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1. 发明授权

US5811080A Process for increased flavor impact in oral care products 失效
标题翻译：在口腔护理产品中增加风味影响的方法
公开(公告)号：US5811080A
公开(公告)日：1998-09-22
申请号：US756450
申请日：1996-11-26
申请人： Steven Carl Burgess , James Grigg Upson , Lowell Alan Sanker
发明人： Steven Carl Burgess , James Grigg Upson , Lowell Alan Sanker
IPC分类号： A61K8/22 , A61K8/24 , A61K8/34 , A61Q11/00 , A61K7/16 , A61K7/18 , A61K7/20
CPC分类号： A61K8/22 , A61K8/24 , A61K8/345 , A61Q11/00
摘要： The method of manufacturing comprises the steps of: (a) preparing a mixture of a favor system, one or more humectants, and one or more aqueous carrier materials; (b) adding tetrasodium pyrophosphate and calcium peroxide, all at once or in portions, under conditions wherein less than about 20% of the total pyrophosphate and calcium peroxide are dissolved in the mixture; and wherein further any remaining aqueous carrier materials not added to the mixture during step (a) are added in whole or in part in step (b) or thereafter, either by themselves or with any remaining amount of the tetrasodium pyrophosphate or calcium peroxide, under conditions such that less than about 20% of the total pyrophosphate and calcium peroxide are dissolved in the mixture; (c) heating the mixture to a temperature range of from about 38.degree. C. (100.degree. F.) to about 71.degree. C. (160.degree. F.) and preferably to a temperature range of from about 52.degree. C. (125.degree. F.) to about 57.degree. C. (135.degree. F.), and (d) homogenizing the mixture in the temperature range for about 15 minutes to about 60 minutes. The tetrasodium pyrophosphate salt and peroxide are two of the last components to be added to the mixture, preferably after all or much of the other sodium-containing salts present in the composition have been added to the process mixture. By these methods, the dissolved tetrasodium pyrophosphate salt is less likely to recrystalize in the form of glass-like crystal particles of tetrasodium pyrophosphate decahydrate.
摘要翻译：制造方法包括以下步骤：（a）制备有利系统，一种或多种湿润剂和一种或多种含水载体材料的混合物; （b）在其中少于约20％的焦磷酸钙和过氧化钙溶解在混合物中的条件下，一次或分批加入焦磷酸四钠和过氧化钙，并且其中在步骤（a）中没有添加到混合物中的任何剩余的水性载体材料在步骤（b）或之后全部或部分地加入，或者单独或任何剩余量的焦磷酸四钠或过氧化钙在下面条件使得少于约20％的焦磷酸钙和过氧化钙溶解在混合物中; （c）将混合物加热至约38℃（100°F）至约71℃（160°F）的温度范围，优选至约52℃的温度范围（125 DEG）至约57℃（135°F），和（d）在约15分钟至约60分钟的温度范围内使混合物均化。焦磷酸四钠盐和过氧化物是添加到混合物中的最后一种组分中的两种，优选在组合物中存在的所有或大部分其它含钠盐已经加入到工艺混合物中之后。通过这些方法，溶解的焦磷酸四钠盐不太可能以焦磷酸四钠十水合物的玻璃状结晶颗粒的形式重结晶。

2. 发明授权

US6042812A Flavor systems for oral care products 失效
标题翻译：口腔护理产品的香味系统
公开(公告)号：US6042812A
公开(公告)日：2000-03-28
申请号：US756671
申请日：1996-11-26
申请人： Lowell Alan Sanker , James Grigg Upson
发明人： Lowell Alan Sanker , James Grigg Upson
IPC分类号： A61K8/21 , A61K8/22 , A61K8/24 , A61K8/92 , A61Q11/00 , A61K7/16 , A61K7/18 , A61K7/20 , A61K7/26
CPC分类号： A61K8/22 , A61K8/21 , A61K8/24 , A61K8/922 , A61Q11/00
摘要： Disclosed are oral compositions comprising a total flavor system and one or more aqueous carriers, wherein the oral composition is a dentifrice or a mouthrinse. The total flavor system comprises a traditional oral care flavor system and a dairy-creme component.
摘要翻译：公开了包含总风味体系和一种或多种含水载体的口服组合物，其中口腔组合物是洁齿剂或漱口水。总风味系统包括传统的口腔护理风味系统和乳制品组分。

3. 发明授权

US5939080A Hydrophobic agents and non-polymeric surfactants use in oral care products 失效
标题翻译：疏水剂和非聚合物表面活性剂用于口腔护理产品
公开(公告)号：US5939080A
公开(公告)日：1999-08-17
申请号：US781222
申请日：1997-01-10
申请人： Daniel Wayne Michael , Gregory Berry , James Grigg Upson
发明人： Daniel Wayne Michael , Gregory Berry , James Grigg Upson
IPC分类号： A61K6/00 , A61K8/34 , A61K8/37 , A61Q11/00 , A61K7/00 , A61K7/16
CPC分类号： A61Q11/00 , A61K8/34 , A61K8/37 , A61K8/375
摘要： Disclosed are oral compositions and methods for reducing plaque in a human or lower animal subject comprising applying to the teeth of the subject an oral composition comprising one or more hydrophobic solvents having one or more characteristics selected from the group consisting of a hydrogen bonding parameter of less than about 7.0 and a water solubility of less than about 10%; one or more non-polymeric surfactants wherein the weight ratio of hydrophobic solvent to non-polymeric surfactant is from about 30:1 to about 1:2; and one or more aqueous carriers; wherein the oral composition is in the form of a toothpaste or mouthrinse, is non-ingestible, and has a pH of from about 5.0 to about 9.5.
摘要翻译：公开了用于减少人或更低级动物受试者中的斑块的口腔组合物和方法，包括向受试者的牙齿施用包含一种或多种具有一种或多种特性的疏水性溶剂的口腔组合物，所述疏水性溶剂具有选自以下的氢键参数：约7.0，水溶性小于约10％; 一种或多种非聚合物表面活性剂，其中疏水性溶剂与非聚合物表面活性剂的重量比为约30:1至约1:2; 和一种或多种含水载体; 其中所述口腔组合物是牙膏或漱口水的形式，是不可摄入的，并且具有约5.0至约9.5的pH。

4. 发明授权

US5827852A Coated pharmaceutical compositions 失效
标题翻译：涂层药物组合物
公开(公告)号：US5827852A
公开(公告)日：1998-10-27
申请号：US307537
申请日：1994-09-16
申请人： Carmelita Macklin Russell , Allen I. Dines , James Grigg Upson
发明人： Carmelita Macklin Russell , Allen I. Dines , James Grigg Upson
IPC分类号： A61K9/28 , A61K9/48 , A61K47/06 , A61K31/495 , A61K31/19 , A61K31/435 , A61K31/44
CPC分类号： A61K9/4891 , A61K9/282
摘要： Pharmaceutical composition suitable for coating comprising a composition for oral administration in unit dosage form wherein said composition has been coated with from about 0.01% to about 10% by weight of the composition with a volatile aromatic compound selected from the group consisting of 3-1-menthoxy propane-1,2-diol, N-substituted-p-menthane-3-carboxamides and acyclic carboxamides and mixtures thereof.
摘要翻译：适用于包衣的药物组合物，其包含用于以单位剂量形式口服给药的组合物，其中所述组合物已经用组合物的约0.01％至约10％重量包含挥发性芳族化合物，所述挥发性芳族化合物选自3-1- 薄荷氧基丙烷-1,2-二醇，N-取代对薄荷烷-3-甲酰胺和无环羧酰胺及其混合物。

5. 发明授权

US5885554A Hydrophobic agents and polymeric surfactants 失效
标题翻译：疏水剂和聚合物表面活性剂
公开(公告)号：US5885554A
公开(公告)日：1999-03-23
申请号：US782470
申请日：1997-01-10
申请人： Daniel Wayne Michael , Gregory Berry , James Grigg Upson
发明人： Daniel Wayne Michael , Gregory Berry , James Grigg Upson
IPC分类号： A61K8/21 , A61K8/34 , A61K8/37 , A61K8/90 , A61Q11/00 , A61K7/16 , A61K7/18 , A61K7/20
CPC分类号： A61Q11/00 , A61K8/21 , A61K8/34 , A61K8/37 , A61K8/90
摘要： Disclosed are oral compositions and methods for reducing plaque in a human or lower animal subject comprising applying to the teeth of the subject one or more hydrophobic solvents having one or more characteristics selected from the group consisting of a hydrogen bonding parameter of less than about 7.0 and a water solubility of less than about 10%; one or more polymeric surfactants wherein the weight ratio of hydrophobic solvent to polymeric surfactant is from about 10:1 to about 1:20; and one or more aqueous carriers; wherein the oral composition is in the form of a toothpaste or mouthrinse, is non-ingestible, and has a pH of from about 5.0 to about 9.5.
摘要翻译：公开了用于减少人或更低级动物受试者中的斑块的口腔组合物和方法，包括向受试者的牙齿施用一种或多种具有一种或多种特征的疏水性溶剂，所述疏水性溶剂具有小于约7.0的氢键参数和水溶性小于约10％; 一种或多种聚合物表面活性剂，其中疏水性溶剂与聚合物表面活性剂的重量比为约10:1至约1:20; 和一种或多种含水载体; 其中所述口腔组合物是牙膏或漱口水的形式，是不可摄入的，并且具有约5.0至约9.5的pH。

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