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    • 3. 发明授权
    • Method and device for performing biopsies on a vesicular object
    • 用于在水泡物体上进行活组织检查的方法和装置
    • US08927272B2
    • 2015-01-06
    • US13986029
    • 2013-03-25
    • Paul J. Taylor
    • Paul J. Taylor
    • C12N5/073B01L3/02
    • G01N1/08A61B10/0283A61B10/0291B01L3/021
    • A method for removing material from a vesicular object by securing the object, penetrating the object with a pipette, such pipette having a sealed distal tip and an aperture, advancing said pipette into the object in such a manner as to place the aperture directly adjacent to the material to be removed from the object, applying vacuum inside the pipette thereby drawing the material to be removed from the object into the pipette, and removing the pipette from the object in such a manner as to cut or otherwise separate the material in the pipette from the object thereby leaving the material removed from the object in the pipette while leaving the object undamaged.
    • 一种用于通过固定物体,用移液管穿透物体的方式从泡囊状物体中去除材料的方法,该移液管具有密封的远端头和孔,使得移液管以将孔直接邻近 要从物体中取出的材料,在移液管内部施加真空,从而将要从物体中取出的材料拉入移液管,并以这样的方式将移液管从物体上取下,以便切割或以其他方式分离移液管中的材料 从而使得物体在移液管中移除,同时保持物体未损坏。
    • 4. 发明申请
    • Method and device for performing biopsies on a vesicular object
    • 用于在水泡物体上进行活组织检查的方法和装置
    • US20140287493A1
    • 2014-09-25
    • US13986029
    • 2013-03-25
    • Paul J. Taylor
    • Paul J. Taylor
    • C12N5/073B01L3/02
    • G01N1/08A61B10/0283A61B10/0291B01L3/021
    • A method for removing material from a vesicular object by securing the object, penetrating the object with a pipette, such pipette having a sealed distal tip and an aperture, advancing said pipette into the object in such a manner as to place the aperture directly adjacent to the material to be removed from the object, applying vacuum inside the pipette thereby drawing the material to be removed from the object into the pipette, and removing the pipette from the object in such a manner as to cut or otherwise separate the material in the pipette from the object thereby leaving the material removed from the object in the pipette while leaving the object undamaged.A device for removing material from a vesicular object, said device being a pipette having a sealed tip at its distal end and an aperture whereby the distal tip of the device is inserted into the target object, the aperture aligned with the material to be removed from the object, vacuum applied to the inside of the device, such vacuum drawing the material into the aperture, and the device being removed from the object in such a manner as to cut or otherwise separate the material in the pipette from the object, the material remaining in the pipette, while leaving the object undamaged.
    • 一种用于通过固定物体,用移液管穿透物体的方式从泡囊状物体中去除材料的方法,该移液管具有密封的远端头和孔,使得移液管以将孔直接邻近 要从物体中取出的材料,在移液管内部施加真空,从而将要从物体中取出的材料拉入移液管,并以这样的方式将移液管从物体上取下,以便切割或以其他方式分离移液管中的材料 从而使得物体在移液管中移除,同时保持物体未损坏。 一种用于从囊状物体去除材料的装置,所述装置是在其远端具有密封末端的移液管和孔,由此将装置的远端插入目标物体中,孔与待从 该物体被施加到装置内部,这样的真空将材料吸入孔中,并且该装置以从切割或以其他方式将移液管中的材料与物体分开的方式从物体上移除,该材料 留在移液器中,同时保持物体没有损坏。
    • 6. 发明申请
    • Device for performing micro-operations on a vesicular object
    • 用于在水泡物体上进行微观操作的装置
    • US20130252318A1
    • 2013-09-26
    • US13986508
    • 2013-05-08
    • Paul J. Taylor
    • Paul J. Taylor
    • C12N5/075
    • C12N5/0609C12M21/06C12M35/00
    • A device for performing micro-operations on a vesicular target, comprising an injection pipette (27); a barrel assembly (9); and an outer assembly (1). The injection pipette, barrel assembly, and outer assembly being designed and situated in relation to each other such that an axial vacuum passage is created between the injection pipette and the barrel assembly, and a radial vacuum passage is created between the barrel assembly and outer assembly, and such vacuum passages are isolated from each other and from atmospheric pressure (FIG. 8). The device also comprises a means of advancing and withdrawing the distal end of the barrel assembly in relation to the distal end of the outer assembly so as to create a holding well (31) and a means of advancing the pipette into, and withdrawing the pipette from, a vesicular object. The elements being designed and situated in relationship to each other to allow the simultaneous holding of the vesicular object by applying negative pressure in the radial vacuum passage; injection into or aspiration from the vesicular object via the pipette; and/or aspiration from the vesicular object by applying negative pressure in the axial vacuum passage.
    • 一种用于在囊泡靶上进行微操作的装置,包括注射吸管(27); 桶组件(9); 和外部组件(1)。 注射移液管,枪管组件和外部组件相对于彼此设计和定位,使得在注射移液管和枪管组件之间产生轴向真空通道,并且在枪管组件和外部组件之间产生径向真空通道 ,并且这些真空通道彼此隔离并且与大气压力隔离(图8)。 该装置还包括相对于外部组件的远端推进和取出筒组件的远端的装置,以便产生保持井(31)和使移液管进入和移出移液管的装置 从一个囊泡的物体。 这些元件被设计和相互关联,以允许通过在径向真空通道中施加负压同时保持囊泡物体; 通过移液管注射或从囊泡物体吸入; 和/或通过在轴向真空通道中施加负压来从囊泡物体抽吸。
    • 9. 发明授权
    • Method and device for performing micro-operations on a vesicular object
    • 用于在水泡物体上进行微操作的方法和装置
    • US08497119B1
    • 2013-07-30
    • US13374195
    • 2011-12-14
    • Paul J. Taylor
    • Paul J. Taylor
    • C12M5/00C12M15/00C12M3/00
    • C12N5/0609C12M21/06C12M35/00
    • A method for performing micro-operations on a vesicular object comprising securing the vesicular object by applying negative pressure in a radial vacuum passage; advancing a pipette into the vesicular object through an axial vacuum passage; ensuring that the axial vacuum passage and the radial vacuum passage are not in fluid contact with each other; controlling the negative pressure in both axial and radial vacuum passages, and the pressure or vacuum in the pipette separately; whereby allowing the simultaneous holding of the vesicular object by applying negative pressure in the radial vacuum passage; injection into or aspiration from the vesicular object via the pipette; and aspiration from the vesicular object by applying negative pressure in the axial vacuum passage.
    • 一种用于在囊泡物体上进行微操作的方法,包括通过在径向真空通道中施加负压来固定囊泡物体; 通过轴向真空通道将移液管推进到水泡物体中; 确保轴向真空通道和径向真空通道彼此不流体接触; 控制轴向和径向真空通道中的负压以及移液管中的压力或真空度; 从而允许通过在径向真空通道中施加负压同时保持囊泡物体; 通过移液管注射或从囊泡物体吸入; 以及通过在轴向真空通道中施加负压从囊泡物体抽吸。