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1. 发明申请

US20070142301A1 Novel inhibitors of Hepatitis C virus NS3 protease 失效
标题翻译：新型丙型肝炎病毒NS3蛋白酶抑制剂
公开(公告)号：US20070142301A1
公开(公告)日：2007-06-21
申请号：US11645181
申请日：2006-12-21
申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
IPC分类号： A61K38/05 , A61K38/04 , C07K5/10 , C07K5/08
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

2. 发明申请

US20050267043A1 Novel inhibitors of hepatitis C virus NS3 protease 失效
标题翻译：新型丙型肝炎病毒NS3蛋白酶抑制剂
公开(公告)号：US20050267043A1
公开(公告)日：2005-12-01
申请号：US11065572
申请日：2005-02-24
申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
IPC分类号： A61K31/401 , A61K31/403 , A61K31/4035 , A61K31/407 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K38/00 , A61K38/04 , C07D207/10 , C07D209/02 , C07D209/52 , C07D209/70 , C07D295/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D491/04 , C07D495/10 , C07K5/02 , C07K5/04 , C07K5/08 , C07K5/083 , C07K5/087 , C07D43/02
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

3. 发明授权

US07423058B2 Inhibitors of hepatitis C virus NS3 protease 失效
标题翻译：丙型肝炎病毒NS3蛋白酶抑制剂
公开(公告)号：US07423058B2
公开(公告)日：2008-09-09
申请号：US11645181
申请日：2006-12-21
申请人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
发明人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

4. 发明授权

US07205330B2 Inhibitors of hepatitis C virus NS3 protease 失效
标题翻译：丙型肝炎病毒NS3蛋白酶抑制剂
公开(公告)号：US07205330B2
公开(公告)日：2007-04-17
申请号：US11065572
申请日：2005-02-24
申请人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
发明人： Stephane L. Bogen , Weidong Pan , Sumei Ruan , Kevin X. Chen , Ashok Arasappan , Srikanth Venkatraman , Latha G. Nair , Mousumi Sannigrahi , Frank Bennett , Anil K. Saksena , F. George Njoroge , Viyyoor M. Girijavallabhan
IPC分类号： A61K31/401 , C07D207/08
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

5. 发明申请

US20050209164A1 Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease 失效
标题翻译：含有环丁烯二酮的化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂
公开(公告)号：US20050209164A1
公开(公告)日：2005-09-22
申请号：US11064574
申请日：2005-02-24
申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , F. Njoroge
发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , F. Njoroge
IPC分类号： A61K38/04 , A61K38/06 , C07D209/52 , C07D413/02 , C07D417/02 , C07D491/04 , C07K5/04 , C07K5/08 , C07K5/087 , C07D43/02
CPC分类号： C07D209/52 , A61K38/06 , C07D491/04 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的疾病的方法。

6. 发明申请

US20080004287A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof 有权
标题翻译：增加P53活性及其用途的替代哌啶子
公开(公告)号：US20080004287A1
公开(公告)日：2008-01-03
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
发明人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
IPC分类号： A61K31/497 , A61P43/00 , C07D401/14
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明公开了作为HDM2蛋白的抑制剂的新化合物，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2相关的一种或多种疾病的方法蛋白质或P53使用这些化合物或药物组合物。

7. 发明申请

US20150274739A1 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权
标题翻译： 2'-氰基取代的核苷衍生物及其用于治疗病毒性疾病的方法
公开(公告)号：US20150274739A1
公开(公告)日：2015-10-01
申请号：US14436697
申请日：2013-10-11
申请人： Vinay Girijavallabhan , Stephane Bogen , Weidong Pan , Qun Dang , Ian Davies
发明人： Vinay Girijavallabhan , Stephane Bogen , Weidong Pan , Qun Dang , Ian Davies
IPC分类号： C07D487/04 , C07F9/6561 , A61K31/7056 , A61K45/06 , A61K47/48 , A61K38/21 , A61K31/706 , C07F9/6574
CPC分类号： C07D487/04 , A61K31/7056 , A61K31/706 , A61K38/212 , A61K45/06 , A61K47/48215 , A61K47/60 , C07F9/65616 , C07F9/65744 , A61K2300/00
摘要： Compounds of Formula (I) are disclosed, wherein R1, R2, R3, R4, R5, and R18 are defined herein. The compounds encompassed by Formula (I) include compounds which are HCV NS5B inhibitors and other compounds which can be metabolized in vivo to HCV NS5B inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
摘要翻译：公开了式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5和R 18在本文中定义。由式（I）包括的化合物包括HCV NS5B抑制剂和可以在体内被代谢为HCV NS5B抑制剂的其它化合物。该化合物及其药学上可接受的盐可用于预防或治疗HCV的感染以及由HCV引起的疾病发作的预防，治疗或延迟。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

8. 发明授权

US09734771B2 Touch-sensitive flat-panel control and interface 有权
公开(公告)号：US09734771B2
公开(公告)日：2017-08-15
申请号：US14686189
申请日：2015-04-14
申请人： Hollis J Gmyr , Weidong Pan , James H Ritchie , Eric Christopher Wood , Andrew S Kadah
发明人： Hollis J Gmyr , Weidong Pan , James H Ritchie , Eric Christopher Wood , Andrew S Kadah
IPC分类号： G09G3/36 , G06F3/044 , G05D23/19 , G06F1/32 , H03K17/96
CPC分类号： G09G3/36 , G05D23/19 , G06F1/3265 , G09G3/3406 , G09G3/3413 , G09G2330/02 , H03K17/9622 , H03K2217/94052 , H03K2217/960755 , H03K2217/96076 , H03K2217/960785 , Y02D10/153 , Y02D50/20
摘要： A touch-screen control panel interface has a dielectric flat or curved front panel and a printed circuit board with a front side and a reverse side which is the component side. Alphanumeric display module(s) or an LCD display and optional protective cap mounted on the reverse side of the circuit board are visible through window cutout(s) on the board. An array of LED indicators can be mounted on the back side of the circuit board and visible through cutouts in the board. Metallized capacitive pads on or adjacent the back side of the front panel at touch locations permit selection of various modes, functions, and settings. These pads may be formed on the flat front side of the circuit board, on the back of the front plate, or on an intermediate membrane. A microprocessor is connected with the various components and with capacitive pad. Icons may be printed onto the flat panel, in registry with the metallized capacitive electrode pads. A potting dam is formed of a back plate configured to adhere to the front panel and an open frame extending rearwards. Synthetic resin potting material fills the frame and hermetically seals the circuit board. Positions of the capacitive touch pads can be illuminated when active, as a guide for the user or operator. A second circuit board may be positioned in the frame directly proximal of the first circuit board, and optionally encapsulated.

9. 发明授权

US09500366B2 Furnace control with safety circuit and non-volatile memory 有权
标题翻译：炉控制带安全电路和非易失性存储器
公开(公告)号：US09500366B2
公开(公告)日：2016-11-22
申请号：US14097978
申请日：2013-12-05
申请人： Andrew S. Kadah , Weidong Pan , Benjamin A. Freer
发明人： Andrew S. Kadah , Weidong Pan , Benjamin A. Freer
IPC分类号： F23Q7/24 , F24D19/10 , F24D5/02 , G05B15/02 , F23N5/24 , F27B9/40
CPC分类号： F23Q7/24 , F23N5/242 , F23N2023/04 , F23N2023/08 , F23N2025/04 , F23N2025/08 , F23N2031/10 , F23N2031/20 , F24D5/02 , F24D19/1084 , F27B9/40 , G05B15/02
摘要： A furnace controller circuit includes a microprocessor with input ports and output ports including ports to issue control signals for actuation of inducer, gas burner, and furnace blower. A temperature-actuated limit switch commences a furnace shut-down sequence when the temperature of the furnace heat exchanger exceeds a predetermined limit temperature, and then resets to permit a turn-on sequence. An LED visible fault indicator is coupled to the microprocessor to provide visible fault messages. A non-volatile memory device coupled with the microprocessor is operative to store fault indications when present. In the event of power restoration after power failure, the limit switch status and other fault status are maintained. A lockout period is computed based on length of furnace run time until fault and recent fault history. Limit switch and other safety faults are recorded and these can be weighted and ranked based on age of each fault occurrence. The stored fault data can be used to identify erratic furnace operations, such as short cycling.
摘要翻译：炉控制器电路包括具有输入端口和输出端口的微处理器，该输出端口包括用于发出用于致动感应器，气体燃烧器和炉式鼓风机的控制信号的端口。当炉热交换器的温度超过预定的极限温度时，温度启动的限位开关开始关闭炉，然后复位以允许开启顺序。 LED可见故障指示器耦合到微处理器以提供可见的故障消息。与微处理器耦合的非易失性存储器件当存在时存储故障指示。断电后电源恢复时，保持限位开关状态和其他故障状态。根据炉子运行时间长短直到故障和最近的故障历史来计算锁定时间。记录限位开关和其他安全故障，可根据每个故障发生的年龄进行加权和排序。存储的故障数据可用于识别不稳定的炉操作，例如短循环。

10. 发明授权

US09008846B2 Lock-setting thermostat with flash-memory key 有权
标题翻译：带闪存锁的锁定恒温器
公开(公告)号：US09008846B2
公开(公告)日：2015-04-14
申请号：US13557556
申请日：2012-07-25
申请人： Weidong Pan , Michael P. Muench , Kevin P. Jobsky
发明人： Weidong Pan , Michael P. Muench , Kevin P. Jobsky
IPC分类号： G05B19/00 , G05D23/19 , F24F11/00
CPC分类号： G05D23/1902 , F24F11/52
摘要： Property-management or lock-setting thermostats have maximum and minimum set points locked in to prevent abuse of management-provided heating and/or air conditioning. An ePROM or similar internal memory device stores heating and cooling limit parameters that are set in by a technician at the time of installation. A plug-in flash memory module contains an unlock code to match the unlock code stored in said ePROM, to unlock the thermostat and allow the settings to be adjusted; when said flash memory module is removed the thermostat reverts to its lock condition. The thermostat can also respond to unusual rates of change of temperature to block furnace or A/C operation temporarily.
摘要翻译：物业管理或锁定设置的恒温器具有锁定的最大和最小设定点，以防止滥用管理提供的加热和/或空调。 ePROM或类似的内部存储设备存储技术人员在安装时设置的加热和冷却限制参数。插入式闪存模块包含解锁代码以匹配存储在所述ePROM中的解锁代码，解锁恒温器并允许调整设置; 当所述闪存模块被移除时，恒温器恢复到其锁定状态。恒温器也可以临时响应异常的温度变化率，阻止炉膛或空调操作。

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