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1. 发明授权

US5789196A Recombinantly produced .beta.4 neuronal nicotinic acetylcholine receptor subunits 失效
标题翻译：重组产生β4神经元烟碱乙酰胆碱受体亚单位
公开(公告)号：US5789196A
公开(公告)日：1998-08-04
申请号：US486801
申请日：1995-06-07
申请人： Stephen Fox Heinemann , Robert Michael Duvoisin , Evan Samuel Deneris , James Warner Patrick
发明人： Stephen Fox Heinemann , Robert Michael Duvoisin , Evan Samuel Deneris , James Warner Patrick
IPC分类号： C12N15/09 , C07K14/00 , C07K14/705 , C12N1/11 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , C12P21/06
CPC分类号： C07K14/70571
摘要： The present invention discloses a new neuronal nicotinic acetylcholine receptor subunit, .beta.4. The new subunit can form functional combinations with other neuronal nicotinic acetylcholine receptor subunits, including, but not limited to, alpha2, alpha3, alpha4 and beta2. A cDNA clone containing the DNA sequences that encode the novel receptor subunit of the invention has been deposited with the American Type Culture Collection for patent purposes.
摘要翻译：本发明公开了一种新的神经元烟碱乙酰胆碱受体亚单位β4。新亚基可以与其它神经元烟碱乙酰胆碱受体亚基形成功能性组合，包括但不限于α2，α3，α4和β2。包含编码本发明的新受体亚单位的DNA序列的cDNA克隆已经保藏在美国典型培养物保藏中心以用于专利。

2. 发明授权

US06967244B1 Neuronal nicotinic acetylcholine receptor compositions 失效
标题翻译：神经元烟碱乙酰胆碱受体组成
公开(公告)号：US06967244B1
公开(公告)日：2005-11-22
申请号：US09580462
申请日：2000-05-26
申请人： Stephen Fox Heinemann , James Warner Patrick , James Richard Boulter , Evan Samuel Deneris , Keiji Wada , Marc Charles Ballivet , Daniel Jay Goldman , John Gerard Connolly , Robert Michael Duvoisin , Eden Deer Heinemann
发明人： Stephen Fox Heinemann , James Warner Patrick , James Richard Boulter , Evan Samuel Deneris , Keiji Wada , Marc Charles Ballivet , Daniel Jay Goldman , John Gerard Connolly , Robert Michael Duvoisin , Eden Deer Heinemann
IPC分类号： C07K14/705 , C12N15/12
CPC分类号： C07K14/70571
摘要： The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding subunits alpha2, alpha3, alpha4, and alpha5, plus non-agonist binding subunits beta2, beta3 and beta4. Representative cDNA clones that contain the DNA sequences of the invention have been deposited with the American Type Culture Collection for patent purposes.
摘要翻译：本发明涉及由神经元激动剂和非激动剂结合亚基组成的神经元烟碱乙酰胆碱受体家族，以及编码这种亚基的DNA序列。这些新型神经元烟碱乙酰胆碱受体亚基包括激动剂结合亚基α2，α3，α4和α5，加上非激动剂结合亚单位β2，β3和β4。含有本发明的DNA序列的代表性cDNA克隆已经保藏在美国典型培养物保藏中心以用于专利。

3. 发明授权

US6136550A Neuronal nicotinic acetylcholihne receptor compositions 失效
标题翻译：神经元烟碱乙酰胆碱受体组成
公开(公告)号：US6136550A
公开(公告)日：2000-10-24
申请号：US349956
申请日：1994-12-06
申请人： Stephen Fox Heinemann , James Warner Patrick , James Richard Boulter , Evan Samuel Deneris , Keiji Wada , Marc Charles Ballivet , Daniel Jay Goldman , John Gerard Connolly , Robert Michael Duvoisin , Eden Deer Heinemann
发明人： Stephen Fox Heinemann , James Warner Patrick , James Richard Boulter , Evan Samuel Deneris , Keiji Wada , Marc Charles Ballivet , Daniel Jay Goldman , John Gerard Connolly , Robert Michael Duvoisin , Eden Deer Heinemann
IPC分类号： C07K14/705 , C12N15/12 , G01N33/566
CPC分类号： C07K14/70571 , G01N33/944 , G01N2500/04
摘要： The present invention relates to a family of neuronal nicotinic acetylcholine receptors comprised of neuronal agonist and non-agonist binding subunits, and DNA sequences encoding such subunits. These novel neuronal nicotinic acetylcholine receptor subunits include the agonist binding subunits alpha2, alpha3, alpha4, and alpha5, plus non-agonist binding subunits beta2, beta3 and beta4. Representative cDNA clones that contain the DNA sequences of the invention have been deposited with the American Type Culture Collection for patent purposes.
摘要翻译：本发明涉及由神经元激动剂和非激动剂结合亚基组成的神经元烟碱乙酰胆碱受体家族，以及编码这种亚基的DNA序列。这些新型神经元烟碱乙酰胆碱受体亚基包括激动剂结合亚基α2，α3，α4和α5，加上非激动剂结合亚单位β2，β3和β4。含有本发明的DNA序列的代表性cDNA克隆已经保藏在美国典型培养物保藏中心以用于专利。

4. 发明授权

US5683912A Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit 失效
标题翻译：新型乙酰胆碱门控离子通道受体亚基的克隆和表达
公开(公告)号：US5683912A
公开(公告)日：1997-11-04
申请号：US278635
申请日：1994-07-21
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： A01K67/027 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
摘要翻译：本发明提供编码α9烟碱型乙酰胆碱受体亚基的分离核酸和由此编码的受体亚基蛋白。还提供了含有本发明的核酸，其转化的宿主细胞，α9烟碱乙酰胆碱受体亚基和功能性烟碱乙酰胆碱受体的载体，其包含在这种宿主细胞中重组表达的至少一个α9亚基以及表达本发明受体的转基因非人哺乳动物亚单位及其突变体。本发明的受体包含至少一个α9烟碱乙酰胆碱亚基，并形成由乙酰胆碱活化但由尼古丁和毒蕈碱胺阻断的阳离子通道。本发明还提供了用于鉴定调节含有至少一个本发明亚单位的功能性受体的离子通道活性的化合物的方法。

5. 发明授权

US6100046A Methods of identifying modulators of alpha9, a novel acetylcholine-gated ion channel receptor subunit 失效
标题翻译：鉴定α9调节剂的方法，一种新的乙酰胆碱门控离子通道受体亚基
公开(公告)号：US6100046A
公开(公告)日：2000-08-08
申请号：US471961
申请日：1995-06-05
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： A01K67/027 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
摘要翻译：本发明提供编码α9烟碱型乙酰胆碱受体亚基的分离核酸和由此编码的受体亚基蛋白。还提供了含有本发明的核酸，其转化的宿主细胞，α9烟碱乙酰胆碱受体亚基和功能性烟碱乙酰胆碱受体的载体，其包含在这种宿主细胞中重组表达的至少一个α9亚基以及表达本发明受体的转基因非人哺乳动物亚单位及其突变体。本发明的受体包含至少一个α9烟碱乙酰胆碱亚基，并形成由乙酰胆碱活化但由尼古丁和毒蕈碱胺阻断的阳离子通道。本发明还提供了用于鉴定调节含有至少一个本发明亚单位的功能性受体的离子通道活性的化合物的方法。

6. 发明授权

US6013766A Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit 失效
公开(公告)号：US6013766A
公开(公告)日：2000-01-11
申请号：US464258
申请日：1995-06-05
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： A01K67/027 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.

7. 发明授权

US06646109B1 Cloning and expression of a novel acetylcholine-gated ion channel receptor subunit 失效
标题翻译：新型乙酰胆碱门控离子通道受体亚基的克隆和表达
公开(公告)号：US06646109B1
公开(公告)日：2003-11-11
申请号：US09345109
申请日：1999-06-29
申请人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
发明人： Ana Belen Elgoyhen , David S. Johnson , James Richard Boulter , Stephen Fox Heinemann
IPC分类号： C07K1628
CPC分类号： C07K14/70571 , A01K2217/05
摘要： The present invention provides isolated nucleic acids encoding alpha9 nicotinic acetylcholine receptor subunit and receptor subunit protein encoded thereby. Also provided are vectors containing the invention nucleic acids, host cells transformed therewith, alpha9 nicotinic acetylcholine receptor subunit and functional nicotinic acetylcholine receptors comprising at least one alpha9 subunit expressed recombinantly in such host cells as well as transgenic non-human mammals that express the invention receptor subunit and mutants thereof. Receptors of the invention comprise at least one alpha9 nicotinic acetylcholine subunit and form cationic channels activated by acetylcholine, but blocked by nicotine and muscarine. The invention also provides methods for identifying compounds that modulate the ion channel activity of the functional invention receptors containing at least one invention subunit.
摘要翻译：本发明提供编码α9烟碱型乙酰胆碱受体亚基的分离核酸和由此编码的受体亚基蛋白。还提供了含有本发明的核酸，其转化的宿主细胞，α9烟碱乙酰胆碱受体亚基和功能性烟碱乙酰胆碱受体的载体，其包含在这种宿主细胞中重组表达的至少一个α9亚基以及表达本发明受体的转基因非人哺乳动物亚单位及其突变体。本发明的受体包含至少一个α9烟碱乙酰胆碱亚基，并形成由乙酰胆碱活化但由尼古丁和毒蕈碱胺阻断的阳离子通道。本发明还提供了用于鉴定调节含有至少一个本发明亚单位的功能性受体的离子通道活性的化合物的方法。

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