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    • 5. 发明授权
    • Preparation of 4-methylpyrimidines
    • 4-甲基嘧啶的制备
    • US5414086A
    • 1995-05-09
    • US199452
    • 1994-02-22
    • Stefan RittingerNorbert Rieber
    • Stefan RittingerNorbert Rieber
    • C07D239/26C07D239/42C07D295/104C07D239/34C07D239/38
    • C07D239/26C07D239/42C07D295/104Y02P20/582
    • A process for the preparation of a 4-methylpyrimidine of the general formula I ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 phenalkyl, C.sub.7 -C.sub.12 alkylphenyl, NH.sub.2, NHCN, OH, and SH,in which a 1-aminovinyl methyl ketone of the general formula II ##STR2## in which R.sup.2 and R.sup.3 denote C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 phenylalkyl, C.sub.7 -C.sub.12 alkylphenyl, C.sub.1 -C.sub.20 hydroxyalkyl or together denote a C.sub.2 -C.sub.7 alkylene chain optionally mono- to tetra-substituted by C.sub.1 -C.sub.4 alkyl and optionally interrupted by oxygen, nitrogen, or sulfur, is caused to react with a carboxamide or amidine or a salt thereof of the general formula III ##STR3## in which R.sup.1 has the aforementioned meanings and x stands for oxygen or NH, at temperatures ranging from 20.degree. to 200.degree. C. and pressures ranging from 0.01 to 50 bar.
    • 制备通式I(I)的4-甲基嘧啶的方法,其中R1表示C1-C20烷基,C3-C8环烷基,芳基,C7-C12苯烷基,C7-C12烷基苯基,NH2,NHCN ,OH和SH,其中通式II的1-氨基乙烯基甲基酮(II)其中R2和R3表示C1-C20烷基,C3-C8环烷基,芳基,C7-C12苯基烷基,C7-C12 烷基苯基,C 1 -C 20羟基烷基或一起表示任选被C 1 -C 4烷基单取代和四取代并任选被氧,氮或硫中断的C 2 -C 7亚烷基链与羧酰胺或脒或盐反应 其中R 1具有上述含义,x代表氧或NH,通常在20℃至200℃的温度和0.01至50巴的压力下进行。