善集群中网络设备之间的通信的装置。被提供。过滤器用于预处理数据包，以确定是否需要由网络设备的处理器进一步处理。如果为真，则分组在总线上呈现或实时或缓冲，并以时间间隔呈现。同步组件用于预处理数据包，以确定它们是否与同步信息，管理信息，过滤器配置信息相关联。

3. 发明授权

US06204704B1 Micropower, minimal area DC sensing power-up reset circuit 有权
标题翻译：微功率，最小面积直流感应上电复位电路
公开(公告)号：US06204704B1
公开(公告)日：2001-03-20
申请号：US09366615
申请日：1999-08-03
申请人： Michael G. Williams , Jonathan Herman Fischer
发明人： Michael G. Williams , Jonathan Herman Fischer
IPC分类号： H03L700
CPC分类号： H03K17/223
摘要： An integrated circuit including a DC sensing power-up reset (PUR) circuit and method for generating a reset signal. The PUR circuit comprises a first terminal for receiving a supply voltage and a second terminal for receiving a reference voltage corresponding to a low logic state. A first transistor is coupled between the first terminal and a first node, wherein the first transistor switches on when the supply voltage is rising and exceeds a rising trip point voltage. A second transistor is coupled between the first terminal and the first node, and switches off when the supply voltage falls below a falling trip point voltage which is less than the rising trip point voltage. A first inverter is coupled at an input terminal to the first node and at an output terminal to a second node. A resistor is coupled between the first node and the second terminal. The resistor pulls the first node down to the reference voltage while the first and second transistors are both off and limits current flowing through the first and second transistors while either or both of the first and second transistors is on.
摘要翻译：包括DC感测上电复位（PUR）电路和产生复位信号的方法的集成电路。 PUR电路包括用于接收电源电压的第一端子和用于接收对应于低逻辑状态的参考电压的第二端子。第一晶体管耦合在第一端子和第一节点之间，其中当电源电压上升并且超过上升跳变点电压时，第一晶体管导通。第二晶体管耦合在第一端子和第一节点之间，并且当电源电压下降到小于上升跳变点电压的下降跳变点电压时关闭。第一反相器在输入端耦合到第一节点，在输出端耦合到第二节点。电阻器耦合在第一节点和第二终端之间。当第一和第二晶体管都断开时，电阻器将第一节点向下拉到参考电压，并且限制在第一和第二晶体管中的任一个或第二晶体管导通的情况下流过第一和第二晶体管的电流。

4. 发明授权

US06174699B1 Disc assay device with inoculation pad and methods of use 有权
标题翻译：具有接种垫的圆盘测定装置和使用方法
公开(公告)号：US06174699B1
公开(公告)日：2001-01-16
申请号：US09264804
申请日：1999-03-09
申请人： Peter D. Wickert , Michael G. Williams
发明人： Peter D. Wickert , Michael G. Williams
IPC分类号： C12Q104
CPC分类号： C12M41/36 , C12M23/12 , C12M23/38 , C12M33/04
摘要： An assay device for detection and enumeration of microorganisms. The device includes absorbent discs on a substrate, an inoculation vehicle to inoculate the discs with sample and an optional coversheet. Methods of use are also disclosed.
摘要翻译：用于检测和计数微生物的测定装置。该装置包括在基底上的吸收盘，用样品和可选的覆盖片接种盘的接种载体。还公开了使用方法。

5. 发明授权

US5512300A Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms 失效
标题翻译：防止布洛芬与固体剂型中的其他治疗剂形成低熔点共晶体
公开(公告)号：US5512300A
公开(公告)日：1996-04-30
申请号：US945203
申请日：1992-09-15
申请人： Timothy H. Weng , Michael G. Williams
发明人： Timothy H. Weng , Michael G. Williams
IPC分类号： A61K9/14 , A61K9/16 , A61K31/192 , A61K9/10 , A61K9/20
CPC分类号： A61K9/143 , A61K31/192 , A61K9/1611 , Y10S514/97
摘要： A method for preparing ibuprofen granulations which exhibit improved stability and resistance to the formation of low melting point eutectics is disclosed. The method includes forging an amalgamation of ibuprofen and an alkali metal in a physical matrix which is suitable for inclusion in a composition without destroying the amalgamation. The stabilized ibuprofen granulation can be combined with other active ingredients and/or excipients to form compositions which have extended shelf life and are resistant to the formation of low melting point eutectics.
摘要翻译：公开了一种制备出具有改善的稳定性和耐低熔点共晶体形成的布洛芬颗粒的方法。该方法包括将物理基质中的布洛芬和碱金属的混合物锻炼，其适于包含在组合物中而不破坏合并。稳定的布洛芬颗粒可以与其它活性成分和/或赋形剂组合以形成具有延长保质期并且耐低熔点共晶体形成的组合物。

6. 发明授权

US09388306B2 Polyethylene stretch film 有权
标题翻译：聚乙烯拉伸膜
公开(公告)号：US09388306B2
公开(公告)日：2016-07-12
申请号：US12867871
申请日：2008-03-04
申请人： Paul M. German , Carlton B. Johnson , Michael G. Williams
发明人： Paul M. German , Carlton B. Johnson , Michael G. Williams
IPC分类号： B32B27/32 , C08L23/06 , C08L23/14 , C08J5/18 , C08L23/08 , B32B27/08 , B32B27/18
CPC分类号： C08L23/142 , B32B27/08 , B32B27/18 , B32B27/32 , B32B2270/00 , B32B2307/30 , B32B2307/50 , B32B2307/51 , B32B2307/514 , B32B2307/54 , B32B2307/558 , B32B2307/704 , B32B2307/72 , B32B2553/00 , C08J5/18 , C08J2323/06 , C08L23/08 , C08L23/0815 , Y10T428/31938 , C08L2666/06
摘要： In one aspect is a film comprising: (a) within the range of from 50 to 99 wt % linear low density polyethylene based on the weight of the core composition; and (b) within the range of from 1 to 50 wt % propylene-α-olefin copolymer based on the weight of the core composition, wherein the propylene-α-olefin copolymer possesses: (i) a melting temperature (Tm) of less than 105° C., and (ii) a heat of fusion (Hf) of less than 75 J/g; wherein the film is a cast or blown film. The films have excellent strength and elasticity and are ideal for such applications as stretch wrap.
摘要翻译：一方面是一种膜，其包含：（a）基于芯组合物的重量，在50至99重量％的线性低密度聚乙烯的范围内; 和（b）基于芯组合物重量的1-50wt％丙烯-α-烯烃共聚物的范围，其中丙烯-α-烯烃共聚物具有：（i）较低的熔融温度（Tm）和（ii）小于75J / g的熔化热（Hf）; 其中所述膜是铸塑或吹塑薄膜。这些薄膜具有优异的强度和弹性，是拉伸包装等应用的理想选择。

7. 发明申请

US20110223250A1 MULTI-VITAMIN AND MINERAL NUTRITIONAL SUPPLEMENTS 审中-公开
标题翻译：多维生素和矿物营养补充剂
公开(公告)号：US20110223250A1
公开(公告)日：2011-09-15
申请号：US13023671
申请日：2011-02-09
申请人： William Bubnis , Richard Cotter , Paul W. Herman , Judith Moreines , Scott W. Poxon , Bruce W. Sutton , Jeffrey V. Vernon , Denise L. Walters , Michael G. Williams , Neil Wittenberg
发明人： William Bubnis , Richard Cotter , Paul W. Herman , Judith Moreines , Scott W. Poxon , Bruce W. Sutton , Jeffrey V. Vernon , Denise L. Walters , Michael G. Williams , Neil Wittenberg
IPC分类号： A61K9/28 , A61K9/20 , A61K33/42 , A61P3/06 , A61K9/00
摘要： The invention provides a nutritional supplement which includes micronutrients to facilitate reduction of cholesterol, and/or reduction of homocystein and/or reduction of low-density lipoprotein-cholesterol (LDL-C) oxidation in humans. In one embodiment the supplement is a multi-vitamin, a mineral supplement which includes at least one component known to reduce cholesterol. The invention further provides a method for tableting one fourth to one half of the daily effective dosage of a phytosterol containing nutritional supplement in a practical sized tablet and a method for reducing blood cholesterol in humans.
摘要翻译：本发明提供一种营养补充剂，其包括促进人体胆固醇降低和/或降低半胱氨酸和/或降低低密度脂蛋白胆固醇（LDL-C）氧化的微量营养素。在一个实施方案中，补充剂是多种维生素，矿物质补充剂，其包括已知降低胆固醇的至少一种组分。本发明还提供了将实用大小的片剂中含有植物甾醇的营养补充剂的每日有效剂量的四分之一到一半的压片和降低人体血液胆固醇的方法。

8. 发明申请

US20070027841A1 Messaging middleware dynamic, continuous search and response agent system 审中-公开
标题翻译：消息中间件动态，连续搜索和响应代理系统
公开(公告)号：US20070027841A1
公开(公告)日：2007-02-01
申请号：US11190502
申请日：2005-07-26
申请人： Michael G. Williams
发明人： Michael G. Williams
IPC分类号： G06F17/30
CPC分类号： G06F16/951 , H04L51/00
摘要： A method and apparatus are provided for searching for information on an Intranet or other suitable private network implemented in a corporation or other business entity or organization, featuring at least one agent in the Intranet that scans email, messaging and/or Intranet resources and provides information in response to a search request from a requesting node. In operation, one or more agents scans the dynamic flow of messaging for search terms and level of authority and issues queries on behalf of the requesting node in order to regulate the secrecy and privacy of the information on the Intranet. In effect, the present invention provides a set of software agents that scan email, messaging or intranet resources during transmission and after storage on the Intranet. These agents issue queries on behalf of verified, authenticated and/or authorised individuals, to messaging accounts related to those messages or documents. These agents also respond to queries from agents in the automatic mode, on behalf of verified, authorised responders. In manual mode, these agents verify the responder's identity and authorisation upon response.
摘要翻译：提供了一种用于搜索在公司或其他商业实体或组织中实现的内联网或其他合适的专用网络上的信息的方法和装置，其特征在于内联网中的至少一个代理扫描电子邮件，消息传递和/或内部网资源并提供信息响应于来自请求节点的搜索请求。在操作中，一个或多个代理扫描用于搜索项和权限级别的消息的动态流程，并代表请求节点发出查询，以便规范内联网上的信息的秘密和隐私。实际上，本发明提供了一组软件代理，其在传输期间和在内联网上存储之后扫描电子邮件，消息或内部网资源。这些代理人代表已验证的，经过身份验证的和/或授权的个人向与这些消息或文档相关的消息传递帐户发出查询。这些代理还可以代表经过验证的授权回复者在自动模式下响应来自代理的查询。在手动模式下，这些代理人在响应时验证响应者的身份和授权。

9. 发明授权

US06756225B2 Automated imaging and harvesting of colonies on thin film culture devices 有权
公开(公告)号：US06756225B2
公开(公告)日：2004-06-29
申请号：US09797343
申请日：2001-03-01
申请人： William Bedingham , Raj Rajagopal , Michael G. Williams
发明人： William Bedingham , Raj Rajagopal , Michael G. Williams
IPC分类号： C12M122
CPC分类号： C12M23/22 , C12M23/04 , C12M23/50 , C12M25/02 , C12M33/04
摘要： Thin film culture devices are described that have positioning structures, as well as methods for harvesting cells from colonies on the culture device based on location of colonies on the device relative to the positioning structures. In addition, a computer readable medium encoded with a computer program is described that identifies position of colonies relative to the positioning structures.

10. 发明授权

US06735305B1 Detection of low tip/ring currents in a line powered DAA 有权
标题翻译：检测线路供电DAA中的低尖端/环形电流
公开(公告)号：US06735305B1
公开(公告)日：2004-05-11
申请号：US09414566
申请日：1999-10-04
申请人： Jonathan H. Fischer , Donald R. Laturell , Lane A. Smith , Michael S. Toth , Michael G. Williams , Keith Eugene Hollenbach , Weilin Zhu
发明人： Jonathan H. Fischer , Donald R. Laturell , Lane A. Smith , Michael S. Toth , Michael G. Williams , Keith Eugene Hollenbach , Weilin Zhu
IPC分类号： H04M100
CPC分类号： H04M1/738 , H04M19/02
摘要： A line powered data access arrangement (DAA) is disclosed which adaptively allows proper operation with power supplied from a telephone line as conditions warrant, while at the same time satisfying the relevant requirements of many countries. In the line powered codec, a startup procedure for the international line powered codec uses register settings, e.g., country-specific register settings, which are powered and maintained from the low voltage side (e.g., from the PC or modem side) of the line powered codec. In this way, even during low line power conditions the programmed state of the line powered codec can be maintained, thus a default condition will not necessarily returned to by the line powered codec upon reset due to a power loss in the telephone line. In another aspect, a charge storage device such as a charge capacitor is charged from a charge pump formed from a differential clock signal from the low voltage side. A current and voltage detection module in the line powered codec is always powered from the telephone line. Upon detection of an off-hook signal or a power down condition, the current detection module determines if/when the current and voltage on the telephone line is sufficient to power certain circuits on the line powered codec. If sufficient power is not present, the line powered codec does not power up. However, the line powered codec will power up if sufficient current is detected. In another aspect, a plurality of power rails may be provided. A first power rail may be associated with the line power, a second power rail may be associated with a low voltage side power source, e.g., a charge storage device. A third (and other) power rails may be switchably connected to either the first power rail or second power rail as line power conditions and on-hook/off-hook conditions warrant.
摘要翻译：公开了一种线路数据访问安排（DAA），其适应性地允许根据条件允许从电话线路提供的电力进行适当的操作，同时满足许多国家的相关要求。在线路供电的编解码器中，用于国际线路供电的编解码器的启动过程使用寄存器设置，例如，国家特定寄存器设置，其由线路的低电压侧（例如，从PC或调制解调器侧）供电和维护电源编解码器。以这种方式，即使在低功率电力条件下，也可以维护线路供电的编解码器的编程状态，因此由于电话线路中的功率损耗，默认条件不一定由线路供电的编解码器复位。另一方面，诸如充电电容器的电荷存储装置从由低电压侧的差分时钟信号形成的电荷泵充电。线路供电编解码器中的电流和电压检测模块始终通过电话线供电。当检测到摘机信号或断电状态时，电流检测模块确定电话线路上的电流和电压是否足以对线路供电的编解码器上的某些电路供电。如果没有足够的电源，线路供电的编解码器不会上电。然而，如果检测到足够的电流，则线路供电的编解码器将上电。另一方面，可以设置多个电源轨。第一电力轨可以与线路电力相关联，第二电力轨道可以与低电压侧电源（例如电荷存储装置）相关联。第三（和其他）电源轨可以切换地连接到第一个电源轨或第二个电源轨，因为线路电源条件和挂机/摘机条件值得。

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