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1. 发明授权

US08110192B2 Human immunodeficiency virus type 1 (HIV-1)-neutralizing human single-chain antibodies with improved breadth and potency 失效
标题翻译：人类免疫缺陷病毒1型（HIV-1） - 中和人单链抗体具有改善的广度和效力
公开(公告)号：US08110192B2
公开(公告)日：2012-02-07
申请号：US12508913
申请日：2009-07-24
申请人： Dimiter S. Dimitrov , Mei-Yun Zhang
发明人： Dimiter S. Dimitrov , Mei-Yun Zhang
IPC分类号： A61K39/42 , A61K39/21 , C07K16/00 , C12P21/08
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/505 , A61K2039/605 , C07K16/1063 , C07K2317/21 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C12N2740/16134
摘要： The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the HIV co-receptor, and related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions and methods of use to inhibit an infection of a human at risk of becoming infected with HIV, to reduce the severity of an infection of a human infected with HIV, and to treat an infection of a human with HIV.
摘要翻译：本发明提供了可识别一种或多种HIV病毒株的人免疫缺陷病毒（HIV）包膜糖蛋白的抗体，其中所述抗体识别的HIV表位是可诱导的，并且其中结合所述表位的抗体通过存在的CD4和HIV共受体，以及相关融合蛋白，缀合物，核酸，载体，宿主细胞，用于抑制感染HIV风险的人的感染的组合物和方法，以降低HIV感染的严重性感染艾滋病毒的人感染艾滋病毒，并治疗感染艾滋病毒的人。

2. 发明授权

US07803913B2 Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries 失效
标题翻译：使用噬菌体展示文库的顺序抗原淘选来鉴定新的广泛交叉反应性中和人单克隆抗体
公开(公告)号：US07803913B2
公开(公告)日：2010-09-28
申请号：US10513725
申请日：2003-05-06
申请人： Dimiter S Dimitrov , Mei-Yun Zhang
发明人： Dimiter S Dimitrov , Mei-Yun Zhang
IPC分类号： C07K16/00 , A61K39/42
CPC分类号： C12N15/1037 , A61K2039/505 , C07K16/005 , C07K16/1063 , C07K2317/21 , C07K2317/55 , C07K2317/73
摘要： The present invention provides a method of identifying novel broadly crossreactive neutralizing monoclonal antibodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, and inhibit cancer.
摘要翻译：本发明提供了使用噬菌体展示文库，根据这种方法获得的抗体以及包含其的融合蛋白和缀合物以及相关的分离或纯化的核酸分子的序列抗原淘选来鉴定新的广泛交叉反应性中和单克隆抗体的方法，载体，宿主细胞，组合物和用于抑制感染的方法，降低感染的严重性，治疗感染和抑制癌症。

3. 发明申请

US20080038280A1 A32 Monoclonal Antibody Fusion Proteins For Use As Hiv Inhibitors And Vaccines 审中-公开
标题翻译： A32单克隆抗体融合蛋白用作HIV抑制剂和疫苗
公开(公告)号：US20080038280A1
公开(公告)日：2008-02-14
申请号：US11577237
申请日：2005-10-11
申请人： Dimiter Dimitrov , Mei-Yun Zhang
发明人： Dimiter Dimitrov , Mei-Yun Zhang
IPC分类号： A61K39/395 , A61K31/711 , A61P31/18 , C07H21/04 , C07K16/08 , C12N5/06
CPC分类号： C07K14/005 , A61K38/00 , A61K2039/505 , C07K16/1063 , C07K2319/00 , C07K2319/32 , C12N2740/16122
摘要： The invention provides a fusion protein, which comprises an antigen binding portion of an A32 human antibody, or variant thereof, and one of the following: (a) an antigen-binding portion of a second antibody or variant thereof, wherein the second antibody binds to an epitope of an envelope protein of a human immunodeficiency virus (HIV) that is exposed upon the HIV binding to a CD4 receptor, (b) an immunogenic portion of an envelope protein of a HIV, or a variant thereof, or (c) a soluble CD4 (sCD4) polypeptide capable of binding to HIV, or a or variant thereof.
摘要翻译：本发明提供了融合蛋白，其包含A32人抗体或其变体的抗原结合部分，以及以下之一：（a）第二抗体或其变体的抗原结合部分，其中第二抗体结合涉及HIV结合到CD4受体时暴露的人类免疫缺陷病毒（HIV）的包膜蛋白的表位，（b）HIV的包膜蛋白的免疫原性部分或其变体，或（c）能够结合HIV的可溶性CD4（sCD4）多肽或其变体。

4. 发明申请

US20070292390A1 Broadly Cross-Reactive Hiv-1 Neutralizing Human Monoclonal Antibodies 审中-公开
标题翻译：广泛交叉反应性Hiv-1中和人单克隆抗体
公开(公告)号：US20070292390A1
公开(公告)日：2007-12-20
申请号：US11718202
申请日：2005-10-28
申请人： Dimiter Dimitrov , Mei-Yun Zhang
发明人： Dimiter Dimitrov , Mei-Yun Zhang
IPC分类号： A61K39/42 , A61K31/7105 , A61K38/20 , C07K16/08 , C12N15/12 , G01N33/53 , C12N15/63 , C12N1/00 , A61P31/18 , A61K38/21
CPC分类号： C07K16/1063 , A61K2039/505 , C07K2317/21 , C07K2317/55
摘要： The invention provides polypeptides that bind with an epitope of the gp41 subunit of the HIV-1 envelope glycoprotein, as well as polypeptides comprising the aforementioned epitopes. The invention also provides methods of inhibiting an HIV infection in a mammal using the polypeptides of the invention, as well as compositions comprising the polypeptides, nucleic acid molecules encoding the polypeptides, and host cells and vectors comprising the nucleic acid molecules. A method of isolating antibodies that bind with an epitope of the gp41 subunit of the HIV-1 envelope glycoprotein using competitive antigen panning (CAP) is also provided. The invention also features the use of the polypeptides to detect the presence of HIV in a mammal, and epitopes that can be used as vaccine immunogens.
摘要翻译：本发明提供了与HIV-1包膜糖蛋白的gp41亚基的表位结合的多肽，以及包含上述表位的多肽。本发明还提供了使用本发明的多肽抑制哺乳动物HIV感染的方法，以及包含多肽的组合物，编码多肽的核酸分子以及宿主细胞和包含核酸分子的载体。还提供了使用竞争性抗原淘选（CAP）分离与HIV-1包膜糖蛋白的gp41亚基的表位结合的抗体的方法。本发明还特征在于多肽用于检测哺乳动物中HIV的存在，以及可用作疫苗免疫原的表位。

5. 发明授权

US08444982B2 Anti-IGF-IR antibodies and uses thereof 有权
标题翻译：抗IGF-1R抗体及其用途
公开(公告)号：US08444982B2
公开(公告)日：2013-05-21
申请号：US12955627
申请日：2010-11-29
申请人： Mei-Yun Zhang
发明人： Mei-Yun Zhang
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2863 , C07K2317/24
摘要： The subject invention provides antibodies, or binding fragments thereof, that specifically bind to human IGF-IR. Also provided are nucleic acid molecules encoding the antibodies and binding fragments of the subject invention and vectors and host cells containing these nucleic acid molecules. The disclosure also provides methods of inhibiting cancer cell growth and metastasis in a mammal using the antibodies described herein, as well as compositions containing the antibodies, nucleic acid molecules encoding the antibodies, and host cells and vectors comprising the nucleic acid molecules. The disclosure also features the use of the polypeptides to detect the presence of IGF-IR in a mammal, and epitopes that can be used as cancer vaccine immunogens.
摘要翻译：本发明提供特异性结合人IGF-1R的抗体或其结合片段。还提供了编码本发明的抗体和结合片段的核酸分子以及含有这些核酸分子的载体和宿主细胞。本公开还提供使用本文所述的抗体抑制哺乳动物的癌细胞生长和转移的方法，以及含有抗体的组合物，编码抗体的核酸分子以及包含核酸分子的载体细胞和载体。本公开还特征在于使用多肽来检测哺乳动物中IGF-1R的存在，以及可用作癌症疫苗免疫原的表位。

6. 发明申请

US20110135663A1 ANTI-IGF-IR ANTIBODIES AND USES THEREOF 有权
标题翻译：抗IGF-1R抗体及其用途
公开(公告)号：US20110135663A1
公开(公告)日：2011-06-09
申请号：US12955627
申请日：2010-11-29
申请人： MEI-YUN ZHANG
发明人： MEI-YUN ZHANG
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , C07H21/00 , A61K31/7088 , A61P35/00
CPC分类号： C07K16/2863 , C07K2317/24
摘要： The subject invention provides antibodies, or binding fragments thereof, that specifically bind to human IGF-IR. Also provided are nucleic acid molecules encoding the antibodies and binding fragments of the subject invention and vectors and host cells containing these nucleic acid molecules. The disclosure also provides methods of inhibiting cancer cell growth and metastasis in a mammal using the antibodies described herein, as well as compositions containing the antibodies, nucleic acid molecules encoding the antibodies, and host cells and vectors comprising the nucleic acid molecules. The disclosure also features the use of the polypeptides to detect the presence of IGF-IR in a mammal, and epitopes that can be used as cancer vaccine immunogens.
摘要翻译：本发明提供特异性结合人IGF-1R的抗体或其结合片段。还提供了编码本发明的抗体和结合片段的核酸分子以及含有这些核酸分子的载体和宿主细胞。本公开还提供使用本文所述的抗体抑制哺乳动物的癌细胞生长和转移的方法，以及含有抗体的组合物，编码抗体的核酸分子以及包含核酸分子的载体细胞和载体。本公开还特征在于使用多肽来检测哺乳动物中IGF-1R的存在，以及可用作癌症疫苗免疫原的表位。

7. 发明申请

US20100317837A1 IDENTIFICATION OF NOVEL BROADLY CROSS-REACTIVE NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES USING SEQUENTIAL ANTIGEN PANNING OF PHAGE DISPLAY LIBRARIES 审中-公开
标题翻译：使用噬菌体展示图案的序列抗原标记来鉴定新的广泛的交叉反应性中和人类单克隆抗体
公开(公告)号：US20100317837A1
公开(公告)日：2010-12-16
申请号：US12869198
申请日：2010-08-26
申请人： Dimiter S. Dimitrov , Mei-Yun Zhang
发明人： Dimiter S. Dimitrov , Mei-Yun Zhang
IPC分类号： C07K16/10
CPC分类号： C12N15/1037 , A61K2039/505 , C07K16/005 , C07K16/1063 , C07K2317/21 , C07K2317/55 , C07K2317/73
摘要： The present invention provides a method of identifying novel broadly crossreactive neutralizing monoclonal antibodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, and inhibit cancer.
摘要翻译：本发明提供了使用噬菌体展示文库，根据这种方法获得的抗体以及包含其的融合蛋白和缀合物以及相关的分离或纯化的核酸分子的序列抗原淘选来鉴定新的广泛交叉反应性中和单克隆抗体的方法，载体，宿主细胞，组合物和用于抑制感染的方法，降低感染的严重性，治疗感染和抑制癌症。

8. 发明申请

US20090291493A1 HUMAN IMMUNODEFICIENCY VIRUS-NEUTRALIZING ANTIBODIES WITH IMPROVED BREADTH AND POTENCY 失效
标题翻译：人类免疫缺陷病毒 - 中性化抗体与改善的BREADTH和POTENCY
公开(公告)号：US20090291493A1
公开(公告)日：2009-11-26
申请号：US12508913
申请日：2009-07-24
申请人： Dimiter S. Dimtrov , Mei-Yun Zhang
发明人： Dimiter S. Dimtrov , Mei-Yun Zhang
IPC分类号： C12N5/16 , C07H21/04 , C12N15/63
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/505 , A61K2039/605 , C07K16/1063 , C07K2317/21 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C12N2740/16134
摘要： The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the HIV co-receptor, and related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions and methods of use to inhibit an infection of a human at risk of becoming infected with HIV, to reduce the severity of an infection of a human infected with HIV, and to treat an infection of a human with HIV.
摘要翻译：本发明提供了可识别一种或多种HIV病毒株的人免疫缺陷病毒（HIV）包膜糖蛋白的抗体，其中所述抗体识别的HIV表位是可诱导的，并且其中结合所述表位的抗体通过存在的CD4和HIV共受体，以及相关融合蛋白，缀合物，核酸，载体，宿主细胞，用于抑制感染HIV风险的人的感染的组合物和方法，以降低HIV感染的严重性感染艾滋病毒的人感染艾滋病毒，并治疗感染艾滋病毒的人。

9. 发明授权

US07566451B2 Human immunodeficiency virus-neutralizing human antibodies with improved breadth and potency 失效
标题翻译：人类免疫缺陷病毒中和人抗体具有改善的广度和效力
公开(公告)号：US07566451B2
公开(公告)日：2009-07-28
申请号：US10512966
申请日：2003-05-06
申请人： Dimiter S. Dimitrov , Mei-Yun Zhang
发明人： Dimiter S. Dimitrov , Mei-Yun Zhang
IPC分类号： A61K39/42 , A61K39/00 , C12P21/08
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/505 , A61K2039/605 , C07K16/1063 , C07K2317/21 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C12N2740/16134
摘要： The present invention provides an antibody to human immunodeficiency virus (HIV) envelope glycoprotein that can recognize one or more strains of HIV, wherein the epitope of HIV recognized by the antibody is inducible, and wherein the antibody binding to the epitope is enhanced by the presence of CD4 and the HIV co-receptor, and related fusion proteins, conjugates, nucleic acids, vectors, host cells, compositions and methods of use to inhibit an infection of a human at risk of becoming infected with HIV, to reduce the severity of an infection of a human infected with HIV, and to treat an infection of a human with HIV.
摘要翻译：本发明提供了可识别一种或多种HIV病毒株的人免疫缺陷病毒（HIV）包膜糖蛋白的抗体，其中所述抗体识别的HIV表位是可诱导的，并且其中结合所述表位的抗体通过存在的CD4和HIV共受体，以及相关融合蛋白，缀合物，核酸，载体，宿主细胞，用于抑制感染HIV风险的人的感染的组合物和方法，以降低HIV感染的严重性感染艾滋病毒的人感染艾滋病毒，并治疗感染艾滋病毒的人。

10. 发明申请

US20070212363A1 Immunoglobulins with Potent and Broad Antiviral Activity 审中-公开
标题翻译：具有强大和广泛的抗病毒活性的免疫球蛋白
公开(公告)号：US20070212363A1
公开(公告)日：2007-09-13
申请号：US10573962
申请日：2004-09-29
申请人： Dimiter Dimitrov , Mei-Yun Zhang
发明人： Dimiter Dimitrov , Mei-Yun Zhang
IPC分类号： A61K39/42 , C07K16/10 , A61K31/7072 , A61K38/13 , A61K38/20 , C07H21/04 , C12P21/06 , A61K39/21
CPC分类号： A61K38/13 , A61K38/2013 , A61K38/2046 , A61K38/208 , A61K38/21 , A61K39/42 , C07K16/1063 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/30 , Y02A50/394 , A61K2300/00
摘要： A (poly)peptide-Fc fusion molecule, such as an scFv-Fc fusion molecule comprising an scFv fragment and an Fc region from an antibody, related nucleic acids, vectors, and host cells, and a method of inhibiting a viral infection in a mammal, which method comprises administering to a mammal in need thereof the fusion molecule, wherein the fusion molecule binds to an epitope of a viral envelope protein that is inaccessible to whole immunoglobulin molecules due to molecular steric hindrance, or a nucleic acid, optionally in the form of a vector, encoding same, wherein the nucleic acid or vector is optionally contained within a host cell.
摘要翻译：（poly）肽-Fc融合分子，例如包含scFv片段和来自抗体的Fc区的scFv-Fc融合分子，相关核酸，载体和宿主细胞，以及抑制病毒感染的方法哺乳动物，该方法包括向有需要的哺乳动物施用融合分子，其中所述融合分子与病毒包膜蛋白的表位结合，所述表位由于分子空间位阻而导致整个免疫球蛋白分子不可接近，或任选地在载体的形式，编码相同，其中核酸或载体任选地包含在宿主细胞内。

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