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1. 发明授权

US07279279B2 Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening 有权
标题翻译：用于确定抗病毒药物敏感性和耐药性以及抗病毒药物筛选的组合物和方法
公开(公告)号：US07279279B2
公开(公告)日：2007-10-09
申请号：US10846181
申请日：2004-05-14
申请人： Daniel J. Capon , Christos J. Petropoulos
发明人： Daniel J. Capon , Christos J. Petropoulos
IPC分类号： C12Q1/68
CPC分类号： C12N15/86 , C12N2740/16043 , C12N2830/00 , C12N2830/15 , C12N2830/60 , C12N2840/20 , C12N2840/203 , C12N2840/206 , C12N2840/44 , C12Q1/18 , C12Q1/6881 , C12Q1/6897 , C12Q1/701 , C12Q1/703 , C12Q1/707 , C12Q2600/158 , G01N33/5023 , G01N2333/16 , G01N2800/52 , C12Q2545/113
摘要： This invention provides a method for determining susceptibility for an anti-viral drug comprising: (a) introducing a resistance test vector Comprising a patient-derived segment and an indicator gene into a host cell; (b) culturing the host cell from (a); (c) measuring expression of the indicator gene in a target host cell; and (d) comparing the expression of the indicator gene from (c) with the expression of the indicator gene measured when steps (a)-(c) are carried out in the absence of the anti-viral drug, wherein a test concentration of the anti-viral drug is present at steps (a)-(c); at steps (b)-(c); or at step (c). This invention also provides a method for determining anti-viral drug resistance in a patient comprising: (a) determining anti-viral drug susceptibility in the patient at a first time using the susceptibility test described above, wherein the patient-derived segment is obtained from the patient at about said time; (b) determining anti-viral drug susceptibility of the same patient at a later time; and (c) comparing the anti-viral drug susceptibilities determined in step (a) and (b), wherein a decrease in anti-viral drug susceptibility at the later time compared to the first time indicates development or progression of anti-viral drug resistance in the patient.
摘要翻译：本发明提供了一种用于确定抗病毒药物的易感性的方法，包括：（a）将包含患者来源区段和指示基因的抗性测试载体导入宿主细胞; （b）从（a）培养宿主细胞; （c）测量靶宿主细胞中指示基因的表达; 和（d）比较来自（c）的指示基因的表达与在不存在抗病毒药物的情况下进行步骤（a） - （c）时测量的指示基因的表达，其中测试浓度在步骤（a） - （c）中存在抗病毒药物; 在步骤（b） - （c）; 或在步骤（c）。本发明还提供了一种用于测定患者抗病毒药物耐药性的方法，包括：（a）使用上述敏感性试验在第一时间确定患者的抗病毒药物敏感性，其中所述患者衍生部分获自病人约在上述时间; （b）以后确定同一病人的抗病毒药物敏感性; 和（c）比较步骤（a）和（b）中确定的抗病毒药物敏感性，其中与第一次相比后来的抗病毒药物敏感性的降低表明抗病毒药物耐药性的发展或进展在病人身上

2. 发明授权

US06406697B1 Hybrid immunoglobulins 失效
标题翻译：混合免疫球蛋白
公开(公告)号：US06406697B1
公开(公告)日：2002-06-18
申请号：US08906549
申请日：1997-08-05
申请人： Daniel J. Capon , Laurence A. Lasky
发明人： Daniel J. Capon , Laurence A. Lasky
IPC分类号： C07K1646
CPC分类号： C07K14/70514 , A61K38/00 , C07K14/705 , C07K16/28 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/32 , C07K2319/705
摘要： Novel polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.
摘要翻译：提供了新的多肽，以及制备和使用它们的方法以及编码它们的核酸。这些多肽可用作细胞表面粘附分子和配体，并且可用于治疗或诊断组合物和方法。

3. 发明授权

US6150584A Human antibodies derived from immunized xenomice 失效
公开(公告)号：US6150584A
公开(公告)日：2000-11-21
申请号：US724752
申请日：1996-10-02
申请人： Raju Kucherlapati , Aya Jakobovits , Daniel G. Brenner , Daniel J. Capon , Sue Klapholz
发明人： Raju Kucherlapati , Aya Jakobovits , Daniel G. Brenner , Daniel J. Capon , Sue Klapholz
IPC分类号： C07K16/12 , C07K16/24 , C07K16/28 , C12N15/07 , A61K48/00 , C12N5/10
CPC分类号： C07K16/2875 , C07K16/1282 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , A01K2217/05 , A01K2217/075 , C07K2317/21 , C07K2317/24
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.

4. 发明授权

US06114598A Generation of xenogeneic antibodies 失效
公开(公告)号：US06114598A
公开(公告)日：2000-09-05
申请号：US464582
申请日：1995-06-05
申请人： Raju Kucherlapati , Aya Jakobovits , Sue Kalpholz , Daniel G. Brenner , Daniel J. Capon
发明人： Raju Kucherlapati , Aya Jakobovits , Sue Kalpholz , Daniel G. Brenner , Daniel J. Capon
IPC分类号： A01K67/027 , A61K38/00 , A61K39/00 , A61K39/395 , C07K14/00 , C07K14/435 , C07K16/00 , C07K16/12 , C07K16/24 , C07K16/28 , C07K16/46 , C07K19/00 , C12N20060101 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/85 , C12P21/00 , C12P21/06 , C12P21/08 , C12R1/91 , A61K48/00 , C12N15/79
CPC分类号： A01K67/0278 , A01K67/0275 , A01K67/0276 , C07K16/00 , C07K16/1282 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C12N15/8509 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A01K2267/0381 , A61K38/00 , C07K2317/21 , C07K2317/24
摘要： The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic modifications of embryonic cells in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci. Chimeric and transgenic mammals, particularly mice, are provided, having stably integrated large, xenogeneic DNA segments. The segments are introduced by fusion with yeast spheroplasts comprising yeast artificial chromosomes (YACs) which include the xenogeneic DNA segments and a selective marker such as HPRT, and embryonic stem cells.

5. 发明授权

US5683905A Vectors and cell lines capable of correctly splicing exon regions 失效
标题翻译：载体和能够正确拼接外显子区域的细胞系
公开(公告)号：US5683905A
公开(公告)日：1997-11-04
申请号：US448171
申请日：1995-05-23
申请人： Daniel J. Capon , Richard M. Lawn , Gordon A. Vehar , William I. Wood
发明人： Daniel J. Capon , Richard M. Lawn , Gordon A. Vehar , William I. Wood
IPC分类号： A61K38/00 , C07K14/755 , C12N15/10 , C12N15/12 , C12N15/62 , C12N15/85 , C12Q1/68 , C12N15/63 , C12N5/00
CPC分类号： C07K14/755 , C12N15/1034 , C12N15/62 , C12N15/85 , C12Q1/6832 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/80 , C12N2800/108 , C12N2830/00 , C12N2830/55 , C12N2840/105 , C12N2840/44 , Y10S435/948 , Y10S930/10
摘要： A recombinant DNA vector is provided that expresses exons of genomic DNA fragments that are inserted into the vector. The vector contains a promoter and a genomic DNA fragment so characterized and configured that the vector, upon transcription in a transfected eukaryotic cell culture, expresses the corresponding RNA segment of the genomic DNA fragment free of any intron.
摘要翻译：提供重组DNA载体，其表达插入到载体中的基因组DNA片段的外显子。载体含有启动子和基因组DNA片段，如此表征并构建为在转染的真核细胞培养物中转录时载体表达不含任何内含子的基因组DNA片段的相应RNA片段。

6. 发明授权

US5618788A Preparation of functional human factor VIII and pharmaceutical treatment therewith 失效
标题翻译：功能性人因子VIII的制备及其药物治疗
公开(公告)号：US5618788A
公开(公告)日：1997-04-08
申请号：US570096
申请日：1990-08-20
申请人： Daniel J. Capon , Richard M. Lawn , Gordon A. Vehar , William I. Wood
发明人： Daniel J. Capon , Richard M. Lawn , Gordon A. Vehar , William I. Wood
IPC分类号： A61K38/00 , C07K14/755 , C12N15/10 , C12N15/12 , C12N15/62 , C12N15/85 , C12Q1/68 , A61K38/37
CPC分类号： C07K14/755 , C12N15/1034 , C12N15/62 , C12N15/85 , C12Q1/6832 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/80 , C12N2800/108 , C12N2830/00 , C12N2830/55 , C12N2840/105 , C12N2840/44 , Y10S435/948 , Y10S930/10
摘要： Functional human factor VIII produced recombinantly is used in the treatment of human beings diagnosed to be deficient in factor VIII coagulant activity. Also provided are DNA isolates and expression vehicles encoding functional human factor VIII, as well as transformed host cells and processes for producing human factor VIII by use of recombinant DNA technology.
摘要翻译：重组产生的功能性人因子VIII用于治疗被诊断为缺乏因子VIII凝血活性的人。还提供了编码功能性人因子VIII的DNA分离物和表达载体，以及通过使用重组DNA技术转化的宿主细胞和用于产生人因子VIII的方法。

7. 发明申请

US20170008950A1 HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE 审中-公开
标题翻译：含有非肽链的杂交免疫抑制剂
公开(公告)号：US20170008950A1
公开(公告)日：2017-01-12
申请号：US15125774
申请日：2015-03-13
申请人： Daniel J. Capon
发明人： Daniel J. Capon
IPC分类号： C07K16/00 , A61K47/48 , C07K16/24 , C07K16/46
CPC分类号： C07K16/00 , A61K47/6801 , A61K47/6855 , A61K47/6875 , A61K47/6889 , C07K16/241 , C07K16/46 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/76
摘要： The present invention provides a compound having the structure: A-B-----Z wherein A is a biologically active structure of the compound; wherein Z is a protein component of the compound, which protein component comprises one or more polypeptides, wherein at least one of the one or more polypeptides comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fc receptor; and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine or selenocysteine; wherein the dashed line between B and Z represents a peptidyl linkage; and wherein the solid line between A and B represents a nonpeptidyl linkage, as well as intermediates dimers thereof, and processes of producing the compounds of the invention.
摘要翻译：其中A是化合物的生物活性结构; 其中Z是所述化合物的蛋白质组分，所述蛋白质组分包含一种或多种多肽，其中所述一种或多种多肽中的至少一种包含连续氨基酸，其（i）与存在于链中的连续氨基酸序列相同的抗体的Fc结构域; （ii）结合Fc受体; 和（iii）在其N-末端具有选自半胱氨酸或硒代半胱氨酸的序列; 其中B和Z之间的虚线表示肽基键; 并且其中A和B之间的实线表示非肽基键，以及其中间体二聚体，以及制备本发明化合物的方法。

8. 发明申请

US20120117669A1 HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENOMICE 审中-公开
标题翻译：从免疫的XENOMICE衍生的人类抗体
公开(公告)号：US20120117669A1
公开(公告)日：2012-05-10
申请号：US12837454
申请日：2010-07-15
申请人： Raju KUCHERLAPATI , Aya Jakobovits , Daniel G. Brenner , Daniel J. Capon , Sue Klapholz
发明人： Raju KUCHERLAPATI , Aya Jakobovits , Daniel G. Brenner , Daniel J. Capon , Sue Klapholz
IPC分类号： A01K67/027 , C12P21/00
CPC分类号： C07K16/2863 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K2317/21 , C07K2317/24
摘要： Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译：针对特定抗原的完全人抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已经被修饰以响应于抗原性攻击而产生这样的抗体，但其内源性位点已被禁用。可以进行各种随后的操作以获得本身或其类似物的抗体。

9. 发明授权

US06657103B1 Human antibodies derived from immunized xenomice 失效
标题翻译：源自免疫的异种小鼠的人抗体
公开(公告)号：US06657103B1
公开(公告)日：2003-12-02
申请号：US08923138
申请日：1997-09-04
申请人： Raju Kucherlapati , Aya Jakobovits , Sue Klapholz , Daniel G. Brenner , Daniel J. Capon
发明人： Raju Kucherlapati , Aya Jakobovits , Sue Klapholz , Daniel G. Brenner , Daniel J. Capon
IPC分类号： C12P2100
CPC分类号： C12N15/90 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2267/01 , A01K2267/0381 , A61K38/00 , A61K2039/505 , C07K16/00 , C07K16/1282 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/248 , C07K16/2812 , C07K16/2854 , C07K16/2875 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C12N15/8509 , C12N15/87 , C12N2840/203
摘要： Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
摘要翻译：具有针对特异性抗原的完全人可变区的抗体可以通过将抗原施用于转基因动物来制备，所述转基因动物已经被修饰以响应于抗原性攻击而产生这样的抗体，但其内源性位点已被禁用。可以进行各种随后的操作以获得本身或其类似物的抗体。

10. 发明授权

US06534285B1 Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use 失效
标题翻译：分子克隆获得性免疫缺陷综合征多肽及其使用方法
公开(公告)号：US06534285B1
公开(公告)日：2003-03-18
申请号：US09547692
申请日：2000-04-12
申请人： Phillip W. Berman , Daniel J. Capon , Laurence A. Lasky
发明人： Phillip W. Berman , Daniel J. Capon , Laurence A. Lasky
IPC分类号： C12P2106
CPC分类号： C07K14/005 , A61K39/00 , C07K14/245 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N15/62 , C12N2740/16122 , C12N2740/16222 , C12Q1/48
摘要： Diagnostic product and vaccine for Acquired Immuno-deficiency Syndrome (AIDS) and methods for making and using same, wherein viral polypeptide sequences from an AIDS associated retrovirus are expressed directly or as a fusion polypeptide in a prokaryotic or mammalian cell expression host to produce a diagnostic product which specifically binds complementary antibody produced by individuals afflicted with AIDS or a vaccine against AIDS which confers resistance to infection by AIDS associated retrovirus. The reverse transcriptase of an AIDS associated retrovirus is used separately or in a whole cell assay to identify compounds which selectively inhibit retroviral reverse transcriptase.
摘要翻译：用于获得性免疫缺陷综合征（AIDS）的诊断产品和疫苗及其制备和使用方法，其中来自AIDS相关逆转录病毒的病毒多肽序列直接表达或作为原核或哺乳动物细胞表达宿主中的融合多肽，以产生诊断特异性结合艾滋病患者产生的互补抗体的产品或抗艾滋病疫苗的抗艾滋病相关逆转录病毒感染的抗体。 AIDS相关逆转录病毒的逆转录酶单独使用或在全细胞测定中用于鉴定选择性抑制逆转录病毒逆转录酶的化合物。

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