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1. 发明申请

US20060240567A1 Method of immobilizing a protein to a zeolite 审中-公开
标题翻译：将蛋白质固定在沸石上的方法
公开(公告)号：US20060240567A1
公开(公告)日：2006-10-26
申请号：US10534162
申请日：2003-11-07
申请人： Stanley Brown , Rune Wendelbo , Sanne Nygaard
发明人： Stanley Brown , Rune Wendelbo , Sanne Nygaard
IPC分类号： G01N33/558
CPC分类号： C07K17/14 , C07K14/001 , C07K19/00 , C07K2319/00
摘要： The present invention relates to a polypeptide tag and a method using said polypeptide tag sequence for immobilizing a protein on a microporous material, said microporous material is selected from the group consisting of zeolite or similar solid surfaces whereby loss of activity of said protein is less than 10% of the initial activity prior to immobilization, the method comprising the steps of: 1. Selecting a polypeptide tag capable of binding to the surface, 2. Immobilizing said protein by the steps of: attaching said polypeptide tag to the protein, and binding said polypeptide tag to the solid surface where step (a) and (b) is performed simultaneously or sequentially and when performed sequentially, the order of step (a) and (b) is random, subject to the limitation that the polypeptide tag does not consist only of histidine residues.
摘要翻译：本发明涉及多肽标签和使用所述多肽标签序列将蛋白质固定在微孔材料上的方法，所述微孔材料选自沸石或类似的固体表面，由此所述蛋白质的活性丧失小于 10％的固定前的初始活性，所述方法包括以下步骤：1.选择能够结合表面的多肽标签; 2.通过以下步骤固定所述蛋白质：将所述多肽标签连接到蛋白质上，并结合所述多肽标签到固体表面，其中步骤（a）和（b）同时或顺序地进行，并且当顺序进行时，步骤（a）和（b）的顺序是随机的，但受限于多肽标签不仅由组氨酸残基组成。

2. 发明授权

US09918577B1 Mail notification system 有权
公开(公告)号：US09918577B1
公开(公告)日：2018-03-20
申请号：US15608639
申请日：2017-05-30
申请人： Stanley Brown
发明人： Stanley Brown
IPC分类号： G08B13/14 , A47G29/122 , G08B5/36
CPC分类号： A47G29/1225 , A47G2029/1226 , G08B5/36 , G08B25/08
摘要： A mail notification system includes an alert unit that is positioned in a mailbox thereby facilitating the alert unit to sense when mail is placed in the mailbox. The alert unit transmits a first alert signal when the mail is placed in the mailbox. A display unit is provided and the display unit is in electrical communication with the alert unit. The display unit transmits a second alert signal when the display unit receives the first alert signal. An electronic device is provided and the electronic device is in wireless electrical communication with the display unit. The electronic device generates an alert when the display unit transmits the second alert signal. In this way the electronic device notifies the user of the mail in the mailbox.

3. 发明申请

US20070161625A1 Wound healing 失效
标题翻译：伤口愈合
公开(公告)号：US20070161625A1
公开(公告)日：2007-07-12
申请号：US11723523
申请日：2007-03-20
申请人： Stanley Brown , Cassandra O'Grady
发明人： Stanley Brown , Cassandra O'Grady
IPC分类号： A61K31/55 , A61K31/5415 , C07D417/14 , C07D417/02
CPC分类号： C09B5/60 , C07D279/28
摘要： A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound to a wound site or the skin, and optionally exposing the wound site or skin to light.
摘要翻译：吩噻嗪鎓化合物，用于促进伤口愈合的组合物和药物，以及通过向伤口部位或皮肤施用或施用吩噻嗪鎓化合物，以及任选地将伤口部位或皮肤暴露于光而促进伤口愈合或化妆品用途的方法。

4. 发明授权

US06518566B1 High-volume specimen block storage system and modular storage receptacle 失效
标题翻译：大容量样品块储存系统和模块化储存容器
公开(公告)号：US06518566B1
公开(公告)日：2003-02-11
申请号：US09715607
申请日：2000-11-20
申请人： Stanley Brown
发明人： Stanley Brown
IPC分类号： H01J502
CPC分类号： G01N35/04 , B01L3/5085 , B01L2300/0609 , G01N1/06 , G01N2035/0425
摘要： A specimen block storage module containing a plurality of shaped cavities into which each of a plurality of specimen blocks “snap”, i.e., are mechanically held in place by structural projections or detents formed on the cavity walls, thus eliminating the possibility of inadvertent dislodgement. Each cavity is indexed, e.g., by letter and number, providing for the rapid, accurate identification of every individual block. Each of the modules has on its undersurface a pressure sensitive adhesive which permits the module to be attached to any appropriate surface; e.g., the inside bottom of a fitted box, or in any combination desired onto a specially-designed, suitably-sized and preferably covered panel that fits into a protective binder (e.g., a standard three-ring binder) for holding a plurality of the panels in the desired order. Many such panels can be stored in a single binder, separated by indexed dividers on which data can be recorded, and, as a consequence of the “snap-in” feature, the binders can be stored in an upright position without the blocks becoming dislodged.
摘要翻译：一个样本块存储模块，其包含多个成形空腔，多个样本块中的每一个“卡扣”，即通过形成在空腔壁上的结构突起或制动器机械地保持就位，从而消除了无意中的移动的可能性。每个空腔例如通过字母和数字进行索引，提供对每个单独块的快速，准确识别。每个模块的下表面都有压敏粘合剂，允许模块连接到任何适当的表面; 例如，装配箱的内部底部，或者任意组合到特别设计的，合适尺寸的和优选的被覆盖的面板上，该面板适合保护粘合剂（例如标准的三环粘合剂），用于保持多个面板按所需顺序。许多这样的面板可以存储在单个的粘合剂中，由可以记录数据的索引的分隔器分隔开，并且作为“卡入”特征的结果，粘合剂可以被保存在直立的位置，而不会妨碍移动。

5. 发明授权

US5316922A Method for indentifying and expressing proteins that recognize and adhere to specific probes 失效
标题翻译：识别和表达识别并粘附于特定探针的蛋白质的方法
公开(公告)号：US5316922A
公开(公告)日：1994-05-31
申请号：US869912
申请日：1992-04-15
申请人： Stanley Brown , Donald Court
发明人： Stanley Brown , Donald Court
IPC分类号： C07K14/00 , C12N15/10 , C12N15/62 , C40B40/02 , G01N33/531 , G01N33/53 , C12Q1/02
CPC分类号： C40B40/02 , C07K14/00 , C12N15/1037 , C12N15/62 , G01N33/531 , C07K2319/00
摘要： This invention provides for improved means to produce binding specific proteins using concatamers of semi-randomly generated oligonucleotides inserted into genes encoding the external domains of bacterial outer membrane proteins. The genes are induced to express and the bacteria are then screened for the ability to bind to predetermined compositions. Those clones carrying the desired binding protein are isolated, cultured and the protein purified. Increased avidity of the binding specific proteins are achieved by reisolating the oligonucleotides which conferred binding affinity and mixing them with new semi-randomly generated oligonucleotides to generate a population enriched for oligonucleotides that had previously conferred to bacteria the desired binding affinity. The enriched population of oligonucleotides is then religated to the gene encoding the external domain of the bacterial protein, the gene is inserted into a bacterial cell and the cells analyzed for increased avidity for the predetermined composition.
摘要翻译：本发明提供了使用插入到编码细菌外膜蛋白的外部结构域的基因的半随机产生寡核苷酸的连接体产生结合特异性蛋白质的改进方法。诱导基因表达，然后筛选细菌以结合预定组合物的能力。分离携带所需结合蛋白的克隆，培养并纯化蛋白质。通过重新分离赋予结合亲和力的寡核苷酸并将其与新的半随机产生的寡核苷酸混合以产生富含以前赋予细菌所需结合亲和力的寡核苷酸的群体来实现结合特异性蛋白质的增加的亲合力。然后将富集的寡核苷酸群重新连接到编码细菌蛋白质的外部结构域的基因，将该基因插入细菌细胞中，分析细胞的预定组成的亲合力。

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