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1. 发明申请

US20110251147A1 Compositions Comprising Quinolone and Methods for Treating or Controlling Infections 审中-公开
标题翻译：组合物包括喹诺酮和治疗或控制感染的方法
公开(公告)号：US20110251147A1
公开(公告)日：2011-10-13
申请号：US13167836
申请日：2011-06-24
申请人： Srini Venkatesh , Hongna Wang , Erning Xia , Matthew S. Jonasse
发明人： Srini Venkatesh , Hongna Wang , Erning Xia , Matthew S. Jonasse
IPC分类号： A61K31/55 , A61K31/7036 , A61P31/12 , A61P31/04 , A61P31/10 , A61K31/7076 , A61K31/7048 , A61K31/551
CPC分类号： A61K31/551 , A61K31/55 , A61K31/553 , A61K31/554 , A61K2300/00
摘要： Compositions for treating or controlling infections comprise a fluoroquinolone having Formulae I-VIII and have a pH in the range from about 3.5 to about 5.5 or from about 10.5 to about 12. Methods for treating or controlling such infection use such compositions. Such compositions and methods can deliver a higher amount of the fluoroquinolone to the affected site.
摘要翻译：用于治疗或控制感染的组合物包含具有式I-VIII的氟喹诺酮，并且pH在约3.5至约5.5或约10.5至约12的范围内。治疗或控制这种感染的方法使用这种组合物。这样的组合物和方法可以将较高量的氟喹诺酮输送到受影响部位。

2. 发明申请

US20080200442A1 Compositions and Methods for Treating, Reducing, Ameliorating, or Preventing Infections of the Ear or Upper Respiratory Tract 审中-公开
标题翻译：治疗，减轻，改善或预防耳朵或上呼吸道感染的组合物和方法
公开(公告)号：US20080200442A1
公开(公告)日：2008-08-21
申请号：US11675930
申请日：2007-02-16
申请人： Srini Venkatesh , Matthew S. Jonasse , Hongna Wang
发明人： Srini Venkatesh , Matthew S. Jonasse , Hongna Wang
IPC分类号： A61K31/33 , A61P11/00
CPC分类号： A61K31/55
摘要： Compositions for treating, reducing, ameliorating, or preventing infection of an ear or upper respiratory tract comprise a fluroquinolone having Formula I, II, or III. Methods for treating, reducing, ameliorating, or preventing such infection use such compositions. Such compositions and methods can be effective against certain antibiotic-resistant microbial pathogens found in such infection.
摘要翻译：用于治疗，减轻，改善或预防耳朵或上呼吸道感染的组合物包含具有式I，II或III的氟喹诺酮。治疗，减轻，改善或预防这种感染的方法使用这种组合物。这种组合物和方法可以有效地抵抗在这种感染中发现的抗生素抗性微生物病原体。

3. 发明申请

US20070142478A1 COMBINATION ANTIMICROBIAL COMPOSITION AND METHOD OF USE 审中-公开
标题翻译：组合抗微生物组合物及其使用方法
公开(公告)号：US20070142478A1
公开(公告)日：2007-06-21
申请号：US11610901
申请日：2006-12-14
申请人： Erning Xia , Hongna Wang , Srini Venkatesh , Pramod Gupta , Norman LaFrance
发明人： Erning Xia , Hongna Wang , Srini Venkatesh , Pramod Gupta , Norman LaFrance
IPC分类号： A61K31/155
CPC分类号： A61K31/155
摘要： Provided herein is a pharmaceutically acceptable composition comprising a biguanide containing antimicrobial agent and an additional antimicrobial agent. The invention further comprises topically administering the pharmaceutically acceptable composition to a patient in need of treatment.
摘要翻译：本文提供了包含含双胍的抗微生物剂和另外的抗微生物剂的药学上可接受的组合物。本发明还包括向需要治疗的患者局部施用药学上可接受的组合物。

4. 发明申请

US20070140897A1 PH STABLE BIGUANIDE COMPOSITION AND METHOD OF TREATMENT AND PREVENTION OF INFECTIONS 审中-公开
标题翻译： PH稳定的双胍组合物和治疗和预防感染的方法
公开(公告)号：US20070140897A1
公开(公告)日：2007-06-21
申请号：US11614504
申请日：2006-12-21
申请人： Hongna Wang , Erning Xia , Srini Venkatesh
发明人： Hongna Wang , Erning Xia , Srini Venkatesh
IPC分类号： A61L2/18
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention includes an ophthalmically acceptable composition for use in the ocular region of a patient, the ophthalmically acceptable composition comprising water, a biguanide containing antimicrobial agent and a pH adjusting agent to adjust the pH to a minimum of 4 and a maximum of 6. The invention further comprises administering the ophthalmically acceptable composition to the eye of a patient in need of treatment.
摘要翻译：本发明包括用于患者眼部区域的眼科可接受的组合物，包含水的眼科可接受的组合物，含双胍的抗微生物剂和pH调节剂，以将pH调节至最小值4和最多6。本发明还包括将眼科可接受的组合物施用于需要治疗的患者的眼睛。

5. 发明申请

US20070134231A1 Method for prolonging activity of autodegradable enzymes and compositions thereof 审中-公开
标题翻译：可延长自可降解酶活性的方法及其组合物
公开(公告)号：US20070134231A1
公开(公告)日：2007-06-14
申请号：US11601389
申请日：2006-11-17
申请人： Dharmendra Jani , Kai Kwok , Gregory McIntire , Bruce Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen Davio
发明人： Dharmendra Jani , Kai Kwok , Gregory McIntire , Bruce Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen Davio
IPC分类号： A61K38/48 , A61K31/198
CPC分类号： C12N9/50 , A61K31/198 , C12N9/6435 , C12N9/96 , C12Y304/21007
摘要： A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.
摘要翻译：长效酶的组合物包含在包含缓冲液和选自氨甲环酸，ε-氨基己酸和除了氨甲环酸和ε-氨基己酸之外的L-赖氨酸的类似物的制剂中的酶，其组合，及其混合物。所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

6. 发明申请

US20100104551A1 METHOD FOR PROLONGING ACTIVITY OF AUTODEGRADABLE ENZYMES AND COMPOSITIONS THEREOF 审中-公开
标题翻译：用于增强可自由可扩链酶活性的方法及其组合物
公开(公告)号：US20100104551A1
公开(公告)日：2010-04-29
申请号：US12603988
申请日：2009-10-22
申请人： Dharmendra M. Jani , Kai Kwok , Gregory L. McIntire , Bruce A. Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen R. Davio
发明人： Dharmendra M. Jani , Kai Kwok , Gregory L. McIntire , Bruce A. Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen R. Davio
IPC分类号： A61K38/48 , A61P27/02
CPC分类号： C12N9/50 , A61K31/198 , C12N9/6435 , C12N9/96 , C12Y304/21007
摘要： A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.
摘要翻译：长效酶的组合物包含在包含缓冲液和添加剂的制剂中的酶，所述缓冲剂和添加剂选自氨甲环酸，氨基己酸和除了氨甲环酸以外的L-赖氨酸和β-氨基己酸酸，其组合，及其混合物。所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

7. 发明授权

US08119112B2 Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid 有权
标题翻译：具有两性表面活性剂和透明质酸的眼科组合物
公开(公告)号：US08119112B2
公开(公告)日：2012-02-21
申请号：US12203384
申请日：2008-09-03
申请人： Erning Xia , Susan E. Burke , Srini Venkatesh , Vicki Barniak
发明人： Erning Xia , Susan E. Burke , Srini Venkatesh , Vicki Barniak
IPC分类号： A61K31/74
CPC分类号： C11D3/48 , A01N33/12 , A01N47/44 , A61K9/0048 , A61K31/155 , A61K31/728 , A61K45/06 , A61L12/14 , A61L12/141 , A61L12/142 , A61L12/143 , C11D1/88 , C11D1/92 , C11D3/0078 , C11D3/227 , C11D3/26 , Y10S514/912 , A01N25/30 , A01N2300/00 , A61K2300/00
摘要： Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 0.15 wt. % of hyaluronic acid; and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
摘要翻译：包含0.1ppm至10ppm的选自双胍类，聚合双胍，季铵化合物及其任何混合物的阳离子抗微生物组分的眼用组合物; 0.005重量％％〜0.15wt。％的透明质酸; 和0.01重量％％〜1.0wt ％的通式I的两性表面活性剂，其中R 1是R或 - （CH 2）n -NHC（O）R，其中R是任选被羟基取代的C 8 -C 16烷基，n是2,3或4; R2和R3各自独立地选自甲基，乙基，丙基或异丙基; 并且R 4是任选被羟基取代的C 2 -C 8亚烷基。本发明还直接涉及使用眼用组合物来清洁和消毒隐形眼镜，特别是柔软的硅酮水凝胶隐形眼镜。

8. 发明授权

US07632794B1 Lens care solutions comprising alkyldimonium hydroxypropyl alkylglucosides 有权
标题翻译：包含烷基二甲基羟丙基烷基葡糖苷的镜片护理溶液
公开(公告)号：US07632794B1
公开(公告)日：2009-12-15
申请号：US12235171
申请日：2008-09-22
申请人： Erning Xia , Kimberly Millard , Srini Venkatesh
发明人： Erning Xia , Kimberly Millard , Srini Venkatesh
IPC分类号： C11D3/22 , C11D1/88 , C11D3/37 , A61L2/18
CPC分类号： A01N43/16 , C11D1/62 , C11D3/0078 , C11D3/48
摘要： A contact lens care solution comprising one or more alkyldimonium hydroxypropyl alkylglucosides of general formula I or general formula II wherein R is a straight or branched C8-C24alkyl; A is —CH2CH(OH)CH2N+(CH3)2R1X−, wherein R1 is a C8-C24alkyl and X− is a common counteranion, n is an average value from 1 to 6 and m is an average value from 1 to 2. The solution is formulated to clean and disinfect contact lenses or the solution is formulated as a rewet eye drop for use with contact lenses.
摘要翻译：一种隐形眼镜护理溶液，其包含一种或多种通式I或通式II的烷基二甲基羟丙基烷基葡糖苷，其中R是直链或支链C 8 -C 24烷基; A是-CH 2 CH（OH）CH 2 N +（CH 3）2 R 1 X-，其中R 1是C 8 -C 24烷基，X是通常的抗衡阴离子，n是1至6的平均值，m是1至2的平均值。配制溶液以对隐形眼镜进行清洁和消毒，或将溶液配制为用于隐形眼镜的再润湿滴眼剂。

9. 发明申请

US20090196846A1 OPHTHALMIC COMPOSITIONS WITH AN AMPHOTERIC SURFACTANT AND HYALURONIC ACID 有权
标题翻译：具有AMPHOTERIC表面活性剂和羟丙酸的眼科组合物
公开(公告)号：US20090196846A1
公开(公告)日：2009-08-06
申请号：US12203384
申请日：2008-09-03
申请人： Erning Xia , Susan E. Burke , Srini Venkatesh , Vicki Barniak
发明人： Erning Xia , Susan E. Burke , Srini Venkatesh , Vicki Barniak
IPC分类号： A01N47/44 , A01P1/00
CPC分类号： C11D3/48 , A01N33/12 , A01N47/44 , A61K9/0048 , A61K31/155 , A61K31/728 , A61K45/06 , A61L12/14 , A61L12/141 , A61L12/142 , A61L12/143 , C11D1/88 , C11D1/92 , C11D3/0078 , C11D3/227 , C11D3/26 , Y10S514/912 , A01N25/30 , A01N2300/00 , A61K2300/00
摘要： Ophthalmic compositions that comprise 0.1 ppm to 10 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 0.15 wt. % of hyaluronic acid; and 0.01 wt. % to 1.0 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C16alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from methyl, ethyl, propyl or iso-propyl; and R4 is a C2-C8alkylene optionally substituted with hydroxyl. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
摘要翻译：包含0.1ppm至10ppm的选自双胍类，聚合双胍，季铵化合物及其任何混合物的阳离子抗微生物组分的眼用组合物; 0.005重量％％〜0.15wt。％的透明质酸; 和0.01重量％％〜1.0wt ％的通式I的两性表面活性剂，其中R 1是R或 - （CH 2）n -NHC（O）R，其中R是任选被羟基取代的C 8 -C 16烷基，n是2,3或4; R2和R3各自独立地选自甲基，乙基，丙基或异丙基; 并且R 4是任选被羟基取代的C 2 -C 8亚烷基。本发明还直接涉及使用眼用组合物来清洁和消毒隐形眼镜，特别是柔软的硅酮水凝胶隐形眼镜。

10. 发明授权

US08664180B2 Ophthalmic compositions containing diglycine 有权
标题翻译：包含二甘氨酸的眼科组合物
公开(公告)号：US08664180B2
公开(公告)日：2014-03-04
申请号：US13366398
申请日：2012-02-06
申请人： Susan E. Burke , Erning Xia , Catherine A. Scheuer , Srini Venkatesh
发明人： Susan E. Burke , Erning Xia , Catherine A. Scheuer , Srini Venkatesh
IPC分类号： A61K38/00 , A61K31/14
CPC分类号： A01N33/12 , A01N37/46 , A01N47/44 , A61L12/142 , A01N55/08
摘要： Ophthalmic composition that includes 0.05% w/v to 2% w/v diglycine or a salt thereof; 0.01 ppm to 3 ppm poly(hexamethylene biguanide); 1 ppm to 10 ppm α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride; and 0.1% w/v to 2% w/v of one or more boron buffering compounds.
摘要翻译：包含0.05％w / v至2％w / v二甘氨酸或其盐的眼用组合物; 0.01ppm至3ppm聚（六亚甲基双胍）; 1ppm至10ppm的α-[4-三（2-羟乙基）氯化铵-2-丁烯基]聚[1-二甲基氯化铵-2-丁烯基] - 三（2-羟乙基）氯化铵; 和0.1％w / v至2％w / v的一种或多种硼缓冲化合物。

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