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1. 发明申请

US20060239996A1 ANTIBODIES SPECIFIC FOR UNGULATE PrP 审中-公开
标题翻译：抗生素特异性
公开(公告)号：US20060239996A1
公开(公告)日：2006-10-26
申请号：US11419688
申请日：2006-05-22
申请人： Stanley Prusiner , Jiri Safar , R. Williamson , Dennis Burton
发明人： Stanley Prusiner , Jiri Safar , R. Williamson , Dennis Burton
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： C07K16/2872 , C07K16/18 , C07K2317/34 , C07K2317/55 , G01N33/6896 , G01N2800/2828
摘要： The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native ungulate PrPC and/or a denatured ungulate PrPSc, but not to a native ungulate PrPSc. Preferred antibodies find native bovine PrPC and treated PrPSc but not native bovine PrPSc and can be used in an assay to determine if a sample is infected with infectious prions, i.e. PrPSc.
摘要翻译：本发明提供了与天然有蹄类动物PrP和/或变性有蹄类动物PrP 特异性结合的抗体，而不是天然有蹄类动物 PrP ^{Sc 。优选的抗体发现天然牛PrP和治疗的PrP 而不是天然牛PrP Sc Sc，并且可用于测定中以确定样品感染了朊病毒，即PrP ^{Sc 。}}

2. 发明申请

US20050158803A1 Antibodies specific for native PrPSc 失效
标题翻译：针对天然PrPSc特异的抗体
公开(公告)号：US20050158803A1
公开(公告)日：2005-07-21
申请号：US11027139
申请日：2004-12-29
申请人： Stanley Prusiner , R. Williamson , Dennis Burton
发明人： Stanley Prusiner , R. Williamson , Dennis Burton
IPC分类号： G01N33/53 , C07K16/18 , C07K16/44 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/08 , G01N33/569 , G01N33/68 , C07K16/42 , C07K16/40 , G01N33/567
CPC分类号： C07K16/18 , C07K2317/55 , G01N33/56983 , G01N33/6896 , G01N2800/2828
摘要： Antibodies are disclosed which specifically bind to native PrPSc in situ. Preferred antibodies bind only to the native PrPSc of a particular species e.g., human, cow, sheep, pig, etc. Particularly preferred antibodies bind specifically to a particular isoform of human PrPSc. Preferred antibodies of the invention are (1) produced by phage display methodology, (2) bind specifically to native PrPSc, (3) neutralizes the infectivity of prions, (4) bind to PrPSc in situ and (5) bind 50% or more of PrPSc in a liquid flowable sample. Antibodies of the invention can be bound to a substrate and used to assay a sample (which has any PrPSc denatured via proteinase K) for the presence of PrPSc of a specific species which PrPSc is associated with disease. Antibodies which specifically bind to human PrPSc can be labeled and injected carrying out an in vivo diagnostic test to determine if the human is infected with prions associated with disease. The antibodies are preferably produced using phage display technology wherein the genetic material in the phage expressing the antibody is obtained from a mammal with an ablated endogenous PrP protein gene and an endogenous chimeric PrP gene which mammal had been inoculated with PrPSc to induce antibody production.
摘要翻译：公开了原位特异性结合天然PrP Sc的抗体。优选的抗体仅结合特定种类例如人，牛，绵羊，猪等的天然PrP Sc。特别优选的抗体特异性结合人PrP < SUP>。本发明优选的抗体是（1）通过噬菌体展示法产生，（2）特异性结合天然PrP ，（3）中和朊病毒感染性，（4）结合PrP < Sc（5）在液体可流动的样品中结合50％以上的PrP Sc 。本发明的抗体可以与底物结合，并用于测定样品（其通过蛋白酶K变性的任何PrP Sc ），以获得特异性的PrP PrP Sc 与疾病相关的物种。可以标记并注射与人PrP标准物质特异性结合的抗体进行体内诊断测试，以确定人是否感染与疾病相关的朊病毒。优选使用噬菌体展示技术产生抗体，其中表达抗体的噬菌体中的遗传物质是从具有消融的内源性PrP蛋白基因的哺乳动物和内源性嵌合PrP基因获得的，哺乳动物已用PrP < SUP>以诱导抗体产生。

3. 发明申请

US20050106149A1 Antibodies abolish prion propagation and remote clearance of infectivity 审中-公开
标题翻译：抗体可以消除朊病毒传播和远程清除感染性
公开(公告)号：US20050106149A1
公开(公告)日：2005-05-19
申请号：US10475558
申请日：2002-04-25
申请人： Stanley Prusiner , David Peretz , R. Williamson , Dennis Burton
发明人： Stanley Prusiner , David Peretz , R. Williamson , Dennis Burton
IPC分类号： G01N33/53 , A61K39/395 , A61P31/00 , C07K16/18 , C12N5/06 , C12N5/28 , C12P21/08
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/55
摘要： Methods are disclosed whereby formulations of molecules are administered rendering cells resistant to infection with infectious proteins such as prions. The formulation preferably comprises a plurality of Fab fragments which (1) recognize and selectively bind to a range of epitopes on the protein of interest, (e.g. epitopes on PrPC) and (2) bind to epitopes which interrupt the chain of events resulting in a change of the protein's conformation to an infectious disease conformation of the protein. The molecules and formulation are also useful in clearing infectious proteins from cells.
摘要翻译：公开了方法，其中给予分子的制剂，使细胞对感染性蛋白如朊病毒感染具有抗性。该制剂优选包含多个Fab片段，其（1）识别并选择性地结合目的蛋白质上的一系列表位（例如PrP上的表位）和（2）与表位结合中断事件链导致蛋白质构象改变为蛋白质的传染病构象。分子和制剂也可用于从细胞中清除感染性蛋白质。

4. 发明申请

US20090110690A1 Hiv Gp120 Crystal Structure and Its Use to Identify Immunogens 审中-公开
标题翻译： Hiv Gp120晶体结构及其用于鉴定免疫原的用途
公开(公告)号：US20090110690A1
公开(公告)日：2009-04-30
申请号：US12065883
申请日：2006-09-06
申请人： Peter D. Kwong , Tongqing Zhou , Ling Xu , Gary Nabel , Barna Dey , Richard Wyatt , James Arthos , Joseph Sodroski , Shi-Hua Xiang , Dennis Burton
发明人： Peter D. Kwong , Tongqing Zhou , Ling Xu , Gary Nabel , Barna Dey , Richard Wyatt , James Arthos , Joseph Sodroski , Shi-Hua Xiang , Dennis Burton
IPC分类号： A61K39/21 , C07K14/16 , C07H21/04 , C12N15/63 , C12N5/06 , A61P31/18 , C12N5/22 , A61K38/16 , A61K31/7052
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： The present disclosure relates to stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, to crystalline forms of the stabilized forms of the HIV gp120 envelope protein in complex with the broadly neutralizing CD4-binding site antibody b12, and to the high resolution structure obtained from these crystals by X-ray diffraction methods. Methods for identifying immunogenic polypeptides based on these structures are also disclosed.
摘要翻译：本公开涉及与广泛中和的CD4结合位点抗体b12复合的HIV gp120包膜蛋白的稳定形式，与广泛中和的CD4结合位点抗体复合的HIV gp120包膜蛋白的稳定形式的结晶形式 b12，以及通过X射线衍射法从这些晶体获得的高分辨率结构。还公开了基于这些结构鉴定免疫原性多肽的方法。

5. 发明申请

US20050208587A1 Peptides that bind to broadly neutralizing anti-HIV antibody-structure of 4E10 Fab fragment complex. uses thereof, compositions therefrom 审中-公开
标题翻译：结合4E10 Fab片段复合物的广泛中和抗HIV抗体结构的肽。其用途，组合物
公开(公告)号：US20050208587A1
公开(公告)日：2005-09-22
申请号：US10946371
申请日：2004-09-20
申请人： Rosa Cardoso , Ian Wilson , Dennis Burton , Philip Dawson
发明人： Rosa Cardoso , Ian Wilson , Dennis Burton , Philip Dawson
IPC分类号： A61K38/00 , A61K38/04 , A61K39/42 , C07K20060101 , C07K14/16 , C07K14/475 , C07K16/00 , C07K16/10 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/569 , G06F15/00 , G06F17/00 , G06F19/00
CPC分类号： G01N33/56988 , A61K38/00 , C07K14/005 , C07K16/1063 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C12N2740/16122 , G01N33/6878 , G01N2469/20 , G16B15/00 , G16B20/00 , G16C20/50
摘要： The present invention relates to the structure of Fab 4E10, e.g., as a complex with herein identified peptide KGND, herein identified as a 4E10 mimetope on gp41, as determined by crystallographic techniques, and the confirmation that peptide KGND has a functional relevant conformation, as well as the determination of key residues on 4E10, and uses thereof and compounds and compositions therefrom. Furthermore, the invention also relates to other peptides and mimetic peptides which bind to Fab 4E10.
摘要翻译：本发明涉及Fab 4E10的结构，例如，作为本文鉴定的肽KGND的复合物，本文鉴定为gp41上的4E10 mimetop，通过晶体学技术测定，以及证实肽KGND具有功能相关构象，如以及4E10上关键残基的测定及其用途及其化合物和组合物。此外，本发明还涉及结合Fab 4E10的其它肽和模拟肽。

6. 发明申请

US20070213278A1 Arrays with cleavable linkers 审中-公开
标题翻译：具有可切割接头的数组
公开(公告)号：US20070213278A1
公开(公告)日：2007-09-13
申请号：US11645273
申请日：2006-12-22
申请人： Chi-Huey Wong , Dennis Burton , Ian Wilson
发明人： Chi-Huey Wong , Dennis Burton , Ian Wilson
IPC分类号： A61K31/70 , G01N33/53
CPC分类号： G01N33/54353 , A61K31/716 , C07H3/06 , G01N33/56972 , G01N33/56988 , G01N33/57415 , G01N2400/02 , G01N2400/14
摘要： The invention provides arrays of molecules where the molecules (e.g., glycans) are attached to the arrays by cleavable linkers. The invention also provides methods for using these arrays, methods for identifying the structural elements of molecules bound to these arrays by using the cleavable linkers, especially the structural elements that are important for binding to test samples. The invention further provides methods for evaluating whether test samples and test molecules can bind to distinct glycans on the arrays and useful glycans identified using the methods and arrays provided herein.
摘要翻译：本发明提供了分子阵列，其中分子（例如，聚糖）通过可切割接头连接到阵列上。本发明还提供了使用这些阵列的方法，通过使用可切割接头，特别是结合测试样品重要的结构元件来鉴定与这些阵列结合的分子的结构元件的方法。本发明还提供了用于评估测试样品和测试分子是否可以结合阵列上的不同聚糖和使用本文提供的方法和阵列鉴定的有用聚糖的方法。

7. 发明申请

US20050080239A1 Autoantibodies to glucose-6-phosphate isomerase and their participation in autoimmune disease 审中-公开
标题翻译：葡萄糖-6-磷酸异构酶的自身抗体及其参与自身免疫性疾病
公开(公告)号：US20050080239A1
公开(公告)日：2005-04-14
申请号：US10630009
申请日：2003-07-29
申请人： Henrik Ditzel , Dennis Burton , Monica Schaller
发明人： Henrik Ditzel , Dennis Burton , Monica Schaller
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/55
摘要： It has been discovered that one of the causes of human rheumatoid arthritis is an autoimmune reaction to human glucose-6-phosphate isomerase. While human glucose-6-phosphate isomerase is a normal constituent of living tissue, and the underlying reasons for the autoimmune reaction are not understood, this discovery enables effective treatment of the disease, especially when the human immune reaction is the primary cause of the rheumatoid arthritis. The human antibody, anti-glucose-6-phosphate isomerase IgG, can be used to develop immunopolypeptides having binding capacity with the antigen. Antibodies and antibody fragments to the antiglucose-6-phosphate isomerase IgG, antisense oligonucleotides, conjugates of human GPI with cytotoxic agents, immobilized human GPI may be used to ameliorate or eliminate the immune reaction. The peptide, nucleotide products as well as methods of diagnosis and treatment are provided.
摘要翻译：已经发现人类类风湿性关节炎的一个原因是对人类葡萄糖-6-磷酸异构酶的自身免疫反应。虽然人类葡萄糖-6-磷酸异构酶是活组织的正常成分，并且自身免疫反应的根本原因尚不清楚，但是这种发现能够有效治疗疾病，特别是当人类免疫反应是类风湿病的主要原因时关节炎。人抗体，抗葡萄糖-6-磷酸异构酶IgG可用于开发与抗原具有结合能力的免疫多肽。可以使用抗葡萄糖-6-磷酸异构酶IgG，反义寡核苷酸，人GPI与细胞毒性剂的缀合物，固定化的人GPI的抗体和抗体片段来改善或消除免疫反应。提供了肽，核苷酸产物以及诊断和治疗方法。

8. 发明申请

US20050287518A1 Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation 失效
公开(公告)号：US20050287518A1
公开(公告)日：2005-12-29
申请号：US11122795
申请日：2005-05-05
申请人： Klaus Hahn , Alexei Toutchkine , Rajeev Muthyala , Vadim Kraynov , Steven Bark , Dennis Burton , Chester Chamberlain
发明人： Klaus Hahn , Alexei Toutchkine , Rajeev Muthyala , Vadim Kraynov , Steven Bark , Dennis Burton , Chester Chamberlain
IPC分类号： C07K1/107 , C07K1/13 , C12Q1/00 , C07K14/435 , C12Q1/68
CPC分类号： C07K1/1077 , C07K1/13
摘要： The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying the optimum probe attachment site. Biosensors are provided having environmentally sensitive dyes that can locate specific biomolecules within living cells and detect chemical and physiological changes in those biomolecules as the living cell is moving, metabolizing and reacting to its environment. Methods are included for detecting GTP activation of a Rho GTPase protein using polypeptide biosensors. When the biosensor binds GTP-activated Rho GTPase protein, the environmentally sensitive dye emits a signal of a different lifetime, intensity or wavelength than when not bound. New fluorophores whose fluorescence responds to environmental changes are also provided that have improved detection and attachment properties, and that can be used in living cells, or in vitro.

9. 发明申请

US20050003347A1 Domain-exchanged binding molecules, methods of use and methods of production 审中-公开
标题翻译：域交换结合分子，使用方法和生产方法
公开(公告)号：US20050003347A1
公开(公告)日：2005-01-06
申请号：US10838153
申请日：2004-04-30
申请人： Daniel Calarese , Dennis Burton , Ian Wilson
发明人： Daniel Calarese , Dennis Burton , Ian Wilson
IPC分类号： C07K16/00 , C07K16/10 , C12N20060101 , C12Q1/70 , G01N33/53 , G01N33/531 , G01N33/569 , G01N33/574 , G01N33/68
CPC分类号： G01N33/56988 , C07K16/00 , C07K16/1063 , C07K2317/55 , C07K2317/56 , G01N33/53 , G01N33/531 , G01N33/574 , G01N33/6845
摘要： Methods for random or rational design of high affinity domain exchanged binding molecules and methods of use are provided herein. Also provided are libraries containing a plurality of such domain exchanged binding molecules.
摘要翻译：本文提供了高亲和力域交换的结合分子的随机或合理设计方法和使用方法。还提供了含有多个这种结构域交换的结合分子的文库。

10. 发明授权

US07223844B2 Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by Env-CD4-co-receptor complexes 失效
标题翻译：通过Env-CD4共同受体复合物选择的针对人类免疫缺陷病毒的广泛交叉反应性中和抗体
公开(公告)号：US07223844B2
公开(公告)日：2007-05-29
申请号：US10492729
申请日：2002-10-16
申请人： Dimiter S. Dimitrov , Maxime Moulard , Xiadong Xiao , Yuuei Shu , Sanjay K. Phogat , Mei-Yun Zhang , Dennis Burton
发明人： Dimiter S. Dimitrov , Maxime Moulard , Xiadong Xiao , Yuuei Shu , Sanjay K. Phogat , Mei-Yun Zhang , Dennis Burton
IPC分类号： C07K16/00
CPC分类号： C07K16/1063 , A61K2039/505 , C07K14/70514 , C07K2317/21 , C07K2317/55 , C07K2319/00
摘要： The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.
摘要翻译：本发明的特征在于特异性结合CD4诱导型HIV gp120表位的抗体和抗体片段，其通过结合HIV的共受体（例如CCR5或CXCR4）而增强，以及包含抗体或抗体片段的药物组合物。本发明还具有编码抗体或抗体片段的核酸，包含编码抗体或抗体片段的核酸，包含核酸的载体和包含载体的细胞的药物组合物。本发明进一步具有鉴定具有对HIV广泛中和活性的抗体或抗体片段的方法。本发明还涉及使用本发明的抗体和核酸来抑制HIV进入细胞的方法和抑制哺乳动物HIV复制的方法。

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