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1. 发明授权

US08895236B2 Composition for cryopreservation comprising nicotinamide, glycerol and red blood cells 有权
标题翻译：用于包含烟酰胺，甘油和红细胞的冷冻保存的组合物
公开(公告)号：US08895236B2
公开(公告)日：2014-11-25
申请号：US13368460
申请日：2012-02-08
申请人： Stephen A. Livesey , Michael Brian Burnett , Jerome Connor , Christopher Todd Wagner
发明人： Stephen A. Livesey , Michael Brian Burnett , Jerome Connor , Christopher Todd Wagner
IPC分类号： A01N1/02 , A61K35/18
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/18
摘要： A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic/metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.
摘要翻译：红细胞储存组合物包括红细胞和生物化学改变试剂的组合物，所述生物化学改变试剂以浓度存在，以便将冻融循环期间的红细胞溶血百分比降低至百分比以下在没有生物化学改变试剂的情况下红细胞溶血。红细胞储存组合物优选包括选自以下的试剂：糖酵解/代谢组分的改性剂，抗氧化剂潜力的改性剂，细胞内离子分布的作用剂，膜流动性的调节剂，细胞骨架结构的改性剂，环加氧酶第二信使途径的作用者，脂氧合酶第二信使通路，己糖单磷酸第二信使途径的作用子，磷酸化第二信使途径的作用剂，特异信使分子的改性剂及其组合。

2. 发明申请

US20120141974A1 CRYOPRESERVATION OF HUMAN RED BLOOD CELLS 有权
标题翻译：人红细胞的CRYOPRESERVATION
公开(公告)号：US20120141974A1
公开(公告)日：2012-06-07
申请号：US13368460
申请日：2012-02-08
申请人： Stephen A. Livesey , Michael Brian Burnett , Jerome Connor , Christopher Todd Wagner
发明人： Stephen A. Livesey , Michael Brian Burnett , Jerome Connor , Christopher Todd Wagner
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/18
摘要： A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic/metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.
摘要翻译：红细胞储存组合物包括红细胞和生物化学改变试剂的组合物，所述生物化学改变试剂以浓度存在，以便将冻融循环期间的红细胞溶血百分比降低至百分比以下在没有生物化学改变试剂的情况下红细胞溶血。红细胞储存组合物优选包括选自以下的试剂：糖酵解/代谢组分的改性剂，抗氧化剂潜力的改性剂，细胞内离子分布的作用剂，膜流动性的调节剂，细胞骨架结构的改性剂，环加氧酶第二信使途径的作用者，脂氧合酶第二信使通路，己糖单磷酸第二信使途径的作用子，磷酸化第二信使途径的作用剂，特异信使分子的改性剂及其组合。

3. 发明授权

US5919614A Composition comprising three platelet lesion inhibitors for platelet storage 失效
标题翻译：组合物，其包含用于血小板储存的三种血小板损伤抑制剂
公开(公告)号：US5919614A
公开(公告)日：1999-07-06
申请号：US852921
申请日：1997-05-08
申请人： Stephen A. Livesey , Jerome Connor , Laura M. Currie
发明人： Stephen A. Livesey , Jerome Connor , Laura M. Currie
IPC分类号： A01N1/02 , A61K35/14 , A61K35/19
CPC分类号： A61K35/19 , A01N1/02 , A01N1/0226
摘要： This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets. In particular, compositions comprising amiloride, adenosine and sodium nitroprusside are disclosed.
摘要翻译：本发明提供了一种在降低的温度下延长人血小板保存的方法。该方法使用抑制剂系统，其使血小板维持其盘状并在储存期间保持其功能完整性。这是通过在储存期间中断正常的血小板功能来实现的，以便有助于保持血小板活化和失去其形状。在使用血小板输血之前，通过将抑制剂系统从血小板上清洗而使其恢复到正常的功能水平。特别地，公开了包含阿米洛利，腺苷和硝普钠的组合物。

4. 发明授权

US06221669B1 Prolonged preservation of blood platelets 失效
标题翻译：长时间保存血小板
公开(公告)号：US06221669B1
公开(公告)日：2001-04-24
申请号：US08600343
申请日：1996-02-13
申请人： Stephen A. Livesey , Jerome Connor , Laura M. Currie
发明人： Stephen A. Livesey , Jerome Connor , Laura M. Currie
IPC分类号： G01N3100
CPC分类号： A01N1/0226 , A01N1/02 , A61K35/19 , Y02A50/471 , Y10T436/108331
摘要： This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to retain their functional integrity during storage. In addition, the inhibitor system prevents the generation of cytokines in the platelet preparation during storage at both 22° C. and 4° C. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.
摘要翻译：本发明提供了一种在降低的温度下延长人血小板保存的方法。该方法使用抑制剂系统，使血小板在储存期间保持其功能完整性。此外，抑制剂系统在22℃和4℃下储存期间可防止血小板制剂中的细胞因子的产生。这是通过在储存期间中断正常的血小板功能来实现的，以帮助血小板激活并失去它们形状。在使用血小板输血之前，通过将抑制剂系统从血小板上清洗而使其恢复到正常的功能水平。

5. 发明授权

US5622867A Prolonged preservation of blood platelets 失效
标题翻译：长时间保存血小板
公开(公告)号：US5622867A
公开(公告)日：1997-04-22
申请号：US326036
申请日：1994-10-19
申请人： Stephen A. Livesey , Jerome Connor , Laura M. Currie
发明人： Stephen A. Livesey , Jerome Connor , Laura M. Currie
IPC分类号： A01N1/02 , A61K35/14 , A61K35/16 , A61K35/19
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/19 , Y10T436/108331 , Y10T436/2525
摘要： This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to maintain their discoid shape and retain their functional integrity during storage. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.
摘要翻译：本发明提供了一种在降低的温度下延长人血小板保存的方法。该方法使用抑制剂系统，其使血小板维持其盘状并在储存期间保持其功能完整性。这是通过在储存期间中断正常的血小板功能来实现的，以便有助于保持血小板活化和失去其形状。在使用血小板输血之前，通过将抑制剂系统从血小板上清洗而使其恢复到正常的功能水平。

6. 发明申请

US20070248575A1 Bone graft composition 审中-公开
标题翻译：骨移植组成
公开(公告)号：US20070248575A1
公开(公告)日：2007-10-25
申请号：US11407446
申请日：2006-04-19
申请人： Jerome Connor , Qing-Qing Qiu
发明人： Jerome Connor , Qing-Qing Qiu
IPC分类号： A01K67/027 , A61K35/12
CPC分类号： A61K35/32 , A61F2002/2835 , A61K35/36 , A61K41/0009 , A61K41/0019 , A61L27/3608 , A61L27/3633 , A61L27/365 , A61L27/3683 , A61L2430/02
摘要： The invention provides methods of making a bone graft composition. Also featured are methods of treatment using the bone graft composition and articles of manufacture that include the bone graft composition.
摘要翻译：本发明提供了制备骨移植组合物的方法。还特征在于使用包括骨移植组合物的骨移植组合物和制品的治疗方法。

7. 发明授权

US09150318B1 Method for sterilizing an acellular tissue matrix 有权
标题翻译：消毒无细胞组织基质的方法
公开(公告)号：US09150318B1
公开(公告)日：2015-10-06
申请号：US12650902
申请日：2009-12-31
申请人： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick Owens
发明人： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick Owens
IPC分类号： B65B55/02 , A61L2/00 , B65B55/08 , B65B55/16 , B65B55/22
CPC分类号： B65B55/02 , A61L2/0029 , A61L2/0035 , A61L2/007 , A61L2430/40 , B65B31/02 , B65B55/08 , B65B55/16 , B65B55/22
摘要： The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.
摘要翻译：本公开提供了用于制备，灭菌和保存组织的各种方法和组合物。本公开还具有通过该方法制备的无细胞组织基质。

8. 发明授权

US09649408B1 Systems and methods for sterilization of bone or bone components 有权
公开(公告)号：US09649408B1
公开(公告)日：2017-05-16
申请号：US12939629
申请日：2010-11-04
申请人： Qiu Qing-Qing , Jerome Connor
发明人： Qiu Qing-Qing , Jerome Connor
IPC分类号： A61F2/00 , A61L27/54
CPC分类号： A61L27/54 , A61L2/0082 , A61L2/0088 , A61L2/186 , A61L2/208
摘要： Systems for sterilization of demineralized bone matrices are provided.

9. 发明申请

US20090035289A1 DRY PLATELET COMPOSITION 审中-公开
标题翻译：干燥组合物
公开(公告)号：US20090035289A1
公开(公告)日：2009-02-05
申请号：US12088067
申请日：2006-09-26
申请人： Christopher T. Wagner , Jerome Connor , John R. Harper
发明人： Christopher T. Wagner , Jerome Connor , John R. Harper
IPC分类号： A61K35/12 , C12N5/00 , A61P17/02
CPC分类号： A61K35/19 , A01N1/0221 , A01N1/0226 , A61K9/19 , A61K31/4965 , A61K31/522 , A61K31/5575 , A61K31/5578 , A61K31/7076 , A61K33/26 , A61K35/16 , A61K45/06 , Y02A50/471 , A61K2300/00
摘要： The invention features a dry platelet composition and methods of making and using the freeze-dried platelet composition.
摘要翻译：本发明的特征在于干血小板组合物和制备和使用冷冻干燥的血小板组合物的方法。

10. 发明申请

US20060127375A1 Cryopreservation of human red blood cells 审中-公开
标题翻译：人类红细胞的冷冻保存
公开(公告)号：US20060127375A1
公开(公告)日：2006-06-15
申请号：US11334950
申请日：2006-01-18
申请人： Stephen Livesey , Michael Burnett , Jerome Connor , Christopher Wagner
发明人： Stephen Livesey , Michael Burnett , Jerome Connor , Christopher Wagner
IPC分类号： A61K35/14 , A01N1/02 , A61K31/70 , A61K31/7048 , A61K31/522 , A61K31/7012
CPC分类号： A01N1/02 , A01N1/0226 , A61K35/18
摘要： A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic/metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.
摘要翻译：红细胞储存组合物包括红细胞和生物化学改变试剂的组合物，所述生物化学改变试剂以浓度存在，以便将冻融循环期间的红细胞溶血百分比降低至百分比以下在没有生物化学改变试剂的情况下红细胞溶血。红细胞储存组合物优选包括选自以下的试剂：糖酵解/代谢组分的改性剂，抗氧化剂潜力的改性剂，细胞内离子分布的作用剂，膜流动性的调节剂，细胞骨架结构的改性剂，环加氧酶第二信使途径的作用者，脂氧合酶第二信使通路，己糖单磷酸第二信使途径的作用子，磷酸化第二信使途径的作用剂，特异信使分子的改性剂及其组合。

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