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1. 发明授权

US08492138B2 Optical instrument including excitation source 有权
公开(公告)号：US08492138B2
公开(公告)日：2013-07-23
申请号：US13611462
申请日：2012-09-12
申请人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
发明人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.

2. 发明授权

US08557569B2 Optical instrument including excitation source 有权
公开(公告)号：US08557569B2
公开(公告)日：2013-10-15
申请号：US12217410
申请日：2008-07-03
申请人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
发明人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
IPC分类号： C12M3/00 , C12M1/34 , F21V9/16
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.

3. 发明授权

US07410793B2 Optical instrument including excitation source 有权
标题翻译：光学仪器包括激发源
公开(公告)号：US07410793B2
公开(公告)日：2008-08-12
申请号：US10440920
申请日：2003-05-19
申请人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
发明人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , G01N21/64 , G01N21/66
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
摘要翻译：提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。还提供了使用光学仪器的分析方法。

4. 发明申请

US20130011848A1 Optical Instrument Including Excitation Source 有权
标题翻译：包括激发源的光学仪器
公开(公告)号：US20130011848A1
公开(公告)日：2013-01-10
申请号：US13611462
申请日：2012-09-12
申请人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
发明人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
IPC分类号： G01N21/75 , C12M1/40
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
摘要翻译：提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。还提供了使用光学仪器的分析方法。

5. 发明申请

US20090009767A1 Optical instrument including excitation source 有权
标题翻译：光学仪器包括激发源
公开(公告)号：US20090009767A1
公开(公告)日：2009-01-08
申请号：US12217410
申请日：2008-07-03
申请人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
发明人： Steven J. Boege , Howard G. King , Eugene F. Young , Johannes P. Sluis , Mark F. Oldham
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , B01L7/52 , C12Q2545/101 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with excitation beams generated by a light source. The light source can include an area light array of light emitting diodes, one or more solid state lasers, one or more micro-wire lasers, or a combination thereof. According to various embodiments, a Fresnel lens can be disposed along a beam bath between the light source and the reaction regions. Methods of analysis using the optical instrument are also provided.
摘要翻译：提供了一种光学仪器，用于同时用由光源产生的激发光束照射两个或更多个间隔开的反应区域。光源可以包括发光二极管的区域光阵列，一个或多个固态激光器，一个或多个微线激光器，或其组合。根据各种实施例，菲涅耳透镜可以沿着光源和反应区域之间的光束槽设置。还提供了使用光学仪器的分析方法。

6. 发明授权

US07599060B2 Optical scanning configurations, systems, and methods involving at least one actuator for scanning a scan head 有权
标题翻译：涉及用于扫描扫描头的至少一个致动器的光学扫描配置，系统和方法
公开(公告)号：US07599060B2
公开(公告)日：2009-10-06
申请号：US12222820
申请日：2008-08-18
申请人： Jon A. Hoshizaki , Howard G. King , Johannes P. Sluis , Steven J. Boege , Mark F. Oldham
发明人： Jon A. Hoshizaki , Howard G. King , Johannes P. Sluis , Steven J. Boege , Mark F. Oldham
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , F21V29/54 , F21V29/677 , F21V29/763 , G01N21/6452 , G01N2021/6439 , G01N2201/062 , G01N2201/1211 , G05D23/1919 , G05D23/20
摘要： An optical system includes a sample substrate having a surface, the surface defining a 2-dimensional sample plane. The system includes an excitation source configured to provide excitation light to the sample substrate. The system further includes an optical detector configured to receive emission light from the sample substrate and generate detection data. The system also includes a scan head configured at least (i) to direct the excitation light towards the sample substrate, (ii) to receive emission light from the sample substrate and direct the emission light towards the optical detector, and (iii) for scanning relative to the sample substrate. The system includes at least one actuator configured to scan the scan head relative to the sample substrate, the at least one actuator being configured to provide at least one of (1) a relative linear motion and a relative angular motion about a rotational axis generally perpendicular to the sample plane and (2) two relative angular motions about two respectively different rotational axes generally perpendicular to the sample plane.
摘要翻译：光学系统包括具有表面的样品基底，该表面限定了二维样品平面。该系统包括被配置为向样品基底提供激发光的激发源。该系统还包括光学检测器，其被配置为接收来自样品基板的发射光并产生检测数据。该系统还包括扫描头，该扫描头至少配置成（i）将激发光引向样品衬底，（ii）接收来自样品衬底的发射光并将发射光引向光学检测器，以及（iii）用于扫描相对于样品基底。所述系统包括至少一个致动器，其构造成相对于样品基板扫描扫描头，所述至少一个致动器被配置为提供以下中的至少一个：（1）相对线性运动和围绕大体垂直的旋转轴线的相对角运动（2）大致垂直于样品平面的两个不同旋转轴的两个相对角运动。

7. 发明授权

US07635588B2 Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength 有权
标题翻译：用于通过激发波长区分多个荧光信号的装置和方法
公开(公告)号：US07635588B2
公开(公告)日：2009-12-22
申请号：US10440852
申请日：2003-05-19
申请人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
发明人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
IPC分类号： C12M1/34 , C12M3/00 , F21V9/16 , G01J1/58
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2201/0612 , G01N2201/062 , G01N2201/0627 , Y10S435/808 , Y10S435/809
摘要： An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.
摘要翻译：提供一种用于通过激发波长区分多个可检测信号的装置和方法。该装置可以包括可以例如在一个井中的样品保留区域中的样品发射相应的激发光波长或波长范围的光源。样品可以包含两种或更多种可检测的标记，例如荧光染料，其中当荧光染料在靶组分存在下被激发时，其能够产生增加的可检测的发射。可检测标记物可以具有与其它可检测标记物的范围重叠的激发波长范围和/或发射波长范围。可以设置检测器，用于检测在至少一个其他标记的重叠波长范围内从第一标记发射的发射波长或波长范围。

8. 发明授权

US10768110B2 Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength 有权
公开(公告)号：US10768110B2
公开(公告)日：2020-09-08
申请号：US12642009
申请日：2009-12-18
申请人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
发明人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
IPC分类号： G01N21/00 , B01L7/00 , G01N21/64
摘要： An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.

9. 发明申请

US20120087832A1 Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength 有权
标题翻译：通过激发波长区分多个荧光信号的装置和方法
公开(公告)号：US20120087832A1
公开(公告)日：2012-04-12
申请号：US13333788
申请日：2011-12-21
申请人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
发明人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
IPC分类号： G01N21/64 , G01N21/63
CPC分类号： G01N21/6428 , B01L7/52 , B01L2300/1805 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/062 , G01N2201/0627 , G01N2201/0628 , Y10S435/808
摘要： An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.
摘要翻译：提供一种用于通过激发波长区分多个可检测信号的装置和方法。该装置可以包括可以例如在一个井中的样品保留区域中的样品发射相应的激发光波长或波长范围的光源。样品可以包含两种或更多种可检测的标记，例如荧光染料，其中当荧光染料在靶组分存在下被激发时，其能够产生增加的可检测的发射。可检测标记物可以具有与其它可检测标记物的范围重叠的激发波长范围和/或发射波长范围。可以设置检测器，用于检测在至少一个其他标记的重叠波长范围内从第一标记发射的发射波长或波长范围。

10. 发明申请

US20100216143A1 Apparatus and Method for Differentiating Multiple Fluorescence Signals by Excitation Wavelength 审中-公开
标题翻译：通过激发波长区分多个荧光信号的装置和方法
公开(公告)号：US20100216143A1
公开(公告)日：2010-08-26
申请号：US12642009
申请日：2009-12-18
申请人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
发明人： Howard G. King , Steven J. Boege , Eugene F. Young , Mark F. Oldham
IPC分类号： C12Q1/68 , G01J1/58
摘要： An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. The sample can contain two or more detectable markers, for example, fluorescent dyes, each of which can be capable of generating increased detectable emissions when excited in the presence of a target component. The detectable markers can have excitation wavelength ranges and/or emission wavelength ranges that overlap with the ranges of the other detectable markers. A detector can be arranged for detecting an emission wavelength or wavelength range emitted from a first marker within the overlapping wavelength range of at least one of the other markers.
摘要翻译：提供一种用于通过激发波长区分多个可检测信号的装置和方法。该装置可以包括可以例如在一个井中的样品保留区域中的样品发射相应的激发光波长或波长范围的光源。样品可以包含两种或更多种可检测的标记，例如荧光染料，其中当荧光染料在靶组分存在下被激发时，其能够产生增加的可检测的发射。可检测标记物可以具有与其它可检测标记物的范围重叠的激发波长范围和/或发射波长范围。可以设置检测器，用于检测在至少一个其他标记的重叠波长范围内从第一标记发射的发射波长或波长范围。

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