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1. 发明申请

US20090221061A1 Array for Rapid Detection of a Microorganism 有权
标题翻译：用于快速检测微生物的阵列
公开(公告)号：US20090221061A1
公开(公告)日：2009-09-03
申请号：US12464149
申请日：2009-05-12
申请人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
发明人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
IPC分类号： C12M1/34
CPC分类号： C12Q1/04
摘要： A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a distinct spectral response (e.g., pattern of colors) or “fingerprint” for a particular microorganism or class of microorganisms. For example, the array may provide a certain spectral response in the presence of one microorganism or class of microoryanisms (e.g., gram-negative bacteria), but provide a completely different spectral response in the presence of another microorganism or class of microorganisms (e.g., gram-positive bacteria). Detection of the spectral response provided by the array may thus allow for differentiation between microorganisms.
摘要翻译：提供了一种用于检测微生物或微生物类别的方法。更具体地，该方法采用包含在固体支持体上以预定图案间隔开的多个离散区域（称为“地址”）的阵列。选择地址使得阵列为特定微生物或微生物类提供不同的光谱响应（例如，颜色图案）或“指纹”。例如，阵列可以在一种微生物或类微生物（例如，革兰氏阴性细菌）的存在下提供特定的光谱响应，但是在另一种微生物或一类微生物的存在下提供完全不同的光谱响应（例如，革兰氏阳性细菌）。由阵列提供的光谱响应的检测因此可以允许微生物之间的分化。

2. 发明申请

US20090111088A1 RAPID ASSESSMENT OF UPPER RESPIRATORY CONDITIONS 审中-公开
标题翻译：快速评估上呼吸道条件
公开(公告)号：US20090111088A1
公开(公告)日：2009-04-30
申请号：US11847569
申请日：2007-08-30
申请人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
发明人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
IPC分类号： C12Q1/70
CPC分类号： G01N33/53 , C12Q1/04 , G01N2333/005 , G01N2333/195
摘要： A method for rapidly assessing upper respiratory conditions is provided. More specifically, the method involves contacting a sample obtained from the upper respiratory tract of a host with a test strip. The test strip contains an indicator that provides a broad spectrum response in the presence of bacteria, mold, yeast, or other microorganisms that is different than its response in the presence of viruses. This allows for a rapid and simple assessment as to whether the test sample is infected with a virus or some other microorganism. To help a clinician identify the proper course of treatment, it may also be desirable to obtain further information about the particular type of microorganism present. In this regard, the test strip contains any array of one or more differentiating indicators that provides a certain spectral response in the presence of different types of microorganisms. For example, the array may provide a certain spectral response in the presence of gram-negative bacteria, but a completely different spectral response in the presence of gram-positive bacteria. Likewise, the array may provide a certain spectral response in the presence of Rhinoviruses (associated with the common cold), but a different response in the presence of Influenza viruses. Detection of the spectral response provided by the indicators may thus allow for rapid differentiation between different types of microorganisms.
摘要翻译：提供了一种快速评估上呼吸道疾病的方法。更具体地，该方法包括使从主体上呼吸道获得的样品与测试条接触。测试条含有指示剂，其在细菌，霉菌，酵母或其它与病毒存在下的反应不同的微生物存在下提供广谱响应。这允许对测试样品是否感染病毒或其他微生物进行快速和简单的评估。为了帮助临床医生识别正确的治疗过程，还可能需要获得关于存在的微生物的特定类型的进一步信息。在这方面，测试条含有任何阵列的一个或多个微分指示剂，在存在不同类型的微生物时提供一定的光谱响应。例如，阵列可以在存在革兰氏阴性细菌的情况下提供一定的光谱响应，但是在存在革兰氏阳性细菌的情况下是完全不同的光谱响应。同样，阵列可以在存在鼻病毒（与常见感冒相关））的情况下提供一定的光谱响应，但是在存在流感病毒的情况下可以提供不同的响应。由指示剂提供的光谱响应的检测因此可以允许不同类型的微生物之间的快速分化。

3. 发明授权

US07531319B2 Array for rapid detection of a microorganism 有权
标题翻译：用于快速检测微生物的阵列
公开(公告)号：US07531319B2
公开(公告)日：2009-05-12
申请号：US11513501
申请日：2006-08-31
申请人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
发明人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
IPC分类号： C12P1/00
CPC分类号： C12Q1/04
摘要： A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a distinct spectral response (e.g., pattern of colors) or “fingerprint” for a particular microorganism or class of microorganisms. For example, the array may provide a certain spectral response in the presence of one microorganism or class of microorganisms (e.g., gram-negative bacteria), but provide a completely different spectral response in the presence of another microorganism or class of microorganisms (e.g., gram-positive bacteria). Detection of the spectral response provided by the array may thus allow for differentiation between microorganisms.
摘要翻译：提供了一种用于检测微生物或微生物类别的方法。更具体地，该方法采用包含在固体支持体上以预定图案间隔开的多个离散区域（称为“地址”）的阵列。选择地址使得阵列为特定微生物或微生物类提供不同的光谱响应（例如，颜色图案）或“指纹”。例如，阵列可以在一种微生物或一类微生物（例如，革兰氏阴性细菌）的存在下提供一定的光谱响应，但在另一种微生物或一类微生物存在下提供完全不同的光谱响应（例如，革兰氏阳性细菌）。由阵列提供的光谱响应的检测因此可以允许微生物之间的分化。

4. 发明申请

US20080057533A1 Array for rapid detection of a microorganism 有权
标题翻译：用于快速检测微生物的阵列
公开(公告)号：US20080057533A1
公开(公告)日：2008-03-06
申请号：US11513501
申请日：2006-08-31
申请人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
发明人： Stephanie M. Martin , J. Gavin MacDonald , Jason Lye , Curtis Sayre , Kimberlee Thompson
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a distinct spectral response (e.g., pattern of colors) or “fingerprint” for a particular microorganism or class of microorganisms. For example, the array may provide a certain spectral response in the presence of one microorganism or class of microorganisms (e.g., gram-negative bacteria), but provide a completely different spectral response in the presence of another microorganism or class of microorganisms (e.g., gram-positive bacteria). Detection of the spectral response provided by the array may thus allow for differentiation between microorganisms.
摘要翻译：提供了一种用于检测微生物或微生物类别的方法。更具体地，该方法采用包含在固体支持体上以预定图案间隔开的多个离散区域（称为“地址”）的阵列。选择地址使得阵列为特定微生物或微生物类提供不同的光谱响应（例如，颜色图案）或“指纹”。例如，阵列可以在一种微生物或一类微生物（例如，革兰氏阴性细菌）的存在下提供一定的光谱响应，但在另一种微生物或一类微生物存在下提供完全不同的光谱响应（例如，革兰氏阳性细菌）。由阵列提供的光谱响应的检测因此可以允许微生物之间的分化。

5. 发明授权

US08617874B2 Array for rapid detection of a microorganism 有权
标题翻译：用于快速检测微生物的阵列
公开(公告)号：US08617874B2
公开(公告)日：2013-12-31
申请号：US12464149
申请日：2009-05-12
申请人： Stephanie Michelle Martin , John Gavin MacDonald , Jason Lye , Curt Sayre , Kimberlee Thompson
发明人： Stephanie Michelle Martin , John Gavin MacDonald , Jason Lye , Curt Sayre , Kimberlee Thompson
IPC分类号： C12M1/34
CPC分类号： C12Q1/04
摘要： A method for detecting a microorganism or class of microorganisms is provided. More specifically, the method employs an array that contains a plurality of discrete regions (referred to as “addresses”) spaced apart on a solid support in a predetermined pattern. The addresses are selected so that the array provides a distinct spectral response (e.g., pattern of colors) or “fingerprint” for a particular microorganism or class of microorganisms. For example, the array may provide a certain spectral response in the presence of one microorganism or class of microoryanisms (e.g., gram-negative bacteria), but provide a completely different spectral response in the presence of another microorganism or class of microorganisms (e.g., gram-positive bacteria). Detection of the spectral response provided by the array may thus allow for differentiation between microorganisms.
摘要翻译：提供了一种用于检测微生物或微生物类别的方法。更具体地，该方法采用包含在固体支持体上以预定图案间隔开的多个离散区域（称为“地址”）的阵列。选择地址使得阵列为特定微生物或微生物类提供不同的光谱响应（例如，颜色图案）或“指纹”。例如，阵列可以在一种微生物或类微生物（例如，革兰氏阴性细菌）的存在下提供特定的光谱响应，但是在另一种微生物或一类微生物的存在下提供完全不同的光谱响应（例如，革兰氏阳性细菌）。由阵列提供的光谱响应的检测因此可以允许微生物之间的分化。

6. 发明授权

US06447629B1 Digital thermal printing process using reactive ink 有权
标题翻译：使用反应性墨水的数字热敏印刷工艺
公开(公告)号：US06447629B1
公开(公告)日：2002-09-10
申请号：US09542570
申请日：2000-04-04
申请人： Kimberlee Thompson , Barbara Wagner , Ming Xu
发明人： Kimberlee Thompson , Barbara Wagner , Ming Xu
IPC分类号： B44C1165
CPC分类号： B41M5/38257 , B41M5/0256 , B41M5/392 , B41M7/0054 , B44C1/1716 , C09D11/03 , D06P1/38 , D06P1/5285 , D06P5/001 , D06P5/007 , D06P5/2077 , D06Q1/10 , D06Q1/12 , Y10S428/914
摘要： A method of digitally printing reactive ink contained in a heat meltable ink layer comprising dyes or pigments or other colorants, using a thermal printer. The ink layer comprises compounds with functional groups capable of reacting with active hydrogen, and compounds with functional groups containing active hydrogen, or functional groups capable of conversion to active hydrogen containing groups. The reactive ink contains one or more blocking agents which prevent initiation of the reaction during thermal printing. An image is thermally printed onto a substrate, at a first temperature, so that the ink is not reacted during the process of printing on to the medium. The image is subsequently transferred or permanently fixed on the substrate by the application of heat and pressure, which removes the blocking agent and reacts the ink, bonding the colorant to the substrate.
摘要翻译：使用热敏打印机数字印刷包含在包含染料或颜料或其它着色剂的热熔性油墨层中的反应性油墨的方法。油墨层包括具有能够与活性氢反应的官能团的化合物，以及含有活性氢的官能团的化合物或能够转化为含活性氢基团的官能团。反应性油墨含有一种或多种在热敏打印期间防止反应开始的封闭剂。在第一温度下将图像热印刷到基底上，使得在印刷过程中墨水不会反应。随后通过施加热量和压力将图像转移或永久地固定在基材上，其除去封闭剂并使油墨反应，将着色剂粘合到基材上。

7. 发明授权

US6105502A Reactive ink printing process 有权
标题翻译：活性油墨印刷工艺
公开(公告)号：US6105502A
公开(公告)日：2000-08-22
申请号：US166057
申请日：1998-10-02
申请人： Barbara Wagner , Kimberlee Thompson , Ming Xu
发明人： Barbara Wagner , Kimberlee Thompson , Ming Xu
IPC分类号： B41M7/00 , D06P5/24 , B41F31/00
CPC分类号： B41M5/025 , B41M7/00 , D06P5/003 , D06P5/007
摘要： A color image is printed onto a first substrate, which acts as an intermediate medium, using lithography, intaglio, gravure, relief printing or other printing process which uses plates. The image is subsequently transferred from the intermediate medium to a final substrate, which may be a textile of natural fabric, such as cotton.Bonding and/or crosslinking of the color images are provided by the reaction between compounds selected from each of two chemical groups. The first group comprises compounds with functional groups capable of reacting with active hydrogen, such as isocyanate or epoxy groups. The second group comprises compounds with functional groups containing active hydrogen, or compounds with functional groups containing active hydrogen after a conversion process. The functional groups of one or both reactive chemical groups are protected either by chemical blocking with blocking agents or by physical barrier such as encapsulating agents. The blocking agents are removed by the application of heat during the transfer of the image from the first substrate to the final substrate.
摘要翻译：使用平版印刷，凹版印刷，凹版印刷，凸版印刷或使用印版的其它印刷工艺，将彩色图像印刷到作为中间介质的第一基板上。随后将图像从中间介质转移到最终的基底，其可以是天然织物如棉花的织物。通过选自两个化学基团中的每一个的化合物之间的反应提供彩色图像的结合和/或交联。第一组包括具有能够与活性氢例如异氰酸酯或环氧基团反应的官能团的化合物。第二组包括具有含有活性氢的官能团的化合物，或在转化过程之后具有含有活性氢的官能团的化合物。一个或两个反应性化学基团的官能团通过用封闭剂的化学阻断或通过物理屏障例如包封剂来保护。在将图像从第一衬底转移到最终衬底期间通过施加热来去除封闭剂。

8. 发明授权

US06402313B1 Substrate reactive printing process 有权
标题翻译：基板反应印刷工艺
公开(公告)号：US06402313B1
公开(公告)日：2002-06-11
申请号：US09156871
申请日：1998-09-18
申请人： Ming Xu , Kimberlee Thompson , Barbara Wagner
发明人： Ming Xu , Kimberlee Thompson , Barbara Wagner
IPC分类号： B41J217
CPC分类号： D06Q1/12 , B41M5/0023 , B41M5/0256 , B41M5/392 , B41M7/009 , B44C1/1716 , C09D11/03 , D06P1/38 , D06P1/5285 , D06P5/001 , D06P5/007 , D06P5/2077 , D06Q1/10
摘要： A method of printing using an ink or meltable ink layer which comprises dyes, pigments or other colorants. Bonding and/or crosslinking of the colorants is provided by the reaction between compounds selected from each of two chemical groups. The first group comprises compounds with functional groups capable of reacting with active hydrogen. The second group comprises compounds with functional groups containing active hydrogen, or compounds with functional groups containing active hydrogen after a conversion process. Either the first group or the second group is present in the ink, and an image is printed with the ink onto a substrate. The substrate comprises either the first or second group, as appropriate, to set up a later reaction with the ink. The reaction is delayed until the image is subsequently transferred to another substrate or is permanently fixed on the substrate, by the presence of protecting or blocking agents, which are removed by the application of heat or other energy. Upon reaction, the colorant is bonded to the substrate.
摘要翻译：使用包含染料，颜料或其它着色剂的油墨或可熔融油墨层进行印刷的方法。通过选自两个化学基团中的每一个的化合物之间的反应提供着色剂的结合和/或交联。第一组包括具有能够与活性氢反应的官能团的化合物。第二组包括具有含有活性氢的官能团的化合物，或在转化过程之后具有含有活性氢的官能团的化合物。油墨中存在第一组或第二组，并且将图像用油墨印刷到基板上。基板适当地包括第一组或第二组，以建立与油墨的稍后反应。反应延迟直到图像随后转移到另一个基底或永久地固定在基底上，通过存在通过施加热或其它能量除去的保护剂或阻断剂。反应后，着色剂与基材结合。

9. 发明授权

US06341856B1 Ink jet printing process using reactive inks 有权
标题翻译：喷墨印刷工艺使用反应性油墨
公开(公告)号：US06341856B1
公开(公告)日：2002-01-29
申请号：US09556176
申请日：2000-04-20
申请人： Kimberlee Thompson , Xiaorong Cai , Ming Xu
发明人： Kimberlee Thompson , Xiaorong Cai , Ming Xu
IPC分类号： G01D1100
CPC分类号： C09D11/34 , B41J2/17 , B41M3/001 , B41M7/009 , C09D11/30 , D06P1/5285 , D06P5/003 , D06P5/007 , D06P5/30
摘要： A method of digitally printing a liquid ink by means of a printer which uses liquid ink such as an ink jet printer. The ink contains dyes or pigments or other colorants, a liquid carrier, and compounds with functional groups capable of reacting with active hydrogen, and compounds with functional groups containing active hydrogen, or functional groups capable of conversion to active hydrogen containing groups. One or more emulsifying agents emulsify the liquid ink. An image is printed onto a substrate, at a relatively low temperature, so that the ink is not activated during the process of printing on to the medium. The image is subsequently transferred or permanently fixed on the substrate by the application of heat and pressure, which activates the ink, and bonds the colorant to the substrate. The reactive compounds may be blocked with blocking agents which are removed by the application of heat or other energy during activation of the ink.
摘要翻译：通过使用诸如喷墨打印机之类的液体墨水的打印机对液体墨水进行数字打印的方法。油墨含有染料或颜料或其它着色剂，液体载体和具有能够与活性氢反应的官能团的化合物，以及含有活性氢的官能团的化合物或能够转化为含活性氢基团的官能团。一种或多种乳化剂乳化液体油墨。在相对较低的温度下将图像印刷到基材上，使得在印刷到介质的过程中油墨不被活化。随后通过施加热和压力将图像转移或永久地固定在基底上，其激活墨水，并将着色剂粘合到基底上。活性化合物可以用封闭剂封闭，封闭剂在油墨活化期间通过施加热或其它能量除去。

10. 发明授权

US08398224B2 Heat activated printing process 有权
标题翻译：热激活打印过程
公开(公告)号：US08398224B2
公开(公告)日：2013-03-19
申请号：US12639029
申请日：2009-12-16
申请人： Nathan Hale , Ming Xu , Kimberlee Thompson , Sukun Zhang
发明人： Nathan Hale , Ming Xu , Kimberlee Thompson , Sukun Zhang
IPC分类号： G01D11/00
CPC分类号： B41J2/315 , B41M5/0017 , B41M5/0023 , B41M5/0041 , B41M5/0047 , B41M5/0052 , B41M5/0256 , B41M5/38257 , B41M5/385 , B41M5/392 , B41M5/395 , B41M7/00 , B41M7/0027 , B41M7/009 , B44C1/1716 , C09D11/03 , C09D11/30 , D06P1/38 , D06P1/5285 , D06P3/10 , D06P3/148 , D06P3/248 , D06P3/54 , D06P3/66 , D06P3/8214 , D06P3/8252 , D06P5/001 , D06P5/003 , D06P5/004 , D06P5/007 , D06P5/2077 , D06P5/30 , D06Q1/10 , D06Q1/12 , G03G9/08764 , G03G9/08793 , G03G9/08797 , G03G11/00 , G03G13/20
摘要： Reactive inks and methods of generating an image on a substrate using both reactive and heat activated inks are presented. An image is printed on a substrate, without reacting the reagents in the ink. Subsequently, the reagents are reacted to fix the image to a substrate, with substantial permanency and fastness. Sublimation or similar heat activated dyes are printed are also printed on the substrate. The sublimation or similar heat activated dyes are activated, and have an affinity for polymer that is applied to the substrate.
摘要翻译：提出了活性油墨和使用活性和热活化油墨在基材上产生图像的方法。将图像印刷在基板上，而不会使墨中的试剂反应。随后，反应试剂以将图像固定在基材上，具有显着的永久性和坚牢度。印刷升华或类似的热活化染料也印在基片上。升华或类似的热激活染料被活化，并且对施加到基底上的聚合物具有亲和性。

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