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1. 发明授权

US09220885B2 Placement devices that enable patients to accurately position medical patches at target locations and methods therefor 有权
标题翻译：使患者能够在目标位置准确定位医疗补丁的放置装置及其方法
公开(公告)号：US09220885B2
公开(公告)日：2015-12-29
申请号：US12642176
申请日：2009-12-18
申请人： Stephen B. Wahlgren , Andrea Slater Tomko , Glenn H. Stahl , Andrew Joseph March , Rochelle Kleinberg , Karin Elise Taylor , Martin J. Nohilly , Michael William Ammerman
发明人： Stephen B. Wahlgren , Andrea Slater Tomko , Glenn H. Stahl , Andrew Joseph March , Rochelle Kleinberg , Karin Elise Taylor , Martin J. Nohilly , Michael William Ammerman
IPC分类号： A61N1/04 , A61N1/05
CPC分类号： A61N1/05 , A61N1/0456 , A61N1/0492 , A61N1/08
摘要： A placement device for a medical patch includes an alignment guide having a shaft with a first end having a first anatomical alignment marker and a second end having a second anatomical alignment marker, a swinging gate both pivotally and rotationally coupled with the first end of the shaft for selectively pivoting the gate toward and away from the shaft and rotating the gate between opposite sides of the shaft, whereby the gate has first and second major faces and a first opening extending through the gate between the first and second major faces. The placement device includes a spacer for selectively adjusting spacing between the gate and the first end of the shaft, and a flexible diaphragm having a flexible dome disposed within the first gate opening. At least one magnet is located in the center of the flexible dome for holding the medical patch within the flexible dome.
摘要翻译：用于医疗贴片的放置装置包括具有轴的对准引导件，第一端具有第一解剖学对准标记，第二端具有第二解剖对准标记，摆动门与轴的第一端枢转地和旋转地联接用于选择性地将门朝向和远离地枢转，并且在所述轴的相对侧之间旋转所述门，由此所述门具有第一和第二主面以及在所述第一和第二主面之间延伸穿过所述门的第一开口。所述放置装置包括用于选择性地调节所述门和所述轴的所述第一端之间的间隔的间隔件，以及具有设置在所述第一门开口内的柔性圆顶的柔性隔膜。至少一个磁体位于柔性圆顶的中心，用于将医疗贴片保持在柔性圆顶内。

2. 发明申请

US20110152987A1 PLACEMENT DEVICES THAT ENABLE PATIENTS TO ACCURATELY POSITION MEDICAL PATCHES AT TARGET LOCATIONS AND METHODS THEREFOR 有权
标题翻译：放置设备，使得患者能够在目标位置上精确定位医疗护理及其方法
公开(公告)号：US20110152987A1
公开(公告)日：2011-06-23
申请号：US12642176
申请日：2009-12-18
申请人： Stephen B. Wahlgren , Andrea Slater Tomko , Glenn H. Stahl , Andrew Joseph March , Rochelle Kleinberg , Karin Elise Taylor , Martin J. Nohilly , Michael William Ammerman
发明人： Stephen B. Wahlgren , Andrea Slater Tomko , Glenn H. Stahl , Andrew Joseph March , Rochelle Kleinberg , Karin Elise Taylor , Martin J. Nohilly , Michael William Ammerman
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/0456 , A61N1/0492 , A61N1/08
摘要： A placement device for a medical patch includes an alignment guide having a shaft with a first end having a first anatomical alignment marker and a second end having a second anatomical alignment marker, a swinging gate both pivotally and rotationally coupled with the first end of the shaft for selectively pivoting the gate toward and away from the shaft and rotating the gate between opposite sides of the shaft, whereby the gate has first and second major faces and a first opening extending through the gate between the first and second major faces. The placement device includes a spacer for selectively adjusting spacing between the gate and the first end of the shaft, and a flexible diaphragm having a flexible dome disposed within the first gate opening. At least one magnet is located in the center of the flexible dome for holding the medical patch within the flexible dome.
摘要翻译：用于医疗贴片的放置装置包括具有轴的对准引导件，第一端具有第一解剖学对准标记，第二端具有第二解剖对准标记，摆动门与轴的第一端枢转地和旋转地联接用于选择性地将门朝向和远离地枢转，并且在所述轴的相对侧之间旋转所述门，由此所述门具有第一和第二主面以及在所述第一和第二主面之间延伸穿过所述门的第一开口。所述放置装置包括用于选择性地调节所述门和所述轴的所述第一端之间的间隔的间隔件，以及具有设置在所述第一门开口内的柔性圆顶的柔性隔膜。至少一个磁体位于柔性圆顶的中心，用于将医疗贴片保持在柔性圆顶内。

3. 发明授权

US08170683B2 Dermatome stimulation devices and methods 有权
标题翻译：皮肤刺激装置和方法
公开(公告)号：US08170683B2
公开(公告)日：2012-05-01
申请号：US11957240
申请日：2007-12-14
申请人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
发明人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
IPC分类号： A61N1/00
CPC分类号： A61N1/0456 , A61N1/0452 , A61N1/0492 , A61N1/36007 , A61N1/36014 , A61N1/36017 , A61N1/36171
摘要： A nerve stimulation device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating nerves within a dermatome, a second waveform generator adapted to generate a first carrier waveform having a second frequency capable of passing through tissue of a mammal, and a third waveform generator adapted to generate a second carrier waveform having a third frequency different than the second frequency and being capable of passing through the tissue of the mammal. The device includes a modulator electrically coupled to the first, second and third waveform generators and adapted to modulate the first waveform, the first carrier waveform, and the second carrier waveform to generate a modulated signal package capable of stimulating the nerves at different depths within the dermatome. The device also has an electrode electrically coupled to the modulator for applying the modulated waveform to the dermatomic region.
摘要翻译：神经刺激装置包括：第一波形发生器，其适于产生具有能够刺激皮肤内的神经的第一频率的第一波形;适于生成具有能够穿过哺乳动物的组织的第二频率的第一载波波形的第二波形发生器以及适于生成具有与第二频率不同的第三频率并且能够通过哺乳动物的组织的第二载波波形的第三波形发生器。该装置包括电耦合到第一，第二和第三波形发生器并且适于调制第一波形，第一载波波形和第二载波波形的调制器，以产生调制信号包，该调制信号包能够在不同深度内刺激神经皮肤病该装置还具有电耦合到调制器的电极，用于将调制波形施加到皮肤原始区域。

4. 发明申请

US20090157149A1 DERMATOME STIMULATION DEVICES AND METHODS 有权
标题翻译： DERMATOME刺激装置和方法
公开(公告)号：US20090157149A1
公开(公告)日：2009-06-18
申请号：US11957240
申请日：2007-12-14
申请人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
发明人： Stephen B. Wahlgren , Michael Tracey , Anthony DiUbaldi
IPC分类号： A61N1/04
CPC分类号： A61N1/0456 , A61N1/0452 , A61N1/0492 , A61N1/36007 , A61N1/36014 , A61N1/36017 , A61N1/36171
摘要： A nerve stimulation device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating nerves within a dermatome, a second waveform generator adapted to generate a first carrier waveform having a second frequency capable of passing through tissue of a mammal, and a third waveform generator adapted to generate a second carrier waveform having a third frequency different than the second frequency and being capable of passing through the tissue of the mammal. The device includes a modulator electrically coupled to the first, second and third waveform generators and adapted to modulate the first waveform, the first carrier waveform, and the second carrier waveform to generate a modulated signal package capable of stimulating the nerves at different depths within the dermatome. The device also has an electrode electrically coupled to the modulator for applying the modulated waveform to the dermatomic region.
摘要翻译：神经刺激装置包括：第一波形发生器，其适于产生具有能够刺激皮肤内的神经的第一频率的第一波形;适于产生具有能够穿过哺乳动物组织的第二频率的第一载波波形的第二波形发生器以及适于生成具有与第二频率不同的第三频率并且能够通过哺乳动物的组织的第二载波波形的第三波形发生器。该装置包括电耦合到第一，第二和第三波形发生器并且适于调制第一波形，第一载波波形和第二载波波形的调制器，以产生调制信号包，该调制信号包能够在不同深度内刺激神经皮肤病该装置还具有电耦合到调制器的电极，用于将调制波形施加到皮肤原始区域。

5. 发明申请

US20080132962A1 SYSTEM AND METHOD FOR AFFECTING GATRIC FUNCTIONS 审中-公开
标题翻译：影响GATRIC功能的系统和方法
公开(公告)号：US20080132962A1
公开(公告)日：2008-06-05
申请号：US11565706
申请日：2006-12-01
申请人： Anthony DiUbaldi , Michael R. Tracey , Stephen B. Wahlgren
发明人： Anthony DiUbaldi , Michael R. Tracey , Stephen B. Wahlgren
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/36014
摘要： A device for transcutaneous electrical stimulation device for affecting gastric function in a patient and a method for performing the same is provided. The device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating a vagus nerve of the patient at a predetermined location, a second waveform generator adapted to generate a carrier waveform having a second frequency capable of passing from the surface of skin of the patient at the predetermined location, through tissue to the vagus nerve, a modulation device electrically coupled to the first, second and third waveform generators and adapted to modulate the first and carrier waveforms to create a modulated signal, and a first electrode electrically coupled to the modulation device and positioned substantially adjacent to the skin of the mammal, and adapted to apply the modulated signal thereto.
摘要翻译：提供了一种用于影响患者胃功能的经皮电刺激装置的装置及其执行方法。该装置包括：第一波形发生器，其适于产生具有能够在预定位置刺激患者的迷走神经的第一频率的第一波形;适于产生具有第二频率的载波波形的第二波形发生器，通过组织到迷走神经的预定位置处的患者皮肤表面，电耦合到第一，第二和第三波形发生器并适于调制第一和载波波形以产生调制信号的调制装置，以及第一电极电耦合到调制装置并且基本上邻近哺乳动物的皮肤定位，并且适于将调制信号施加到其上。

6. 发明授权

US08260439B2 Nerve stimulation patches and methods for stimulating selected nerves 有权
标题翻译：神经刺激斑块和刺激选择神经的方法
公开(公告)号：US08260439B2
公开(公告)日：2012-09-04
申请号：US11941508
申请日：2007-11-16
申请人： Anthony DiUbaldi , Michael Tracey , Rex O. Bare , Bradley Sargent , Stephen B. Wahlgren
发明人： Anthony DiUbaldi , Michael Tracey , Rex O. Bare , Bradley Sargent , Stephen B. Wahlgren
IPC分类号： A61N1/18
CPC分类号： A61N1/0456 , A61N1/0452 , A61N1/0492 , A61N1/0496 , A61N1/36007 , A61N1/36014 , A61N1/36021 , A61N1/375 , A61N1/3756 , A61N1/3758 , H05K3/281 , H05K2201/2018
摘要： A selective nerve stimulation patch includes a substrate having a top surface and a bottom surface, integrated components overlying the top surface of the substrate and being electrically interconnected with one another for generating at least one nerve stimulating signal, electrodes integrated into the substrate and exposed at the bottom surface thereof for applying the at least one nerve stimulating signal to a target nerve, a waterproof, breathable cover overlying the substrate and the integrated components, and a support flange surrounding the substrate and coupling the cover and the substrate together. The support flange has a top surface that slopes downwardly toward an outer perimeter thereof, and at least a portion of the cover conforms to the sloping top surface of the support flange. In one embodiment, the patch generates a high frequency waveform with properties such as amplitude, frequency and the like chosen so as to overcome tissue impedance and the stimulation threshold of the target nerve. The modulated waveform is the waveform obtained by modulating the carrier waveform by a pulse envelope.
摘要翻译：选择性神经刺激贴片包括具有顶表面和底表面的基底，整合的元件覆盖在基底的顶表面上并且彼此电互连以产生至少一种神经刺激信号，集成到基底中并暴露于其底表面用于将至少一个神经刺激信号施加到目标神经，覆盖在基底和集成部件上的防水透气盖，以及围绕基底并将盖和基底连接在一起的支撑凸缘。支撑凸缘具有朝向其外周向下倾斜的顶表面，并且盖的至少一部分符合支撑凸缘的倾斜顶表面。在一个实施例中，贴片产生具有所选择的诸如振幅，频率等特性的高频波形，以便克服组织阻抗和目标神经的刺激阈值。调制波形是通过用脉冲包络调制载波波形而获得的波形。

7. 发明申请

US20090132018A1 Nerve Stimulation Patches And Methods For Stimulating Selected Nerves 有权
标题翻译：神经刺激补丁和刺激所选神经的方法
公开(公告)号：US20090132018A1
公开(公告)日：2009-05-21
申请号：US11941508
申请日：2007-11-16
申请人： Anthony DiUbaldi , Michael Tracey , Rex O. Bare , Bradley Sargent , Stephen B. Wahlgren
发明人： Anthony DiUbaldi , Michael Tracey , Rex O. Bare , Bradley Sargent , Stephen B. Wahlgren
IPC分类号： A61N1/04
CPC分类号： A61N1/0456 , A61N1/0452 , A61N1/0492 , A61N1/0496 , A61N1/36007 , A61N1/36014 , A61N1/36021 , A61N1/375 , A61N1/3756 , A61N1/3758 , H05K3/281 , H05K2201/2018
摘要： A selective nerve stimulation patch includes a substrate having a top surface and a bottom surface, integrated components overlying the top surface of the substrate and being electrically interconnected with one another for generating at least one nerve stimulating signal, electrodes integrated into the substrate and exposed at the bottom surface thereof for applying the at least one nerve stimulating signal to a target nerve, a waterproof, breathable cover overlying the substrate and the integrated components, and a support flange surrounding the substrate and coupling the cover and the substrate together. The support flange has a top surface that slopes downwardly toward an outer perimeter thereof, and at least a portion of the cover conforms to the sloping top surface of the support flange. In one embodiment, the patch generates a high frequency waveform with properties such as amplitude, frequency and the like chosen so as to overcome tissue impedance and the stimulation threshold of the target nerve. The modulated waveform is the waveform obtained by modulating the carrier waveform by a pulse envelope.
摘要翻译：选择性神经刺激贴片包括具有顶表面和底表面的基底，整合的元件覆盖在基底的顶表面上并且彼此电互连以产生至少一种神经刺激信号，集成到基底中并暴露于其底表面用于将至少一个神经刺激信号施加到目标神经，覆盖在基底和集成部件上的防水透气盖，以及围绕基底并将盖和基底连接在一起的支撑凸缘。支撑凸缘具有朝向其外周向下倾斜的顶表面，并且盖的至少一部分符合支撑凸缘的倾斜顶表面。在一个实施例中，贴片产生具有所选择的诸如振幅，频率等特性的高频波形，以便克服组织阻抗和目标神经的刺激阈值。调制波形是通过用脉冲包络调制载波波形而获得的波形。

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