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1. 发明授权

US08486640B2 Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease 有权
标题翻译： Ileal小袋肛门吻合术（IPAA）治疗炎症性肠病的因素
公开(公告)号：US08486640B2
公开(公告)日：2013-07-16
申请号：US12530390
申请日：2008-03-21
申请人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
发明人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/564 , G01N2333/195 , G01N2800/065
摘要： A common long term problem after Ileal Pouch-Anal Anastomosis (IPAA) is the inflammation of the pouch, called pouchitis. Additionally, about 5-10% of patients undergoing IPAA with a diagnosis of ulcerative colitis at the time of surgery are subsequently diagnosed with Crohn's disease. In one embodiment, the present invention provides methods of diagnosing and predicting susceptibility to pouchitis after IPAA by detecting the presence or absence of pANCA and/or Cbir1 Flagellin expression.
摘要翻译： Ileal Pouch-Anal Anastomosis（IPAA）后常见的长期问题是袋的炎症，称为囊泡炎。此外，约5-10％的接受IPAA诊断为手术时溃疡性结肠炎的患者随后被诊断为克罗恩病。在一个实施方案中，本发明提供了通过检测pANCA和/或Cbir1鞭毛蛋白表达的存在或不存在来诊断和预测IPAA后脑泡易感性的方法。

2. 发明申请

US20100105044A1 ILEAL POUCH-ANAL ANASTOMOSIS (IPAA) FACTORS IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 有权
标题翻译： ILEAL POUCH-ANAL ANASTOMOSIS（IPAA）治疗炎症性皮肤疾病的因素
公开(公告)号：US20100105044A1
公开(公告)日：2010-04-29
申请号：US12530390
申请日：2008-03-21
申请人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
发明人： Phillip R. Fleshner , Eric A. Vasiliauskas , Gil Melmed , Stephan R. Targan
IPC分类号： C12Q1/68
CPC分类号： G01N33/564 , G01N2333/195 , G01N2800/065
摘要： A common long term problem after Ileal Pouch-Anal Anastomosis (IPAA) is the inflammation of the pouch, called pouchitis. Additionally, about 5-10% of patients undergoing IPAA with a diagnosis of ulcerative colitis at the time of surgery are subsequently diagnosed with Crohn's disease. In one embodiment, the present invention provides methods of diagnosing and predicting susceptibility to pouchitis after IPAA by detecting the presence or absence of pANCA and/or Cbir1 Flagellin expression.
摘要翻译： Ileal Pouch-Anal Anastomosis（IPAA）后常见的长期问题是袋的炎症，称为囊泡炎。此外，约5-10％的接受IPAA诊断为手术时溃疡性结肠炎的患者随后被诊断为克罗恩病。在一个实施方案中，本发明提供了通过检测pANCA和/或Cbir1鞭毛蛋白表达的存在或不存在来诊断和预测IPAA后脑泡易感性的方法。

3. 发明申请

US20100240077A1 METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2 SEROLOGIC RESPONSE 有权
标题翻译：通过I2感染反应评估冠心病患者的方法
公开(公告)号：US20100240077A1
公开(公告)日：2010-09-23
申请号：US12645394
申请日：2009-12-22
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

4. 发明授权

US07662569B2 Methods of assessing Crohn's disease patient phenotype by I2 serologic response 有权
标题翻译：通过I2血清学反应评估克罗恩病患者表型的方法
公开(公告)号：US07662569B2
公开(公告)日：2010-02-16
申请号：US10413501
申请日：2003-04-11
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

5. 发明申请

US20120208212A1 METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2, OMPC AND ASCA SEROLOGIC RESPONSE 审中-公开
标题翻译：通过I2，OMPC和ASCA行为反应来评估冠心病患者的方法
公开(公告)号：US20120208212A1
公开(公告)日：2012-08-16
申请号：US13312960
申请日：2011-12-06
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/566
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

6. 发明授权

US08163501B2 Methods of assessing Crohn's disease patient phenotype by I2 serologic response 有权
标题翻译：通过I2血清学反应评估克罗恩病患者表型的方法
公开(公告)号：US08163501B2
公开(公告)日：2012-04-24
申请号：US12645394
申请日：2009-12-22
申请人： Stephen R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephen R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/53 , G01N33/542 , G01N33/00
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译：本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明该受试者具有克罗恩病的临床亚型。在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法）。本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型结肠炎。

7. 发明授权

US5932429A Methods of diagnosing clinical subtypes of crohn's disease 失效
标题翻译：诊断克罗恩病临床亚型的方法
公开(公告)号：US5932429A
公开(公告)日：1999-08-03
申请号：US837059
申请日：1997-04-11
申请人： Stephan R. Targan , Eric A. Vasiliauskas , Scott E. Plevy , Mary J. Barry
发明人： Stephan R. Targan , Eric A. Vasiliauskas , Scott E. Plevy , Mary J. Barry
IPC分类号： C12Q1/68 , G01N33/569 , G01N33/68 , G01N33/564
CPC分类号： C12Q1/6883 , G01N33/56972 , G01N33/6893 , G01N2800/065 , Y10S435/975
摘要： Provided herein is a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibody (pANCA) is present in a patient with CD, where the presence of pANCA indicates a clinical subtype of CD with features of ulcerative colitis (UC). Also provided is a method of diagnosing a clinical subtype of Crohn's disease in a patient with CD by determining whether pANCA or speckling anti-pan polymorphonuclear antibody (SAPPA) is present in the patient with CD, where the presence of pANCA indicates a clinical subtype of CD with features of ulcerative colitis and where the presence of SAPPA indicates a clinical subtype of CD having perforating, fistulizing or small bowel obstructive disease. The invention further provides a method of diagnosing a clinical subtype of Crohn's disease in a patient with CD by determining the presence or absence of ANCA, pANCA, SAPPA and anti-Saccharomyces cerevisiae antibodies (ASCA) in the patient with CD, where the presence of pANCA combined with the absence of ASCA indicate a clinical subtype of CD with features of UC, the presence of SAPPA indicates a clinical subtype of CD having perforating or fistulizing disease or small bowel obstructive disease, and the presence of ASCA combined with the absence of ANCA indicates a clinical subtype of CD lacking features of ulcerative colitis and having perforating or fistulizing disease or small bowel obstructive disease. Kits for diagnosing a clinical subtype of Crohn's disease, which contain neutrophil and antigen specific for ASCA, also are provided.
摘要翻译：本文提供了通过确定是否存在CD患者中存在核周抗中性粒细胞抗体（pANCA）来诊断克罗恩病（CD）的临床亚型的方法，其中pANCA的存在表示具有溃疡特征的CD的临床亚型结肠炎（UC）。还提供了通过确定患有CD的患者中是否存在pANCA或斑点抗泛多晶核抗体（SAPPA）来诊断患有CD的克罗恩病的临床亚型的方法，其中pANCA的存在表示临床亚型 CD具有溃疡性结肠炎的特征，并且其中SAPPA的存在表示具有穿孔，瘘管或小肠阻塞性疾病的CD的临床亚型。本发明还提供了一种通过在CD患者中确定ANCA，pANCA，SAPPA和抗Saccharomyces cerevisiae抗体（ASCA）的存在或不存在来诊断患有CD的克罗恩病的临床亚型的方法，其中与无ASCA相结合表明具有UC特征的CD的临床亚型，SAPPA的存在表明CD具有穿孔或瘘阻碍性疾病或小肠阻塞性疾病的临床亚型，并且ASCA的存在与不存在ANCA 表示缺乏溃疡性结肠炎特征的CD的临床亚型，具有穿孔或瘘管疾病或小肠阻塞性疾病。还提供了用于诊断克罗恩病临床亚型的试剂盒，其中含有嗜中性粒细胞和ASCA特异性抗原。

8. 发明授权

US5916748A Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis 失效
标题翻译：诊断具有溃疡性结肠炎特征的克罗恩病的临床亚型的方法
公开(公告)号：US5916748A
公开(公告)日：1999-06-29
申请号：US689873
申请日：1996-08-15
申请人： Stephan R. Targan , Eric A. Vasiliauskas , Scott E. Plevy , Huiying Yang , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , Scott E. Plevy , Huiying Yang , Jerome I. Rotter
IPC分类号： C12Q1/68 , G01N33/569 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6893 , C12Q1/6883 , G01N33/56972 , C12Q2600/112 , C12Q2600/156 , G01N2800/065
摘要： The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical subtype of CD with features of ulcerative colitis (UC). The invention also provides a method of diagnosing a clinical subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates a clinical subtype of CD with features of ulcerative colitis. In addition, the invention provides a method of diagnosing a pANCA-positive subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates the pANCA-positive subtype of CD.
摘要翻译：本发明提供了一种诊断克罗恩氏病（CD）的临床亚型的方法，该方法是通过确定是否存在CD患者中的核周抗中性粒细胞抗体（pANCA），其中pANCA的存在表示CD的临床亚型，溃疡性结肠炎（UC）。本发明还提供了通过检测患有CD的患者的ICAM-1位点处的Arg241等位基因来诊断CD的临床亚型的方法，其中Arg241等位基因表示具有溃疡性结肠炎特征的CD的临床亚型。另外，本发明提供了通过检测患有CD的患者中ICAM-1位点处的Arg241等位基因来诊断CD的pANCA阳性亚型的方法，其中Arg241等位基因指示CD的pANCA阳性亚型。

9. 发明授权

US5874233A Methods of diagnosing a clinical subtype of Crohn's disease with features of ulcerative colitis 失效
标题翻译：诊断具有溃疡性结肠炎特征的克罗恩病的临床亚型的方法
公开(公告)号：US5874233A
公开(公告)日：1999-02-23
申请号：US689870
申请日：1996-08-15
申请人： Stephan R. Targan , Eric A. Vasiliauskas , Scott E. Plevy
发明人： Stephan R. Targan , Eric A. Vasiliauskas , Scott E. Plevy
IPC分类号： C12Q1/68 , G01N33/569 , G01N33/68 , G01N33/543 , G01N33/564
CPC分类号： C12Q1/6883 , G01N33/56972 , G01N33/6893 , G01N2800/065
摘要： The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical subtype of CD with features of ulcerative colitis (UC). The invention also provides a method of diagnosing a clinical subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates a clinical subtype of CD with features of ulcerative colitis. In addition, the invention provides a method of diagnosing a pANCA-positive subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates the pANCA-positive subtype of CD.
摘要翻译：本发明提供了一种诊断克罗恩氏病（CD）的临床亚型的方法，该方法是通过确定是否存在CD患者中的核周抗中性粒细胞抗体（pANCA），其中pANCA的存在表示CD的临床亚型，溃疡性结肠炎（UC）。本发明还提供了通过检测患有CD的患者的ICAM-1位点处的Arg241等位基因来诊断CD的临床亚型的方法，其中Arg241等位基因表示具有溃疡性结肠炎特征的CD的临床亚型。另外，本发明提供了通过检测患有CD的患者中ICAM-1位点处的Arg241等位基因来诊断CD的pANCA阳性亚型的方法，其中Arg241等位基因指示CD的pANCA阳性亚型。

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