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1. 发明授权

US07148054B2 Evolution of whole cells and organisms by recursive sequence recombination 有权
标题翻译：通过递归序列重组进行全细胞和生物体的进化
公开(公告)号：US07148054B2
公开(公告)日：2006-12-12
申请号：US10194686
申请日：2002-07-11
申请人： Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steve Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen delCardayre , Matthew Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steve Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
IPC分类号： C12N1/16 , C12N1/18
CPC分类号： C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
摘要翻译：本发明提供了使用重组和选择/筛选整个细胞和生物体以获得所需性质的进化的迭代循环的方法。这些性质的实例包括增加的重组原型，基因组拷贝数和蛋白质和次级代谢物的表达和/或分泌能力。

2. 发明申请

US20110190140A1 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION 有权
标题翻译：通过重新序列重组实现全细胞和有机体的发育
公开(公告)号：US20110190140A1
公开(公告)日：2011-08-04
申请号：US12580056
申请日：2009-10-15
申请人： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswatan Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
IPC分类号： C40B10/00 , C12N15/04
CPC分类号： C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
摘要翻译：本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。

3. 发明申请

US20120252681A1 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION 有权
标题翻译：通过重新序列重组实现全细胞和有机体的发育
公开(公告)号：US20120252681A1
公开(公告)日：2012-10-04
申请号：US13310332
申请日：2011-12-02
申请人： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen del Cardayre , Matthew Tobin , Willem P.C. Stemmer , Jon E. Ness , Jeremy Minshull , Phillip Patten , Venkiteswaran Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Tony Cox , Gjalt Huisman , Ling Yuan , Joseph A. Affholter
IPC分类号： C40B10/00
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
摘要翻译：本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。

4. 发明授权

US08377681B2 Evolution of whole cells and organisms by recursive sequence recombination 有权
公开(公告)号：US08377681B2
公开(公告)日：2013-02-19
申请号：US13310332
申请日：2011-12-02
申请人： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
IPC分类号： C12N1/16 , C12N1/18
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.

5. 发明授权

US07629170B2 Evolution of whole cells and organisms by recursive sequence recombination 有权
公开(公告)号：US07629170B2
公开(公告)日：2009-12-08
申请号：US11506215
申请日：2006-08-17
申请人： Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen delCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
IPC分类号： C12N15/00 , C12N15/87 , C12N15/63
CPC分类号： C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.

6. 发明授权

US08076138B2 Evolution of whole cells and organisms by recursive sequence recombination 有权
标题翻译：通过递归序列重组进行全细胞和生物体的进化
公开(公告)号：US08076138B2
公开(公告)日：2011-12-13
申请号：US12580056
申请日：2009-10-15
申请人： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
发明人： Stephen DelCardayre , Matthew B. Tobin , Willem P. C. Stemmer , Jon E. Ness , Jeremy S. Minshull , Phillip A. Patten , Venkiteswatan Mani Subramanian , Linda A. Castle , Claus M. Krebber , Steven H. Bass , Ying-Xin Zhang , Anthony R. Cox , Gjalt W. Huisman , Ling Yuan , Joseph A. Affholter
IPC分类号： C12N15/00 , C12N15/87 , C12N15/63
CPC分类号： C12R1/465 , A01K2267/02 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12N15/90 , C12P17/162 , C12Q1/6811 , C12Q1/6827
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
摘要翻译：本发明提供了采用迭代循环重组和选择/筛选全细胞和生物体以获得所需性质的方法的方法。这些性质的实例包括增加的重组原性，基因组拷贝数以及蛋白质和次级代谢物的表达和/或分泌能力。

7. 发明授权

US07462469B2 Integrated system for diversity generation and screening 失效
标题翻译：用于多样化生成和筛选的综合系统
公开(公告)号：US07462469B2
公开(公告)日：2008-12-09
申请号：US10154936
申请日：2002-05-23
申请人： Steven H. Bass , S. Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claes Gustafsson , Brian Carr , Stephane Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
发明人： Steven H. Bass , S. Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claes Gustafsson , Brian Carr , Stephane Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
摘要： Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
摘要翻译：提供了用于多样化生成和筛选的集成系统和方法。该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。

8. 发明授权

US08014961B2 Integrated systems and methods for diversity generation and screening 有权
标题翻译：用于多样化生成和筛选的综合系统和方法
公开(公告)号：US08014961B2
公开(公告)日：2011-09-06
申请号：US11677505
申请日：2007-02-21
申请人： Steven H. Bass , Simon Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy S. Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephan J. Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
发明人： Steven H. Bass , Simon Christopher Davis , Phillip A. Patten , Matthew Tobin , Jeremy S. Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephan J. Jenne , Sun Ai Raillard , Andreas Crameri , Willem P. C. Stemmer , Robin Emig , Pascal Longchamp , Stanley Goldman , Lorraine J. Giver , Joseph A. Affholter
IPC分类号： G01N33/48
CPC分类号： C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
摘要： Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
摘要翻译：提供了用于多样化生成和筛选的集成系统和方法。该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。

9. 发明授权

US6071515A Dimer and multimer forms of single chain polypeptides 失效
标题翻译：单链和多聚体形式的单链多肽
公开(公告)号：US6071515A
公开(公告)日：2000-06-06
申请号：US463903
申请日：1995-06-05
申请人： Peter S. Mezes , Ruth A. Richard , Joseph A. Affholter , Nicolas J. Kotite
发明人： Peter S. Mezes , Ruth A. Richard , Joseph A. Affholter , Nicolas J. Kotite
IPC分类号： A61K38/00 , A61K51/10 , A61P37/04 , C07K16/30 , C07K16/46 , C12P21/08 , A61K39/395 , G01N33/53 , G01N33/574
CPC分类号： A61K51/10 , C07K16/3046 , C07K16/468 , A61K2123/00 , A61K38/00 , C07K2317/626
摘要： The present invention discloses novel proteins which are dimers and multimers of single chain polypeptides. The single chain polypeptides having two domains derived from the immunoglobulin superfamily which are joined by a peptide linker. The dimers and multimers being formed by non-covalent linking of the single chain polypeptides.
摘要翻译：本发明公开了作为单链多肽的二聚体和多聚体的新型蛋白质。具有两个衍生自免疫球蛋白超家族的结构域的单链多肽，其通过肽接头连接。二聚体和多聚体通过单链多肽的非共价连接形成。

10. 发明授权

US09291043B1 In situ retorting of hydrocarbons and a selected metal 有权
标题翻译：碳氢化合物和选定金属的原位蒸馏
公开(公告)号：US09291043B1
公开(公告)日：2016-03-22
申请号：US14158941
申请日：2014-01-20
申请人： Joseph A. Affholter , Gilman A. Hill
发明人： Joseph A. Affholter , Gilman A. Hill
IPC分类号： E21B43/24 , E21B43/30
CPC分类号： E21B43/305 , E21B43/2408 , E21B43/243 , E21B43/26
摘要： A method of producing hydrocarbons in situ from a fixed-bed hydrocarbon formation disposed below a ground surface and having a higher permeability zone substantially parallel to, and between a top lower permeability zone and a bottom lower permeability zone. The steps include providing at least one injection well and first and second production wells in the higher permeability zone, injecting a heated thermal-energy carrier fluid (TECF) into the injection well, circulating the carrier fluid through the zone and creating a substantially horizontal situ heating element (ISHE) between the injection well and the production wells for mobilizing the hydrocarbons.
摘要翻译：一种从固定床烃地层原位生产碳氢化合物的方法，该固定床烃地层布置在地表下方并且具有基本上平行于顶部低渗透性区域和底部低渗透性区域之间以及之间的较高渗透性区域。这些步骤包括在较高渗透性区域中提供至少一个注入井和第一和第二生产井，将加热的热能载体流体（TECF）注入注入井，使载体流体循环通过区域并创建基本上水平的位置注入井和用于动员烃的生产井之间的加热元件（ISHE）。

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