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1. 发明授权

US07575568B2 Catheter distal tip 有权
标题翻译：导管远端
公开(公告)号：US07575568B2
公开(公告)日：2009-08-18
申请号：US10732983
申请日：2003-12-10
申请人： Thomas J. Holman , Daniel K. Tomaschko , Leo M. Klisch , Richard Olson , Joseph M Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas J. Holman , Daniel K. Tomaschko , Leo M. Klisch , Richard Olson , Joseph M Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61M29/00
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

2. 发明申请

US20090299284A1 Balloon Catheter Tip Design 有权
标题翻译：气球导管尖端设计
公开(公告)号：US20090299284A1
公开(公告)日：2009-12-03
申请号：US12537324
申请日：2009-08-07
申请人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61M25/10 , A61M25/16
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

3. 发明授权

US08303537B2 Balloon catheter tip design 有权
标题翻译：气球导管尖端设计
公开(公告)号：US08303537B2
公开(公告)日：2012-11-06
申请号：US12537324
申请日：2009-08-07
申请人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , Nie Tang , Lixiao Wang , David Griswold
发明人： Thomas J. Holman , Daniel Keith Tomaschko , Leo M. Klisch , Richard Olson , Joseph M. Lyver , Richard Dunn , Nie Tang , Lixiao Wang , David Griswold
IPC分类号： A61M29/00
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

4. 发明申请

US20050131445A1 Balloon catheter tip design 有权
标题翻译：气球导管尖端设计
公开(公告)号：US20050131445A1
公开(公告)日：2005-06-16
申请号：US10732983
申请日：2003-12-10
申请人： Thomas Holman , Daniel Tomaschko , Leo Klisch , Richard Olson , Joseph Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
发明人： Thomas Holman , Daniel Tomaschko , Leo Klisch , Richard Olson , Joseph Lyver , Richard Dunn , David Griswold , Nie Tang , Lixiao Wang
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/1034 , A61M25/0069 , A61M25/104 , A61M2025/1093
摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.
摘要翻译：本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

5. 发明申请

US20090096134A1 Process and Apparatus for Forming Medical Device Balloons 有权
标题翻译：用于形成医疗器械气球的过程和装置
公开(公告)号：US20090096134A1
公开(公告)日：2009-04-16
申请号：US12336073
申请日：2008-12-16
申请人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C44/02
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

6. 发明授权

US07465164B2 Apparatus for forming medical device balloons 有权
标题翻译：用于形成医疗装置气囊的装置
公开(公告)号：US07465164B2
公开(公告)日：2008-12-16
申请号：US11849913
申请日：2007-09-04
申请人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C49/64
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

7. 发明授权

US06837897B2 Lumen support for welding 有权
标题翻译：流明支持焊接
公开(公告)号：US06837897B2
公开(公告)日：2005-01-04
申请号：US09939276
申请日：2001-08-24
申请人： Thomas J. Holman , Kristi Flury , Scott A. Olson , Jan Seppala , Richard Dunn , Gina L. Sandvick , Fernando DiCaprio , Justin E. Plessel
发明人： Thomas J. Holman , Kristi Flury , Scott A. Olson , Jan Seppala , Richard Dunn , Gina L. Sandvick , Fernando DiCaprio , Justin E. Plessel
IPC分类号： A61F2/84 , A61F2/06 , A61F2/82 , A61M25/00 , B23K26/00 , B23K26/18 , B23K26/20 , B29C65/00 , B29C65/14 , B29C65/16 , A61M29/00
CPC分类号： A61F2/958 , A61F2002/9583 , B23K26/009 , B23K26/18 , B23K2101/06 , B29C65/14 , B29C65/16 , B29C65/1619 , B29C65/1641 , B29C66/1122 , B29C66/53241 , B29C66/5344 , B29C66/636 , B29C66/71 , B29C66/73921 , B29C66/81267 , B29C66/81268 , B29K2995/0027 , B29L2031/7542 , B29L2031/7543 , B29K2021/003 , B29K2023/06 , B29K2023/065 , B29K2055/02 , B29K2067/00 , B29K2067/003 , B29K2069/00 , B29K2075/00 , B29K2077/00 , B29K2081/04 , B29K2083/00 , B29K2096/005
摘要： A medical device comprising a support member adjacent to a first member and a second member, the first and second members may be laser welded to one another by directing radiation absorbable by the first and second members at the first and second members. The support member is provided adjacent to the first member and is constructed and arranged to substantially reflect or substantially transmit radiation at one or more frequencies absorbable by at least one of the first member and the second member.
摘要翻译：包括与第一构件和第二构件相邻的支撑构件的医疗装置，第一构件和第二构件可以通过引导第一构件和第二构件在第一构件和第二构件可吸收的辐射而彼此激光焊接。支撑构件设置成与第一构件相邻并且被构造和布置成在由第一构件和第二构件中的至少一个可吸收的一个或多个频率处基本上反射或基本上透射辐射。

8. 发明授权

US07264458B2 Process and apparatus for forming medical device balloons 有权
标题翻译：用于形成医疗装置气囊的方法和装置
公开(公告)号：US07264458B2
公开(公告)日：2007-09-04
申请号：US10753043
申请日：2004-01-07
申请人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
发明人： Thomas J. Holman , Nam H. Hoang , Jeffrey S. Lindquist , Richard Dunn , Scott Schewe , Kevin Silberg , David Parsons , Ken Xiao Kang Zhang , Afsar Ali
IPC分类号： B29C49/64
CPC分类号： A61M25/1029 , B29C49/6445 , B29L2031/7542
摘要： Medical device balloons are formed from a tubular parison by a process or apparatus which establishes a controlled location (initiation zone) on the parison where radial expansion is initiated. Initiation within the initiation zone is achieved by heating the parison in that location to a higher temperature than the remainder of the parison for at least a portion of the blowing time. A variety of apparatus configurations are provided, some of which allow for the size and location of the initiation zone to be readily reconfigured. Balloons can also be modified, post-blowing, using heating apparatus and methods described.
摘要翻译：医疗装置气囊由管状型坯通过工艺或装置形成，该方法或装置在径向膨胀开始的型坯上建立受控的位置（起始区）。在起始区域内的起始是通过将该位置的型坯加热到比型坯的其余部分高的至少一部分吹制时间的温度来实现的。提供了各种装置配置，其中一些允许容易重新配置启动区域的大小和位置。气球也可以改装，后吹，使用加热装置和方法描述。

9. 发明授权

US06953470B2 Catheter support 有权
标题翻译：导管支持
公开(公告)号：US06953470B2
公开(公告)日：2005-10-11
申请号：US10241138
申请日：2002-09-11
申请人： Thomas J. Holman , Richard Dunn , Jan Seppala
发明人： Thomas J. Holman , Richard Dunn , Jan Seppala
IPC分类号： A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61M25/0043 , A61M25/0054 , A61M25/0069 , A61M2025/1063
摘要： A balloon catheter comprises a balloon, an inner shaft, an outer shaft and a transition shaft. The transition shaft has a proximal portion and a distal portion joined by a tapered portion. The proximal portion has a diameter greater than the distal portion. The proximal portion has a first end portion engaged to at least a portion of the outer shaft at a first engagement site. At least a portion of the proximal waist is engaged to the proximal portion of the transition shaft at a second engagement site. At least a portion of the end region of the inner shaft is engaged to the distal portion of the transition shaft at a third engagement site. The distal portion extends through the balloon wherein at least a portion of the distal waist of the balloon is engaged to the distal portion of the transition shaft at a forth engagement site.
摘要翻译：球囊导管包括球囊，内轴，外轴和过渡轴。过渡轴具有通过锥形部分连接的近端部分和远端部分。近端部分的直径大于远端部分。近端部分具有在第一接合位置处接合到外轴的至少一部分的第一端部。近端腰部的至少一部分在第二接合位置处接合到过渡轴的近侧部分。内轴的端部区域的至少一部分在第三配合位置处接合到过渡轴的远端部分。远端部分延伸穿过球囊，其中球囊的远端腰部的至少一部分在第四接合位置处接合到过渡轴的远侧部分。

10. 发明授权

US09551702B2 Microcantilever sensor with bimorph actuation and piezoresistive read-out 有权
标题翻译：具有双压电晶片驱动和压阻读取的微型悬臂传感器
公开(公告)号：US09551702B2
公开(公告)日：2017-01-24
申请号：US14119874
申请日：2012-05-25
申请人： Vladislav Djakov , Richard Dunn
发明人： Vladislav Djakov , Richard Dunn
IPC分类号： G01N33/53 , G01N33/543 , G01N29/02 , G01N27/12
CPC分类号： G01N33/5304 , G01N27/128 , G01N29/022 , G01N33/54373 , G01N33/5438
摘要： There is provided a method of monitoring one or more specified reactions in a fluid medium sample using a thermal signature, comprising providing at least one micro-cantilever sensor, said micro-cantilever sensor comprising at least two materials having different coefficients of thermal expansion, and having a heater and piezo-resistive sensor integrated therein, calibrating the at least one micro-cantilever response to thermal changes to form a calibrated micro-cantilever response characteristic, starting the specified reaction in the fluid medium sample, pulsing the heater with one or more electrical pulses to induce heat generation in the micro-cantilever, sampling the output of the integrated piezo-resistive sensor to characterize a response of the micro-cantilever during the specified reaction in the fluid medium, and subtracting the calibrated micro-cantilever response characteristic from the sampled output to determine a characteristic of the one or more specified reactions in the fluid medium sample. There is also provided a method for measuring at least one thermal property of a fluid medium sample, and a fluid medium sample reaction detection apparatus.
摘要翻译：提供了一种使用热特征来监测流体介质样品中的一个或多个指定反应的方法，包括提供至少一个微悬臂传感器，所述微悬臂传感器包括具有不同热膨胀系数的至少两种材料，以及具有集成在其中的加热器和压阻传感器，校准至少一个微悬臂响应于热变化以形成校准的微悬臂梁响应特性，启动流体介质样品中的指定反应，用一个或多个电脉冲以在微悬臂中引起发热，对集成的压阻传感器的输出进行采样，以在流体介质中指定的反应期间表征微悬臂梁的响应，并从校准的微悬臂梁响应特性中减去采样输出以确定t中的一个或多个指定反应的特性他流体介质样品。还提供了一种用于测量流体介质样品的至少一种热性质和流体介质样品反应检测装置的方法。

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