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    • 5. 发明授权
    • Genetic testing for determining the risk of pouchitis development
    • 用于确定囊泡发育风险的遗传测试
    • US06348316B1
    • 2002-02-19
    • US09556868
    • 2000-04-12
    • Kent D. TaylorHuiyang YangJerome I. RotterPhillip R. Fleshner
    • Kent D. TaylorHuiyang YangJerome I. RotterPhillip R. Fleshner
    • C12Q168
    • C12Q1/6883C12Q2600/156
    • The present invention provides a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is created in a patient with ulcerative colitis. The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele linked to an interferon &ggr; receptor locus, where the presence of the pouchitis-associated allele indicates an increased risk of pouchitis development. The interferon &ggr; receptor locus to which the pouchitis-associated allele is linked can be, for example, an interferon &ggr; receptor 1 gene. A pouchitis-associated allele useful in the invention can be, for example, an allele located within the sixth intron of the interferon &ggr; receptor 1 gene, such as a FA1 microsatellite 171 allele.
    • 本发明提供了一种确定在具有溃疡性结肠炎的患者中产生内部小袋的外科手术后的囊泡炎发展风险的方法。 该方法通过在患者中确定是否存在与干扰素γ受体基因座连接的绒球菌相关等位基因来实现,其中与肠道炎相关等位基因的存在表明增加的囊肿发展的风险。 与脑膜炎相关的等位基因连接的干扰素γ受体位点可以是例如干扰素γ受体1基因。 可用于本发明的囊泡炎相关等位基因可以是例如位于干扰素γ受体1基因第六内含子内的等位基因,例如FA1微卫星171等位基因。