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1. 发明授权

US07555344B2 Selective neurostimulation for treating epilepsy 有权
标题翻译：选择性神经刺激治疗癫痫
公开(公告)号：US07555344B2
公开(公告)日：2009-06-30
申请号：US11261182
申请日：2005-10-28
申请人： Steven E. Maschino , Stephen K. Brannan
发明人： Steven E. Maschino , Stephen K. Brannan
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61M2005/1726 , A61M2205/054 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N2/006
摘要： A method and device for treating epilepsy are disclosed which provide for electrical, chemical or magnetic stimulation of certain areas of the brain to modulate neuronal activity of areas associated with symptoms of epilepsy. Deep brain stimulation is combined with vagus nerve stimulation to enhance symptomatic relief of the disorder. Some embodiments also employ a sensing capability to optimize the therapeutic treatment regimen.
摘要翻译：公开了用于治疗癫痫的方法和装置，其提供对脑的某些区域的电，化学或磁刺激以调节与癫痫症状相关的区域的神经元活动。深部脑刺激与迷走神经刺激相结合，增强症状缓解症状。一些实施例还采用感测能力来优化治疗治疗方案。

2. 发明授权

US08483846B2 Multi-electrode assembly for an implantable medical device 有权
标题翻译：用于可植入医疗装置的多电极组件
公开(公告)号：US08483846B2
公开(公告)日：2013-07-09
申请号：US12757002
申请日：2010-04-08
申请人： Steven E. Maschino , Bryan P. Byerman
发明人： Steven E. Maschino , Bryan P. Byerman
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0553 , Y10T29/49218
摘要： A method, system, and apparatus are provided for an electrode assembly comprising a plurality of electrodes for use with an implantable medical device for conducting an electrical signal between the implantable medical device and a target tissue. The electrode assembly includes a helical member and first and second electrodes formed upon the helical member. The first and second electrodes are adapted to deliver the electrical signal. The electrode assembly also includes a first conductive element formed upon the helical member and operatively coupled to the first electrode. The electrode assembly also includes a second conductive element formed upon the helical member and operatively coupled to the second electrode.
摘要翻译：提供了一种用于电极组件的方法，系统和装置，其包括用于在可植入医疗装置和目标组织之间传导电信号的可植入医疗装置的多个电极。电极组件包括螺旋构件和形成在螺旋构件上的第一和第二电极。第一和第二电极适于传送电信号。电极组件还包括形成在螺旋构件上并可操作地耦合到第一电极的第一导电元件。电极组件还包括形成在螺旋构件上并可操作地耦合到第二电极的第二导电元件。

3. 发明授权

US08204603B2 Blocking exogenous action potentials by an implantable medical device 有权
标题翻译：通过植入式医疗装置阻断外源动作电位
公开(公告)号：US08204603B2
公开(公告)日：2012-06-19
申请号：US12109467
申请日：2008-04-25
申请人： Steven E. Maschino
发明人： Steven E. Maschino
IPC分类号： A63B21/00 , A61N1/18
CPC分类号： A61N1/0551 , A61N1/36114
摘要： An implantable medical device (IMD) to treat a medical condition in a patient comprises an electrical signal generator; a cathode and an anode operatively coupled to the electrical signal generator and a cranial nerve of the patient; and a third electrode operatively coupled to the electrical signal generator and implanted within the patient's body; wherein the electrical signal generator is capable of generating and delivering at least one electrical signal effective at the anode to block at least a sufficient portion of action potentials induced by the at least one electrical signal in the cranial nerve proximate the cathode to reduce a side effect of said induced action potentials.
摘要翻译：用于治疗患者的医疗状况的可植入医疗装置（IMD）包括电信号发生器; 可操作地耦合到电信号发生器和患者的颅神经的阴极和阳极; 以及第三电极，其可操作地耦合到所述电信号发生器并植入患者体内; 其中所述电信号发生器能够产生和递送在所述阳极处有效的至少一个电信号，以阻挡由靠近所述阴极的所述颅神经中由所述至少一个电信号引起的至少足够部分的动作电位以减少副作用的所述诱导动作电位。

4. 发明授权

US07899540B2 Noninvasively adjustable gastric band 有权
标题翻译：非侵入性可调节胃带
公开(公告)号：US07899540B2
公开(公告)日：2011-03-01
申请号：US11118980
申请日：2005-04-29
申请人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
发明人： Steven E. Maschino , Steven M. Parnis , Scott A. Armstrong
IPC分类号： A61N1/36
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007
摘要： A method and apparatus for treatment of an eating disorder includes electrically stimulating the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. A device comprising a gastric band including stimulation electrodes may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. A programmable implantable stimulus generator may be operatively coupled to a nerve electrode. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导迷走神经的传入动作电位。包括刺激电极的胃带的装置可以在植入后进行非侵入性调整，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可编程植入式刺激发生器可以可操作地耦合到神经电极。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

5. 发明授权

US07869884B2 Non-surgical device and methods for trans-esophageal vagus nerve stimulation 失效
标题翻译：用于经食道性迷走神经刺激的非手术装置和方法
公开(公告)号：US07869884B2
公开(公告)日：2011-01-11
申请号：US11796158
申请日：2007-04-26
申请人： Timothy L. Scott , Steven E. Maschino
发明人： Timothy L. Scott , Steven E. Maschino
IPC分类号： A61N1/32
CPC分类号： A61N1/0517 , A61N1/0551 , A61N1/36114
摘要： Devices and methods of non-surgically providing vagus nerve therapy trans-esophageally to treat a variety of medical conditions are disclosed herein. In an embodiment, an implantable medical device comprises a support member having an outer surface. The support member is adapted to engage the inner wall of an esophagus. The IMD also comprises at least one electrode disposed on the outer surface of the support member. The at least one electrode is capable of applying a trans-esophageal electrical signal to the vagus nerve through the wall of the esophagus from the inner lumen thereof. The implantable medical device further comprises a signal generator coupled to the support member and to the at least one electrode. The signal generator causes the at least one electrode to apply an electrical signal to the vagus nerve to treat a medical condition.
摘要翻译：本文公开了通过食管外通道提供迷走神经治疗多种医学病症的装置和方法。在一个实施例中，可植入医疗装置包括具有外表面的支撑构件。支撑构件适于接合食道的内壁。 IMD还包括设置在支撑构件的外表面上的至少一个电极。所述至少一个电极能够通过食管的壁从其内腔向迷走神经施加经食管的电信号。可植入医疗装置还包括耦合到支撑构件和至少一个电极的信号发生器。信号发生器使至少一个电极向迷走神经施加电信号以治疗医疗状况。

6. 发明授权

US07706874B2 Stimulating cranial nerve to treat disorders associated with the thyroid gland 有权
标题翻译：刺激颅神经治疗与甲状腺相关的疾病
公开(公告)号：US07706874B2
公开(公告)日：2010-04-27
申请号：US11191340
申请日：2005-07-28
申请人： Steven E. Maschino , Steven M. Parnis , William R. Buras , Albert W. Guzman
发明人： Steven E. Maschino , Steven M. Parnis , William R. Buras , Albert W. Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/36053
摘要： A method, system, and an apparatus for stimulating a cranial nerve of a patient to treat a disorder, such as a metabolic or an endocrine disorder associated with the thyroid gland with an implantable medical device are provided. The method comprises coupling an electrode to the cranial nerve selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve. The method further includes generating an electrical signal to treat a disorder associated with the thyroid gland. The electrical signal may be applied to the cranial nerve using the electrode to provide electrical nerve stimulation therapy to the patient. For treating a patient with a metabolic or an endocrine disorder associated with the thyroid gland, a neurostimulator may be adapted to apply an electrical stimulus to the vagus nerve and/or a branch of the vagus nerve associated with the thyroid gland. By balancing hormonal imbalance, the neurostimulator may provide electrical nerve stimulation therapy to the patient, thereby treating a target metabolic or an endocrine disorder associated with the thyroid gland.
摘要翻译：提供了一种用于通过可植入医疗装置刺激患者的颅神经以治疗诸如与甲状腺相关的代谢或内分泌紊乱的病症的方法，系统和装置。该方法包括将电极连接到选自迷走神经，三叉神经和咽舌神经的颅神经中。该方法还包括产生电信号以治疗与甲状腺相关的病症。可以使用电极将电信号施加到颅神经，以向患者提供电神经刺激治疗。为了治疗患有与甲状腺相关的代谢或内分泌紊乱的患者，神经刺激器可适用于向迷走神经和/或与甲状腺相关的迷走神经的分支施加电刺激。通过平衡激素不平衡，神经刺激器可以向患者提供电神经刺激疗法，从而治疗与甲状腺相关的靶代谢或内分泌紊乱。

7. 发明授权

US07620455B2 Cranial nerve stimulation to treat eating disorders 有权
标题翻译：颅神经刺激治疗进食障碍
公开(公告)号：US07620455B2
公开(公告)日：2009-11-17
申请号：US11258764
申请日：2005-10-25
申请人： Steven E. Maschino
发明人： Steven E. Maschino
IPC分类号： A61N1/36
CPC分类号： A61N1/36085
摘要： Methods and systems of treating a patient having an eating disorder involving coupling at least one electrode to at least one cranial nerve of the patient, implanting a sensory stimulation device in the patient, applying a sensory stimulus to the patient using the sensory stimulation device, detecting the patient's response to the sensory stimulus, and applying an electrical signal to the cranial nerve using the electrode after detecting the response to treat the eating disorder. The methods and systems are effective in treating bulimia.
摘要翻译：治疗患有进食障碍的患者的方法和系统涉及将至少一个电极耦合到患者的至少一个颅神经，在患者体内植入感觉刺激装置，使用感觉刺激装置向患者施加感觉刺激，检测患者对感觉刺激的反应，以及在检测到应答之后使用电极向颅神经施加电信号以治疗进食障碍。方法和系统有效治疗贪食症。

8. 发明申请

US20080023010A1 RF Shielding In MRI For Safety Of Implantable Medical Devices 审中-公开
标题翻译： MRI中的RF屏蔽可植入医疗器械的安全性
公开(公告)号：US20080023010A1
公开(公告)日：2008-01-31
申请号：US11460266
申请日：2006-07-27
申请人： D. Michael Inman , Steven E. Maschino
发明人： D. Michael Inman , Steven E. Maschino
IPC分类号： A61F5/37
CPC分类号： A61N1/08 , A61N1/3718 , G01R33/422
摘要： Methods and apparatus for reducing the heating of an implantable medical device due to RF energy. An RF shield is disclosed which provides localized RF shielding of an implantable medical device while allowing other portions of a patient's body to be exposed. The RF shield described is made from an RF energy absorbing fabric which circumferentially wraps around a portion of a patient's body. The RF energy absorbing fabric can be composed of carbon fibers, conductive metal fibers, or combinations thereof. An advantage of the disclosed RF shield is that it need not be implanted within a patient.
摘要翻译：由于RF能量而减少可植入医疗装置的加热的方法和装置。公开了RF屏蔽，其提供可植入医疗装置的局部RF屏蔽，同时允许患者身体的其它部分被暴露。所描述的RF屏蔽由围绕患者身体的一部分周向包裹的RF能量吸收织物制成。 RF能量吸收织物可以由碳纤维，导电金属纤维或其组合构成。所公开的RF屏蔽的优点在于它不需要植入患者体内。

9. 发明授权

US08972013B2 Using physiological sensor data with an implantable medical device 有权
标题翻译：使用可植入医疗设备的生理传感器数据
公开(公告)号：US08972013B2
公开(公告)日：2015-03-03
申请号：US13072430
申请日：2011-03-25
申请人： Steven E. Maschino
发明人： Steven E. Maschino
IPC分类号： A61N1/36 , A61N1/32 , A61N1/362
CPC分类号： A61N1/32 , A61N1/36053 , A61N1/36064 , A61N1/36082 , A61N1/36135 , A61N1/3627
摘要： An implantable medical system includes an implantable medical device (IMD) and an electrode coupleable to the IMD. The electrode is operative to deliver a first electrical signal from the IMD to a neural structure. The system includes a sensor coupleable to the IMD. The sensor is operative to sense a physiological parameter. The physiological parameter may include at least one of a neurotransmitter parameter, a neurotransmitter breakdown product parameter, a neuropeptide parameter, a norepinephrine parameter, a glucocorticoid (GC) parameter, a neuromodulator parameter, a neuromodulator breakdown product parameter, an amino acid parameter, and a hormone parameter. The IMD includes a controller operative to change a parameter of the first electrical signal based upon at least one sensed physiological parameter to generate a second electrical signal and to apply the second electrical signal to the neural structure.
摘要翻译：可植入医疗系统包括可植入医疗装置（IMD）和可耦合到IMD的电极。电极可操作以将第一电信号从IMD传递到神经结构。该系统包括可耦合到IMD的传感器。传感器用于感测生理参数。生理参数可以包括神经递质参数，神经递质分解产物参数，神经肽参数，去甲肾上腺素参数，糖皮质激素（GC）参数，神经调节剂参数，神经调节剂分解产物参数，氨基酸参数和激素参数。 IMD包括控制器，其操作以基于至少一个感测到的生理参数来改变第一电信号的参数，以产生第二电信号并将第二电信号应用于神经结构。

10. 发明授权

US08150524B2 Selective neurostimulation for treating epilepsy 有权
标题翻译：选择性神经刺激治疗癫痫
公开(公告)号：US08150524B2
公开(公告)日：2012-04-03
申请号：US12467804
申请日：2009-05-18
申请人： Steven E. Maschino , Stephen Brannan
发明人： Steven E. Maschino , Stephen Brannan
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61M2005/1726 , A61M2205/054 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N2/006
摘要： A method and device for treating epilepsy are disclosed which provide for electrical, chemical or magnetic stimulation of certain areas of the brain to modulate neuronal activity of areas associated with symptoms of epilepsy. Deep brain stimulation is combined with vagus nerve stimulation to enhance symptomatic relief of the disorder. Some embodiments also employ a sensing capability to optimize the therapeutic treatment regimen.
摘要翻译：公开了用于治疗癫痫的方法和装置，其提供对脑的某些区域的电，化学或磁刺激以调节与癫痫症状相关的区域的神经元活动。深部脑刺激与迷走神经刺激相结合，增强症状缓解症状。一些实施例还采用感测能力来优化治疗治疗方案。

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