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1. 发明申请

US20060151171A1 Delayed-gelation solution 有权
标题翻译：延迟凝胶溶液
公开(公告)号：US20060151171A1
公开(公告)日：2006-07-13
申请号：US10524364
申请日：2003-08-20
申请人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michael Bruggen , Arnaud Der Beken
发明人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michael Bruggen , Arnaud Der Beken
IPC分类号： E21B33/138
CPC分类号： C09K8/572 , C09K8/5045
摘要： The invention concerns an aqueous delayed-gelation solution and a method of selectively placing a delayed-gelation solution in a hydrocarbon well. According to the invention, the aqueous delayed-gelation solution a dissolved metal salt which, in use, hydrolyses to form a gel, wherein the solution contains suspended inorganic particles and the method comprises the steps of providing the aqueous delayed-gelation solution, and—injecting the solution into the hydrocarbon well, whereby the suspended inorganic particles reduce or block the flow of the delayed-gelation solution to relatively low permeability formation zones thereby selectively placing the solution in a relatively high permeability formation zone. Applications of the invention relate to the treatment of hydrocarbon wells.
摘要翻译：本发明涉及一种水性延迟凝胶化溶液和选择性地将延迟凝胶化溶液置于烃井中的方法。根据本发明，水性延迟凝胶溶液是溶解的金属盐，其在使用中水解形成凝胶，其中溶液含有悬浮的无机颗粒，并且该方法包括以下步骤：提供水性延迟凝胶溶液，和 - 将溶液注入到烃阱中，由此悬浮的无机颗粒减少或阻止延迟凝胶化溶液流向相对低渗透性的形成区域，从而选择性地将溶液置于相对高渗透性的形成区域中。本发明的应用涉及烃井的处理。

2. 发明授权

US07622430B2 Delayed-gelation solution 有权
标题翻译：延迟凝胶溶液
公开(公告)号：US07622430B2
公开(公告)日：2009-11-24
申请号：US11841199
申请日：2007-08-20
申请人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michel Van Bruggen , Arnaud Van Der Beken
发明人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michel Van Bruggen , Arnaud Van Der Beken
IPC分类号： C09K8/74
CPC分类号： C09K8/572 , C09K8/5045
摘要： The invention concerns an aqueous delayed-gelation solution for use in hydrocarbon wells. According to the invention, the aqueous delayed-gelation solution a dissolved metal salt which, in use, hydrolyses to form a gel, wherein the solution contains suspended inorganic particles and the method comprises the steps of—providing the aqueous delayed-gelation solution, and—injecting the solution into the hydrocarbon well, whereby the suspended inorganic particles reduce or block the flow of the delayed-gelation solution to relatively low permeability formation zones thereby selectively placing the solution in a relatively high permeability formation zone.
摘要翻译：本发明涉及用于烃井的含水延迟凝胶化溶液。根据本发明，水性延迟凝胶溶液是溶解的金属盐，其在使用中水解形成凝胶，其中溶液含有悬浮的无机颗粒，并且该方法包括以下步骤：提供水性延迟凝胶溶液，以及将溶液注入烃井中，由此悬浮的无机颗粒减少或阻止延迟凝胶化溶液流向相对低渗透性的形成区域，从而选择性地将溶液置于相对高渗透性的形成区域中。

3. 发明申请

US20070284102A1 DELAYED-GELATION SOLUTION 有权
标题翻译：延迟解决方案
公开(公告)号：US20070284102A1
公开(公告)日：2007-12-13
申请号：US11841199
申请日：2007-08-20
申请人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michel Van Bruggen , Arnaud Van Der Beken
发明人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michel Van Bruggen , Arnaud Van Der Beken
IPC分类号： E21B33/13
CPC分类号： C09K8/572 , C09K8/5045
摘要： The invention concerns an aqueous delayed-gelation solution for use in hydrocarbon wells. According to the invention, the aqueous delayed-gelation solution a dissolved metal salt which, in use, hydrolyses to form a gel, wherein the solution contains suspended inorganic particles and the method comprises the steps of—providing the aqueous delayed-gelation solution, and—injecting the solution into the hydrocarbon well, whereby the suspended inorganic particles reduce or block the flow of the delayed-gelation solution to relatively low permeability formation zones thereby selectively placing the solution in a relatively high permeability formation zone.
摘要翻译：本发明涉及用于烃井的含水延迟凝胶化溶液。根据本发明，水性延迟凝胶溶液是溶解的金属盐，其在使用中水解形成凝胶，其中溶液含有悬浮的无机颗粒，并且该方法包括以下步骤：提供水性延迟凝胶溶液，以及将溶液注入烃井中，由此悬浮的无机颗粒减少或阻止延迟凝胶化溶液流向相对低渗透性的形成区域，从而选择性地将溶液置于相对高渗透性的形成区域中。

4. 发明授权

US07273101B2 Delayed-gelation solution 有权
标题翻译：延迟凝胶溶液
公开(公告)号：US07273101B2
公开(公告)日：2007-09-25
申请号：US10524364
申请日：2003-08-20
申请人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michel Van Bruggen , Arnaud Van Der Beken
发明人： Stephen Davies , Trevor Hughes , Henk Lekkerkerker , Michel Van Bruggen , Arnaud Van Der Beken
IPC分类号： E21B33/138
CPC分类号： C09K8/572 , C09K8/5045
摘要： The invention concerns an aqueous delayed-gelation solution and a method of selectively placing a delayed-gelation solution in a hydrocarbon well. According to the invention, the aqueous delayed-gelation solution a dissolved metal salt which, in use, hydrolyses to form a gel, wherein the solution contains suspended inorganic particles and the method comprises the steps of—providing the aqueous delayed-gelation solution, and—injecting the solution into the hydrocarbon well, whereby the suspended inorganic particles reduce or block the flow of the delayed-gelation solution to relatively low permeability formation zones thereby selectively placing the solution in a relatively high permeability formation zone. Applications of the invention relate to the treatment of hydrocarbon wells.
摘要翻译：本发明涉及一种水性延迟凝胶化溶液和选择性地将延迟凝胶化溶液置于烃井中的方法。根据本发明，水性延迟凝胶溶液是溶解的金属盐，其在使用中水解形成凝胶，其中溶液含有悬浮的无机颗粒，并且该方法包括以下步骤：提供水性延迟凝胶溶液，以及将溶液注入烃井中，由此悬浮的无机颗粒减少或阻止延迟凝胶化溶液流向相对低渗透性的形成区域，从而选择性地将溶液置于相对高渗透性的形成区域中。本发明的应用涉及烃井的处理。

5. 发明授权

US07081439B2 Methods for controlling the fluid loss properties of viscoelastic surfactant based fluids 有权
标题翻译：用于控制基于粘弹性表面活性剂的流体的流体损失特性的方法
公开(公告)号：US07081439B2
公开(公告)日：2006-07-25
申请号：US10707011
申请日：2003-11-13
申请人： Philip Sullivan , Yenny Christanti , Isabelle Couillet , Stephen Davies , Trevor Hughes , Alexander Wilson
发明人： Philip Sullivan , Yenny Christanti , Isabelle Couillet , Stephen Davies , Trevor Hughes , Alexander Wilson
IPC分类号： C09K8/00
CPC分类号： C09K8/845 , C09K8/602 , C09K8/665 , C09K8/68 , C09K2208/10 , C09K2208/30 , E21B33/138
摘要： Disclosed are methods of treating subterranean formations by first providing a suspension of colloidal particles prior to the injection of viscoelastic based treatment fluid, and injecting the treatment fluid into a well. The colloidal particles reduce fluid loss into the formation. According to a second embodiment, the treating fluid includes a hydrophobically-modified polymer, said hydrophobically-modified polymer being present at a concentration between approximately its overlap concentration c* and approximately its entanglement concentration ce. The method is particularly useful for fracturing operations in medium to high permeability formations.
摘要翻译：公开的是通过首先在注入基于粘弹性的处理流体之前提供胶体颗粒的悬浮液并将处理流体注入井中来处理地下地层的方法。胶体颗粒将液体流失减少到地层中。根据第二实施方案，处理流体包括疏水改性的聚合物，所述疏水改性的聚合物以大约其重叠浓度c *与其约束的缠结浓度c e之间的浓度存在。该方法特别适用于中高渗透性地层的压裂作业。

6. 发明申请

US20050107265A1 Methods For Controlling The Fluid Loss Properties Of Viscoelastic Surfactants Based Fluids 有权
标题翻译：用于控制基于粘弹性表面活性剂的流体的流体损失特性的方法
公开(公告)号：US20050107265A1
公开(公告)日：2005-05-19
申请号：US10707011
申请日：2003-11-13
申请人： Philip Sullivan , Yenny Christanti , Isabelle Couillet , Stephen Davies , Trevor Hughes , Alexander Wilson
发明人： Philip Sullivan , Yenny Christanti , Isabelle Couillet , Stephen Davies , Trevor Hughes , Alexander Wilson
IPC分类号： C09K8/60 , C09K8/66 , C09K8/68 , C09K8/84 , E21B33/138 , E21B43/00
CPC分类号： C09K8/845 , C09K8/602 , C09K8/665 , C09K8/68 , C09K2208/10 , C09K2208/30 , E21B33/138
摘要： It is proposed a method of treating a subterranean formation including providing a suspension of colloidal particles prior to the injection of a treating fluid based on an aqueous fluid comprising a thickening amount of a viscoelastic surfactant. The colloidal particles help to reduce fluid losses into the formation. According to a second embodiment, the treating fluid includes a hydrophobically-modified polymer, said hydrophobically-modified polymer being present at a concentration between approximately its overlap concentration c* and approximately its entanglement concentration ce. The method is particularly useful for fracturing operation in medium to high permeability formation.
摘要翻译：提出了一种处理地下地层的方法，包括在基于包含增稠量的粘弹性表面活性剂的水性流体注入处理流体之前提供胶体颗粒的悬浮液。胶体颗粒有助于减少进入地层的流体损失。根据第二实施方案，处理流体包括疏水改性的聚合物，所述疏水改性的聚合物以大约其重叠浓度c *与其约束的缠结浓度c e之间的浓度存在。该方法特别适用于中高渗透性地层的压裂作业。

7. 发明申请

US20090099185A1 P38 Map Kinase Inhibitors 有权
标题翻译： P38图激酶抑制剂
公开(公告)号：US20090099185A1
公开(公告)日：2009-04-16
申请号：US12299333
申请日：2007-05-01
申请人： David Charles Festus Moffat , Stephane Pintat , Stephen Davies
发明人： David Charles Festus Moffat , Stephane Pintat , Stephen Davies
IPC分类号： A61K31/4412 , C07D211/76 , C12N9/99 , C07D413/12 , A61K31/5377 , A61P1/00 , A61P17/06 , A61P11/06 , A61P3/10 , A61P19/02 , A61P37/00 , A61P37/06
CPC分类号： C07D213/73
摘要： Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: wherein: G is —N═ or —CH═; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R6 is hydrogen or optionally substituted C1-C3 alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula -A-(CH2), —X1-L1-Y—NH—CHR1R2 wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members; z, Y, L1, and X1 are as defined in the specification; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2 is the side chain of a natural or non-natural alpha amino acid.
摘要翻译：式（I）化合物是p38MAP激酶的抑制剂，因此可用于治疗特别是炎性病症，包括类风湿性关节炎和COPD：其中：G是-N-或-CH-; D是任选取代的具有5-13个环成员的二价单环或双环芳基或杂芳基; R6是氢或任选取代的C 1 -C 3烷基; P表示氢，U表示式（IA）的基团; 或U表示氢，P表示式-A-（CH2），-X1-L1-Y-NH-CHR1R2的基团，其中A表示任选取代的具有5-13个环成员的二价单环或双环碳环或杂环基; z，Y，L1和X1如说明书中所定义; R 1是羧酸基团（-COOH）或可被一个或多个细胞内酯酶水解成羧酸基团的酯基; R2是天然或非天然α氨基酸的侧链。

8. 发明申请

US20080226609A1 Transplantation of Glial Restricted Precursor-Derived Astrocytes for Promotion of Axon Growth 审中-公开
标题翻译：移植胶质受限前体衍生的星形胶质细胞促进轴突生长
公开(公告)号：US20080226609A1
公开(公告)日：2008-09-18
申请号：US12064778
申请日：2006-08-28
申请人： Chris Proschel , Margot Mayer-Proschel , Jeannette Davies , Stephen Davies , Mark Noble
发明人： Chris Proschel , Margot Mayer-Proschel , Jeannette Davies , Stephen Davies , Mark Noble
IPC分类号： C12N5/06 , A61K35/30 , A61P25/28
CPC分类号： C12N5/0622 , A61K35/30 , C12N2501/155
摘要： Provided herein are compositions and methods for the treatment of central nervous system (CNS) lesions comprising administration of glial restricted precursor (GRP) derived astrocytes (GDAs).
摘要翻译：本文提供了用于治疗中枢神经系统（CNS）损伤的组合物和方法，其包括施用神经抑制前体（GRP）衍生的星形胶质细胞（GDAs）。

9. 发明申请

US20070135314A1 Composition and Method for Treating a Subterranean Formation 有权
标题翻译：用于处理地层的组合物和方法
公开(公告)号：US20070135314A1
公开(公告)日：2007-06-14
申请号：US11673008
申请日：2007-02-09
申请人： Wayne Frenier , Murtaza Ziauddin , Stephen Davies , Frank Chang
发明人： Wayne Frenier , Murtaza Ziauddin , Stephen Davies , Frank Chang
IPC分类号： C09K8/60
CPC分类号： C09K8/52 , C09K8/74 , C09K8/845 , C09K8/86 , Y10S507/933
摘要： An aqueous oilfield treatment fluid containing a chelating agent and an HF source is described. This fluid is effective at dissolving siliceous materials such as clays and keeping the dissolved materials in solution. In particular it is effective at preventing re-precipitation of initially-dissolved silicon as silica and therefore reduces damage to sandstones with which it is contacted. Methods are given for using this fluid for sandstone matrix stimulation, removal of clay-containing drilling fluid components and filter cakes from wellbores, sandstone acid fracturing, and gravel pack and proppant pack cleaning.
摘要翻译：描述了含有螯合剂和HF源的含水油田处理液。该溶液有效地溶解硅质材料如粘土并将溶解的材料保持在溶液中。特别是，防止初始溶解的硅作为二氧化硅再沉淀，因此减少与其接触的砂岩的损害。给出了使用这种流体用于砂岩基质刺激，去除含粘土的钻井液组分和来自井筒，砂岩酸压裂以及砾石填料和支撑剂填料清洁的滤饼的方法。

10. 发明申请

US20050112615A1 Genetic circuit inverting amplifier 审中-公开
标题翻译：遗传电路反相放大器
公开(公告)号：US20050112615A1
公开(公告)日：2005-05-26
申请号：US10861415
申请日：2004-06-07
申请人： Stephen Davies , Gianna DeRubertis
发明人： Stephen Davies , Gianna DeRubertis
IPC分类号： H03F99/00 , C12Q1/68 , H03F21/00
CPC分类号： H03F21/00
摘要： We describe methods and compositions for setting the level of gene expression in a cell. The instant invention is of an amplifier, an analog circuit. It is directly analogous to the inverting amplifier commonly used in electronics. This circuit produces an output wherein an increase in the input signal leads to a proportional decrease in the output. Similarly, a decrease in the input leads to an increase in the output signal. Here the inputs and outputs may be concentrations of intracellular molecular species. The circuit is implemented as nucleic acid constructs. By analogy with the similar circuit found in analog electronics, such a circuit is expected to have improved signal to noise ratio, improved stability, and increased accuracy. It should aid in the development of intracellular instrumentation and hence the diagnosis and treatment of disease.
摘要翻译：我们描述了设置细胞中基因表达水平的方法和组合物。本发明是放大器，模拟电路。它直接类似于电子学中通常使用的反相放大器。该电路产生输出，其中输入信号的增加导致输出的比例减小。类似地，输入的减小导致输出信号的增加。这里的输入和输出可以是细胞内分子种类的浓度。电路实现为核酸构建体。通过与模拟电子学中类似的电路类似，预计这种电路具有改善的信噪比，改进的稳定性和增加的精度。它应该有助于细胞内仪器的发展，从而有助于疾病的诊断和治疗。

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