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1. 发明申请

US20110005932A1 UNIVERSAL SAMPLE PREPARATION SYSTEM AND USE IN AN INTEGRATED ANALYSIS SYSTEM 有权
标题翻译：通用样品制备系统及其在综合分析系统中的应用
公开(公告)号：US20110005932A1
公开(公告)日：2011-01-13
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. JOVANOVICH , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： G01N27/447 , H01J5/16 , G01J1/58 , G01N21/64
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.
摘要翻译：本发明提供一种可以处理原始生物样品，进行生化反应并提供分析读数的系统。例如，该系统可以从拭子中提取DNA，从DNA扩增STR基因座，并分析样品中扩增的位点和STR标记。该系统通过使用微流体组件来集成这些功能，以连接什么是宏流动功能。在一个实施方案中，该系统包括样品纯化模块，反应模块，反应后净化模块，毛细管电泳模块和计算机。在某些实施例中，该系统包括用于执行分析物捕获的一次性盒。墨盒可以包括流体歧管，该流体歧管具有与微流体芯片配合的大流动腔室，所述微流体芯片在腔室之间引导液体。该系统适合不超过10英尺3的外壳。并且可以是封闭的，便携式的和/或电池供电的系统。该系统可用于在不到4小时内从原始样品进行分析。

2. 发明授权

US08394642B2 Universal sample preparation system and use in an integrated analysis system 有权
公开(公告)号：US08394642B2
公开(公告)日：2013-03-12
申请号：US12795515
申请日：2010-06-07
申请人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
发明人： Stevan B. Jovanovich , William D. Nielsen , David S. Cohen , Michael Recknor , Mattias Vangbo , Ezra Van Gelder , Lars Majlof , Omar El-Sissi
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： C12Q1/6806 , G01J3/4406 , G01N1/31 , G01N1/405 , G01N21/64 , G01N27/44721 , G01N27/44791 , G01N27/745 , G01N35/00029 , G01N2035/00148 , G01N2035/00247 , G01N2201/06113 , G01N2201/062 , Y10T436/11 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.

3. 发明申请

US20120305087A1 High Efficiency and High Precision Microfluidic Devices and Methods 有权
标题翻译：高效率和高精度微流控器件及方法
公开(公告)号：US20120305087A1
公开(公告)日：2012-12-06
申请号：US13439390
申请日：2012-04-04
申请人： David S. Cohen , Jing Wang , Andrew May , Robert C. Jones , Hany Nassef
发明人： David S. Cohen , Jing Wang , Andrew May , Robert C. Jones , Hany Nassef
IPC分类号： B01F13/00
CPC分类号： B01L3/502738 , B01L3/5025 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , B01L2400/0605 , B01L2400/0638 , B01L2400/0655 , B33Y80/00 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/0318 , Y10T137/85938
摘要： New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
摘要翻译：新的高密度微流体装置和方法提供流体体积的精确计量和计量体积的有效混合。将第一溶液引入与反应室流体连通的流动通道的段中。第二溶液流过该段，使得第一溶液移入反应室，并且第二溶液的体积进入该室。然后可以分离室，并且可以启动和/或检测室内的反应。遗传分析的高通量方法可以比以前更高的精度进行。

4. 发明授权

US09579830B2 Method and system for manufacturing integrated fluidic chips 有权
标题翻译：集成流体芯片制造方法和系统
公开(公告)号：US09579830B2
公开(公告)日：2017-02-28
申请号：US13813625
申请日：2009-07-23
申请人： David S. Cohen
发明人： David S. Cohen
IPC分类号： B01L3/00 , B32B37/18 , B32B38/00 , B29C41/02 , G01N30/60 , B29K83/00 , B29L9/00 , B29L31/00
CPC分类号： B29C41/02 , B01L3/502 , B01L3/502707 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B29K2083/00 , B29L2009/00 , B29L2031/755 , B32B37/182 , B32B38/0008 , B32B2309/105 , B32B2383/00 , G01N30/6095
摘要： An integrated fluidic chip includes a substrate defined by a lateral surface area greater than 28 square inches. The integrated fluidic chip also includes a first elastomeric layer having a mold surface and a top surface. The mold surface of the first elastomeric layer is joined to a portion of the substrate. The first elastomeric layer includes a plurality of first channels extending normally from the substrate to a first dimension inside the first elastomeric layer. The integrated fluidic chip further includes a second elastomeric layer having a mold surface and a top surface. The mold surface of the second elastomeric layer is joined to at least a portion of the top surface of the first elastomeric layer.
摘要翻译：集成流体芯片包括由大于28平方英寸的侧表面积限定的基板。集成流体芯片还包括具有模具表面和顶表面的第一弹性体层。第一弹性体层的模具表面连接到基底的一部分。第一弹性体层包括多个第一通道，其从基底正常延伸到第一弹性体层内的第一尺寸。集成流体芯片还包括具有模具表面和顶表面的第二弹性体层。第二弹性体层的模具表面连接到第一弹性体层的顶表面的至少一部分。

5. 发明申请

US20080223721A1 High Efficiency and High Precision Microfluidic Devices and Methods 有权
标题翻译：高效率和高精度微流控器件及方法
公开(公告)号：US20080223721A1
公开(公告)日：2008-09-18
申请号：US12018138
申请日：2008-01-22
申请人： David S. Cohen , Jing Wang , Andrew May , Robert C. Jones , Hany Nassef
发明人： David S. Cohen , Jing Wang , Andrew May , Robert C. Jones , Hany Nassef
IPC分类号： G01N27/26
CPC分类号： B01L3/502738 , B01L3/5025 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , B01L2400/0605 , B01L2400/0638 , B01L2400/0655 , B33Y80/00 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/0318 , Y10T137/85938
摘要： New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
摘要翻译：新的高密度微流体装置和方法提供流体体积的精确计量和计量体积的有效混合。将第一溶液引入与反应室流体连通的流动通道的段中。第二溶液流过该段，使得第一溶液移入反应室，并且第二溶液的体积进入该室。然后可以分离室，并且可以启动和/或检测室内的反应。遗传分析的高通量方法可以比以前更高的精度进行。

6. 发明授权

US5044322A Strap device 失效
标题翻译：表带设备
公开(公告)号：US5044322A
公开(公告)日：1991-09-03
申请号：US548565
申请日：1990-07-05
申请人： David S. Cohen , Melvin I. Loman
发明人： David S. Cohen , Melvin I. Loman
IPC分类号： A01K27/00
CPC分类号： A01K25/00 , A01K27/00 , A01K27/001 , A01K27/002 , Y10S119/907
摘要： A strap device adapted to be secured to an animal is provided which has a strap with at least one end portion adapted to be formed into a loop which is closed with a fastener comprising a boss or rivet having exposed smooth surfaces. The section of the strap device adajcent the strap end after forming the loop is thicker than the remaining section of the strap and has a top surface which inclines from a height substantially equal to the strap end portion down to the section of the stap having a thinner thickness. The fastener is designed to fit tightly within two holes in the strap so the loop can not be removed by hand.
摘要翻译：提供了一种适于固定在动物上的绑带装置，其具有至少一个端部部分的带子，该端部适于形成一个环，该钩环包括具有暴露的平滑表面的凸台或铆钉。带状装置在形成环之后连接带端部的部分比带的剩余部分厚，并且具有从基本上等于带端部的高度向下倾斜到具有较薄的缝合部的部分的顶表面厚度。紧固件被设计成紧密地配合在带的两个孔中，使得环不能用手去除。

7. 发明授权

US08591834B2 High efficiency and high precision microfluidic devices and methods 有权
标题翻译：高效率和高精度的微流体装置和方法
公开(公告)号：US08591834B2
公开(公告)日：2013-11-26
申请号：US13439390
申请日：2012-04-04
申请人： David S. Cohen , Robert C. Jones , Andrew May , Hany Nassef , Jing Wang
发明人： David S. Cohen , Robert C. Jones , Andrew May , Hany Nassef , Jing Wang
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/5025 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , B01L2400/0605 , B01L2400/0638 , B01L2400/0655 , B33Y80/00 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/0318 , Y10T137/85938
摘要： New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
摘要翻译：新的高密度微流体装置和方法提供流体体积的精确计量和计量体积的有效混合。将第一溶液引入与反应室流体连通的流动通道的段中。第二溶液流过该段，使得第一溶液移入反应室，并且第二溶液的体积进入该室。然后可以分离室，并且可以启动和/或检测室内的反应。遗传分析的高通量方法可以比以前更高的精度进行。

8. 发明授权

US07775991B2 Device for sampling blood 有权
标题翻译：血液取样装置
公开(公告)号：US07775991B2
公开(公告)日：2010-08-17
申请号：US11217091
申请日：2005-08-31
申请人： Shawn R. Feaster , Rosann M. Kaylor , David S. Cohen , Udo Leuschner , Michael Strehl
发明人： Shawn R. Feaster , Rosann M. Kaylor , David S. Cohen , Udo Leuschner , Michael Strehl
IPC分类号： A61B5/00 , A61B17/14 , A61B17/32 , B65D81/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150519 , A61B5/150541 , A61B5/150618 , A61B5/150717 , A61B5/15111 , A61B5/15117 , A61B5/15142
摘要： A blood sampling device includes a lancet having a skin piercing member disposed at an end thereof. The lancet is slidable within and releasably engaged with an elongated lancet guide that remains stationary with use of the device. A shell is axially movable relative to the lancet guide between a rest position and an actuate position, with the lancet being spring loaded within the lancet guide by movement of the shell from the rest position to the actuate position.
摘要翻译：采血装置包括具有设置在其端部的皮肤穿刺构件的刺血针。刺血针可以在使用该装置保持静止的细长刺血针引导件内并可释放地接合。外壳可在静止位置和致动位置之间相对于柳叶刀导向器轴向移动，借助于壳体从静止位置移动到致动位置，柳叶刀通过弹簧加载在刺血针引导件内。

9. 发明授权

US5165222A Racing blanket for greyhound dogs 失效
标题翻译：雪橇犬为雪橇犬
公开(公告)号：US5165222A
公开(公告)日：1992-11-24
申请号：US775426
申请日：1991-10-15
申请人： David S. Cohen , Melvin I. Loman
发明人： David S. Cohen , Melvin I. Loman
IPC分类号： A01K13/00
CPC分类号： A01K13/006
摘要： A racing blanket for greyhound dogs is provided wherein a rearward section of the blanket is secured about the dog's stomach by a single buckle comprising two buckle sections attached to elastic straps. The engaged buckle is positioned on the blanket at the dog's side and a loop is positioned to hold the buckle away from direct contact with the dog.
摘要翻译：提供了一种用于灰狗的赛车毯，其中毯子的后部通过单个带扣固定在狗的胃部上，该单个扣环包括附接到弹性带的两个扣环部分。接合的扣环位于狗侧的毯子上，并且定位环以将扣扣远离与狗的直接接触。

10. 发明申请

US20150273735A1 METHOD AND SYSTEM FOR MANUFACTURING INTEGRATED FLUIDIC CHIPS 有权
标题翻译：用于制造集成流体液体的方法和系统
公开(公告)号：US20150273735A1
公开(公告)日：2015-10-01
申请号：US13813625
申请日：2009-07-23
申请人： David S. Cohen
发明人： David S. Cohen
IPC分类号： B29C41/02 , B32B38/00 , B01L3/00 , B32B37/18
CPC分类号： B29C41/02 , B01L3/502 , B01L3/502707 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B29K2083/00 , B29L2009/00 , B29L2031/755 , B32B37/182 , B32B38/0008 , B32B2309/105 , B32B2383/00 , G01N30/6095
摘要： An integrated fluidic chip includes a substrate defined by a lateral surface area greater than 28 square inches. The integrated fluidic chip also includes a first elastomeric layer having a mold surface and a top surface. The mold surface of the first elastomeric layer is joined to a portion of the substrate. The first elastomeric layer includes a plurality of first channels extending normally from the substrate to a first dimension inside the first elastomeric layer. The integrated fluidic chip further includes a second elastomeric layer having a mold surface and a top surface. The mold surface of the second elastomeric layer is joined to at least a portion of the top surface of the first elastomeric layer.
摘要翻译：集成流体芯片包括由大于28平方英寸的侧表面积限定的基板。集成流体芯片还包括具有模具表面和顶表面的第一弹性体层。第一弹性体层的模具表面连接到基底的一部分。第一弹性体层包括多个第一通道，其从基底正常延伸到第一弹性体层内的第一尺寸。集成流体芯片还包括具有模具表面和顶表面的第二弹性体层。第二弹性体层的模具表面连接到第一弹性体层的顶表面的至少一部分。

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