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1. 发明授权

US5837446A Process for the manufacture of wholly microfabricated biosensors 失效
标题翻译：制造完全微生物传感器的方法
公开(公告)号：US5837446A
公开(公告)日：1998-11-17
申请号：US482517
申请日：1995-06-07
申请人： Stephen N. Cozzette , Graham Davis , Jeanne Itak , Imants R. Lauks , Sylvia Piznik , Nicolaas Smit , Susan Steiner , Paul Van Der Werf , Henry J. Wieck , Randall M. Mier, deceased
发明人： Stephen N. Cozzette , Graham Davis , Jeanne Itak , Imants R. Lauks , Sylvia Piznik , Nicolaas Smit , Susan Steiner , Paul Van Der Werf , Henry J. Wieck , Randall M. Mier, deceased
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00 , G01N33/53 , G01N33/68
CPC分类号： B01L3/0268 , B01L3/5027 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01V9/00 , G10K11/006 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over he dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对其在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理意义的新方法，其产生选自二氧和过氧化氢的电活性物质浓度的变化。

2. 发明授权

US5837454A Process for the manufacture of wholly microfabricated biosensors 失效
公开(公告)号：US5837454A
公开(公告)日：1998-11-17
申请号：US484095
申请日：1995-06-07
申请人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier, deceased , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck , Susan Steiner , Jeanne Itak
发明人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier, deceased , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck , Susan Steiner , Jeanne Itak
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00 , G01N33/545
CPC分类号： B01L3/0268 , B01L3/5027 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01V9/00 , G10K11/006 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

3. 发明授权

US5063081A Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor 失效
标题翻译：制造具有固定化的配体受体的多个均匀的微制造感测装置的方法
公开(公告)号：US5063081A
公开(公告)日：1991-11-05
申请号：US567870
申请日：1990-08-15
申请人： Stephen N. Cozzette , Graham Davis , Jeanne Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan Steiner , Paul Van Der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Jeanne Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan Steiner , Paul Van Der Werf , Henry J. Wieck
IPC分类号： B01L3/00 , B01L3/02 , C12Q1/00 , G01N33/543 , G01N35/00 , G01N35/10
CPC分类号： B01L3/0268 , B01L3/502707 , C12Q1/001 , G01N33/5438 , G01N35/0099 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109
摘要： A plurality of uniform microfabricated sensing devices are produced by establishing a plurality of base sensors on a substrate wafer, forming over at least a portion of each base sensor a permselective layer, superimposing a photoformable proteinaceous photoresist layer over a substantial portion of the permselective layer, and forming a topmost layer of an immobilized ligand receptor. The ligand receptor and corresponding ligand may be immunoreactive species.
摘要翻译：通过在衬底晶片上建立多个基底传感器来制造多个均匀的微制造感测装置，在每个基底传感器的至少一部分上形成选择性选择层，将可光成像的蛋白质光致抗蚀剂层叠加在选择性选择层的大部分上，并形成固定的配体受体的最上层。配体受体和相应的配体可以是免疫反应性物质。

4. 发明授权

US06306594B1 Methods for microdispensing patterened layers 失效
标题翻译：微分配图案的方法
公开(公告)号：US06306594B1
公开(公告)日：2001-10-23
申请号：US09193370
申请日：1998-11-17
申请人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van der Werf , Henry J. Wieck
IPC分类号： G01N3350
CPC分类号： B01L3/5027 , B01L3/0268 , B01L3/502707 , B01L3/5088 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/089 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01N35/109 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , Y10S435/81 , Y10S436/809
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理意义的新方法，其产生选自二氧和过氧化氢的电活性物质浓度的变化。

5. 发明授权

US5554339A Process for the manufacture of wholly microfabricated biosensors 失效
公开(公告)号：US5554339A
公开(公告)日：1996-09-10
申请号：US109507
申请日：1993-08-19
申请人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00 , G01N21/00 , C12M1/00 , G01N21/01 , G01N30/00
CPC分类号： B01L3/0268 , B01L3/5027 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01V9/00 , G10K11/006 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

6. 发明授权

US07074610B2 System and method of microdispensing and arrays of biolayers provided by same 失效
标题翻译：微分配系统和方法以及由其提供的生物层阵列
公开(公告)号：US07074610B2
公开(公告)日：2006-07-11
申请号：US09941661
申请日：2001-08-30
申请人： Stephen N. Cozzette , Graham Davis , Jeanne A. Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan J. Steiner , Paul Van Der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Jeanne A. Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan J. Steiner , Paul Van Der Werf , Henry J. Wieck
IPC分类号： C12M3/00
CPC分类号： B01L3/5027 , B01L3/0268 , B01L3/502707 , B01L3/5088 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/089 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01N35/109 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , Y10S435/81 , Y10S436/809
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using a substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理学意义的新方法，其产生选自二氧和过氧化氢的电活性物质的浓度变化。

7. 发明授权

US5466575A Process for the manufacture of wholly microfabricated biosensors 失效
标题翻译：制造完全微生物传感器的方法
公开(公告)号：US5466575A
公开(公告)日：1995-11-14
申请号：US943345
申请日：1992-09-10
申请人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Paul Van Der Werf , Henry J. Wieck
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00
CPC分类号： B01L3/0268 , B01L3/5027 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01V9/00 , G10K11/006 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理意义的新方法，其产生选自二氧和过氧化氢的电活性物质浓度的变化。

8. 发明授权

US5200051A Wholly microfabricated biosensors and process for the manufacture and use thereof 失效
标题翻译：专用微生物传感器及其制造及其使用过程
公开(公告)号：US5200051A
公开(公告)日：1993-04-06
申请号：US432714
申请日：1989-11-07
申请人： Stephen N. Cozzette , Graham Davis , Jeanne A. Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan J. Steiner , Paul Van Der Werf , Henry J. Wieck
发明人： Stephen N. Cozzette , Graham Davis , Jeanne A. Itak , Imants R. Lauks , Randall M. Mier , Sylvia Piznik , Nicolaas Smit , Susan J. Steiner , Paul Van Der Werf , Henry J. Wieck
IPC分类号： H04R1/44 , B01L3/00 , B01L3/02 , C12Q1/00 , G01N1/28 , G01N27/07 , G01N27/327 , G01N27/333 , G01N27/414 , G01N27/416 , G01N33/543 , G01N35/00 , G01N35/10 , G01V9/00 , G10K11/00 , H04R20060101 , H04R1/02 , H04R15/00
CPC分类号： B01L3/0268 , B01L3/5027 , C12Q1/001 , G01N33/5438 , G01N35/0099 , G01V9/00 , G10K11/006 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109 , Y10S435/817 , Y10S436/806
摘要： An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand/ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate/label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.
摘要翻译：描述了适用于分析生物学重要的分析物种的电子装置的微细加工的有效方法。本发明的技术允许对在合适的衬底上建立的各种组件和层的尺寸特征进行密切的控制。这种控制延伸到结合生物组分的装置的那些部分，使得这些装置能够用作生物传感器。因此，本文公开的材料和方法提供了用于批量生产均匀的全微生物传感器的有效手段。本文描述了装置本身的各种实施例，其特别适用于临床环境中的生物样品的实时分析。特别地，本发明描述了可以使用某些基于配体/配体受体的生物传感器实施方案进行的测定。本发明还公开了一种利用基板/标记信号产生对电化学检测特定分析物种的生物学和生理意义的新方法，其产生选自二氧和过氧化氢的电活性物质浓度的变化。

9. 发明授权

US5112455A Method for analytically utilizing microfabricated sensors during wet-up 失效
标题翻译：在润湿期间分析利用微波传感器的方法
公开(公告)号：US5112455A
公开(公告)日：1992-05-12
申请号：US555976
申请日：1990-07-20
申请人： Stephen N. Cozzette , Graham Davis , Lisa A. Holleritter , Imants R. Lauks , Sylvia Piznik , Nicolaas J. Smit , Jody A. Tirinato , Henry J. Wieck , Michael P. Zelin
发明人： Stephen N. Cozzette , Graham Davis , Lisa A. Holleritter , Imants R. Lauks , Sylvia Piznik , Nicolaas J. Smit , Jody A. Tirinato , Henry J. Wieck , Michael P. Zelin
IPC分类号： G01N27/26 , G01N27/27 , G01N27/327 , G01N27/414 , G01N27/416 , G01N33/543
CPC分类号： G01N27/3274
摘要： A method of determining the concentration of a preselected analyte species present in a sample fluid is disclosed, which method comprises: (a) providing an external computational means, a reference electrode and at least one substantially dry-stored sensor capable of exhibiting a response to changes in the concentration of a preselected analyte species before the sensor attains full equilibrated wet-up; (b) establishing electrical contact between the sensor, reference electrode and external computational means; (c) contacting the sensor and reference electrode with a calibrant fluid; (d) performing a first signal measurement in a first time window in the presence of the calibrant fluid; (e) displacing the calibrant fluid after performing the first signal measurement; (f) contacting the sensor and reference electrode with a sample fluid; (g) performing a second signal measurement in a second time window in the presence of the sample fluid; and (h) relating the first and second signal measurements to determine the concentration of the preselected analyte species in the sample fluid before said sensor attains full equilibrated wet-up. Alternative methods are disclosed further for collecting, relating and manipulating the results of the signal measurements to provide useful estimates of the analyte concentrations of interest.
摘要翻译：公开了一种确定存在于样品流体中的预先选择的分析物种的浓度的方法，该方法包括：（a）提供外部计算装置，参考电极和至少一个基本上干燥储存的传感器，其能够显示对在传感器达到完全平衡润湿之前，预选的分析物种的浓度变化; （b）建立传感器，参比电极和外部计算装置之间的电接触; （c）使传感器和参比电极与校准液接触; （d）在存在校准液的情况下在第一时间窗中执行第一信号测量; （e）在执行第一信号测量之后移动校准液; （f）使传感器和参比电极接触样品流体; （g）在存在样品流体的情况下在第二时间窗中执行第二信号测量; 和（h）将第一和第二信号测量值相关联，以确定在所述传感器达到完全平衡的润湿之前样品流体中预先选择的分析物种的浓度。进一步披露替代方法来收集，相关和操纵信号测量结果，以提供感兴趣的分析物浓度的有用估计。

10. 发明授权

US5212050A Method of forming a permselective layer 失效
标题翻译：形成选择层的方法
公开(公告)号：US5212050A
公开(公告)日：1993-05-18
申请号：US568441
申请日：1990-08-15
申请人： Randall M. Mier , Sylvia Piznik , Imants R. Lauks , Graham Davis
发明人： Randall M. Mier , Sylvia Piznik , Imants R. Lauks , Graham Davis
IPC分类号： B01L3/00 , B01L3/02 , C12Q1/00 , G01N33/543 , G01N35/00 , G01N35/10
CPC分类号： B01L3/0268 , B01L3/502707 , C12Q1/001 , G01N33/5438 , G01N35/0099 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L3/5088 , G01N2035/00059 , G01N2035/00237 , G01N2035/00455 , G01N2035/00534 , G01N2035/1034 , G01N2035/1076 , G01N35/109
摘要： A method of forming a permselective layer on preselected areas of a substantially planar sensing device is disclosed. The claimed method includes establishing and confining a liquid film, derived from a silane compound mixed in a suitable solvent, within a predetermined area of the sensing device. The process relates to photolithographic imaging and developing methods coupled to a film-curing step that provides a patterned permselective layer having the desired semipermeable characteristics.
摘要翻译：公开了一种在基本上平面的感测装置的预选区域上形成选择渗透层的方法。要求保护的方法包括建立并限制衍生自混合在合适溶剂中的硅烷化合物的液膜在感测装置的预定区域内。该方法涉及耦合到膜固化步骤的光刻成像和显影方法，其提供具有所需半透性特征的图案化选择层。

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