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1. 发明申请

US20100104551A1 METHOD FOR PROLONGING ACTIVITY OF AUTODEGRADABLE ENZYMES AND COMPOSITIONS THEREOF 审中-公开
标题翻译：用于增强可自由可扩链酶活性的方法及其组合物
公开(公告)号：US20100104551A1
公开(公告)日：2010-04-29
申请号：US12603988
申请日：2009-10-22
申请人： Dharmendra M. Jani , Kai Kwok , Gregory L. McIntire , Bruce A. Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen R. Davio
发明人： Dharmendra M. Jani , Kai Kwok , Gregory L. McIntire , Bruce A. Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen R. Davio
IPC分类号： A61K38/48 , A61P27/02
CPC分类号： C12N9/50 , A61K31/198 , C12N9/6435 , C12N9/96 , C12Y304/21007
摘要： A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.
摘要翻译：长效酶的组合物包含在包含缓冲液和添加剂的制剂中的酶，所述缓冲剂和添加剂选自氨甲环酸，氨基己酸和除了氨甲环酸以外的L-赖氨酸和β-氨基己酸酸，其组合，及其混合物。所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

2. 发明申请

US20070134231A1 Method for prolonging activity of autodegradable enzymes and compositions thereof 审中-公开
标题翻译：可延长自可降解酶活性的方法及其组合物
公开(公告)号：US20070134231A1
公开(公告)日：2007-06-14
申请号：US11601389
申请日：2006-11-17
申请人： Dharmendra Jani , Kai Kwok , Gregory McIntire , Bruce Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen Davio
发明人： Dharmendra Jani , Kai Kwok , Gregory McIntire , Bruce Pfeffer , Afshin Shafiee , Ruiwen Shi , Srini Venkatesh , Hongna Wang , Yan Huang , Stephen Davio
IPC分类号： A61K38/48 , A61K31/198
CPC分类号： C12N9/50 , A61K31/198 , C12N9/6435 , C12N9/96 , C12Y304/21007
摘要： A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.
摘要翻译：长效酶的组合物包含在包含缓冲液和选自氨甲环酸，ε-氨基己酸和除了氨甲环酸和ε-氨基己酸之外的L-赖氨酸的类似物的制剂中的酶，其组合，及其混合物。所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

3. 发明申请

US20080095754A1 OPHTHALMIC COMPOSITIONS COMPRISING DIGLYCINE 审中-公开
标题翻译：包含DIGLYCINE的眼科组合物
公开(公告)号：US20080095754A1
公开(公告)日：2008-04-24
申请号：US11854608
申请日：2007-09-13
申请人： Susan E. Burke , Erning Xia , Kai Kwok , Stephen R. Davio
发明人： Susan E. Burke , Erning Xia , Kai Kwok , Stephen R. Davio
IPC分类号： A61K31/195 , A61K38/40 , A61K38/47 , A61P27/04 , C11D3/48
CPC分类号： A61K31/194 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , C11D3/0078 , C11D3/33 , C11D7/3245
摘要： An ophthalmic composition that includes an epithelium cell stabilizer component. The epithelium cell stabilizer component may be one or more of diglycine, triglycine, tetraglycine, pentaglycine. The invention is also directed to a method of treating or preventing dry eye comprising administering an effective amount of the ophthalmic composition to the eye.
摘要翻译：一种眼科组合物，其包含上皮细胞稳定剂成分。上皮细胞稳定剂组分可以是二甘氨酸，三甘氨酸，四甘氨酸，五聚肌氨酸中的一种或多种。本发明还涉及治疗或预防干眼症的方法，包括向眼睛施用有效量的眼用组合物。

4. 发明申请

US20070102414A1 Steam ironing device 有权
标题翻译：蒸汽熨烫设备
公开(公告)号：US20070102414A1
公开(公告)日：2007-05-10
申请号：US10582908
申请日：2004-12-10
申请人： Yong Jiang , Bas Oosterman , Boon Ching , Kai Kwok , Mohankumar Valiyambath Krishnan
发明人： Yong Jiang , Bas Oosterman , Boon Ching , Kai Kwok , Mohankumar Valiyambath Krishnan
IPC分类号： D06F75/08
CPC分类号： D06F75/22 , D06F75/10 , D06F75/18
摘要： The invention relates to a steam ironing device (1) comprising a water supply device (4), a steam generator (6) for generating steam, heating means (13) for heating the steam generator, at least one atomizating device (10, 15), a valve (11) provided in a flow path (9) between the steam generator and the atomizing device, and an electric pump (5) for delivering water from said water supply device to said steam generator. To obtain wet steam at the atomizing device the ironing device comprises control means (7) for controlling the power of the heating means (13) of the steam generator, for controlling the flow rate of the pump, and for controlling the opening and closing of said valve, said valve being open if the ratio between the flow rate (g/min) of the pump and the power (W) of the heating means is in a range of 1:20 to 1:38.
摘要翻译：本发明涉及一种蒸汽熨烫装置（1），包括供水装置（4），用于产生蒸汽的蒸汽发生器（6），用于加热蒸汽发生器的加热装置（13），至少一个雾化装置），设置在蒸汽发生器和雾化装置之间的流路（9）中的阀（11）和用于将水从所述供水装置输送到所述蒸汽发生器的电动泵（5）。为了在雾化装置获得湿蒸汽，熨烫装置包括用于控制蒸汽发生器的加热装置（13）的功率的控制装置（7），用于控制泵的流量，并且用于控制泵的打开和关闭所述阀，如果泵的流量（g / min）与加热装置的功率（W）之间的比率在1:20至1:38的范围内，则阀门打开。

5. 发明申请

US20060186112A1 Domestic appliance and heating structure for a domestic appliance 有权
标题翻译：家用电器和家用电器的供暖结构
公开(公告)号：US20060186112A1
公开(公告)日：2006-08-24
申请号：US10566553
申请日：2004-07-22
申请人： Mokankumar Valiyambath Krishnan , Kai Kwok , Gerard Cnossen
发明人： Mokankumar Valiyambath Krishnan , Kai Kwok , Gerard Cnossen
IPC分类号： H05B1/02
CPC分类号： H05B1/0213 , D06F75/26 , H05B1/0269
摘要： An electric heating structure of a domestic appliance includes at least one first electric heating track (23) having a positive temperature coefficient and at least one additional electric heating track (27, 28). A control structure (22, 25, 29) is provided for controlling electric power supply to said first and additional heating tracks (23, 27, 28) and is sensitive to the heating of said at least one first heating track (23) for switching on said at least one additional electric heating track (27, 28) in parallel and in addition to said at least one first heating track (23) when said at least one first heating track (23) has been heated to at least a predetermined extent.
摘要翻译：家用电器的电加热结构包括至少一个具有正温度系数的第一电加热轨道（23）和至少一个附加电加热轨道（27,28）。提供控制结构（22,25,29），用于控制对所述第一和另外的加热轨道（23,27,28）的电力供应，并且对所述至少一个第一加热轨道（23）的加热敏感，用于切换在所述至少一个附加电加热轨道（27,28）上并联并且当所述至少一个第一加热轨道（23）已经被加热到至少预定的程度时，除了所述至少一个第一加热轨道（23）。

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