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    • 3. 发明申请
    • Surface reconstruction and registration with a Helmholtz reciprocal image pair
    • 用Helmholtz倒数图像对进行表面重建和配准
    • US20050074162A1
    • 2005-04-07
    • US10678244
    • 2003-10-03
    • Peter TuJames MillerPaulo MendoncaJames Ross
    • Peter TuJames MillerPaulo MendoncaJames Ross
    • G01B11/24G01B11/245G06K9/00G06T1/00G06T7/00G06T7/60
    • G06T7/593G06T7/507G06T7/74G06T7/80
    • A method of image reconstruction comprising: obtaining a Helmholtz reciprocal pair of images of an object, the images comprising a first image and a corresponding reciprocal image; determining an imaging geometry associated with the obtaining; selecting a plurality of points in the first image and identifying corresponding candidate points in the corresponding reciprocal image; matching a selected point of the plurality of points and a candidate point of the corresponding candidate points. A method of image registration with an object comprising: obtaining a Helmholtz reciprocal pair of images of an object, the Helmholtz reciprocal pair of images comprising a first image and a corresponding reciprocal image; estimating a pose for the object; predicting an estimated image corresponding to the pose and one image of the reciprocal pair of images; comparing the estimated image with a corresponding actual image from the pair of images; and refining the estimating a pose based on the comparing.
    • 一种图像重建方法,包括:获得对象的亥姆霍兹倒数对图像,所述图像包括第一图像和相应的倒数图像; 确定与所述获取相关联的成像几何; 选择所述第一图像中的多个点并识别所述对应的倒数图像中的相应候选点; 匹配多个点中的选定点和相应候选点的候选点。 一种用对象进行图像配准的方法,包括:获得对象的亥姆霍兹倒数对图像,所述亥姆霍兹倒数对图像包括第一图像和对应的倒数图像; 估计物体的姿势; 预测对应于所述姿势的估计图像和所述倒数对图像的一个图像; 将估计图像与来自该对图像的对应实际图像进行比较; 并根据比较精化估计姿势。
    • 7. 发明申请
    • Circuits and methods for artifact elimination
    • 电路和消除方法
    • US20070178579A1
    • 2007-08-02
    • US11511794
    • 2006-08-29
    • James RossEdgar BrownRichard BlumStephen DeWeerth
    • James RossEdgar BrownRichard BlumStephen DeWeerth
    • C12M1/36C12M1/00C12Q1/00C12M1/38A61B5/05
    • G01N37/00A61B5/04A61B5/04001A61B5/7217A61N1/3605A61N1/3704G01N33/4836
    • Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants.
    • 公开了提供电刺激物理系统的能力的装置和方法,并且主动地消除由刺激产生的信号采集(伪影)的干扰。 在电路中实现的技术和消除干扰的方法将放电路径连接到系统的物理接口,以去除在刺激期间积累的电荷。 通过将放电路径放置在包括记录前置放大器和AC耦合电路的反馈回路中,物理接口被带回其预刺激偏移电压。 所公开的装置和方法可以与压电换能器,超声波装置,光二极管以及可极化和不可极化的电极一起使用。 所公开的装置可用于可植入装置,体外或体内用脊椎动物和无脊椎动物神经组织,肌肉纤维,胰岛细胞,成骨细胞,破骨细胞,细菌,藻类,真菌,原生生物和植物的装置。
    • 9. 发明授权
    • Premix for hog feed and a method of feeding a hog to produce DHA and EPA enriched pork
    • 用于猪饲料的预混料和喂养猪的方法来生产DHA和富含EPA的猪肉
    • US08501251B2
    • 2013-08-06
    • US12354445
    • 2009-01-15
    • Martin CluniesJames RossIan Ross
    • Martin CluniesJames RossIan Ross
    • A23K1/18A23K1/00A23B7/10A23L1/20A23L1/325
    • A23K50/30A23K20/158A23K20/30
    • A premix for hog feed and a method of feeding a hog that produces DHA and EPA enriched pork while avoiding or reducing negative effects to the taste, color, texture, aroma, pH and shelf life which are significant enough to make the pork unacceptable to consumers. One embodiment of the method of feeding a hog involves feeding a hog over several days with a hog feed supplemented with the premix. The premix includes marine-sourced docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and plant-sourced alpha-linolenic acid (ALA). The hogs are fed until their total DHA, EPA and ALA intakes are in a certain range per kilogram of the hog's weight. The hogs are then slaughtered and processed into pork products. This results in pork with an enrichment of omega-3 EFAs in the range of about 2.5% to about 4.5% of fat.
    • 用于猪饲料的预混物和喂养产生DHA和EPA富含猪肉的猪的方法,同时避免或减少对味道,颜色,质地,香气,pH和保质期的负面影响,这足以使猪肉不能被消费者接受 。 喂养猪的方法的一个实施例涉及用补充有预混物的猪饲料喂养几天的猪。 预混物包括海洋来源的二十二碳六烯酸(DHA)和二十碳五烯酸(EPA)和植物来源的α-亚麻酸(ALA)。 喂养猪直到它们的总DHA,EPA和ALA摄入量在每千克猪的重量上在一定范围内。 然后将猪屠宰并加工成猪肉产品。 这导致猪肉富含ω-3 EFAs在脂肪的约2.5%至约4.5%的范围内。
    • 10. 发明申请
    • APPARATUS AND METHODS FOR HIGH THROUGHPUT NETWORK ELECTROPHYSIOLOGY AND CELLULAR ANALYSIS
    • 高通量网络电生理与细胞分析的装置与方法
    • US20100120626A1
    • 2010-05-13
    • US12615778
    • 2009-11-10
    • James RossEdgar A. BrownSwaminathan RajaramanMark G. AllenBruce Wheeler
    • James RossEdgar A. BrownSwaminathan RajaramanMark G. AllenBruce Wheeler
    • C40B30/00B32B37/00C40B60/12C12N13/00
    • C12N13/00B32B2535/00C12M1/42G01N33/4836G01N33/48728G01N33/48735Y10T156/10
    • Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications.
    • 本文提供了与开发用于高通量网络电生理学和细胞分析的仪器相关的装置和方法。 更具体地,本文提供了多孔微电极阵列(MEA)和用于以便宜的方式开发这种装置的方法,其具有柔性的符合ANSI / SBS(美国国家标准学会/生物分子筛选学会)的格式。 微电极阵列是用于刺激和感测电活性细胞,网络和组织的紧密间隔的微电极的网格。 本文所述的技术涉及使用微加工与已经用于实现符合ANSI / SBS的培养孔格式的多孔MEA的某些大面积方法的组合,其对于倒置/背面显微镜兼容性也是透明的。 这些多孔MEA可用于以高通量方式研究电活性细胞和组织如心脏,神经和肌肉的两维和三维网络。 同样符合ANSI / SBS标准,它们与制药行业开发用于药物筛选应用的机械和机器人兼容。