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1. 发明授权

US5223285A Nutritional product for pulmonary patients 失效
标题翻译：肺部病人营养产品
公开(公告)号：US5223285A
公开(公告)日：1993-06-29
申请号：US860857
申请日：1992-03-31
申请人： Stephen J. DeMichele , Timothy J. Gregory
发明人： Stephen J. DeMichele , Timothy J. Gregory
IPC分类号： A23L1/29 , A23L1/30 , A23L1/302 , A23L1/304
CPC分类号： A23L33/16 , A23L33/12 , A23L33/40 , Y10S426/80 , Y10S426/801 , Y10S514/904
摘要： A liquid nutritional product for enteral feeding contains a fat source which provides desirable effects when fed to pulmonary patients. The fat source having by weight a ratio of [n-(6) to n-(3)] fatty acids from the group consisting of Linoleic acid (18:2n6), Gamma-Linolenic acid (18:3n6), and Arachidonic acid (20:4n6) to fatty acids from the group consisting of Alpha-Linolenic acid (18:3n3), Stearidonic acid (18:4n3), Eicosapentaenoic acid (20:5n3), Docosapentaenoic acid (22:5n3) and Docosahexaenoic acid (22:6n3) in the range of about 1.5 to about 3.0, a ratio of Linoleic acid (18:2n6) to Alpha-Linolenic acid (18:3n3) in the range of about 3.0 to about 10.0, and a ratio of the sum of Eicosapentaenoic acid (20:5n3) and Docosahexaenoic acid (22:6n3) to Gamma-Linolenic acid (18:3n6) in the range of about 1.0 to about 10.0. In a preferred embodiment the nutritional product contains quantities of nutrients having anti-oxidant properties in vivo, such as beta-carotene, vitamin E, vitamin C, selenium, and taurine.
摘要翻译：用于肠内喂养的液体营养产品含有脂肪源，其在喂给肺部患者时提供期望的效果。脂肪源以亚油酸（18：2n6），γ-亚麻酸（18：3n6）和花生四烯酸（18：3n6）组成的组中的[n-（6）与正（3）]脂肪酸的重量比（18:3n3），十八碳烯酸（18:4n3），二十碳五烯酸（20:5n3），二十二碳五烯酸（22:5n3）和二十二碳六烯酸（二十二碳六烯酸）的脂肪酸（20:4n6） 22：6n3）在约1.5至约3.0的范围内，亚油酸（18：2n6）与α-亚麻酸（18：3n3）的比例在约3.0至约10.0的范围内，二十碳五烯酸（20:5n3）和二十二碳六烯酸（22：6n3）至约1.0至约10.0范围内的γ-亚麻酸（18：3n6）。在一个优选的实施方案中，营养产品含有在体内具有抗氧化性质的营养物质，例如β-胡萝卜素，维生素E，维生素C，硒和牛磺酸。

2. 发明授权

US6117655A Nucleic acid encoding adhesion variants 失效
标题翻译：编码粘附变体的核酸
公开(公告)号：US6117655A
公开(公告)日：2000-09-12
申请号：US457918
申请日：1995-06-01
申请人： Daniel J. Capon , Timothy J. Gregory
发明人： Daniel J. Capon , Timothy J. Gregory
IPC分类号： A61K38/00 , A61K47/48 , C07K14/73 , C07K16/00 , C12N15/13 , C12N15/62 , C12N15/63
CPC分类号： C07K14/70514 , A61K47/48276 , C07K16/00 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/55
摘要： Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.
摘要翻译：提供了与免疫球蛋白超家族（粘合剂）同源的细胞表面蛋白质的新型衍生物。将氨基酸序列变异引入到粘连中，其中最值得注意的是跨膜和优选细胞质结构域在功能上无活性，其中粘附细胞外结构域替代免疫球蛋白可变区的那些。这些变体在治疗或诊断中是有用的，特别是CD4变体在治疗HIV感染中是治疗上有用的。

3. 发明授权

US5674984A Method for isolation of unclipped HIV envelope protein 失效
标题翻译：分离未剪切的HIV包膜蛋白的方法
公开(公告)号：US5674984A
公开(公告)日：1997-10-07
申请号：US226162
申请日：1994-04-11
申请人： Phillip W. Berman , Brian M. Fendly , Timothy J. Gregory , Florian M. Wurm
发明人： Phillip W. Berman , Brian M. Fendly , Timothy J. Gregory , Florian M. Wurm
IPC分类号： A61K39/00 , A61K39/21 , A61K39/395 , A61P31/12 , A61P31/18 , C07K14/16 , C07K16/10 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/91 , C12R1/92 , C07K1/22
CPC分类号： C07K14/005 , C07K16/1063 , A61K39/00 , C07K2317/34 , C12N2740/16122
摘要： Methods for producing and isolating unclipped HIV env proteins are provided. According to the methods, an antibody directed to an HIV epitope spanning the env clip site is used to selectively separate unclipped HIV env protein from clipped env protein.
摘要翻译：提供了生产和分离未剪切的HIV env蛋白的方法。根据该方法，使用针对跨越env剪切位点的HIV表位的抗体来选择性地将未剪切的HIV env蛋白与剪切的env蛋白分离。

4. 发明授权

US5565335A Adhesion variants 失效
标题翻译：粘附变体
公开(公告)号：US5565335A
公开(公告)日：1996-10-15
申请号：US236311
申请日：1994-05-02
申请人： Daniel J. Capon , Timothy J. Gregory
发明人： Daniel J. Capon , Timothy J. Gregory
IPC分类号： A61K38/00 , A61K47/48 , C07K14/73 , C07K16/00 , C12N15/13 , C07K14/705 , C07K14/00 , C12N15/62
CPC分类号： C07K14/70514 , A61K47/48276 , C07K16/00 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/55
摘要： Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into the adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.
摘要翻译：提供了与免疫球蛋白超家族（粘合剂）同源的细胞表面蛋白质的新型衍生物。氨基酸序列变异被引入到粘附素中，其中最值得注意的是其中跨膜和优选细胞质结构域在功能上无活性，其中粘附细胞外结构域替代免疫球蛋白可变区的那些。这些变体在治疗或诊断中是有用的，特别是CD4变体在治疗HIV感染中是治疗上有用的。

5. 发明授权

US07041293B1 HIV env antibodies 失效
标题翻译： HIV env抗体
公开(公告)号：US07041293B1
公开(公告)日：2006-05-09
申请号：US09103262
申请日：1998-06-23
申请人： Phillip W. Berman , Brian M. Fendly , Timothy J. Gregory , Florian M. Wurm
发明人： Phillip W. Berman , Brian M. Fendly , Timothy J. Gregory , Florian M. Wurm
IPC分类号： A61K39/42
CPC分类号： C07K16/1063
摘要： The invention provides antibodies specific for HIV env, including monoclonal antibodies and related hybridomas. The antibodies block CD4/g120 binding and reduce reverse transcriptase activity in vitro.
摘要翻译：本发明提供对HIV环境特异的抗体，包括单克隆抗体和相关杂交瘤。抗体阻断CD4 / g120结合并降低体外逆转录酶活性。

6. 发明授权

US06710169B2 Adheson variants 失效
标题翻译：粘合剂变体
公开(公告)号：US06710169B2
公开(公告)日：2004-03-23
申请号：US10157408
申请日：2002-05-28
申请人： Daniel J. Capon , Timothy J. Gregory
发明人： Daniel J. Capon , Timothy J. Gregory
IPC分类号： C07K14705
CPC分类号： C07K14/34 , A61K38/00 , A61K47/6425 , C07K14/70514 , C07K16/00 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/55 , G01N33/6854
摘要： Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.
摘要翻译：提供了与免疫球蛋白超家族（粘合剂）同源的细胞表面蛋白质的新型衍生物。将氨基酸序列变异引入到粘连中，其中最值得注意的是跨膜和优选细胞质结构域在功能上无活性，其中粘附细胞外结构域替代免疫球蛋白可变区的那些。这些变体在治疗或诊断中是有用的，特别是CD4变体在治疗HIV感染中是治疗上有用的。

7. 发明授权

US5849533A Method for making unclipped HIV envelope protein 失效
标题翻译：制备未切割的HIV包膜蛋白的方法
公开(公告)号：US5849533A
公开(公告)日：1998-12-15
申请号：US802361
申请日：1997-02-19
申请人： Phillip W. Berman , Brian M. Fendly , Timothy J. Gregory , Elorian M. Wurm
发明人： Phillip W. Berman , Brian M. Fendly , Timothy J. Gregory , Elorian M. Wurm
IPC分类号： A61K39/00 , A61K39/21 , A61K39/395 , A61P31/12 , A61P31/18 , C07K14/16 , C07K16/10 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/91 , C12R1/92 , C12P21/00
CPC分类号： C07K14/005 , C07K16/1063 , A61K39/00 , C07K2317/34 , C12N2740/16122
摘要： Methods for making unclipped HIV env proteins are provided. According to the methods, a genetically engineered cell line comprising an nucleic acid sequence encoding an HIV env protein is cultured to produce unclipped HIV env protein, which is recovered from the cell culture.
摘要翻译：提供了制备未切割的HIV env蛋白的方法。根据该方法，培养包含编码HIV env蛋白的核酸序列的遗传工程改造的细胞系以产生从细胞培养物中回收的未剪切的HIV env蛋白。

8. 发明授权

US5336603A CD4 adheson variants 失效
标题翻译： CD4粘附变体
公开(公告)号：US5336603A
公开(公告)日：1994-08-09
申请号：US936190
申请日：1992-08-26
申请人： Daniel J. Capon , Timothy J. Gregory
发明人： Daniel J. Capon , Timothy J. Gregory
IPC分类号： A61K38/00 , A61K47/48 , C07K14/73 , C07K16/00 , C12N15/13 , C07K13/00 , C12N15/62
CPC分类号： C07K14/70514 , A61K47/48276 , C07K16/00 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/55
摘要： Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amino acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics.
摘要翻译：提供了与免疫球蛋白超家族（粘合剂）同源的细胞表面蛋白质的新型衍生物。将氨基酸序列变异引入到粘连中，其中最值得注意的是跨膜和优选细胞质结构域在功能上无活性，其中粘附细胞外结构域替代免疫球蛋白可变区的那些。这些变体可用于治疗或诊断。

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