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1. 发明申请

US20080294035A1 VESSEL SIZE IMAGING FOR ANTIANGIOGENIC THERAPY 有权
标题翻译：用于抗生素治疗的血管尺寸成像
公开(公告)号：US20080294035A1
公开(公告)日：2008-11-27
申请号：US12124681
申请日：2008-05-21
申请人： Stefan Zwick , Ralph Strecker , Fabian Kiessling , Arne Hengerer , Sebastian Schmidt
发明人： Stefan Zwick , Ralph Strecker , Fabian Kiessling , Arne Hengerer , Sebastian Schmidt
IPC分类号： A61B5/055 , A61K49/00
CPC分类号： A61B5/055 , A61B5/0515 , G06T7/60
摘要： A system and method of evaluating the effectiveness of antiangionetic therapy is described. A patient or test animal is treated with an antiangionetic substance. Magnetic resonance imaging data is obtained prior to and subsequent to the treatment. The parameters of the imaging process are configured so that, by administering a intravascular contrast agent, the relative size of the microvascular and the total vascular volumes in a region of interest may be obtained, so as to form a vascular size index. The value of the vascular size index and other pharmacokinetic data obtained by the administration of a diffusible contrast agent are used to assess the efficacy of the treatment or the antiangionetic substance being studied.
摘要翻译：描述了评估抗血管治疗疗效的系统和方法。患者或测试动物用抗血友病药物治疗。在治疗之前和之后获得磁共振成像数据。成像过程的参数被配置为使得通过施用血管内造影剂可以获得感兴趣区域中的微血管的相对大小和总血管体积，从而形成血管尺寸指数。使用通过施用可扩散造影剂获得的血管尺寸指数和其他药代动力学数据的值来评估所研究的治疗或抗血小球药物的功效。

2. 发明授权

US08195275B2 Vessel size imaging for antiangiogenic therapy 有权
标题翻译：抗血管生成治疗的血管尺寸成像
公开(公告)号：US08195275B2
公开(公告)日：2012-06-05
申请号：US12124681
申请日：2008-05-21
申请人： Stefan Zwick , Ralph Strecker , Fabian Kiessling , Arne Hengerer , Sebastian Schmidt
发明人： Stefan Zwick , Ralph Strecker , Fabian Kiessling , Arne Hengerer , Sebastian Schmidt
IPC分类号： A61B5/055 , G06K9/00
CPC分类号： A61B5/055 , A61B5/0515 , G06T7/60
摘要： A system and method of evaluating the effectiveness of antiangionetic therapy is described. A patient or test animal is treated with an antiangionetic substance. Magnetic resonance imaging data is obtained prior to and subsequent to the treatment. The parameters of the imaging process are configured so that, by administering a intravascular contrast agent, the relative size of the microvascular and the total vascular volumes in a region of interest may be obtained, so as to form a vascular size index. The value of the vascular size index and other pharmacokinetic data obtained by the administration of a diffusible contrast agent are used to assess the efficacy of the treatment or the antiangionetic substance being studied.
摘要翻译：描述了评估抗血管治疗疗效的系统和方法。患者或测试动物用抗血友病药物治疗。在治疗之前和之后获得磁共振成像数据。成像过程的参数被配置为使得通过施用血管内造影剂可以获得感兴趣区域中的微血管的相对大小和总血管体积，从而形成血管尺寸指数。使用通过施用可扩散造影剂获得的血管尺寸指数和其他药代动力学数据的值来评估所研究的治疗或抗血小球药物的功效。

3. 发明申请

US20090062630A1 Sensor permitting detection of a substance in the body of a living being 审中-公开
标题翻译：传感器允许检测生物体内的物质
公开(公告)号：US20090062630A1
公开(公告)日：2009-03-05
申请号：US12222776
申请日：2008-08-15
申请人： Arne Hengerer , Robert Krieg , Sebastian Schmidt , Ralph Strecker
发明人： Arne Hengerer , Robert Krieg , Sebastian Schmidt , Ralph Strecker
IPC分类号： A61B5/145 , C12Q1/00 , A61B5/05 , A61F2/06
CPC分类号： A61B5/415 , A61B5/05 , A61B5/06 , A61B5/418 , A61K49/16 , A61K49/18 , A61K49/1875 , B82Y5/00 , G01R33/50 , G01R33/5601
摘要： A sensor is disclosed for permitting detection of a substance in the body of a living being. In at least one embodiment, the sensor includes probe molecules, for binding the substance that is to be detected, and marking elements designed in such a way that the binding of the probe molecules to the substance to be detected is detectable by way of an imaging modality. For example, antigens or pathogens that are present only in a low concentration can be detected.
摘要翻译：公开了用于允许检测生物体内物质的传感器。在至少一个实施例中，传感器包括用于结合要检测的物质的探针分子和以使得探针分子与待检测物质的结合可通过成像检测的方式设计的标记元件模态例如，可以检测出仅存在低浓度的抗原或病原体。

4. 发明申请

US20170103523A1 RECONSTRUCTION OF AN IMAGE ON THE BASIS OF ONE OR MORE IMAGING MODALITIES 审中-公开
公开(公告)号：US20170103523A1
公开(公告)日：2017-04-13
申请号：US15285626
申请日：2016-10-05
申请人： David Grodzki , Arne Hengerer , Michael Kaus , Elena Nioutsikou , Sebastian Schmidt
发明人： David Grodzki , Arne Hengerer , Michael Kaus , Elena Nioutsikou , Sebastian Schmidt
IPC分类号： G06T7/00 , G06T11/00
CPC分类号： G06T7/0012 , G06T11/006 , G06T11/008 , G06T2207/10081 , G06T2207/10088
摘要： The embodiments relate to a reconstructing an image of an examination object, a medical imaging apparatus, and a computer program product where a first image data record is acquired with a first imaging modality and at least one further image data record of at least one further imaging modality is provided. At least one first image is reconstructed on the basis of the first image data record using the at least one further image data record.

5. 发明申请

US20130320975A1 METHOD AND DEVICE FOR DETERMINING A CHANGE OVER TIME IN A BIOMARKER IN A REGION TO BE EXAMINED 有权
标题翻译：用于确定一个地区的生物标志物的时间变化的方法和装置
公开(公告)号：US20130320975A1
公开(公告)日：2013-12-05
申请号：US13894623
申请日：2013-05-15
申请人： Björn Heismann , Arne Hengerer , Sebastian Schmidt
发明人： Björn Heismann , Arne Hengerer , Sebastian Schmidt
IPC分类号： G01R33/483
CPC分类号： G01R33/485 , A61B5/055 , G01R33/48 , G01R33/4806 , G01R33/483 , G01R33/5616 , G01R33/56366
摘要： A method for determining a change over time in a biomarker in a region to be examined of a patient is provided. The change is determined from magnetic resonance data using a magnetic resonance measuring system with sequences and protocols for measuring the biomarkers by functional resting state connectivity by rsfMRI, perfusion values, magnetic resonance spectra of voxels, or morphometry of organs. A control unit has programs which evaluates the biomarker and a data memory which stores the results of the evaluation and additional data. During a first examination, a quantity result of the biomarkers is determined and stored in the data memory. During a follow-up examination, at least one previous item of the result and additional data from the first examination stored in the data memory are used for determining a quantitative change in the biomarker.
摘要翻译：提供了一种用于确定待检查区域中的生物标志物随时间变化的方法。使用具有用于通过rsfMRI，灌注值，体素的磁共振光谱或器官形态测定的功能静止状态连通性来测量生物标志物的序列和方案的磁共振测量系统从磁共振数据确定变化。控制单元具有评估生物标志物的程序和存储评估结果和附加数据的数据存储器。在第一次检查期间，确定生物标志物的数量结果并将其存储在数据存储器中。在随访检查期间，使用结果的至少一个先前项目和存储在数据存储器中的第一次检查的附加数据来确定生物标志物的定量变化。

6. 发明授权

US08386017B2 Method for implementing an imaging examination method 有权
标题翻译：实施成像检查方法的方法
公开(公告)号：US08386017B2
公开(公告)日：2013-02-26
申请号：US12458761
申请日：2009-07-22
申请人： Arne Hengerer , Sebastian Schmidt , Carsten Warmuth
发明人： Arne Hengerer , Sebastian Schmidt , Carsten Warmuth
IPC分类号： A61B5/055 , A61B5/02
CPC分类号： A61B5/0263 , A61B5/02007 , A61B5/055 , G01R33/4812 , G01R33/543 , G01R33/5601 , G01R33/5635
摘要： A method is disclosed for implementing an imaging examination method. In at least one embodiment, the method includes creating an overview data record containing angiography data relating to a patient; simulating flow conditions in vessels of the patient; determining a strain on the vascular walls with the aid of the simulation; identifying vascular regions, in which the strain on the vascular wall exceeds a threshold value and implementing an imaging examination in at least one of the identified vascular regions.
摘要翻译：公开了一种用于实现成像检查方法的方法。在至少一个实施例中，该方法包括创建包含与患者相关的血管造影数据的概览数据记录; 模拟患者血管中的流动状况; 借助于模拟确定血管壁上的应变; 识别血管壁的血管区域，其中血管壁上的应变超过阈值，并且在至少一个所识别的血管区域中实施成像检查。

7. 发明授权

US09651639B2 Method and device for determining a change over time in a biomarker in a region to be examined 有权
公开(公告)号：US09651639B2
公开(公告)日：2017-05-16
申请号：US13894623
申请日：2013-05-15
申请人： Björn Heismann , Arne Hengerer , Sebastian Schmidt
发明人： Björn Heismann , Arne Hengerer , Sebastian Schmidt
IPC分类号： G01R33/48 , G01R33/483 , A61B5/055 , G01R33/485 , G01R33/563
CPC分类号： G01R33/485 , A61B5/055 , G01R33/48 , G01R33/4806 , G01R33/483 , G01R33/5616 , G01R33/56366
摘要： A method for determining a change over time in a biomarker in a region to be examined of a patient is provided. The change is determined from magnetic resonance data using a magnetic resonance measuring system with sequences and protocols for measuring the biomarkers by functional resting state connectivity by rsfMRI, perfusion values, magnetic resonance spectra of voxels, or morphometry of organs. A control unit has programs which evaluates the biomarker and a data memory which stores the results of the evaluation and additional data. During a first examination, a quantity result of the biomarkers is determined and stored in the data memory. During a follow-up examination, at least one previous item of the result and additional data from the first examination stored in the data memory are used for determining a quantitative change in the biomarker.

8. 发明申请

US20160073925A1 Obtaining a Three-dimensional Image of a Medical Instrument with a Magnetic Resonance Tomography Device 审中-公开
标题翻译：获得具有磁共振断层成像装置的医疗仪器的三维图像
公开(公告)号：US20160073925A1
公开(公告)日：2016-03-17
申请号：US14837060
申请日：2015-08-27
申请人： David Grodzki , Annemarie Hausotte , Björn Heismann , Arne Hengerer , Mark-Aleksi Keller-Reichenbecher , Sebastian Schmidt
发明人： David Grodzki , Annemarie Hausotte , Björn Heismann , Arne Hengerer , Mark-Aleksi Keller-Reichenbecher , Sebastian Schmidt
IPC分类号： A61B5/06 , A61B5/055 , G06T11/60 , G06T11/00 , G06T7/00 , A61N5/10 , A61B5/00
CPC分类号： G06T11/60 , A61B5/055 , A61B5/064 , A61B34/20 , A61B90/39 , A61N5/1001 , A61N5/1049 , A61N2005/1055 , G01R33/286
摘要： An apparatus is provided for obtaining a spatial instrument image of a medical instrument with a magnetic resonance tomography device, wherein the apparatus includes a medical instrument, a magnetic resonance tomography device, and a computing and control device. The medical instrument includes at least one marker material in at least one region, the marker material having a nuclear spin resonance outside of the proton resonance and wherein the computing and control device is configured to control the magnetic resonance tomography device such that a nuclear spin tomography imaging may be implemented by the magnetic resonance tomography device with the nuclear spin resonance of the at least one marker material in order to obtain a spatial instrument image, and wherein the computing and control device is configured to accept the instrument image. A corresponding medical instrument and a corresponding method are also provided.
摘要翻译：提供一种用于获得具有磁共振断层摄影装置的医疗器械的空间仪器图像的装置，其中所述装置包括医疗器械，磁共振断层摄影装置和计算和控制装置。所述医疗器械在至少一个区域中包括至少一种标记材料，所述标记材料在所述质子共振之外具有核自旋共振，并且其中所述计算和控制装置被配置为控制所述磁共振断层摄影装置，使得核自旋断层扫描成像可以通过具有至少一种标记材料的核自旋共振的磁共振断层摄影装置来实现，以获得空间仪器图像，并且其中计算和控制装置被配置为接受仪器图像。还提供了相应的医疗仪器和相应的方法。

9. 发明申请

US20110046893A1 METHOD FOR NORMALIZING THE RESULTS OF AN IN-VITRO ANALYTICAL METHOD 审中-公开
标题翻译：用于正常化体内分析方法的结果的方法
公开(公告)号：US20110046893A1
公开(公告)日：2011-02-24
申请号：US12859429
申请日：2010-08-19
申请人： Arne HENGERER , Marcus Pfister , Sebastian Schmidt
发明人： Arne HENGERER , Marcus Pfister , Sebastian Schmidt
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： A61B6/00 , G06T1/00
摘要： A method is disclosed for normalizing the results of an in-vitro analytical method for one or more diagnostically and/or prognostically relevant substances in an organism (biomarker) or one or more substances supplied to an organism from the outside. In at least one embodiment of the method a) one or more concentration values of the substance(s) in an organism, said concentration value(s) being obtained in an in-vitro analytical method is (are) provided, b) data obtained from an imaging study of the same organism are provided, c) from the data according to b), one or more quantitative values are determined as imaging value(s), d) from the values according to a) and c), one or more diagnostic parameters are determined by relating the values according to a) and c) to one another, and also to the use of this method for the type-correct dosage finding of drugs and for the in-vitro diagnosis, prognosis and monitoring the course of a disease. In addition, at least one embodiment of the invention relates to a program for a data processing system which, when carried out in a suitable computer system, carries out the above method, and also to an electronically readable data carrier having electronically readable control information stored thereon, which control information is configured in such a manner that they carry out the above method when a suitable data carrier is used in a suitable computer system.
摘要翻译：公开了一种用于使生物体（生物标志物）中的一种或多种诊断和/或预后相关物质或从外部提供给生物体的一种或多种物质的体外分析方法的结果归一化的方法。在方法的至少一个实施方案中a）提供生物体内物质的一个或多个浓度值，所述浓度值在体外分析方法中获得，b）得到的数据提供来自相同生物体的成像研究，c）根据b）的数据，一个或多个定量值被确定为成像值，d）根据a）和c）的值，一个或多个通过将根据a）和c）的值相互关联来确定更多的诊断参数，并且还使用该方法用于药物的类型正确剂量发现和用于体外诊断，预后和监测过程的疾病此外，本发明的至少一个实施例涉及一种用于数据处理系统的程序，当在合适的计算机系统中执行时，执行上述方法，并且还涉及具有存储的电子可读控制信息的电子可读数据载体在其上配置有这样的控制信息，即当在合适的计算机系统中使用合适的数据载体时，它们执行上述方法。

10. 发明授权

US10297023B2 Reconstruction of an image on the basis of one or more imaging modalities 有权
公开(公告)号：US10297023B2
公开(公告)日：2019-05-21
申请号：US15285626
申请日：2016-10-05
申请人： David Grodzki , Arne Hengerer , Michael Kaus , Elena Nioutsikou , Sebastian Schmidt
发明人： David Grodzki , Arne Hengerer , Michael Kaus , Elena Nioutsikou , Sebastian Schmidt
IPC分类号： G06K9/00 , G06T7/00 , G06T11/00
摘要： The embodiments relate to a reconstructing an image of an examination object, a medical imaging apparatus, and a computer program product where a first image data record is acquired with a first imaging modality and at least one further image data record of at least one further imaging modality is provided. At least one first image is reconstructed on the basis of the first image data record using the at least one further image data record.

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