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1. 发明授权

US08393556B2 Preparation of nanoscalar UV absorbers 有权
标题翻译：纳米级紫外线吸收剂的制备
公开(公告)号：US08393556B2
公开(公告)日：2013-03-12
申请号：US12664429
申请日：2008-06-27
申请人： Stefan Müller , Bernd Herzog
发明人： Stefan Müller , Bernd Herzog
IPC分类号： B02C15/00
CPC分类号： C07D251/24 , A61K8/4966 , A61K2800/412 , A61K2800/413 , A61Q17/04 , B82Y5/00
摘要： Disclosed is a method of preparing a composition, comprising a micronized insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus comprising yttrium-stabilized zirconium oxide grinding beads, in the presence of alkyl polyglucoside having the formula CnH2n+1O(C6H10O5)xH, in which n is an integer ranging from 8 to 16 and x is the mean polymerisation level of the glucoside moiety (C6H10O5) and ranges from 1.4 to 1.6, or an ester thereof and in the presence of an antifoam agent as dispersingagent auxiliary.
摘要翻译：公开了一种制备组合物的方法，该组合物包含微粉化的不溶性有机UV吸收剂，该方法包括在包含钇稳定的氧化锆研磨珠的研磨装置中，在烷基存在下研磨粗颗粒形式的不溶性有机UV吸收剂具有式C n H 2n + 10（C 6 H 10 O 5）x H的聚葡萄糖苷，其中n是8至16的整数，x是葡萄糖苷部分（C 6 H 10 O 5）的平均聚合水平，范围为1.4至1.6，或其酯，消泡剂作为分散助剂的存在。

2. 发明授权

US08535648B2 Stabilization of UV-sensitive active ingredients 有权
标题翻译：紫外线敏感活性成分的稳定化
公开(公告)号：US08535648B2
公开(公告)日：2013-09-17
申请号：US12520880
申请日：2008-01-16
申请人： Barbara Wagner , Bernd Herzog , Stefan Müller , Thomas Ehlis
发明人： Barbara Wagner , Bernd Herzog , Stefan Müller , Thomas Ehlis
IPC分类号： A61K8/00
CPC分类号： A61K8/41 , A61K8/35 , A61K8/44 , A61K2800/52 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q17/04 , A61Q19/004 , A61Q19/04
摘要： Disclosed is the use of merocyanine derivatives of formula (1) for stabilizing UV-sensitive active ingredients like dibenzoylmethane derivatives.
摘要翻译：公开了式（1）的部花青衍生物用于稳定紫外线敏感活性成分如二苯甲酰甲烷衍生物的用途。

3. 发明申请

US20100143272A1 Photo-stable cosmetic or dermatological compositions 有权
标题翻译：光稳定化妆品或皮肤病学成分
公开(公告)号：US20100143272A1
公开(公告)日：2010-06-10
申请号：US11663610
申请日：2005-09-19
申请人： Stefan Müller , Bernd Herzog , Katja Quass
发明人： Stefan Müller , Bernd Herzog , Katja Quass
IPC分类号： A61K8/36 , A61Q17/04
CPC分类号： A61K8/066 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/415 , A61K8/893 , A61K8/97 , A61K2800/52 , A61K2800/57 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00
摘要： Disclosed is the use of an effective photo-stabilizing amount of stabilizing agent (a) selected from a diphenylacrylate UV filter (a1), a benzylidene amphor derivative (a2), an organosiloxane comprising benzalemalonate groups (a3), a fluoren derivative (a4), and a naphthalene dicarboxylic acid derivative (a5) for improving the stability with respect to UV radiation of a cosmetic or dermatological composition comprising a UV filter combination of at least one dibenzoylmethane derivative (b) and of at least one specific amino-substituted 2-hydroxybenzophenone derivative (c).
摘要翻译：公开了使用有效的光稳定剂量的选自二苯基丙烯酸酯紫外线过滤器（a1），亚苄基双酚衍生物（a2），包含亚苄基丙二酸酯基（a3）的有机硅氧烷，芴衍生物（a4）和用于提高化妆品或皮肤病学组合物的UV辐射稳定性的萘二羧酸衍生物（a5），其包含至少一种二苯甲酰甲烷衍生物（b）和至少一种特定氨基取代的2- 羟基二苯甲酮衍生物（c）。

4. 发明授权

US11103733B2 Water based concentrated product forms of oil-soluble organic UV absorbers 有权
公开(公告)号：US11103733B2
公开(公告)日：2021-08-31
申请号：US12664666
申请日：2008-06-30
申请人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
发明人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
IPC分类号： A61Q17/04 , A61K8/11 , A61K8/58 , A61K8/37 , A61K8/35 , A61K8/44 , A61K8/81 , A61K8/893 , A61K8/49
摘要： The instant invention refers to the use of a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising (a) a polymer carrier prepared by heterophase radical polymerization of at least one ethylenically unsaturated monomer in the presence of (b) an oil-soluble organic UV absorber selected from the class of p-aminobenzoic acid derivatives; salicylic acid derivatives; benzophenone derivatives; diphenyl acrylate derivatives; benzofuran derivatives; polymeric UV absorbers, comprising one or more organosilicon radicals; cinnamic acid derivatives; camphor derivatives; s-triazine derivatives; trianilino-s-triazine derivatives; menthyl anthranilates; and benzotriazole derivatives; wherein the weight ratio of the oil-soluble organic UV absorber (b) to polymer carrier (a) is greater than 50 parts UV absorber per 100 parts of carrier; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The concentrated aqueous polymer dispersions show unexpectedly high sunscreen effects and a positive skin feeling.

5. 发明申请

US20100008873A1 Use of benzotriazole derivatives for photostabilisation 有权
标题翻译：苯并三唑衍生物用于光稳定化
公开(公告)号：US20100008873A1
公开(公告)日：2010-01-14
申请号：US11919104
申请日：2006-04-20
申请人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
发明人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
IPC分类号： A61K8/49 , A61P17/04
CPC分类号： A61Q17/04 , A61K8/496 , A61K2800/52
摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.
摘要翻译：式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

6. 发明授权

US08361446B2 Use of benzotriazole derivatives for photostabilisation 有权
标题翻译：苯并三唑衍生物用于光稳定化
公开(公告)号：US08361446B2
公开(公告)日：2013-01-29
申请号：US11919104
申请日：2006-04-20
申请人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
发明人： Stefan Müller , Jochen Giesinger , Thomas Ehlis , Bernd Herzog , Peter König , Gilbert Kreyer , Katja Quass
IPC分类号： A61K8/49 , A61P17/04
CPC分类号： A61Q17/04 , A61K8/496 , A61K2800/52
摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.
摘要翻译：式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

7. 发明授权

US08119107B2 Photo-stable cosmetic or dermatological compositions 有权
标题翻译：光稳定化妆品或皮肤病学成分
公开(公告)号：US08119107B2
公开(公告)日：2012-02-21
申请号：US11663610
申请日：2005-09-19
申请人： Stefan Müller , Bernd Herzog , Katja Quass
发明人： Stefan Müller , Bernd Herzog , Katja Quass
IPC分类号： A61Q17/02
CPC分类号： A61K8/066 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/415 , A61K8/893 , A61K8/97 , A61K2800/52 , A61K2800/57 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00
摘要： Disclosed is the use of an effective photo-stabilizing amount of stabilizing agent (a) selected from a diphenylacrylate UV filter (a1), a benzylidene amphor derivative (a2), an organosiloxane comprising benzalemalonate groups (a3), a fluoren derivative (a4), and a naphthalene dicarboxylic acid derivative (a5) for improving the stability with respect to UV radiation of a cosmetic or dermatological composition comprising a UV filter combination of at least one dibenzoylmethane derivative (b) and of at least one specific amino-substituted 2-hydroxybenzophenone derivative (c).
摘要翻译：公开了使用有效的光稳定剂量的选自二苯基丙烯酸酯紫外线过滤器（a1），亚苄基双酚衍生物（a2），包含亚苄基丙二酸酯基（a3）的有机硅氧烷，芴衍生物（a4）和用于提高化妆品或皮肤病学组合物的UV辐射稳定性的萘二羧酸衍生物（a5），其包含至少一种二苯甲酰甲烷衍生物（b）和至少一种特定氨基取代的2- 羟基二苯甲酮衍生物（c）。

8. 发明申请

US20100284950A1 WATER BASED CONCENTRATED PRODUCT FORMS OF OIL-SOLUBLE ORGANIC UV ABSORBERS 审中-公开
标题翻译：水溶性有机紫外线吸收剂的基于水的浓缩产品形式
公开(公告)号：US20100284950A1
公开(公告)日：2010-11-11
申请号：US12664666
申请日：2008-06-30
申请人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
发明人： Stefan Müller , Brigitte Lindemann , Bernd Herzog
IPC分类号： A61K8/37 , A61K8/33 , A61K8/49 , A61Q17/04 , A61Q5/00
CPC分类号： A61Q17/04 , A61K8/11 , A61K8/35 , A61K8/37 , A61K8/44 , A61K8/445 , A61K8/496 , A61K8/4966 , A61K8/585 , A61K8/8152 , A61K8/893 , A61K2800/413
摘要： The instant invention refers to the use of a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising (a) a polymer carrier prepared by heterophase radical polymerization of at least one ethylenically unsaturated monomer in the presence of (b) an oil-soluble organic UV absorber selected from the class of p-aminobenzoic acid derivatives; salicylic acid derivatives; benzophenone derivatives; diphenyl acrylate derivatives; benzofuran derivatives; polymeric UV absorbers, comprising one or more organosilicon radicals; cinnamic acid derivatives; camphor derivatives; s-triazine derivatives; trianilino-s-triazine derivatives; menthyl anthranilates; and benzotriazole derivatives; wherein the weight ratio of the oil-soluble organic UV absorber (b) to polymer carrier (a) is greater than 50 parts UV absorber per 100 parts of carrier; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The concentrated aqueous polymer dispersions show unexpectedly high sunscreen effects and a positive skin feeling.
摘要翻译：本发明涉及使用平均粒度小于1000nm的浓缩水性聚合物分散体，其包含（a）通过至少一种烯键式不饱和单体的异相自由基聚合制备的聚合物载体，所述聚合物载体在（b）选自对氨基苯甲酸衍生物类的油溶性有机UV吸收剂; 水杨酸衍生物; 二苯甲酮衍生物; 二苯基丙烯酸酯衍生物; 苯并呋喃衍生物; 包含一个或多个有机硅基团的聚合物UV吸收剂; 肉桂酸衍生物; 樟脑衍生物三嗪衍生物; 三苯胺三嗪衍生物; 薄荷基邻氨基苯甲酸酯; 和苯并三唑衍生物; 其中油溶性有机UV吸收剂（b）与聚合物载体（a）的重量比相对于100份载体大于50份UV吸收剂; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。浓缩的水性聚合物分散体表现出意想不到的高防晒效果和阳性皮肤感觉。

9. 发明授权

US08987011B2 Method for determining the structure of a transistor 有权
标题翻译：确定晶体管结构的方法
公开(公告)号：US08987011B2
公开(公告)日：2015-03-24
申请号：US13391916
申请日：2010-08-18
申请人： Klaus Köhler , Stefan Müller , Patrick Waltereit
发明人： Klaus Köhler , Stefan Müller , Patrick Waltereit
IPC分类号： H01L27/088 , H01L29/66 , H01L29/778 , H01L29/20
CPC分类号： H01L29/66462 , H01L29/2003 , H01L29/7787
摘要： A method for determining the structure of a transistor having at least one first layer including GaN, one second layer including AlxGa1-xN disposed on the first layer, and one fourth layer including a metal or an alloy disposed on the second layer. The method includes setting the layer thickness of the second layer, setting the aluminum content x of the second layer, producing at least the second layer and the first layer, determining the surface potential of formula (I) and/or the charge carrier density n, and/or the charge carrier motility μ after producing the second layer and the first layer, and selecting the material of the fourth layer as a function of the at least one measurement result.
摘要翻译：一种用于确定晶体管的结构的方法，所述晶体管具有包括GaN的至少一个第一层，设置在所述第一层上的包括Al x Ga 1-x N的一个第二层以及包括设置在所述第二层上的金属或合金的第四层。该方法包括设定第二层的层厚度，设定第二层的铝含量x，产生至少第二层和第一层，确定式（I）的表面电位和/或电荷载流子密度n ，和/或产生第二层和第一层之后的电荷载流子运动μ，以及根据至少一个测量结果选择第四层的材料。

10. 发明申请

US20140302172A1 MARKERS FOR SUSCEPTIBILITY TO AN INHIBITOR OF AN SRC-FAMILY KINASE 有权
标题翻译：不符合SRC家族激素抑制剂的标记
公开(公告)号：US20140302172A1
公开(公告)日：2014-10-09
申请号：US14239067
申请日：2012-08-16
申请人： Christoph Schaab , Klaus Godl , Martin Klammer , Andreas Tebbe , Stefan Müller
发明人： Christoph Schaab , Klaus Godl , Martin Klammer , Andreas Tebbe , Stefan Müller
IPC分类号： C12Q1/68 , G01N33/569
CPC分类号： C12Q1/6881 , G01N33/56966 , G01N33/574 , G01N2333/70546
摘要： The present invention relates to a method for predicting the responsiveness of a mammalian tumor cell or cancer cell to an inhibitor of a kinase of the Src family, such as dasatinib, bosutinib, saracatinib or ponatinib. The present invention also provides for a method for predicting the responsiveness of an individual to an inhibitor of a kinase of the Src family, whereby the individual is suspected to suffer from cancer. These methods involve the evaluation of the status of integrin β4, wherein said status is indicative for the responsiveness to the inhibitor. Furthermore, a kit useful for carrying out the methods described herein as well as an oligo- or polynucleotide and/or antibodies capable of detecting the expression level of integrin β4 for predicting the responsiveness to the inhibitor are provided.
摘要翻译：本发明涉及一种用于预测哺乳动物肿瘤细胞或癌细胞对Src家族的激酶抑制剂（如达沙替尼，波斯库替尼，沙拉单抗或番茄碱）的反应性的方法。本发明还提供了一种用于预测个体对Src家族的激酶抑制剂的反应性的方法，由此该个体怀疑患有癌症。这些方法包括评价整联蛋白的状态; 4，其中所述状态指示对抑制剂的反应性。此外，提供了可用于实施本文所述方法的试剂盒以及能够检测整联蛋白4的表达水平以预测对抑制剂的反应性的寡核苷酸和/或多核苷酸和/或抗体。

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