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1. 发明授权

US10052414B2 Method and applicator for the perioperative disinfection of medical instruments to be inserted through non-natural openings 有权
公开(公告)号：US10052414B2
公开(公告)日：2018-08-21
申请号：US14373488
申请日：2013-01-22
申请人： Stefan Margraf , Jan Stange
发明人： Stefan Margraf , Jan Stange
IPC分类号： A61L29/16 , B05C1/06 , A61L29/08 , A61L31/16 , A61M25/01 , A01N43/40 , A61M25/00
CPC分类号： A61L29/16 , A01N43/40 , A61L2/18 , A61L2/232 , A61L2/235 , A61L29/08 , A61L31/16 , A61L2202/15 , A61L2202/24 , A61L2300/404 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/0045 , A61M25/0111 , A61M2025/0056 , B05C1/06 , A01N25/10 , A01N25/34 , A01N2300/00
摘要： The invention relates to means and methods for the disinfection of an insertion channel to prevent in particular catheter sepsis, which significantly reduces the carry-over of germs even out of deeper skin layers by means of medical instruments, such as catheters, to be introduced into non-natural openings and also permits the decontamination of perioperatively contaminated medical instruments. The disinfection of the insertion channel is achieved by means of a method for the perioperative coating of a medical instrument to be inserted into an invasively produced bodily opening before use, comprising the application of a preferably viscous or foam-like composition containing at least one anti-infective compound, preferably a gel having octenidine, by means of an applicator, such that when said gel is used, the composition is also specifically effective in the first millimeters of the insertion channel. Furthermore, an immediate disinfecting action is provided over the entire coated surface.

2. 发明申请

US20140370067A1 Method and applicator for the perioperative disinfection of medical instruments to be inserted through non-natural openings 审中-公开
标题翻译：用于通过非自然开口插入的医疗器械围手术期消毒的方法和涂抹器
公开(公告)号：US20140370067A1
公开(公告)日：2014-12-18
申请号：US14373488
申请日：2013-01-22
申请人： Stefan Margraf , Jan Stange
发明人： Stefan Margraf , Jan Stange
IPC分类号： A61L29/16 , B05C1/06 , A61L29/08
CPC分类号： A61L29/16 , A01N43/40 , A61L29/08 , A61L31/16 , A61L2202/15 , A61L2202/24 , A61L2300/404 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/0111 , A61M2025/0056 , B05C1/06 , A01N25/10 , A01N25/34 , A01N2300/00
摘要： The invention relates to means and methods for the disinfection of an insertion channel to prevent in particular catheter sepsis, which significantly reduces the carry-over of germs even out of deeper skin layers by means of medical instruments, such as catheters, to be introduced into non-natural openings and also permits the decontamination of perioperatively contaminated medical instruments. The disinfection of the insertion channel is achieved by means of a method for the perioperative coating of a medical instrument to be inserted into an invasively produced bodily opening before use, comprising the application of a preferably viscous or foam-like composition containing at least one anti-infective compound, preferably a gel having octenidine, by means of an applicator, such that when said gel is used, the composition is also specifically effective in the first millimeters of the insertion channel. Furthermore, an immediate disinfecting action is provided over the entire coated surface.
摘要翻译：本发明涉及用于消除插入通道以防止特别是导管败血症的装置和方法，其通过诸如导管之类的医疗器械显着地减少甚至从较深层皮肤层移除细菌的细菌，以引入非自然开口，也允许对围手术期污染的医疗器械进行去污。插入通道的消毒通过在使用前插入入侵生成的身体开口中的医疗器械的围手术期涂层的方法来实现，包括施用优选粘稠或泡沫状组合物，其包含至少一种抗有益的化合物，优选具有奥丁啶的凝胶，借助于施用器，使得当使用所述凝胶时，组合物在第一毫米的插入通道中也是特别有效的。此外，在整个涂覆表面上提供立即消毒作用。

3. 发明申请

US20180318471A1 Method and applicator for the perioperative disinfection of medical instruments to be inserted through non-natural openings 审中-公开
公开(公告)号：US20180318471A1
公开(公告)日：2018-11-08
申请号：US16035132
申请日：2018-07-13
申请人： Stefan Margraf , Jan Stange
发明人： Stefan Margraf , Jan Stange
IPC分类号： A61L29/16 , A61L2/18 , A61L29/08 , A61M25/01
CPC分类号： A61L29/16 , A01N43/40 , A61L2/18 , A61L2/232 , A61L2/235 , A61L29/08 , A61L31/16 , A61L2202/15 , A61L2202/24 , A61L2300/404 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/0045 , A61M25/0111 , A61M2025/0056 , B05C1/06 , A01N25/10 , A01N25/34 , A01N2300/00
摘要： The invention relates to means and methods for the disinfection of an insertion channel to prevent in particular catheter sepsis, which significantly reduces the carry-over of germs even out of deeper skin layers by means of medical instruments, such as catheters, to be introduced into non-natural openings and also permits the decontamination of perioperatively contaminated medical instruments. The disinfection of the insertion channel is achieved by means of a method for the perioperative coating of a medical instrument to be inserted into an invasively produced opening before use, comprising the application of a viscous or foam-like composition containing at least one anti-infective compound, preferably a gel having octenidine, by means of an applicator, such that when said gel is used, the composition is also specifically effective in the first millimeters of the insertion channel. Furthermore, an immediate disinfecting action is provided over the entire coated surface.

4. 发明申请

US20110230772A1 METHOD AND DEVICE FOR INVASIVE BLOOD PRESSURE MEASUREMENT IN A VASCULAR ACCESS 审中-公开
标题翻译：用于在血管通路中进行入血血压测量的方法和装置
公开(公告)号：US20110230772A1
公开(公告)日：2011-09-22
申请号：US13131721
申请日：2009-11-26
申请人： Sebastian Koball , Heiko Hickstein , Jan Stange , Steffen Mitzner
发明人： Sebastian Koball , Heiko Hickstein , Jan Stange , Steffen Mitzner
IPC分类号： A61B5/021 , A61M1/14
CPC分类号： A61B5/0215 , A61B5/02108 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M2205/3344 , A61M2230/30
摘要： A device and method for invasive blood pressure measurement in a vascular access under continuous blood flows in a treatment device in extracorporeal detoxification methods is provided. Systemic arterial pressure is directly measured using an existing vascular access for dialysis, or in which the systemic arterial pressure and the temporal progression of such pressure are determined indirectly. A valve-controlled bypass system which goes around a blood pumping unit is provided so that the blood flow in the treatment device is not interrupted, and alarms are suppressed The bypass module is easily connectable to measuring equipment on various treatment units without having to adjust the same.
摘要翻译：提供了一种用于在体外解毒方法的治疗装置中的连续血流下的血管通路中的侵入性血压测量的装置和方法。使用现有的血液通路直接测量全身动脉压力，或间接确定全身动脉压和这种压力的时间进展。提供了一种围绕血液泵送单元的阀控旁通系统，使得处理装置中的血流不中断，并且抑制报警。旁路模块可容易地连接到各种处理单元上的测量设备，而不必调整相同。

5. 发明授权

US07285218B2 Method for the extra-corporeal qualitative and/or quantitative recording of neurotoxic substances in the blood plasma of an individual 有权
标题翻译：用于个体血浆中神经毒物质的额外定性和/或定量记录的方法
公开(公告)号：US07285218B2
公开(公告)日：2007-10-23
申请号：US10476440
申请日：2002-05-03
申请人： Jan Loock , Steffen R. Mitzner , Dieter G. Weiss , Jan Stange , Gunter W. Gross , Alexandra Gramowski , Dietmar Schiffmann
发明人： Jan Loock , Steffen R. Mitzner , Dieter G. Weiss , Jan Stange , Gunter W. Gross , Alexandra Gramowski , Dietmar Schiffmann
IPC分类号： B01D11/00 , C12N13/00 , G01V3/00 , B01D61/00
CPC分类号： G01N33/5088 , Y10S436/811 , Y10S436/82 , Y10S436/825
摘要： The invention relates to a method for the extra-corporeal qualitative and/or quantitative recording of neuro-toxic substances in the blood plasma of an individual. According to said method, a system containing neurones or neuronal networks, which have been cultivated on or applied to a micro-electrode array or a neuro-chip, in addition to a device for measuring the electrical activity of at least one or several of said neurones are provided, the neurones are brought into contact with a prepared sample of plasma and the electrical activity of the neurones is measured. The aim of the invention is to develop and improve said method in such a way that it supplies reliable, reproducible results for the recording of neuro-toxic substances in the blood plasma of an individual, in particular in the case of encephalopathic conditions, such as for example hepatic failure, or of coma conditions of various origins. To achieve this, prior to measurement, the blood plasma of an individual is prepared by being subjected to a filtration method, preferably an ultra-filtration method, whereby an exclusion limit, which causes the most extensive separation possible of the plasma protein from the other dissolved substances is selected, and/or prior to measurement, the blood plasma of an individual is prepared by being subjected to an extraction of liposoluble substances, using a solvent for liposoluble substances, and the ultra-filtrate or the extract containing the liposoluble substances, or both are used in succession or are blended together for the measurement.
摘要翻译：本发明涉及一种用于个体血浆中神经毒性物质的体外定性和/或定量记录的方法。根据所述方法，除了用于测量所述微电极阵列或神经芯片中的至少一个或几个的电活动的装置之外，还包括已经培养在微电极阵列或神经芯片上的神经元或神经元网络的系统提供神经元，使神经元与制备的血浆样品接触，并测量神经元的电活性。本发明的目的是开发和改进所述方法，使得其为个体血浆中的神经毒性物质的记录提供可靠且可重现的结果，特别是在脑病条件下，例如例如肝衰竭，或各种起因的昏迷状况。为了实现这一点，在测量之前，通过进行过滤方法，优选超滤方法来制备个体的血浆，由此排除极限，其导致血浆蛋白质与其他蛋白质的最广泛分离选择溶解物质，和/或测定前，通过使用脂溶性物质的溶剂，超滤液或含有脂溶性物质的提取物进行脂溶性物质的提取，制备个体的血浆，或两者连续使用或混合在一起用于测量。

6. 发明授权

US06509147B1 Method for therapeutic immunmodulation of plasma 有权
标题翻译：血浆治疗免疫调节方法
公开(公告)号：US06509147B1
公开(公告)日：2003-01-21
申请号：US09352987
申请日：1999-07-14
申请人： Jens Altrichter , Jens Freytag , Steffen Mitzner , Jan Stange
发明人： Jens Altrichter , Jens Freytag , Steffen Mitzner , Jan Stange
IPC分类号： C12N500
CPC分类号： A61K35/16 , A61M1/3489
摘要： A process and set-up of therapeutic immunomodulation is provided for medicine. Many illnesses (i.e. Sepsis) are, among other things, characterized by a disruption of the immune system. In spite of previous therapies using antibiotics, the mortality rate is still very high. The administration of individual cytokins has not yet resulted in any convincing results. The use of cells in an extra-corporal circulation that can adsorb or self-release immunomodulatory effect substances is a completely new type of complex therapeutic approach to such illnesses, which leads to an improvement in the health of the affected patients.
摘要翻译：为医学提供了治疗性免疫调节的过程和设置。许多疾病（即败血症）其特征在于免疫系统的破坏。尽管以前使用抗生素的疗法，死亡率仍然很高。单个细胞因子的管理尚未产生任何令人信服的结果。使用可以吸附或自我释放免疫调节作用物质的体外循环中的细胞是这种疾病的全新的复杂治疗方法，导致受影响患者的健康状况得到改善。

7. 发明授权

US5744042A Method for the separation of protein-bound substances from a protein-containing liquid by dialysis 失效
标题翻译：通过透析从含蛋白质的液体中分离蛋白质结合物质的方法
公开(公告)号：US5744042A
公开(公告)日：1998-04-28
申请号：US570816
申请日：1995-12-12
申请人： Jan Stange , Steffen Mitzner , Wolfgang Ramlow
发明人： Jan Stange , Steffen Mitzner , Wolfgang Ramlow
IPC分类号： A61M1/14 , A61M1/16 , A61M1/34 , B01D61/24 , B01D69/02 , B01D69/14 , B01D71/16 , B01D71/42 , B01D71/48 , B01D71/50 , B01D71/64 , B01D71/68
CPC分类号： B01D61/243 , A61M1/1654 , A61M1/1696 , A61M1/3475 , B01D69/02 , B01D69/141 , Y10T436/25375 , Y10T436/255
摘要： The present invention provides a process of separating substances bound to a first protein in a first liquid by means of a membrane separating the first liquid from a second liquid, the process comprising the steps of: a) impregnating the membrane by passing along the membrane a solution comprising a first acceptor protein having an acceptor function for the substances to be separated; b) dialyzing the first liquid against the second liquid, the second liquid comprising a second acceptor protein having an acceptor function for the substances to be separated, wherein the membrane separating the first and second liquids contains tunnel-like structures that permit passage of the substances to be separated to the second liquid but exclude passage of the first protein and the second acceptor protein.
摘要翻译：本发明提供了通过将第一液体与第二液体分离的膜分离在第一液体中与第一蛋白质结合的物质的方法，该方法包括以下步骤：a）通过沿着膜a浸渍膜溶液，其包含具有待分离物质的受体功能的第一受体蛋白质; b）将第一液体透析到第二液体上，第二液体包含具有用于待分离物质的受体功能的第二受体蛋白，其中分离第一和第二液体的膜包含允许物质通过的隧道状结构被分离成第二液体，但不排除第一蛋白质和第二受体蛋白质的通过。

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