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1. 发明授权

US08163501B2 Methods of assessing Crohn's disease patient phenotype by I2 serologic response 有权
标题翻译：通过I2血清学反应评估克罗恩病患者表型的方法
公开(公告)号：US08163501B2
公开(公告)日：2012-04-24
申请号：US12645394
申请日：2009-12-22
申请人： Stephen R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephen R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

2. 发明申请

US20100240077A1 METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE 有权
标题翻译：通过I2感染反应评估冠心病患者的方法
公开(公告)号：US20100240077A1
公开(公告)日：2010-09-23
申请号：US12645394
申请日：2009-12-22
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

3. 发明授权

US07662569B2 Methods of assessing Crohn's disease patient phenotype by I2 serologic response 有权
标题翻译：通过I2血清学反应评估克罗恩病患者表型的方法
公开(公告)号：US07662569B2
公开(公告)日：2010-02-16
申请号：US10413501
申请日：2003-04-11
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

4. 发明申请

US20120208212A1 METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2, OMPC AND ASCA SEROLOGIC RESPONSE 审中-公开
标题翻译：通过I2，OMPC和ASCA行为反应来评估冠心病患者的方法
公开(公告)号：US20120208212A1
公开(公告)日：2012-08-16
申请号：US13312960
申请日：2011-12-06
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/566
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

5. 发明授权

US06348316B1 Genetic testing for determining the risk of pouchitis development 有权
标题翻译：用于确定囊泡发育风险的遗传测试
公开(公告)号：US06348316B1
公开(公告)日：2002-02-19
申请号：US09556868
申请日：2000-04-12
申请人： Kent D. Taylor , Huiyang Yang , Jerome I. Rotter , Phillip R. Fleshner
发明人： Kent D. Taylor , Huiyang Yang , Jerome I. Rotter , Phillip R. Fleshner
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is created in a patient with ulcerative colitis. The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele linked to an interferon &ggr; receptor locus, where the presence of the pouchitis-associated allele indicates an increased risk of pouchitis development. The interferon &ggr; receptor locus to which the pouchitis-associated allele is linked can be, for example, an interferon &ggr; receptor 1 gene. A pouchitis-associated allele useful in the invention can be, for example, an allele located within the sixth intron of the interferon &ggr; receptor 1 gene, such as a FA1 microsatellite 171 allele.
摘要翻译：本发明提供了一种确定在具有溃疡性结肠炎的患者中产生内部小袋的外科手术后的囊泡炎发展风险的方法。该方法通过在患者中确定是否存在与干扰素γ受体基因座连接的绒球菌相关等位基因来实现，其中与肠道炎相关等位基因的存在表明增加的囊肿发展的风险。与脑膜炎相关的等位基因连接的干扰素γ受体位点可以是例如干扰素γ受体1基因。可用于本发明的囊泡炎相关等位基因可以是例如位于干扰素γ受体1基因第六内含子内的等位基因，例如FA1微卫星171等位基因。

6. 发明授权

US08486640B2 Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease 有权
标题翻译： Ileal小袋肛门吻合术（IPAA）治疗炎症性肠病的因素
公开(公告)号：US08486640B2
公开(公告)日：2013-07-16
申请号：US12530390
申请日：2008-03-21
申请人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
发明人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/564 , G01N2333/195 , G01N2800/065
摘要： A common long term problem after Ileal Pouch-Anal Anastomosis (IPAA) is the inflammation of the pouch, called pouchitis. Additionally, about 5-10% of patients undergoing IPAA with a diagnosis of ulcerative colitis at the time of surgery are subsequently diagnosed with Crohn's disease. In one embodiment, the present invention provides methods of diagnosing and predicting susceptibility to pouchitis after IPAA by detecting the presence or absence of pANCA and/or Cbir1 Flagellin expression.
摘要翻译： Ileal Pouch-Anal Anastomosis（IPAA）后常见的长期问题是袋的炎症，称为囊泡炎。此外，约5-10％的接受IPAA诊断为手术时溃疡性结肠炎的患者随后被诊断为克罗恩病。在一个实施方案中，本发明提供了通过检测pANCA和/或Cbir1鞭毛蛋白表达的存在或不存在来诊断和预测IPAA后脑泡易感性的方法。

7. 发明申请

US20100105044A1 ILEAL POUCH-ANAL ANASTOMOSIS (IPAA) FACTORS IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 有权
标题翻译： ILEAL POUCH-ANAL ANASTOMOSIS（IPAA）治疗炎症性皮肤疾病的因素
公开(公告)号：US20100105044A1
公开(公告)日：2010-04-29
申请号：US12530390
申请日：2008-03-21
申请人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
发明人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
IPC分类号： C12Q1/68
CPC分类号： G01N33/564 , G01N2333/195 , G01N2800/065
摘要： A common long term problem after Ileal Pouch-Anal Anastomosis (IPAA) is the inflammation of the pouch, called pouchitis. Additionally, about 5-10% of patients undergoing IPAA with a diagnosis of ulcerative colitis at the time of surgery are subsequently diagnosed with Crohn's disease. In one embodiment, the present invention provides methods of diagnosing and predicting susceptibility to pouchitis after IPAA by detecting the presence or absence of pANCA and/or Cbir1 Flagellin expression.
摘要翻译： Ileal Pouch-Anal Anastomosis（IPAA）后常见的长期问题是袋的炎症，称为囊泡炎。此外，约5-10％的接受IPAA诊断为手术时溃疡性结肠炎的患者随后被诊断为克罗恩病。在一个实施方案中，本发明提供了通过检测pANCA和/或Cbir1鞭毛蛋白表达的存在或不存在来诊断和预测IPAA后脑泡易感性的方法。

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