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1. 发明申请

US20060121085A1 Formulations for cell-schedule dependent anticancer agents 审中-公开
标题翻译：细胞计划依赖抗癌剂的制剂
公开(公告)号：US20060121085A1
公开(公告)日：2006-06-08
申请号：US11222668
申请日：2005-09-09
申请人： Stephen Warren , Eric Dadey , Mingxing Zhou , Richard Dunn
发明人： Stephen Warren , Eric Dadey , Mingxing Zhou , Richard Dunn
IPC分类号： A61K31/7072 , A61F2/00 , A61K9/14
CPC分类号： A61L27/54 , A61K9/0024 , A61K31/7072 , A61L27/18 , A61L27/50 , A61L27/58 , A61L2300/416 , A61L2300/426 , A61L2300/434 , A61L2300/602 , A61L2300/802 , A61L2400/06 , C08L67/04
摘要： The present invention provides a flowable composition suitable for use as a controlled release implant. The composition includes: (a) a biodegradable, biocompatible thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid; (b) a cell-cycle dependent biological agent, a schedule-dependent biological agent, a metabolite thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof; and (c) a biocompatible organic liquid, at standard temperature and pressure, in which the thermoplastic polymer is soluble. The present invention also provides a method of treating cancer in a mammal. The present invention also provides a method of blocking, impeding, or otherwise interfering with cell cycle progression at the G1-phase, G1/S interphase, S-phase, G2/M interface or M-phase of the cell cycle in a mammal. The methods includes administering to a mammal an effective amount of a flowable composition of the present invention.
摘要翻译：本发明提供适合用作控释剂的可流动组合物。组合物包括：（a）可生物降解的生物相容性热塑性聚合物，其至少基本上不溶于水性介质，水或体液; （b）细胞周期依赖性生物制剂，计划依赖性生物制剂，其代谢物，其药学上可接受的盐或其前药; 和（c）在标准温度和压力下的热塑性聚合物可溶的生物相容性有机液体。本发明还提供了一种治疗哺乳动物癌症的方法。本发明还提供在哺乳动物的细胞周期的G1期，G1 / S间期，S期，G2 / M界面或M期，阻断，阻碍或以其他方式干扰细胞周期进程的方法。所述方法包括向哺乳动物施用有效量的本发明的可流动组合物。

2. 发明授权

US09551702B2 Microcantilever sensor with bimorph actuation and piezoresistive read-out 有权
标题翻译：具有双压电晶片驱动和压阻读取的微型悬臂传感器
公开(公告)号：US09551702B2
公开(公告)日：2017-01-24
申请号：US14119874
申请日：2012-05-25
申请人： Vladislav Djakov , Richard Dunn
发明人： Vladislav Djakov , Richard Dunn
IPC分类号： G01N33/53 , G01N33/543 , G01N29/02 , G01N27/12
CPC分类号： G01N33/5304 , G01N27/128 , G01N29/022 , G01N33/54373 , G01N33/5438
摘要： There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterize a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample. There is also provided a method for measuring at least one thermal property of a fluid medium sample, and a fluid medium sample reaction detection apparatus.
摘要翻译：提供了一种使用热特征来监测流体介质样品中的一个或多个指定反应的方法，包括提供至少一个微悬臂传感器，所述微悬臂传感器包括具有不同热膨胀系数的至少两种材料，以及具有集成在其中的加热器和压阻传感器，校准至少一个微悬臂响应于热变化以形成校准的微悬臂梁响应特性，启动流体介质样品中的指定反应，用一个或多个电脉冲以在微悬臂中引起发热，对集成的压阻传感器的输出进行采样，以在流体介质中指定的反应期间表征微悬臂梁的响应，并从校准的微悬臂梁响应特性中减去采样输出以确定t中的一个或多个指定反应的特性他流体介质样品。还提供了一种用于测量流体介质样品的至少一种热性质和流体介质样品反应检测装置的方法。

3. 发明申请

US20090096134A1 Process and Apparatus for Forming Medical Device Balloons 有权
标题翻译：用于形成医疗器械气球的过程和装置
公开(公告)号：US20090096134A1
公开(公告)日：2009-04-16
申请号：US12336073
申请日：2008-12-16
申请人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C44/02
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

4. 发明授权

US07708928B2 Process for forming medical device balloons 有权
标题翻译：用于形成医疗器械气囊的方法
公开(公告)号：US07708928B2
公开(公告)日：2010-05-04
申请号：US12336073
申请日：2008-12-16
申请人： Thomas Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C49/64
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

5. 发明申请

US20090299284A1 Balloon Catheter Tip Design 有权
标题翻译：气球导管尖端设计
公开(公告)号：US20090299284A1
公开(公告)日：2009-12-03
申请号：US12537324
申请日：2009-08-07
申请人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61M25/10 , A61M25/16
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

6. 发明授权

US07575568B2 Catheter distal tip 有权
标题翻译：导管远端
公开(公告)号：US07575568B2
公开(公告)日：2009-08-18
申请号：US10732983
申请日：2003-12-10
申请人： Thomas J. Holman , Daniel K. Tomaschko , Leo M. Klisch , Richard Olson , Joseph M Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas J. Holman , Daniel K. Tomaschko , Leo M. Klisch , Richard Olson , Joseph M Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61M29/00
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

7. 发明申请

US20070104759A1 Polymeric delivery formulations of leuprolide with improved efficacy 审中-公开
标题翻译：具有改善功效的亮丙瑞林的聚合物递送配方
公开(公告)号：US20070104759A1
公开(公告)日：2007-05-10
申请号：US11643505
申请日：2006-12-21
申请人： Richard Dunn , John Garrett , Harish Ravivarapu , Bhagya Chandrashekar
发明人： Richard Dunn , John Garrett , Harish Ravivarapu , Bhagya Chandrashekar
IPC分类号： A61K38/09 , A61F2/02
CPC分类号： A61K38/09 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K47/22 , A61K47/34 , B65D81/3205
摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.
摘要翻译：本发明涉及适合用作控释植入物的可流动组合物。可流动组合物包括至少基本上不溶于水性介质或体液的可生物降解的热塑性聚酯。可流动组合物还包括生物相容的极性非质子溶剂。生物相容的极性非质子溶剂可混溶于水性介质或体液中。可流动组合物还包括醋酸亮丙瑞林。

8. 发明授权

US08303537B2 Balloon catheter tip design 有权
标题翻译：气球导管尖端设计
公开(公告)号：US08303537B2
公开(公告)日：2012-11-06
申请号：US12537324
申请日：2009-08-07
申请人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , Nie Tang , Lixiao Wang , David Griswold
发明人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , Nie Tang , Lixiao Wang , David Griswold
IPC分类号： A61M29/00
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

9. 发明授权

US07465164B2 Apparatus for forming medical device balloons 有权
标题翻译：用于形成医疗装置气囊的装置
公开(公告)号：US07465164B2
公开(公告)日：2008-12-16
申请号：US11849913
申请日：2007-09-04
申请人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C49/64
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

10. 发明申请

US20080050462A1 Process and Apparatus for Forming Medical Device Balloons 有权
标题翻译：用于形成医疗器械气球的过程和装置
公开(公告)号：US20080050462A1
公开(公告)日：2008-02-28
申请号：US11849913
申请日：2007-09-04
申请人： Thomas Holman , Nam Hoang , Jeffrey Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Zhang , Afsar Ali
发明人： Thomas Holman , Nam Hoang , Jeffrey Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Zhang , Afsar Ali
IPC分类号： B29C45/78
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

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