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1. 发明申请

US20090082250A1 Control of gene expression using a complex of an oligonucleotide and a regulatory peptide 审中-公开
标题翻译：使用寡核苷酸和调节肽的复合物控制基因表达
公开(公告)号：US20090082250A1
公开(公告)日：2009-03-26
申请号：US12152175
申请日：2008-05-13
申请人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C. G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C. G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
IPC分类号： C12N15/11 , A61K38/02 , A01H1/06 , G01N33/53 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译：一种抑制细胞中所选择的基因表达的方法，包括向细胞中引入分子，所述分子包含（1）核酸结合部分，所述核酸结合部分结合位点或与所选基因相关联，所述基因存在于基因组中，（2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。提供了用于本发明方法的分子。阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。

2. 发明申请

US20120077270A1 Control of Gene Expression Using a Complex of an Oligonucleotide and a Regulatory Peptide 审中-公开
标题翻译：使用寡核苷酸和调节肽的复合物控制基因表达
公开(公告)号：US20120077270A1
公开(公告)日：2012-03-29
申请号：US13251627
申请日：2011-10-03
申请人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
IPC分类号： C12N5/071 , C07K1/00 , C07K14/00 , C12N5/04 , C12N1/20
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译：一种用于抑制细胞中所选基因表达的方法，所述方法包括向细胞中引入包含（1）结合位点或与选定基因相关的核酸结合部分的分子，该位点存在于基因组中和（2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。提供了用于本发明方法的分子。阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。

3. 发明申请

US20050136040A1 Control of gene expression using a complex of an oligonucleotide and a regulatory peptide 审中-公开
标题翻译：使用寡核苷酸和调节肽的复合物控制基因表达
公开(公告)号：US20050136040A1
公开(公告)日：2005-06-23
申请号：US10824584
申请日：2004-04-08
申请人： Stephen Hart , Simak Ali , Boris PuFong , Andrew Porter , Laki Buluwela , Satu Vainikka , John Jenkinson , Patrick Kanda
发明人： Stephen Hart , Simak Ali , Boris PuFong , Andrew Porter , Laki Buluwela , Satu Vainikka , John Jenkinson , Patrick Kanda
IPC分类号： A61K9/127 , A61K48/00 , C07H21/04 , C12N5/04 , C12N15/113 , C12N15/63 , C12N5/08
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/63 , C12N2310/15 , C12N2310/335 , C12N2310/336 , C12N2310/3513
摘要： A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要翻译：一种抑制细胞中所选择的基因表达的方法，包括向细胞中引入分子，所述分子包含（1）核酸结合部分，所述核酸结合部分结合位点或与所选基因相关联，所述基因存在于基因组中，（2）表达阻遏物部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。提供了用于本发明方法的分子。阻遏物可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。

4. 发明申请

US20060247192A1 Control of apoptosis 审中-公开
标题翻译：凋亡控制
公开(公告)号：US20060247192A1
公开(公告)日：2006-11-02
申请号：US10536664
申请日：2003-12-05
申请人： John Jenkinson , Patrick Kanda , Satu Vainikka
发明人： John Jenkinson , Patrick Kanda , Satu Vainikka
IPC分类号： A61K48/00
CPC分类号： C12N15/1135 , A61K38/45 , C12N2310/11 , C12N2310/15 , C12N2310/3513 , C12Q1/6811 , A61K2300/00
摘要： A method for suppressing the expression of a selected apoptosis-related gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site at or associated with the selected gene which site is present in a genome and (2) a modifying portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor or modifying portion may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase. The nucleic acid binding portion may be a triplex forming oligonucleotide (TFO). The apoptosis-related gene may be Bcl-2. The methods and molecules
摘要翻译：一种抑制细胞中选择的细胞凋亡相关基因表达的方法，包括向细胞中引入分子，该分子包含（1）核酸结合部分，所述核酸结合部分结合选定基因所在位点或与所选基因相关，该位点存在在基因组中和（2）修饰部分，其中所述核酸结合部分包含寡核苷酸或寡核苷酸模拟物或类似物，并且其中所述阻遏物部分包含多肽或肽模拟物。提供了用于本发明方法的分子。阻遏物或修饰部分可以是能够募集组蛋白脱乙酰酶或DNA甲基化酶的组蛋白脱乙酰酶或DNA甲基化酶或多肽的一部分。核酸结合部分可以是形成三链体的寡核苷酸（TFO）。凋亡相关基因可能是Bcl-2。方法和分子

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