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1. 发明授权

US09797895B2 Stabilizing compositions for immobilized biomolecules 有权
公开(公告)号：US09797895B2
公开(公告)日：2017-10-24
申请号：US13262542
申请日：2010-03-31
申请人： Stefan Margraf , Anja Breuer , Martin Scholz , Jens Altrichter
发明人： Stefan Margraf , Anja Breuer , Martin Scholz , Jens Altrichter
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G06N99/005 , G01N33/54393 , G06F19/704
摘要： The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the composition according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.

2. 发明申请

US20120118825A1 BLOOD FILTER AND METHOD FOR FILTERING BLOOD 审中-公开
标题翻译：血液过滤器和过滤血液的方法
公开(公告)号：US20120118825A1
公开(公告)日：2012-05-17
申请号：US13378991
申请日：2010-06-17
申请人： Stefan Margraf , Martin Scholz
发明人： Stefan Margraf , Martin Scholz
IPC分类号： B01D61/00 , B01D63/00
CPC分类号： A61M1/34 , A61M1/3403 , A61M2205/3331 , B01D63/087 , B01D2313/10 , G01N33/491
摘要： The present invention relates to a method for filtering blood to produce plasma or serum and to a blood filter for the production of plasma or serum from a blood sample. The invention further relates to a kit comprising a blood filter for the production of plasma or serum from a blood sample and a syringe.
摘要翻译：本发明涉及一种用于过滤血液以产生血浆或血清的方法和用于从血液样品产生血浆或血清的血液过滤器。本发明还涉及一种试剂盒，其包括用于从血液样品和注射器产生血浆或血清的血液过滤器。

3. 发明申请

US20100291665A1 BIOCOMPATIBLE THREE DIMENSIONAL MATRIX FOR THE IMMOBILIZATION OF BIOLOGICAL SUBSTANCES 审中-公开
标题翻译：用于生物物质固定的生物成分三维矩阵
公开(公告)号：US20100291665A1
公开(公告)日：2010-11-18
申请号：US12741369
申请日：2008-11-07
申请人： Stefan Margraf , Martin Scholz , Jens Altrichter
发明人： Stefan Margraf , Martin Scholz , Jens Altrichter
IPC分类号： C12M1/34 , G01N33/566 , B05D3/02 , B05D3/06 , B05D3/00 , B01L3/00 , B01D15/08
CPC分类号： C07K17/14 , C07K17/02
摘要： The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a method for the contacting, filtration or cleaning of blood, lymph or liquor cerebrospinalis of a patient, a method for the diagnosis of a disease and a diagnostic composition.
摘要翻译：本发明涉及一种生产携带生物材料的固体涂层载体的方法。此外，本发明涉及附着有生物材料的固体涂覆载体和用于制备医疗产品的固体涂覆载体的用途。此外，本发明提供了一种用于接触，过滤或清洁患者的血液，淋巴或脑脊髓液的方法，用于诊断疾病的方法和诊断组合物。

4. 发明申请

US20100261223A1 DEVICE FOR DETECTING COMPONENTS IN A FLUID 审中-公开
标题翻译：用于检测流体中组分的装置
公开(公告)号：US20100261223A1
公开(公告)日：2010-10-14
申请号：US12740817
申请日：2008-10-31
申请人： Stefan Margraf , Martin Scholz
发明人： Stefan Margraf , Martin Scholz
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： B01L3/502753 , B01L2200/027 , B01L2200/0684 , B01L2300/049 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/0481 , B01L2400/049
摘要： A device and a method for detecting components in blood, in particular for determining the concentration of components in blood or water is provided. Moreover, a use of a device and/or a method for determining components in blood is provided and a kit including the device and a fluorescence standard.
摘要翻译：提供了用于检测血液中的成分的装置和方法，特别是用于确定血液或水中组分的浓度。此外，提供使用用于测定血液成分的装置和/或方法，以及包括该装置和荧光标准的试剂盒。

5. 发明申请

US20120107829A1 STABILIZING COMPOSITIONS FOR IMMOBILIZED BIOMOLECULES 有权
标题翻译：稳定生物分子固定化组合物
公开(公告)号：US20120107829A1
公开(公告)日：2012-05-03
申请号：US13262542
申请日：2010-03-31
申请人： Stefan Margraf , Anja Breuer , Martin Scholz , Jens Altrichter
发明人： Stefan Margraf , Anja Breuer , Martin Scholz , Jens Altrichter
IPC分类号： G01N33/569 , C12N11/00 , C07K17/00 , A61L2/14 , C07C53/00 , A61L2/20 , A61L2/08 , A61L2/04 , G01N33/53 , C07H21/00
CPC分类号： G06N99/005 , G01N33/54393 , G06F19/704
摘要： The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the composition according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.
摘要翻译：本发明涉及组合物的用途，所述组合物包含（a）至少三种不同氨基酸，（b）至少两种不同氨基酸和皂角苷或（c）至少一种二肽或三肽用于稳定固定在固体上的生物分子载体本发明还涉及一种用于生产稳定的生物分子的方法，包括将生物分子包埋在根据本发明的组合物中，以及制备具有附着有生物分子的固体载体的方法。本发明还涉及通过本发明的方法生产或生产的固体载体和使用本发明的载体诊断疾病的方法。

6. 发明授权

US09926383B2 Biocompatible three dimensional matrix for the immobilization of biological substances 有权
公开(公告)号：US09926383B2
公开(公告)日：2018-03-27
申请号：US12299382
申请日：2007-05-07
申请人： Stefan Margraf , Martin Scholz
发明人： Stefan Margraf , Martin Scholz
IPC分类号： G01N33/53 , C07K17/14 , C07K17/02
CPC分类号： C07K17/14 , C07K17/02
摘要： The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a method for the contacting, filtration or cleaning of blood, lymph or liquor cerebrospinalis of a patient, a method for the diagnosis of a disease and a diagnostic composition.

7. 发明申请

US20090269778A1 BIOCOMPATIBLE THREE DIMENSIONAL MATRIX FOR THE IMMOBILIZATION OF BIOLOGICAL SUBSTANCES 有权
标题翻译：用于生物物质固定的生物成分三维矩阵
公开(公告)号：US20090269778A1
公开(公告)日：2009-10-29
申请号：US12299382
申请日：2007-05-07
申请人： Stefan Margraf , Martin Scholz
发明人： Stefan Margraf , Martin Scholz
IPC分类号： G01N33/53
CPC分类号： C07K17/14 , C07K17/02
摘要： The present invention relates to a method of producing a solid coated carrier carrying biological material. Furthermore, the invention relates to a solid coated carrier to which biological material is attached and uses of the solid coated carrier for the preparation of a medical product. Moreover, the invention provides a method for the contacting, filtration or cleaning of blood, lymph or liquor cerebrospinalis of a patient, a method for the diagnosis of a disease and a diagnostic composition.
摘要翻译：本发明涉及一种生产携带生物材料的固体涂层载体的方法。此外，本发明涉及附着有生物材料的固体涂覆载体和用于制备医疗产品的固体涂覆载体的用途。此外，本发明提供了一种用于接触，过滤或清洁患者的血液，淋巴或脑脊髓液的方法，用于诊断疾病的方法和诊断组合物。

8. 发明授权

US09858318B2 Managing data entities using collaborative filtering 有权
公开(公告)号：US09858318B2
公开(公告)日：2018-01-02
申请号：US14372976
申请日：2012-01-20
申请人： Shyam Sundar Rajaram , Craig Peter Sayers , Rajan Lukose , Martin Scholz
发明人： Shyam Sundar Rajaram , Craig Peter Sayers , Rajan Lukose , Martin Scholz
IPC分类号： G06F17/30
CPC分类号： G06F17/3053 , G06F17/30029
摘要： In a method for managing a plurality of data entities, data pertaining to transactions by a plurality of users with respect to the data entities is collected and a collaborative filtering operation is applied on the data entities to determine similarity levels of the data entities with respect to each other. In addition, for at least one of the data entities, remaining ones of the data entities are ranked according to the determined similarities while discounting for popularities of the data entities. Moreover, identifications of at least another one of the data entities having the highest rankings to the at least one of the data entities are presented to a first user to recommend the at least another one of the data entities for use by the first user.

9. 发明授权

US08954893B2 Visually representing a hierarchy of category nodes 有权
标题翻译：目视表示类别节点的层次结构
公开(公告)号：US08954893B2
公开(公告)日：2015-02-10
申请号：US12614193
申请日：2009-11-06
申请人： Craig Peter Sayers , Ignacio Zendejas , Rajan Lukose , Martin Scholz , Shyamsundar Rajaram
发明人： Craig Peter Sayers , Ignacio Zendejas , Rajan Lukose , Martin Scholz , Shyamsundar Rajaram
IPC分类号： G06F3/048 , G06F17/30 , G06F3/00
CPC分类号： G06F17/30873
摘要： In a method of visually representing a hierarchy of category nodes that identify one or more concepts, accesses to documents are tracked and one or more concepts that are relevant to the accessed documents are determined. In addition, one or more category paths through the hierarchy of category nodes for the determined one or more concepts are determined and relevance levels for the category nodes with respect to the determined one or more concepts are determined based upon the generated one or more category paths. Moreover, a graph depicting a visual representation of the relevance levels determined for each of the category nodes in the hierarchy of category nodes is constructed.
摘要翻译：在可视地表示标识一个或多个概念的类别节点的层次结构的方法中，跟踪对文档的访问，并确定与被访问文档相关的一个或多个概念。此外，确定用于确定的一个或多个概念的通过类别节点的层次结构的一个或多个类别路径，并且基于所生成的一个或多个类别路径来确定关于所确定的一个或多个概念的类别节点的相关性级别。此外，构造描绘对于类别节点的层次结构中的每个类别节点确定的相关性级别的视觉表示的图形。

10. 发明授权

US08713533B2 Module-code verification layer to automatically validate user input 有权
标题翻译：模块代码验证层自动验证用户输入
公开(公告)号：US08713533B2
公开(公告)日：2014-04-29
申请号：US11924257
申请日：2007-10-25
申请人： Martin Scholz , Christian Behrens , Steffen Rotsch
发明人： Martin Scholz , Christian Behrens , Steffen Rotsch
IPC分类号： G06F9/44
CPC分类号： G06F9/451
摘要： Methods and systems for verifying module codes are presented. The module code may be verified by associating the module code with a user interface screen and determining whether the module code was generated from the user interface screen. A module corresponding to the module code may be executed if the module code is verified. The module code may be verified by using routines from a user interface framework system. The module code may be verified by determining whether a user interface element associated with the module code is disabled. The module code may be verified by determining whether each user interface element associated with the module code is enabled. The module code may be verified by insuring that the module code was generated by the selection of a user interface element. The module codes may be received from a front-end system and verified on a back-end system.
摘要翻译：介绍验证模块代码的方法和系统。可以通过将模块代码与用户界面屏幕相关联并且确定模块代码是否从用户界面屏幕生成来验证模块代码。如果模块代码被验证，则可以执行对应于模块代码的模块。可以通过使用来自用户界面框架系统的例程来验证模块代码。可以通过确定与模块代码相关联的用户界面元素是否被禁用来验证模块代码。可以通过确定与模块代码相关联的每个用户界面元素是否被启用来验证模块代码。可以通过确保通过选择用户界面元素生成模块代码来验证模块代码。可以从前端系统接收模块代码并在后端系统上进行验证。

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