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1. 发明授权

US5059175A Implantable drug delivery system with piston actuation 失效
标题翻译：具有活塞致动的植入式药物输送系统
公开(公告)号：US5059175A
公开(公告)日：1991-10-22
申请号：US594271
申请日：1990-10-09
申请人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
发明人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61K9/0024 , A61M31/002
摘要： An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.
摘要翻译：可植入药物输送系统包括具有基端和排出端的壳体，用于在排出端保持药物溶液，设置在排出端处的阀，以允许药物溶液从壳体内部流过阀门并出口的壳体，其中所述壳体被施加到所述阀上;活塞，其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动，以迫使溶液朝向排出端并排出所述阀;以及弹簧，设置在所述壳体中的所述活塞和其基端用于将活塞推向排出端。多个不同长度的系绳在一端连接到活塞，另一端连接到位于壳体基端的相应的释放节点。每个释放节点保持系链中相应一个的另一端，直到接收释放信号，此时它释放系绳。定时电路设置在基座的外壳中，以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号，以便当释放系绳时，允许活塞向排放端移动从而将药物溶液从壳体排出或推出，直到下一个最短的未释放的系链停止活塞的进一步移动。

2. 发明授权

US5196002A Implantable drug delivery system with piston acutation 失效
标题翻译：具有活塞功能的可植入药物递送系统
公开(公告)号：US5196002A
公开(公告)日：1993-03-23
申请号：US716926
申请日：1991-06-18
申请人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
发明人： Barry K. Hanover , Stephen C. Jacobsen , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61K9/0024 , A61M31/002
摘要： An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.
摘要翻译：可植入药物输送系统包括具有基端和排出端的壳体，用于在排出端保持药物溶液，设置在排出端处的阀，以允许药物溶液从壳体内部流过阀门并出口的壳体，其中所述壳体被施加到所述阀上;活塞，其可滑动地设置在所述壳体中以在所述基端和排出端之间滑动，以迫使溶液朝向排出端并排出所述阀;以及弹簧，设置在所述壳体中的所述活塞和其基端用于将活塞推向排出端。多个不同长度的系绳在一端连接到活塞，另一端连接到位于壳体基端的相应的释放节点。每个释放节点保持系链中相应一个的另一端，直到接收释放信号，此时它释放系绳。定时电路设置在基座的外壳中，以便按照最短系链节点到最长系绳节点的顺序向节点顺序地提供释放信号，以便当释放系绳时，允许活塞向排放端移动从而将药物溶液从壳体排出或推出，直到下一个最短的未释放的系链停止活塞的进一步移动。

3. 发明授权

US5167625A Multiple vesicle implantable drug delivery system 失效
标题翻译：多种植入式药物输送系统
公开(公告)号：US5167625A
公开(公告)日：1992-12-01
申请号：US595087
申请日：1990-10-09
申请人： Stephen C. Jacobsen , Barry K. Hanover , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
发明人： Stephen C. Jacobsen , Barry K. Hanover , Eric M. Simon , Tomasz Petelenz , Michael G. Mladejovsky
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61M31/002
摘要： An implantable drug delivery system includes a housing having a plurality of compartments each of which includes an opening on one side thereof and a floor generally opposite the opening. Also included are a plurality of flexible drug containment sacks, each having a mouth circumscribing an opening in the sack, with the sack being disposed in a respective compartment with the mouth affixed to the opening of that compartment to seal the inside of the sack from the inside of the compartment and to enable holding a drug formulation in the sack. A plurality of covers are disposed over a respective compartment opening for preventing the release of drug formulation contained in the sacks in the compartment covered, until ruptured or removed. A plurality of gas generating elements are disposed at the floor of a respective compartment under the sack in that compartment and are responsive to initiation signals for producing gas to force the sacks and drug formulations against the covers to thereby rupture or remove the covers and force the formulations out of the housing. An electrical circuit supplies initiation signals to the gas generating means to initiate production of the gas and thus discharge of the drug formulation.
摘要翻译：可植入药物输送系统包括具有多个隔室的壳体，每个隔室在其一侧包括一个开口和与开口大致相对的底板。还包括多个柔性药物容纳袋，每个袋具有围绕袋中的开口的口，其中袋被设置在相应的隔室中，口中固定有该隔室的开口以将袋的内部从在隔间内部，并且能够在药袋中保持药物制剂。多个盖设置在相应的隔室开口上，用于防止包装在被覆盖的隔室中的袋中的药物制剂的释放，直到破裂或移除。多个气体发生元件设置在该隔间中的袋下面的相应隔室的底板处，并响应于产生气体的起始信号，以迫使袋和药物制剂抵靠盖，从而破裂或移除盖并迫使制剂出了房屋。电路将起始信号提供给气体发生装置以启动气体的产生，从而释放药物制剂。

4. 发明申请

US20130150755A1 SYSTEMS, DEVICES, AND METHODS FOR PROVIDING FOOT LOADING FEEDBACK TO PATIENTS AND PHYSICIANS DURING A PERIOD OF PARTIAL WEIGHT BEARING 审中-公开
标题翻译：系统，设备和方法，用于在部分重量轴承期间为患者和医生提供足部装载反馈
公开(公告)号：US20130150755A1
公开(公告)日：2013-06-13
申请号：US13757559
申请日：2013-02-01
申请人： Erik N. Kubiak , Kylee North , Tomasz Petelenz , Robert W. Hitchcock
发明人： Erik N. Kubiak , Kylee North , Tomasz Petelenz , Robert W. Hitchcock
IPC分类号： A61B5/103 , A61B5/11 , A61B5/00
CPC分类号： A61B5/1036 , A61B5/0002 , A61B5/1038 , A61B5/11 , A61B5/4833 , A61B5/486 , A61B5/6807 , A61B5/6829 , A61B5/7275 , A61B5/742 , A61B5/743 , A61B5/746 , A61B5/7475 , A61B2562/0247 , A61B2562/0252
摘要： Systems, devices, and methods for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria are described. A computer system receives force data from a non-compressible force transmitter that is assigned to a user, and accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range. The pressure compliance range specifies a prescribed range of pressure that is to be applied during a PWB period. The computer system then receives a compliance data request from the user or the user's physician and communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to the user and/or the user's physician.
摘要翻译：描述了关于符合一组偏重（PWB）标准的用户反馈的系统，设备和方法。计算机系统从分配给用户的不可压缩力传递器接收力数据，并且访问从不可压缩力发射器接收的力数据，以确定用户是否处于预定的压力一致性范围内。压力一致性范围指定在PWB期间施加的规定的压力范围。然后，计算机系统从用户或用户的医生接收合规数据请求，并将表示用户遵从性的符合性数据在PWB期间内传达到用户和/或用户医师的PWB期间内的规定压力范围。

5. 发明申请

US20070112316A1 Cochlear drug delivery system and method 审中-公开
公开(公告)号：US20070112316A1
公开(公告)日：2007-05-17
申请号：US11650193
申请日：2007-01-04
申请人： Stephen Jacobsen , Tomasz Petelenz
发明人： Stephen Jacobsen , Tomasz Petelenz
IPC分类号： A61M5/00
CPC分类号： A61F11/00 , A61M5/142 , A61M5/145 , A61M2205/35 , A61M2205/50 , A61M2205/8206 , A61M2210/0662
摘要： A drug administration system configured to administer a drug to a user's ear includes a housing, sized and shaped to substantially fit behind the user's ear, and configured to pump the drug in controlled amounts to the user's middle ear. A drug reservoir is disposed in the housing and includes a drug configured to treat an inner ear condition. A catheter is operatively coupled to the drug reservoir and is sized and shaped to extend from the drug administration unit into the user's middle ear.

6. 发明申请

US20080009787A1 Method and apparatus for presetting device operating levels with display 失效
标题翻译：用显示器预设设备工作电平的方法和装置
公开(公告)号：US20080009787A1
公开(公告)日：2008-01-10
申请号：US11804592
申请日：2007-05-17
申请人： Stephen Jacobsen , Shane Olsen , Tomasz Petelenz
发明人： Stephen Jacobsen , Shane Olsen , Tomasz Petelenz
IPC分类号： A61M5/142
CPC分类号： A61M5/14244 , A61M2005/1405 , A61M2205/6018 , A61M2205/6045
摘要： Techniques for control of fluid delivery from a fluid reservoir by a medical infusion pump are described. Setting of at least one electronically-controllable pumping parameter is determined by the use of one or more mechanical keys. The mechanical key actuates one or more electronic switches of a mechanical key receptacle coupled to the medical infusion pump. The electronic switches are coupled to the medical infusion pump to control the at least one electronically-controllable pumping parameter. Keys can be differently configured to actuate different switches corresponding to particular settings and can include display indicia showing the particular parameter value set by the key.
摘要翻译：描述了用于通过医用输液泵控制从流体储存器输送流体的技术。通过使用一个或多个机械钥匙来确定至少一个电子可控泵送参数的设定。机械钥匙致动耦合到医用输液泵的机械钥匙插座的一个或多个电子开关。电子开关耦合到医用输液泵以控制至少一个电子可控的泵送参数。键可以被不同地配置为致动对应于特定设置的不同开关，并且可以包括显示由键设置的特定参数值的显示标记。

7. 发明授权

US10595748B2 Systems, devices, and methods for providing foot loading feedback to patients and physicians during a period of partial weight bearing 有权
公开(公告)号：US10595748B2
公开(公告)日：2020-03-24
申请号：US13757559
申请日：2013-02-01
申请人： Erik N. Kubiak , Kylee North , Tomasz Petelenz , Robert W. Hitchcock
发明人： Erik N. Kubiak , Kylee North , Tomasz Petelenz , Robert W. Hitchcock
IPC分类号： A61B5/103 , A61B5/00 , A61B5/11
摘要： Systems, devices, and methods for providing user feedback regarding compliance with a set of partial weight bearing (PWB) criteria are described. A computer system receives force data from a non-compressible force transmitter that is assigned to a user, and accesses the force data received from the non-compressible force transmitter to determine whether the user is within a predefined pressure compliance range. The pressure compliance range specifies a prescribed range of pressure that is to be applied during a PWB period. The computer system then receives a compliance data request from the user or the user's physician and communicates compliance data representing the user's compliance with the prescribed range of pressure during the PWB period to the user and/or the user's physician.

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