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1. 发明授权

US07899540B2 Noninvasively adjustable gastric band 有权
标题翻译：非侵入性可调节胃带
公开(公告)号：US07899540B2
公开(公告)日：2011-03-01
申请号：US11118980
申请日：2005-04-29
申请人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
发明人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007
摘要： A method and apparatus for treatment of an eating disorder includes electrically stimulating the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. A device comprising a gastric band including stimulation electrodes may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. A programmable implantable stimulus generator may be operatively coupled to a nerve electrode. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导迷走神经的传入动作电位。包括刺激电极的胃带的装置可以在植入后进行非侵入性调整，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可编程植入式刺激发生器可以可操作地耦合到神经电极。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

2. 发明授权

US07835796B2 Weight loss method and device 有权
标题翻译：减肥方法和装置
公开(公告)号：US07835796B2
公开(公告)日：2010-11-16
申请号：US11118452
申请日：2005-04-29
申请人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
发明人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61F5/0003
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

3. 发明授权

US07310557B2 Identification of electrodes for nerve stimulation in the treatment of eating disorders 有权
标题翻译：鉴别用于治疗进食障碍的神经刺激电极
公开(公告)号：US07310557B2
公开(公告)日：2007-12-18
申请号：US11118861
申请日：2005-04-29
申请人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
发明人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
IPC分类号： A61N1/00
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007 , A61N1/36082 , A61N1/36185 , A61N1/3686
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

4. 发明授权

US08660647B2 Stimulating cranial nerve to treat pulmonary disorder 有权
标题翻译：刺激颅神经治疗肺部疾病
公开(公告)号：US08660647B2
公开(公告)日：2014-02-25
申请号：US11191896
申请日：2005-07-28
申请人： Steven M. Parnis , Steven E. Maschino , William R. Buras , Albert W. Guzman
发明人： Steven M. Parnis , Steven E. Maschino , William R. Buras , Albert W. Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： A method for stimulating a portion of a vagus nerve of a patient to treat a pulmonary disorder is provided. At least one electrode is coupled to at least one portion of a left vagus nerve and/or a right vagus nerve of the patient. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pulmonary disorder. The electrical signal may perform a blocking of an intrinsic neural activity on said at least one portion of the left vagus nerve and said right vagus nerve.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗肺部疾病的方法。至少一个电极耦合到患者的左迷走神经和/或右侧迷走神经的至少一部分。使用电极将电信号施加到迷走神经的部分以治疗肺部疾病。电信号可以在左迷走神经和右迷走神经的所述至少一部分上执行内在神经活动的阻断。

5. 发明授权

US07706874B2 Stimulating cranial nerve to treat disorders associated with the thyroid gland 有权
标题翻译：刺激颅神经治疗与甲状腺相关的疾病
公开(公告)号：US07706874B2
公开(公告)日：2010-04-27
申请号：US11191340
申请日：2005-07-28
申请人： Steven E. Maschino , Steven M. Parnis , William R. Buras , Albert W. Guzman
发明人： Steven E. Maschino , Steven M. Parnis , William R. Buras , Albert W. Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/36053
摘要： A method, system, and an apparatus for stimulating a cranial nerve of a patient to treat a disorder, such as a metabolic or an endocrine disorder associated with the thyroid gland with an implantable medical device are provided. The method comprises coupling an electrode to the cranial nerve selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve. The method further includes generating an electrical signal to treat a disorder associated with the thyroid gland. The electrical signal may be applied to the cranial nerve using the electrode to provide electrical nerve stimulation therapy to the patient. For treating a patient with a metabolic or an endocrine disorder associated with the thyroid gland, a neurostimulator may be adapted to apply an electrical stimulus to the vagus nerve and/or a branch of the vagus nerve associated with the thyroid gland. By balancing hormonal imbalance, the neurostimulator may provide electrical nerve stimulation therapy to the patient, thereby treating a target metabolic or an endocrine disorder associated with the thyroid gland.
摘要翻译：提供了一种用于通过可植入医疗装置刺激患者的颅神经以治疗诸如与甲状腺相关的代谢或内分泌紊乱的病症的方法，系统和装置。该方法包括将电极连接到选自迷走神经，三叉神经和咽舌神经的颅神经中。该方法还包括产生电信号以治疗与甲状腺相关的病症。可以使用电极将电信号施加到颅神经，以向患者提供电神经刺激治疗。为了治疗患有与甲状腺相关的代谢或内分泌紊乱的患者，神经刺激器可适用于向迷走神经和/或与甲状腺相关的迷走神经的分支施加电刺激。通过平衡激素不平衡，神经刺激器可以向患者提供电神经刺激疗法，从而治疗与甲状腺相关的靶代谢或内分泌紊乱。

6. 发明申请

US20110178569A1 STIMULATING CRANIAL NERVE TO TREAT PULMONARY DISORDER 审中-公开
标题翻译：刺激性神经痛治疗肺动脉疾病
公开(公告)号：US20110178569A1
公开(公告)日：2011-07-21
申请号：US13075662
申请日：2011-03-30
申请人： Steven M. Parnis , Steven E. Maschino , William R. Buras , Albert W. Guzman
发明人： Steven M. Parnis , Steven E. Maschino , William R. Buras , Albert W. Guzman
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： Systems and methods to treat a pulmonary disorder are provided. A particular method includes positioning an electrode in a patient's body at a location proximate a branch of a vagus nerve. The branch of the vagus nerve includes at least one of a bronchial branch of the vagus nerve and a pulmonary plexus. The method also includes activating the electrode such that energy is delivered from the electrode to the branch of the vagus nerve so as to block intrinsic neural activity in the branch of the vagus nerve to treat the pulmonary disorder.
摘要翻译：提供了治疗肺部疾病的系统和方法。一种特定的方法包括将电极定位在靠近迷走神经分支的位置处的患者体内。迷走神经的分支包括迷走神经的支气管分支和肺丛中的至少一个。该方法还包括激活电极，使得能量从电极传递到迷走神经的分支，以阻止迷走神经的分支中的内在神经活动以治疗肺部疾病。

7. 发明授权

US07856273B2 Autonomic nerve stimulation to treat a gastrointestinal disorder 有权
标题翻译：自主神经刺激治疗胃肠道疾病
公开(公告)号：US07856273B2
公开(公告)日：2010-12-21
申请号：US11191846
申请日：2005-07-28
申请人： Steven E. Maschino , Steven M. Parnis , William R. Buras , Albert W. Guzman
发明人： Steven E. Maschino , Steven M. Parnis , William R. Buras , Albert W. Guzman
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36007
摘要： A method and apparatus for stimulating a portion of a vagus nerve of a patient to treat a gastrointestinal disorder is provided. At least one electrode is coupled to at least one portion of a vagus nerve of the patient. The portion of the a vagus nerve may include an esophageal plexus, a myenteric plexus of aurbach, a submucous plexus of the meissner, a principal nerve of the lesser curvature of the stomach, and a gastric branch of said vagus nerve. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the gastrointestinal disorder.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗胃肠道疾病的方法和装置。至少一个电极耦合到患者的迷走神经的至少一部分。迷走神经的一部分可以包括食道丛，aurbach的肌间神经丛，meissner的粘膜下神经丛，胃的较小曲率的主要神经和所述迷走神经的胃分支。使用电极将电信号施加到迷走神经的部分以治疗胃肠道疾病。

8. 发明授权

US07840280B2 Cranial nerve stimulation to treat a vocal cord disorder 有权
标题翻译：颅神经刺激治疗声带紊乱
公开(公告)号：US07840280B2
公开(公告)日：2010-11-23
申请号：US11191121
申请日：2005-07-27
申请人： Steven M. Parnis , Steven E. Maschino , Albert W. Guzman
发明人： Steven M. Parnis , Steven E. Maschino , Albert W. Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0456 , A61N1/36014 , A61N1/36053
摘要： Disclosed is a method of treating a patient having a vocal cord disorder, comprising coupling at least one electrode to at least one cranial nerve of the patient, wherein the cranial nerve is selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve, and applying an electrical signal to the cranial nerve using the electrode to treat the vocal cord disorder. The electrode may be coupled to a branch of the vagus nerve selected from the group consisting of a recurrent laryngeal nerve, the external branch of a superior laryngeal nerve, the internal branch of a superior laryngeal nerve, and a pharyngeal plexus. Also disclosed is a computer readable program storage device encoded with instructions that, when executed by a computer, perform the method, and a medical device and a vocal cord disorder treatment system that may be used in performance of the method.
摘要翻译：公开了一种治疗具有声带病症的患者的方法，包括将至少一个电极耦合到患者的至少一个颅神经，其中所述颅神经选自迷走神经，三叉神经和舌咽神经，并使用电极将电信号施加到颅神经以治疗声带紊乱。电极可以耦合到迷走神经的分支，其选自复发性喉神经，上喉神经的外分支，上喉神经的内分支和咽神经丛。还公开了一种计算机可读程序存储装置，其编码有当由计算机执行时执行该方法的指令，以及可用于执行该方法的医疗装置和声带紊乱处理系统。

9. 发明授权

US06721603B2 Nerve stimulation as a treatment for pain 有权
标题翻译：神经刺激作为治疗疼痛
公开(公告)号：US06721603B2
公开(公告)日：2004-04-13
申请号：US10055021
申请日：2002-01-25
申请人： Jacob Zabara , Burke T. Barrett , Steven M. Parnis
发明人： Jacob Zabara , Burke T. Barrett , Steven M. Parnis
IPC分类号： A61N134
CPC分类号： A61N1/36071
摘要： A method and apparatus are disclosed for treating patients suffering from severe, unrelenting pain. A therapeutic stimulation signal is selectively applied from a stimulus generator, when activated, to at least some of plural electrodes implanted in stimulating relation to at least two nerves among the patient's trigeminal, vagus, glossopharyngeal and sympathetic nerves, and the stimulus generator is activated to generate the therapeutic stimulation signal to alleviate the pain under treatment. Alternatively, the therapeutic stimulation signal is selectively applied to at least one electrode implanted in stimulating relation to at least one of the patient's trigeminal, vagus, glossopharyngeal and sympathetic nerves, and if the selected nerve is the vagus nerve, the signal is applied to a supra-diaphragmatic or sub-diaphragmatic site, either unilaterally or bilaterally to one or both branches, respectively, of the vagus nerve.
摘要翻译：公开了一种用于治疗患有严重，不懈疼痛的患者的方法和装置。治疗刺激信号从被刺激发生器被激活时选择性地施加到在患者的三叉神经，迷走神经，舌咽和交感神经之间与至少两个神经刺激关系植入的多个电极中的至少一些，并且刺激发生器被激活产生治疗刺激信号以减轻治疗期间的疼痛。或者，将治疗刺激信号选择性地施加到植入与患者的三叉神经，迷走神经，舌咽和交感神经中的至少一个刺激关系的至少一个电极，并且如果选择的神经是迷走神经，则将信号施加到分别为迷走神经的一个或两个分支单侧或双侧的膈上或膈下部位。

10. 发明授权

US08403823B2 Ventricular connector 有权
标题翻译：心室连接器
公开(公告)号：US08403823B2
公开(公告)日：2013-03-26
申请号：US10799534
申请日：2004-03-12
申请人： Long Sheng Yu , Peter Piferi , Steven M. Parnis
发明人： Long Sheng Yu , Peter Piferi , Steven M. Parnis
IPC分类号： A61M1/12
CPC分类号： A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/1025 , A61M1/122 , A61M1/3659
摘要： A ventricular apex connector for quick connection and disconnection of an inflow tube of a ventricular assist device, comprising a sewing ring, a cylindrical ring, gripping pins, a spring ring and a sealing O-ring is provided. The cylindrical ring defines two openings, diametrically opposed to each other, in its walls. Gripping pins, comprising rods with gripping pads, are placed in the openings in the cylindrical ring so that the gripping pads are at rest within the inner circumference of the cylindrical ring. The spring ring is placed around the cylindrical ring and the rods of the gripping pads, which extend out of the outer wall of the cylindrical ring, are welded to the spring ring. The gripping pins are thus biased towards each other by the force of the spring ring. When the spring ring is squeezed, at points away from the gripping pin connection points, the deformation of the spring ring causes the gripping pads to be pulled out towards the inner wall of the cylindrical ring. An inflow tube of a heart pump may then be inserted into the ventricular apex connector, and upon the release of the spring ring, the inflow tube is sealedly held within the ventricle of the heart. In an embodiment an adapter sleeve may be attached to the inflow tube. In a further embodiment, the inflow tube may include an inner sleeve that is slidably and rotatably mounted therein. The inflow tube may have a bend at an end.
摘要翻译：提供了一种用于快速连接和断开心室辅助装置的流入管的心室顶端连接器，包括缝合环，圆柱形环，夹紧销，弹簧环和密封O形环。圆柱形环在其壁中限定了彼此直径相对的两个开口。包括具有夹紧垫的杆的夹持销被放置在圆柱形环中的开口中，使得夹紧垫在圆柱形环的内圆周内静止。弹簧环放置在圆柱形环周围，并且从圆柱形环的外壁延伸出的夹持杆的杆被焊接到弹簧环。夹紧销因此被弹簧圈的力彼此偏置。当弹簧环被挤压时，在远离夹紧销连接点的点处，弹簧环的变形使夹持垫朝向圆柱形环的内壁拉出。然后将心脏泵的流入管插入心室顶端连接器中，并且当弹簧环释放时，流入管被密封地保持在心脏的心室内。在一个实施例中，适配器套筒可以附接到流入管。在另一个实施例中，流入管可以包括可滑动地和可旋转地安装在其中的内套筒。流入管可以在一端具有弯曲。

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